Details of the Target

General Information of Target

Target ID LDTP01051
Target Name Target of Myb1 membrane trafficking protein (TOM1)
Gene Name TOM1
Gene ID 10043
Synonyms
Target of Myb1 membrane trafficking protein; Target of Myb protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVG
NKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNL
IQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDS
VGTDSSQQEDSGQHAAPLPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTE
LVPTQAEPADLELLQELNRTCRAMQQRVLELIPQIANEQLTEELLIVNDNLNNVFLRHER
FERFRTGQTTKAPSEAEPAADLIDMGPDPAATGNLSSQLAGMNLGSSSVRAGLQSLEASG
RLEDEFDMFALTRGSSLADQRKEVKYEAPQATDGLAGALDARQQSTGAIPVTQACLMEDI
EQWLSTDVGNDAEEPKGVTSEEFDKFLEERAKAADRLPNLSSPSAEGPPGPPSGPAPRKK
TQEKDDDMLFAL
Target Bioclass
Transporter and channel
Family
TOM1 family
Subcellular location
Cytoplasm
Function
Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways . Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures. Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes. MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN. Binds to polyubiquitinated proteins via its GAT domain. In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes. The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin. Mediates clathrin recruitment to early endosomes by ZFYVE16. Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking. Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation. PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation. Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling.
Uniprot ID
O60784
Ensemble ID
ENST00000411850.5
HGNC ID
HGNC:11982

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.P463L .
HCT15 SNV: p.Q26Ter .
HT1376 SNV: p.L198V .
IGR1 SNV: p.Q245Ter .
PC3 SNV: p.E433K .
SNU1 SNV: p.E315D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K147(7.18)  LDD0277  [1]
m-APA
 Probe Info  		11.72  LDD0403  [2]
DA-P3
 Probe Info  		4.75  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C415(2.81)  LDD0171  [4]
HHS-475
 Probe Info  		Y386(0.90)  LDD0264  [5]
DBIA
 Probe Info  		C77(1.09); C415(1.00)  LDD1492  [6]
1d-yne
 Probe Info  		N.A.  LDD0358  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C070
 Probe Info  		8.57  LDD1766  [10]
C293
 Probe Info  		19.97  LDD1963  [10]
C296
 Probe Info  		13.55  LDD1966  [10]
C397
 Probe Info  		10.20  LDD2056  [10]
FFF probe13
 Probe Info  		20.00  LDD0475  [11]
FFF probe2
 Probe Info  		15.13  LDD0463  [11]
OEA-DA
 Probe Info  		16.94  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C415(2.81)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C415(0.97); C77(0.87)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C415(1.05); C77(0.98)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C37(0.97); C415(1.17); C77(0.99)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C37(0.97); C415(1.14); C77(1.01)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C37(1.19); C415(1.23); C77(0.91)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C37(0.93); C415(1.25); C77(1.10)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C415(1.06); C77(0.80)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C415(0.97); C77(0.92)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C37(0.76); C415(1.13); C77(0.87)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C415(1.02); C77(0.95)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C37(0.96); C415(1.00); C77(0.98)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C415(1.14); C77(1.00)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C37(0.91); C415(1.07); C77(1.09)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C37(1.34); C415(1.05); C77(1.04)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C37(1.06); C415(1.10); C77(0.91)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C415(1.08); C77(0.87)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C415(1.09); C77(0.91)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C37(1.19); C415(1.13); C77(1.08)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C37(1.01); C415(1.02); C77(0.98)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C415(1.16); C77(1.04)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C37(0.93); C415(1.10); C77(1.02)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C37(1.01); C415(0.99); C77(0.97)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C37(1.11); C415(1.05); C77(0.96)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C37(1.02); C415(1.10); C77(0.98)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C415(1.00); C77(0.79)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C415(1.12); C77(1.00)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C37(0.92); C415(1.17); C77(1.07)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C37(1.13); C415(1.02); C77(1.11)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C415(1.16); C77(1.00)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C37(0.87); C415(1.11); C77(0.97)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C37(0.84); C415(1.11); C77(0.98)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C37(1.12); C415(1.04); C77(1.05)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C37(1.10); C415(1.02); C77(0.95)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C415(1.04); C77(0.79)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C415(1.07); C77(1.07)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C37(0.89); C415(1.19); C77(0.91)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C37(1.12); C415(0.94); C77(0.95)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C415(1.12); C77(1.06)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C37(0.88); C415(1.21); C77(0.96)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C37(0.91); C415(1.23); C77(1.10)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C37(1.02); C415(1.24); C77(0.97)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C415(1.12); C77(0.77)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C415(1.08); C77(1.09)  LDD1551  [6]
