Details of the Target

General Information of Target

Target ID LDTP12315
Target Name RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72)
Gene Name SSU72
Gene ID 29101
Synonyms
RNA polymerase II subunit A C-terminal domain phosphatase SSU72; CTD phosphatase SSU72; EC 3.1.3.16
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEAELVKGRLQAITDKRKIQEEISQKRLKIEEDKLKHQHLKKKALREKWLLDGISSGKE
QEEMKKQNQQDQHQIQVLEQSILRLEKEIQDLEKAELQISTKEEAILKKLKSIERTTEDI
IRSVKVEREERAEESIEDIYANIPDLPKSYIPSRLRKEINEEKEDDEQNRKALYAMEIKV
EKDLKTGESTVLSSIPLPSDDFKGTGIKVYDDGQKSVYAVSSNHSAAYNGTDGLAPVEVE
ELLRQASERNSKSPTEYHEPVYANPFYRPTTPQRETVTPGPNFQERIKIKTNGLGIGVNE
SIHNMGNGLSEERGNNFNHISPIPPVPHPRSVIQQAEEKLHTPQKRLMTPWEESNVMQDK
DAPSPKPRLSPRETIFGKSEHQNSSPTCQEDEEDVRYNIVHSLPPDINDTEPVTMIFMGY
QQAEDSEEDKKFLTGYDGIIHAELVVIDDEEEEDEGEAEKPSYHPIAPHSQVYQPAKPTP
LPRKRSEASPHENTNHKSPHKNSISLKEQEESLGSPVHHSPFDAQTTGDGTEDPSLTALR
MRMAKLGKKVI
Target Bioclass
Enzyme
Family
SSU72 phosphatase family
Subcellular location
Nucleus
Function
Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. Plays a role in pre-mRNA polyadenylation via its interaction with SYMPK.
Uniprot ID
Q9NP77
Ensemble ID
ENST00000291386.4
HGNC ID
HGNC:25016
ChEMBL ID
CHEMBL3317331

