Details of the Target

General Information of Target

Target ID LDTP13846
Target Name Nuclease EXOG, mitochondrial (EXOG)
Gene Name EXOG
Gene ID 9941
Synonyms
ENDOGL1; ENDOGL2; ENGL; Nuclease EXOG, mitochondrial; EC 3.1.30.-; Endonuclease G-like 1; Endo G-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFPKMRLMYICLLVLGALCLYFSMYSLNPFKEQSFVYKKDGNFLKLPDTDCRQTPPFLV
LLVTSSHKQLAERMAIRQTWGKERMVKGKQLKTFFLLGTTSSAAETKEVDQESQRHGDII
QKDFLDVYYNLTLKTMMGIEWVHRFCPQAAFVMKTDSDMFINVDYLTELLLKKNRTTRFF
TGFLKLNEFPIRQPFSKWFVSKSEYPWDRYPPFCSGTGYVFSGDVASQVYNVSKSVPYIK
LEDVFVGLCLERLNIRLEELHSQPTFFPGGLRFSVCLFRRIVACHFIKPRTLLDYWQALE
NSRGEDCPPV
Target Bioclass
Enzyme
Family
DNA/RNA non-specific endonuclease family
Subcellular location
Mitochondrion inner membrane
Function Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
Uniprot ID
Q9Y2C4
Ensemble ID
ENST00000287675.10
HGNC ID
HGNC:3347

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MEWO SNV: p.S295F DBIA    Probe Info 
SUDHL6 SNV: p.H283R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C76(2.40)  LDD3383  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C397
 Probe Info  		56.49  LDD2056  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C76(1.16)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C76(1.08)  LDD1508  [7]
 LDCM0270  AC15 HEK-293T C76(0.74)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C76(0.98)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C76(1.13)  LDD1516  [7]
 LDCM0279  AC2 HEK-293T C76(1.12)  LDD1518  [7]
 LDCM0281  AC21 HEK-293T C76(1.01)  LDD1520  [7]
 LDCM0283  AC23 HEK-293T C76(0.79)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C76(0.94)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C76(1.07)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C76(0.95)  LDD1525  [7]
 LDCM0289  AC29 HEK-293T C76(1.00)  LDD1528  [7]
 LDCM0292  AC31 HEK-293T C76(0.82)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C76(0.88)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C76(1.08)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C76(1.17)  LDD1534  [7]
 LDCM0298  AC37 HEK-293T C76(1.03)  LDD1537  [7]
 LDCM0300  AC39 HEK-293T C76(1.17)  LDD1539  [7]
 LDCM0302  AC40 HEK-293T C76(1.02)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C76(0.96)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C76(0.98)  LDD1543  [7]
 LDCM0307  AC45 HEK-293T C76(0.84)  LDD1546  [7]
 LDCM0309  AC47 HEK-293T C76(1.04)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C76(0.97)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C76(1.01)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C76(0.93)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C76(0.90)  LDD1552  [7]
 LDCM0316  AC53 HEK-293T C76(0.78)  LDD1555  [7]
 LDCM0318  AC55 HEK-293T C76(0.86)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C76(0.91)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C76(0.95)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C76(1.33)  LDD1560  [7]
 LDCM0325  AC61 HEK-293T C76(1.00)  LDD1564  [7]
 LDCM0327  AC63 HEK-293T C76(0.72)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C76(1.15)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C76(0.90)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C76(1.06)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C76(0.88)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C76(0.92)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C76(0.94)  LDD1514  [7]
 LDCM0367  CL1 HEK-293T C76(0.90)  LDD1571  [7]
 LDCM0370  CL101 HEK-293T C76(1.13)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C76(0.85)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C76(1.03)  LDD1576  [7]
 LDCM0374  CL105 HEK-293T C76(1.06)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C76(0.86)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C76(1.03)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C76(1.22)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C76(1.10)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C76(0.97)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C76(1.02)  LDD1585  [7]
 LDCM0383  CL113 HEK-293T C76(1.21)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C76(1.15)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C76(1.03)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C76(1.31)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C76(0.91)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C76(1.28)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C76(1.06)  LDD1594  [7]
 LDCM0392  CL121 HEK-293T C76(1.03)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C76(0.89)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C76(1.15)  LDD1598  [7]
 LDCM0396  CL125 HEK-293T C76(1.09)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C76(0.89)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C76(0.91)  LDD1602  [7]
 LDCM0400  CL13 HEK-293T C76(1.20)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C76(0.85)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C76(0.98)  LDD1606  [7]
 LDCM0404  CL17 HEK-293T C76(0.94)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C76(0.97)  LDD1609  [7]
 LDCM0407  CL2 HEK-293T C76(0.99)  LDD1611  [7]
 LDCM0409  CL21 HEK-293T C76(0.88)  LDD1613  [7]
 LDCM0411  CL23 HEK-293T C76(0.91)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C76(0.79)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C76(1.02)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C76(0.86)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C76(0.92)  LDD1619  [7]
 LDCM0417  CL29 HEK-293T C76(0.85)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C76(1.06)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C76(0.94)  LDD1623  [7]
 LDCM0422  CL33 HEK-293T C76(0.71)  LDD1626  [7]
 LDCM0424  CL35 HEK-293T C76(0.70)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C76(0.84)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C76(1.33)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C76(1.21)  LDD1632  [7]
 LDCM0431  CL41 HEK-293T C76(1.18)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C76(1.01)  LDD1636  [7]
 LDCM0435  CL45 HEK-293T C76(0.76)  LDD1639  [7]
 LDCM0437  CL47 HEK-293T C76(0.74)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C76(0.84)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C76(1.01)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C76(0.93)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C76(0.99)  LDD1645  [7]
 LDCM0444  CL53 HEK-293T C76(1.02)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C76(1.33)  LDD1648  [7]
 LDCM0448  CL57 HEK-293T C76(0.85)  LDD1651  [7]
 LDCM0450  CL59 HEK-293T C76(1.19)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C76(1.55)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C76(0.92)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C76(1.02)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C76(0.91)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C76(0.80)  LDD1658  [7]
 LDCM0457  CL65 HEK-293T C76(0.88)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C76(1.09)  LDD1661  [7]
 LDCM0461  CL69 HEK-293T C76(0.81)  LDD1664  [7]
 LDCM0464  CL71 HEK-293T C76(0.86)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C76(0.92)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C76(1.26)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C76(0.91)  LDD1670  [7]
 LDCM0470  CL77 HEK-293T C76(0.84)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C76(1.24)  LDD1674  [7]
 LDCM0475  CL81 HEK-293T C76(0.82)  LDD1678  [7]
 LDCM0477  CL83 HEK-293T C76(0.78)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C76(1.02)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C76(1.14)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C76(0.98)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C76(1.10)  LDD1684  [7]
 LDCM0483  CL89 HEK-293T C76(1.01)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C76(0.96)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C76(0.97)  LDD1688  [7]
 LDCM0488  CL93 HEK-293T C76(0.98)  LDD1691  [7]
 LDCM0490  CL95 HEK-293T C76(0.84)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C76(1.60)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C76(1.02)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C76(0.91)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C76(1.07)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C76(0.85)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C76(1.07)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C76(0.93)  LDD1631  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 42-MG-BA C76(1.34)  LDD2244  [2]
 LDCM0023  KB03 42-MG-BA C76(1.31)  LDD2661  [2]
 LDCM0024  KB05 OVCAR-5 C76(2.40)  LDD3383  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402