 LDCM0313  AC50 HEK-293T C415(1.06); C77(1.01)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C37(1.09); C415(1.13); C77(1.00)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C37(1.24); C415(1.05); C77(1.05)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C415(1.09); C77(1.00)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C37(0.94); C415(1.19); C77(0.99)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C37(1.09); C415(1.31); C77(0.96)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C37(1.09); C415(1.30); C77(0.96)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C415(1.04); C77(0.86)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C415(1.00); C77(1.07)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C37(1.07); C415(1.05); C77(0.92)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C37(1.23); C415(1.14); C77(0.97)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C37(1.01); C415(1.06); C77(1.03)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C415(1.03); C77(1.10)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C37(1.01); C415(1.14); C77(0.99)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C37(1.08); C415(1.14); C77(1.00)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C37(1.02); C415(1.07); C77(1.04)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C37(0.97); C415(1.16); C77(1.03)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C37(0.97); C415(1.03); C77(1.05)  LDD1569  [6]
 LDCM0248  AKOS034007472 HEK-293T C415(1.14); C77(1.12)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C415(1.07); C77(0.80)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C37(1.02); C415(1.50); C77(0.98)  LDD1514  [6]
 LDCM0156  Aniline NCI-H1299 11.72  LDD0403  [2]
 LDCM0367  CL1 HEK-293T C37(1.23); C415(1.08); C77(1.01)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C37(0.95); C415(1.02); C77(1.03)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C37(0.97); C415(1.09); C77(0.93)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C37(1.03); C415(1.11); C77(0.91)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C37(0.99); C415(1.03); C77(0.99)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C37(0.94); C415(1.01); C77(1.01)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C37(1.02); C415(1.07); C77(0.97)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C37(1.10); C415(1.01); C77(0.97)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C37(1.29); C415(1.11); C77(1.02)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C37(1.03); C415(1.20); C77(1.01)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C37(0.97); C415(0.98); C77(1.00)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C37(1.21); C415(1.11); C77(0.97)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C37(1.26); C415(1.22); C77(1.22)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C37(0.75); C415(0.97); C77(0.96)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C37(0.89); C415(1.01); C77(1.00)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C37(0.92); C415(0.98); C77(0.89)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C37(0.94); C415(1.07); C77(0.92)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C37(1.17); C415(0.94); C77(0.93)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C37(0.92); C415(1.19); C77(1.09)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C37(0.99); C415(1.06); C77(0.99)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C37(1.21); C415(1.19); C77(0.97)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C37(1.15); C415(1.17); C77(1.00)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C37(0.98); C415(1.32); C77(1.09)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C37(1.02); C415(1.11); C77(1.06)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C37(1.01); C415(1.05); C77(0.98)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C37(0.96); C415(1.07); C77(1.01)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C37(1.06); C415(1.16); C77(1.03)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C37(0.92); C415(1.07); C77(0.96)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C37(1.04); C415(1.08); C77(0.90)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C37(0.91); C415(1.20); C77(1.05)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C37(0.92); C415(1.16); C77(1.08)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C37(0.94); C415(1.03); C77(1.00)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C37(0.96); C415(0.93); C77(1.04)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C37(0.86); C415(1.10); C77(0.90)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C37(0.96); C415(1.09); C77(0.94)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C37(0.94); C415(0.88); C77(1.00)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C37(1.14); C415(1.12); C77(0.98)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C415(1.04); C77(0.82)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C415(1.07); C77(1.01)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C37(1.08); C415(1.15); C77(1.17)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C37(1.13); C415(1.15); C77(1.02)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C37(0.98); C415(1.12); C77(1.17)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C415(1.09); C77(1.22)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C37(1.19); C415(1.13); C77(1.32)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C37(1.69); C415(1.07); C77(1.17)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C37(1.09); C415(1.02); C77(1.14)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C37(1.02); C415(1.06); C77(0.95)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C37(0.79); C415(1.05); C77(1.12)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C37(0.94); C415(1.12); C77(1.00)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C37(0.97); C415(1.01); C77(0.97)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C415(1.10); C77(0.86)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C37(0.91); C415(1.10); C77(1.14)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C415(1.01); C77(1.15)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C37(1.28); C415(1.18); C77(1.01)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C37(1.17); C415(0.99); C77(1.15)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C415(0.99); C77(0.81)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C37(0.95); C415(1.12); C77(1.13)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C37(1.13); C415(1.07); C77(0.99)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C37(1.08); C415(1.18); C77(1.01)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C37(0.99); C415(1.12); C77(0.86)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C37(0.91); C415(1.08); C77(1.00)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C37(1.07); C415(1.01); C77(0.98)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C37(0.92); C415(0.97); C77(0.94)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C415(1.03); C77(0.87)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C415(1.00); C77(1.06)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