Details of the Target

General Information of Target

Target ID LDTP09719
Target Name Progesterone-induced-blocking factor 1 (PIBF1)
Gene Name PIBF1
Gene ID 10464
Synonyms
C13orf24; PIBF; Progesterone-induced-blocking factor 1; PIBF; Centrosomal protein of 90 kDa; CEP90
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRKISKESKKVNISSSLESEDISLETTVPTDDISSSEEREGKVRITRQLIERKELLHNI
QLLKIELSQKTMMIDNLKVDYLTKIEELEEKLNDALHQKQLLTLRLDNQLAFQQKDASKY
QELMKQEMETILLRQKQLEETNLQLREKAGDVRRNLRDFELTEEQYIKLKAFPEDQLSIP
EYVSVRFYELVNPLRKEICELQVKKNILAEELSTNKNQLKQLTETYEEDRKNYSEVQIRC
QRLALELADTKQLIQQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERS
ELSKEVVTLEQTVTLLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYE
KYVASRDHYKTEYENKLHDELEQIRLKTNQEIDQLRNASREMYERENRNLREARDNAVAE
KERAVMAEKDALEKHDQLLDRYRELQLSTESKVTEFLHQSKLKSFESERVQLLQEETARN
LTQCQLECEKYQKKLEVLTKEFYSLQASSEKRITELQAQNSEHQARLDIYEKLEKELDEI
IMQTAEIENEDEAERVLFSYGYGANVPTTAKRRLKQSVHLARRVLQLEKQNSLILKDLEH
RKDQVTQLSQELDRANSLLNQTQQPYRYLIESVRQRDSKIDSLTESIAQLEKDVSNLNKE
KSALLQTKNQMALDLEQLLNHREELAAMKQILVKMHSKHSENSLLLTKTEPKHVTENQKS
KTLNVPKEHEDNIFTPKPTLFTKKEAPEWSKKQKMKT
Target Bioclass
Other
Subcellular location
Secreted; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Plays a role in ciliogenesis.; [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity. Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation. Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2.; [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect. Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein.
Uniprot ID
Q8WXW3
Ensemble ID
ENST00000326291.11
HGNC ID
HGNC:23352

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1937 Deletion: .
SNV: p.S20F		 .
HT SNV: p.Q483P .
JURKAT Insertion: p.L495IfsTer10 .
MDST8 SNV: p.S300G DBIA    Probe Info 
MEWO SNV: p.K318N .
NCIH1793 SNV: p.E611Q .
NCIH716 SNV: p.Y491N .
SISO SNV: p.E550K .
TCCSUP SNV: p.S15C .
TOV21G SNV: p.K318R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C199(2.02)  LDD0080  [1]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C313
 Probe Info  		12.38  LDD1980  [2]
C362
 Probe Info  		26.17  LDD2023  [2]
C397
 Probe Info  		10.06  LDD2056  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C484(1.28); C488(1.28)  LDD1093  [1]
 LDCM0215  AC10 HCT 116 C484(1.01); C488(1.01)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C484(1.02)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C484(0.90)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C484(1.33)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C484(1.18)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C484(1.27)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C484(0.86)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C484(0.94)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C484(1.24)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C484(1.03)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C484(0.98)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C484(0.96); C488(0.96)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C484(1.78)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C484(2.14)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C484(1.90)  LDD0827  [1]
 LDCM0230  AC113 HCT 116 C484(0.90); C488(0.90)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C484(0.72); C488(0.72)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C484(0.82); C488(0.82)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C484(0.84); C488(0.84)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C484(0.83); C488(0.83)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C484(0.82); C488(0.82)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C484(0.85); C488(0.85)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C484(1.15); C488(1.15)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C484(0.65); C488(0.65)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C484(0.85); C488(0.85)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C484(1.00); C488(1.00)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C484(0.89); C488(0.89)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C484(0.79); C488(0.79)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C484(0.89); C488(0.89)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C484(0.92); C488(0.92)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C484(0.89); C488(0.89)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C484(1.44); C488(1.44)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C484(0.97); C488(0.97)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C484(1.29); C488(1.29)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C484(1.00); C488(1.00)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C484(1.02); C488(1.02)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C484(1.22); C488(1.22)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C484(1.42); C488(1.42)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C484(1.27); C488(1.27)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C484(1.07); C488(1.07)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C484(0.98); C488(0.98)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C484(1.30); C488(1.30)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C484(1.39); C488(1.39)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C484(1.12); C488(1.12)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C484(1.15); C488(1.15)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C484(1.15); C488(1.15)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C484(1.34); C488(1.34)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C484(0.89); C488(0.89)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C488(0.94); C484(1.07)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C488(0.83); C484(0.87)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C484(0.92); C488(0.95)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C488(0.88); C484(0.92)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C488(1.00); C484(1.28)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C488(1.01); C484(1.29)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C484(0.91); C488(0.91)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C488(0.85); C484(0.94)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C488(0.82); C484(0.88)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C484(1.01); C488(1.12)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C488(1.32); C484(1.48)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C484(0.99); C488(0.93)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C484(0.94); C488(1.08)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C484(0.99); C488(0.96)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C484(0.99); C488(0.94)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C484(0.72); C488(0.72)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C484(0.60); C488(0.60)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C484(0.68); C488(0.68)  LDD0595  [1]
 LDCM0279  AC2 PaTu 8988t C484(0.95); C488(0.95)  LDD1158  [1]
 LDCM0280  AC20 HCT 116 C484(0.70); C488(0.70)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C484(0.90); C488(0.90)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C484(1.07); C488(1.07)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C484(1.07); C488(1.07)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C484(0.76); C488(0.76)  LDD0601  [1]
