Details of the Target

General Information of Target

Target ID LDTP00777
Target Name Prominin-1 (PROM1)
Gene Name PROM1
Gene ID 8842
Synonyms
PROML1; Prominin-1; Antigen AC133; Prominin-like protein 1; CD antigen CD133
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALVLGSLLLLGLCGNSFSGGQPSSTDAPKAWNYELPATNYETQDSHKAGPIGILFELVH
IFLYVVQPRDFPEDTLRKFLQKAYESKIDYDKPETVILGLKIVYYEAGIILCCVLGLLFI
ILMPLVGYFFCMCRCCNKCGGEMHQRQKENGPFLRKCFAISLLVICIIISIGIFYGFVAN
HQVRTRIKRSRKLADSNFKDLRTLLNETPEQIKYILAQYNTTKDKAFTDLNSINSVLGGG
ILDRLRPNIIPVLDEIKSMATAIKETKEALENMNSTLKSLHQQSTQLSSSLTSVKTSLRS
SLNDPLCLVHPSSETCNSIRLSLSQLNSNPELRQLPPVDAELDNVNNVLRTDLDGLVQQG
YQSLNDIPDRVQRQTTTVVAGIKRVLNSIGSDIDNVTQRLPIQDILSAFSVYVNNTESYI
HRNLPTLEEYDSYWWLGGLVICSLLTLIVIFYYLGLLCGVCGYDRHATPTTRGCVSNTGG
VFLMVGVGLSFLFCWILMIIVVLTFVFGANVEKLICEPYTSKELFRVLDTPYLLNEDWEY
YLSGKLFNKSKMKLTFEQVYSDCKKNRGTYGTLHLQNSFNISEHLNINEHTGSISSELES
LKVNLNIFLLGAAGRKNLQDFAACGIDRMNYDSYLAQTGKSPAGVNLLSFAYDLEAKANS
LPPGNLRNSLKRDAQTIKTIHQQRVLPIEQSLSTLYQSVKILQRTGNGLLERVTRILASL
DFAQNFITNNTSSVIIEETKKYGRTIIGYFEHYLQWIEFSISEKVASCKPVATALDTAVD
VFLCSYIIDPLNLFWFGIGKATVFLLPALIFAVKLAKYYRRMDSEDVYDDVETIPMKNME
NGNNGYHKDHVYGIHNPVMTSPSQH
Target Type
Clinical trial
Target Bioclass
Transporter and channel
Family
Prominin family
Subcellular location
Apical cell membrane
Function
May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner.
TTD ID
T37434
Uniprot ID
O43490
DrugMap ID
TTXMZ81
Ensemble ID
ENST00000447510.7
HGNC ID
HGNC:9454

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.D200V .
AU565 SNV: p.Q755K .
CALU1 SNV: p.S232I DBIA    Probe Info 
COLO792 SNV: p.F722S .
CORL23 SNV: p.E210K .
HUH1 SNV: p.I121F .
IM95 SNV: p.G568D .
LS180 SNV: p.A613T .
NALM6 SNV: p.P425H .
NCIH2291 Deletion: p.V813Ter
SNV: p.Q864E		 .
NUGC3 SNV: p.S561N .
SUDHL4 SNV: p.S328G .
SW1271 SNV: p.Y453F .
TE4 SNV: p.L436V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TG42
 Probe Info  		16.29  LDD0326  [1]
DBIA
 Probe Info  		C624(2.85)  LDD3368  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Calu-1 C139(3.28)  LDD2292  [2]
 LDCM0023  KB03 Calu-1 C139(3.22)  LDD2709  [2]
 LDCM0024  KB05 OAW-28 C624(2.85)  LDD3368  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone deacetylase 6 (HDAC6) Histone deacetylase family Q9UBN7

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Anti-cd133-car Vector-transduced T Cells CAR T Cell Therapy D09HRH
Ict-121 Vaccine D09NBH
Preclinical
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Car-t Cells Targeting Cd133 CAR T Cell Therapy D04JSI

References

1 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840