C37(1.41); C415(1.10); C77(1.10)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C37(1.02); C415(0.88); C77(0.96)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C415(1.03); C77(1.12)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C37(1.01); C415(1.07); C77(1.07)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C37(0.92); C415(0.98); C77(1.03)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C37(1.00); C415(1.12); C77(1.04)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C37(1.12); C415(1.12); C77(1.02)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C415(1.01); C77(0.81)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C37(1.01); C415(0.99); C77(1.08)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C37(1.02); C415(1.14); C77(0.91)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C415(1.00); C77(0.85)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C415(1.04); C77(1.00)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C37(1.41); C415(1.17); C77(1.28)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C37(1.16); C415(1.26); C77(1.24)  LDD1650  [6]
 LDCM0448  CL57 HEK-293T C415(1.12); C77(1.22)  LDD1651  [6]
 LDCM0449  CL58 HEK-293T C37(0.91); C415(1.06); C77(1.18)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C37(1.58); C415(1.05); C77(1.20)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C415(1.00); C77(1.03)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C37(1.04); C415(1.06); C77(1.20)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C37(1.05); C415(1.11); C77(0.94)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C37(1.08); C415(1.13); C77(1.01)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C37(0.99); C415(1.24); C77(1.06)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C37(0.99); C415(1.10); C77(0.94)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C415(1.11); C77(0.86)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C415(1.01); C77(1.12)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C37(1.17); C415(1.10); C77(1.07)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C37(1.00); C415(0.85); C77(1.19)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C415(1.03); C77(1.21)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C37(0.91); C415(1.26); C77(1.01)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C37(1.12); C415(1.15); C77(1.07)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C37(1.35); C415(1.07); C77(1.15)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C37(1.13); C415(1.16); C77(1.10)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C37(1.13); C415(1.12); C77(1.00)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C37(0.94); C415(1.28); C77(0.99)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C37(0.96); C415(1.04); C77(0.92)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C415(1.01); C77(0.68)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C415(1.04); C77(0.99)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C37(0.92); C415(1.12); C77(1.13)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C37(0.83); C415(0.67); C77(1.09)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C37(0.93); C415(1.08); C77(1.18)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C415(1.12); C77(1.10)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C37(0.97); C415(1.11); C77(0.98)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C37(1.39); C415(1.02); C77(1.09)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C37(1.05); C415(1.00); C77(0.91)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C37(0.90); C415(1.22); C77(0.95)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C37(0.99); C415(1.11); C77(1.05)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C37(0.88); C415(1.08); C77(1.08)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C37(1.02); C415(0.93); C77(0.93)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C415(1.12); C77(0.81)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C415(1.12); C77(1.27)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C415(0.99); C77(1.01)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C37(0.99); C415(1.07); C77(1.21)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C37(1.22); C415(1.05); C77(1.03)  LDD1690  [6]
 LDCM0488  CL93 HEK-293T C415(1.00); C77(1.01)  LDD1691  [6]
 LDCM0489  CL94 HEK-293T C37(0.98); C415(1.09); C77(1.05)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C37(1.07); C415(0.97); C77(0.94)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C37(1.02); C415(1.09); C77(1.20)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C37(1.23); C415(1.01); C77(0.90)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C37(1.19); C415(0.96); C77(1.05)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C37(0.84); C415(1.02); C77(1.11)  LDD1697  [6]
 LDCM0027  Dopamine HEK-293T 4.75  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C37(0.89); C415(1.10); C77(1.21)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C37(1.04); C415(1.18); C77(0.92)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C37(0.97); C415(1.13); C77(0.95)  LDD1631  [6]
 LDCM0116  HHS-0101 DM93 Y386(0.90)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y386(0.82)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y386(1.01)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y386(0.84)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y386(0.89)  LDD0268  [5]
 LDCM0022  KB02 HEK-293T C77(1.09); C415(1.00)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C77(1.06); C415(1.20)  LDD1497  [6]
 LDCM0024  KB05 HEK-293T C77(1.15); C415(0.98)  LDD1502  [6]
 LDCM0029  Quercetin HEK-293T 7.40  LDD0181  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 11 (NAA11) Acetyltransferase family Q9BSU3
cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) AGC Ser/Thr protein kinase family P17612
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Ras-related C3 botulinum toxin substrate 1 (RAC1) Rho family P63000
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrin beta-1 (ITGB1) Integrin beta chain family P05556
Zinc finger FYVE domain-containing protein 16 (ZFYVE16) . Q7Z3T8
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Syndecan-2 (SDC2) Syndecan proteoglycan family P34741
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
TOM1-like protein 1 (TOM1L1) TOM1 family O75674
BAG family molecular chaperone regulator 5 (BAG5) . Q9UL15
DAZ-associated protein 2 (DAZAP2) . Q15038
Leucine-rich repeat-containing protein 20 (LRRC20) . Q8TCA0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570