 LDCM0285  AC25 HCT 116 C484(0.85); C488(0.85)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C484(0.81); C488(0.81)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C484(0.77); C488(0.77)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C484(0.68); C488(0.68)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C484(0.78); C488(0.78)  LDD0606  [1]
 LDCM0290  AC3 PaTu 8988t C484(0.88); C488(0.88)  LDD1169  [1]
 LDCM0291  AC30 HCT 116 C484(0.65); C488(0.65)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C484(0.79); C488(0.79)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C484(0.73); C488(0.73)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C484(0.72); C488(0.72)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C484(0.77); C488(0.77)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C484(1.02); C488(1.02)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C484(0.93); C488(0.93)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C484(0.98); C488(0.98)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C484(0.93); C488(0.93)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C484(0.95); C488(0.95)  LDD0617  [1]
 LDCM0301  AC4 PaTu 8988t C484(0.80); C488(0.80)  LDD1180  [1]
 LDCM0302  AC40 HCT 116 C484(1.08); C488(1.08)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C484(1.03); C488(1.03)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C484(0.94); C488(0.94)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C484(1.26); C488(1.26)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C484(1.11); C488(1.11)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C484(1.23); C488(1.23)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C484(1.01); C488(1.01)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C484(1.05); C488(1.05)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C484(1.60); C488(1.60)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C484(1.41); C488(1.41)  LDD0628  [1]
 LDCM0312  AC5 PaTu 8988t C484(1.04); C488(1.04)  LDD1191  [1]
 LDCM0313  AC50 HCT 116 C484(1.43); C488(1.43)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C484(1.12); C488(1.12)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C484(1.04); C488(1.04)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C484(1.22); C488(1.22)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C484(1.15); C488(1.15)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C484(1.51); C488(1.51)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C484(2.11); C488(2.11)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C484(0.67); C488(0.67)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C484(0.83); C488(0.83)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C484(0.76); C488(0.76)  LDD0639  [1]
 LDCM0323  AC6 HCT 116 C484(0.96); C488(0.96)  LDD0640  [1]
 LDCM0324  AC60 HCT 116 C484(0.69); C488(0.69)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C484(0.80); C488(0.80)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C484(0.82); C488(0.82)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C484(0.73); C488(0.73)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C484(0.88); C488(0.88)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C484(0.69); C488(0.69)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C484(0.59); C488(0.59)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C484(0.76); C488(0.76)  LDD0648  [1]
 LDCM0334  AC7 HCT 116 C484(1.04); C488(1.04)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C484(0.88); C488(0.88)  LDD0662  [1]
 LDCM0349  AC83 HCT 116 C484(1.02); C488(1.02)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C484(0.83); C488(0.83)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C484(0.72); C488(0.72)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C484(0.72); C488(0.72)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C484(0.89); C488(0.89)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C484(0.65); C488(0.65)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C484(0.82); C488(0.82)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C484(1.15); C488(1.15)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C484(1.13); C488(1.13)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C484(0.96); C488(0.96)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C484(0.65); C488(0.65)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C484(0.73); C488(0.73)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C484(1.41); C488(1.41)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C484(0.79); C488(0.79)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C484(0.74); C488(0.74)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C484(0.95)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C484(0.82)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C484(1.07); C488(1.07)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C484(0.98); C488(0.98)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C484(1.35); C488(1.35)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C484(1.61); C488(1.61)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C484(1.57); C488(1.57)  LDD0685  [1]
 LDCM0369  CL100 PaTu 8988t C484(1.03); C488(1.03)  LDD1248  [1]
 LDCM0370  CL101 HCT 116 C484(1.12); C488(1.12)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C484(1.05); C488(1.05)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C484(1.54); C488(1.54)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C484(1.06); C488(1.06)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C484(0.79); C488(0.79)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C484(1.00); C488(1.00)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C484(0.75); C488(0.75)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C484(0.79); C488(0.79)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C484(0.83); C488(0.83)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C484(1.65); C488(1.65)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C484(0.95); C488(0.95)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C484(0.82); C488(0.82)  LDD0698  [1]
 LDCM0382  CL112 HCT 116 C484(1.05); C488(1.05)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C484(0.69); C488(0.69)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C484(1.09); C488(1.09)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C484(0.78); C488(0.78)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C484(0.76); C488(0.76)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C484(1.56); C488(1.56)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C484(1.10); C488(1.10)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C484(1.16); C488(1.16)  LDD0706  [1]
 LDCM0390  CL12 HCT 116 C484(1.69); C488(1.69)  LDD0707  [1]
