Details of the Target

General Information of Target

Target ID LDTP14421
Target Name Ladinin-1 (LAD1)
Gene Name LAD1
Gene ID 3898
Synonyms
LAD; Ladinin-1; Lad-1; Linear IgA disease antigen; LADA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPKNKKRNTPHRGSSAGGGGSGAAAATAATAGGQHRNVQPFSDEDASIETMSHCSGYSDP
SSFAEDGPEVLDEEGTQEDLEYKLKGLIDLTLDKSAKTRQAALEGIKNALASKMLYEFIL
ERRMTLTDSIERCLKKGKSDEQRAAAALASVLCIQLGPGIESEEILKTLGPILKKIICDG
SASMQARQTCATCFGVCCFIATDDITELYSTLECLENIFTKSYLKEKDTTVICSTPNTVL
HISSLLAWTLLLTICPINEVKKKLEMHFHKLPSLLSCDDVNMRIAAGESLALLFELARGI
ESDFFYEDMESLTQMLRALATDGNKHRAKVDKRKQRSVFRDVLRAVEERDFPTETIKFGP
ERMYIDCWVKKHTYDTFKEVLGSGMQYHLQSNEFLRNVFELGPPVMLDAATLKTMKISRF
ERHLYNSAAFKARTKARSKCRDKRADVGEFF
Target Bioclass
Other
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function Anchoring filament protein which is a component of the basement membrane zone.
Uniprot ID
O00515
Ensemble ID
ENST00000391967.7
HGNC ID
HGNC:6472

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		5.82  LDD0326  [1]
C-Sul
 Probe Info  		31.37  LDD0066  [2]
AZ-9
 Probe Info  		E116(1.37)  LDD2209  [3]
IPM
 Probe Info  		N.A.  LDD0241  [4]
Probe 1
 Probe Info  		Y362(83.92)  LDD3495  [5]
DBIA
 Probe Info  		C428(0.96)  LDD0531  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [7]
PF-06672131
 Probe Info  		N.A.  LDD0017  [8]
W1
 Probe Info  		N.A.  LDD0236  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C428(0.96)  LDD0531  [6]
 LDCM0216  AC100 HCT 116 C428(0.93)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C428(0.92)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C428(0.84)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C428(1.12)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C428(0.95)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C428(0.97)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C428(0.95)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C428(0.95)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C428(0.83)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C428(0.81)  LDD0542  [6]
 LDCM0227  AC110 HCT 116 C428(0.81)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C428(1.01)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C428(1.13)  LDD0546  [6]
 LDCM0246  AC128 HCT 116 C428(1.10)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C428(0.93)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C428(1.03)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C428(1.32)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C428(0.72)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C428(0.87)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C428(1.04)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C428(0.85)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C428(0.93)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C428(0.73)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C428(0.72)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C428(0.86)  LDD0575  [6]
 LDCM0260  AC140 HCT 116 C428(0.89)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C428(0.87)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C428(0.74)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C428(1.14)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C428(0.97)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C428(1.04)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C428(1.15)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C428(0.76)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C428(0.74)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C428(1.16)  LDD0586  [6]
 LDCM0271  AC150 HCT 116 C428(1.01)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C428(1.30)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C428(1.08)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C428(0.49)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C428(1.24)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C428(0.92)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C428(1.05)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C428(1.06)  LDD2161  [6]
 LDCM0279  AC2 HCT 116 C428(1.12)  LDD0596  [6]
 LDCM0290  AC3 HCT 116 C428(1.00)  LDD0607  [6]
 LDCM0301  AC4 HCT 116 C428(0.94)  LDD0618  [6]
 LDCM0312  AC5 HCT 116 C428(0.84)  LDD0629  [6]
 LDCM0320  AC57 HCT 116 C428(1.05)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C428(1.06)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C428(1.00)  LDD0639  [6]
 LDCM0324  AC60 HCT 116 C428(1.18)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C428(0.87)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C428(1.04)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C428(1.30)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C428(1.13)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C428(1.10)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C428(1.08)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C428(1.07)  LDD0648  [6]
 LDCM0365  AC98 HCT 116 C428(1.32)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C428(0.87)  LDD0683  [6]
 LDCM0020  ARS-1620 HCC44 C428(1.17)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C428(2.03)  LDD2227  [9]
 LDCM0369  CL100 HCT 116 C428(1.06)  LDD0686  [6]
 LDCM0396  CL125 HCT 116 C428(1.25)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C428(1.32)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C428(1.11)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C428(0.97)  LDD0716  [6]
 LDCM0436  CL46 HCT 116 C428(1.38)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C428(1.32)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C428(0.97)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C428(1.18)  LDD0756  [6]
 LDCM0441  CL50 HCT 116 C428(1.11)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C428(0.91)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C428(0.91)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C428(0.97)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C428(1.27)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C428(1.14)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C428(1.54)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C428(1.17)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C428(1.03)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C428(1.18)  LDD0767  [6]
 LDCM0452  CL60 HCT 116 C428(1.89)  LDD0769  [6]
 LDCM0486  CL91 HCT 116 C428(1.08)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C428(1.01)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C428(1.13)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C428(1.31)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C428(0.94)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C428(1.08)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C428(1.01)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C428(1.00)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C428(1.11)  LDD0811  [6]
 LDCM0021  THZ1 HCT 116 C428(1.17)  LDD2173  [6]
 LDCM0111  W14 Hep-G2 C428(23.04)  LDD0238  [4]
 LDCM0113  W17 Hep-G2 C428(12.29)  LDD0240  [4]

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
8 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264