 LDCM0391  CL120 HCT 116 C484(1.18); C488(1.18)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C484(2.31); C488(2.31)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C484(1.04); C488(1.04)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C484(1.65); C488(1.65)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C484(1.40); C488(1.40)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C484(0.77); C488(0.77)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C484(0.69); C488(0.69)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C484(0.71); C488(0.71)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C484(0.75); C488(0.75)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C484(1.33); C488(1.33)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C484(1.43); C488(1.43)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C484(2.01); C488(2.01)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C484(0.80); C488(0.80)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C484(1.17); C488(1.17)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C484(1.51); C488(1.51)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C484(1.09); C488(1.09)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C484(1.11); C488(1.11)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C484(0.98); C488(0.98)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C484(1.24); C488(1.24)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C484(1.87); C488(1.87)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C484(0.94); C488(0.94)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C484(1.15); C488(1.15)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C484(1.10); C488(1.10)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C484(0.83); C488(0.83)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C484(1.00); C488(1.00)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C484(1.30); C488(1.30)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C484(1.02); C488(1.02)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C484(1.03); C488(1.03)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C484(0.86); C488(0.86)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C484(1.14)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C484(1.11)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C484(1.39)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C484(1.32)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C484(1.40)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C484(1.18)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C484(1.17)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C484(1.88)  LDD1026  [1]
 LDCM0429  CL4 HCT 116 C484(1.07); C488(1.07)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C484(1.21)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C484(1.57)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C484(1.99)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C484(1.77)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C484(1.31)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C484(1.77)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C484(1.14); C488(1.14)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C484(0.93); C488(0.93)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C484(1.23); C488(1.23)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C484(0.98); C488(0.98)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C484(1.13); C488(1.13)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C484(1.18); C488(1.18)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C484(1.04); C488(1.04)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C484(1.13); C488(1.13)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C484(0.97); C488(0.97)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C484(1.10); C488(1.10)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C484(1.03); C488(1.03)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C484(0.84); C488(0.84)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C484(1.42); C488(1.42)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C484(1.07); C488(1.07)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C484(0.98); C488(0.98)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C484(1.47); C488(1.47)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C484(0.95); C488(0.95)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C484(0.97); C488(0.97)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C484(0.96); C488(0.96)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C484(0.93); C488(0.93)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C484(1.14); C488(1.14)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C484(0.86); C488(0.86)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C484(1.08); C488(1.08)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C484(0.98); C488(0.98)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C484(1.02); C488(1.02)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C484(2.12); C488(2.12)  LDD0778  [1]
 LDCM0462  CL7 HCT 116 C484(1.35); C488(1.35)  LDD0779  [1]
 LDCM0463  CL70 HCT 116 C484(1.06); C488(1.06)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C484(0.95); C488(0.95)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C484(0.92); C488(0.92)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C484(1.00); C488(1.00)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C484(0.99); C488(0.99)  LDD0784  [1]
 LDCM0469  CL76 HCT 116 C484(1.23); C488(1.23)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C484(1.12); C488(1.12)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C484(0.89); C488(0.89)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C484(1.13); C488(1.13)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C484(1.76); C488(1.76)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C484(1.64); C488(1.64)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C484(0.92); C488(0.92)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C484(1.39); C488(1.39)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C484(1.16); C488(1.16)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C484(1.54); C488(1.54)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C484(0.85); C488(0.85)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C484(0.75); C488(0.75)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C484(0.85); C488(0.85)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C484(1.23); C488(1.23)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C484(1.85); C488(1.85)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C484(1.19); C488(1.19)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C484(1.08); C488(1.08)  LDD0802  [1]
 LDCM0486  CL91 PaTu 8988t C484(0.95); C488(0.95)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C484(1.05); C488(1.05)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C484(0.97); C488(0.97)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C484(0.89); C488(0.89)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C484(1.17); C488(1.17)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C484(1.20); C488(1.20)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C484(0.98); C488(0.98)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C484(1.37); C488(1.37)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C484(0.89); C488(0.89)  LDD1373  [1]
 LDCM0495  E2913 HEK-293T C199(0.87)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C484(1.08); C488(1.08)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C484(1.40)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C199(2.02)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C199(1.57)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C199(2.30)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 63 kDa (CEP63) CEP63 family Q96MT8

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402