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.S183T DBIA    Probe Info 
CFPAC1 SNV: p.E113D .
HEC1 SNV: p.V42M DBIA    Probe Info 
HEC1B SNV: p.V42M IA-alkyne    Probe Info 
MOLT4 Substitution: p.V134M IA-alkyne    Probe Info 
SW948 SNV: p.G184D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.01  LDD0402  [1]
STPyne
 Probe Info  		K43(7.99)  LDD2217  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
Probe 1
 Probe Info  		Y61(9.57); Y116(19.31)  LDD3495  [4]
DBIA
 Probe Info  		C192(1.55); C12(1.23)  LDD3310  [5]
BTD
 Probe Info  		C12(0.95)  LDD2093  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
1d-yne
 Probe Info  		N.A.  LDD0358  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C111(0.00); C192(0.00); C12(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C111(0.00); C192(0.00); C12(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C111(0.00); C192(0.00); C12(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
Acrolein
 Probe Info  		N.A.  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
W1
 Probe Info  		N.A.  LDD0236  [3]
NAIA_5
 Probe Info  		C111(0.00); C192(0.00); C12(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C284
 Probe Info  		24.76  LDD1954  [13]
C397
 Probe Info  		10.41  LDD2056  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C12(0.79); C111(1.19)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C192(0.65)  LDD0813  [16]
 LDCM0216  AC100 HEK-293T C192(0.72)  LDD0814  [16]
 LDCM0217  AC101 HEK-293T C192(0.78)  LDD0815  [16]
 LDCM0218  AC102 HEK-293T C192(0.80)  LDD0816  [16]
 LDCM0219  AC103 HEK-293T C192(0.74)  LDD0817  [16]
 LDCM0220  AC104 HEK-293T C192(0.93)  LDD0818  [16]
 LDCM0221  AC105 HEK-293T C192(0.69)  LDD0819  [16]
 LDCM0222  AC106 HEK-293T C192(0.95)  LDD0820  [16]
 LDCM0223  AC107 HEK-293T C192(0.88)  LDD0821  [16]
 LDCM0224  AC108 HEK-293T C192(0.87)  LDD0822  [16]
 LDCM0225  AC109 HEK-293T C192(0.85)  LDD0823  [16]
 LDCM0226  AC11 HEK-293T C192(0.71)  LDD0824  [16]
 LDCM0227  AC110 HEK-293T C192(0.57)  LDD0825  [16]
 LDCM0228  AC111 HEK-293T C192(0.65)  LDD0826  [16]
 LDCM0229  AC112 HEK-293T C192(0.57)  LDD0827  [16]
 LDCM0237  AC12 HEK-293T C192(0.85)  LDD0835  [16]
 LDCM0246  AC128 HEK-293T C192(1.02)  LDD0844  [16]
 LDCM0247  AC129 HEK-293T C192(0.91)  LDD0845  [16]
 LDCM0249  AC130 HEK-293T C192(0.72)  LDD0847  [16]
 LDCM0250  AC131 HEK-293T C192(0.88)  LDD0848  [16]
 LDCM0251  AC132 HEK-293T C192(0.85)  LDD0849  [16]
 LDCM0252  AC133 HEK-293T C192(1.13)  LDD0850  [16]
 LDCM0253  AC134 HEK-293T C192(0.79)  LDD0851  [16]
 LDCM0254  AC135 HEK-293T C192(0.98)  LDD0852  [16]
 LDCM0255  AC136 HEK-293T C192(0.99)  LDD0853  [16]
 LDCM0256  AC137 HEK-293T C192(1.00)  LDD0854  [16]
 LDCM0257  AC138 HEK-293T C192(1.20)  LDD0855  [16]
 LDCM0258  AC139 HEK-293T C192(1.11)  LDD0856  [16]
 LDCM0259  AC14 HEK-293T C192(0.60)  LDD0857  [16]
 LDCM0260  AC140 HEK-293T C192(0.76)  LDD0858  [16]
 LDCM0261  AC141 HEK-293T C192(0.85)  LDD0859  [16]
 LDCM0262  AC142 HEK-293T C192(0.73)  LDD0860  [16]
 LDCM0270  AC15 HEK-293T C192(0.68)  LDD0868  [16]
 LDCM0276  AC17 HEK-293T C192(1.18)  LDD0874  [16]
 LDCM0277  AC18 HEK-293T C192(1.14)  LDD0875  [16]
 LDCM0278  AC19 HEK-293T C192(0.76)  LDD0876  [16]
 LDCM0279  AC2 HEK-293T C12(0.86); C111(1.06); C192(0.94)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C192(0.90)  LDD0878  [16]
 LDCM0281  AC21 HEK-293T C192(1.17)  LDD0879  [16]
 LDCM0282  AC22 HEK-293T C192(0.89)  LDD0880  [16]
 LDCM0283  AC23 HEK-293T C192(0.59)  LDD0881  [16]
 LDCM0284  AC24 HEK-293T C192(1.15)  LDD0882  [16]
 LDCM0285  AC25 HEK-293T C12(0.85); C111(1.10)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C12(1.02); C111(0.91); C192(0.91)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C12(1.22)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C12(1.06)  LDD1527  [15]
 LDCM0290  AC3 HEK-293T C12(1.03)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C12(1.03); C111(1.10); C192(0.94)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C111(0.97)  LDD1531  [15]
 LDCM0294  AC33 HEK-293T C12(0.88); C111(1.05)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C12(0.91); C111(0.88); C192(1.07)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C12(1.00)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C12(1.03)  LDD1536  [15]
 LDCM0299  AC38 HEK-293T C12(1.12); C111(1.11); C192(1.03)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C111(1.05)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C12(1.01)  LDD1540  [15]
 LDCM0303  AC41 HEK-293T C12(0.91); C111(1.07)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C12(0.97); C111(0.95); C192(0.89)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C12(1.17)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C12(1.21)  LDD1545  [15]
 LDCM0308  AC46 HEK-293T C12(1.05); C111(1.09); C192(1.14)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C111(1.11)  LDD1548  [15]
 LDCM0311  AC49 HEK-293T C12(1.14); C111(1.06)  LDD1550  [15]
 LDCM0313  AC50 HEK-293T C12(1.01); C111(0.94); C192(0.93)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C12(1.08)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C12(1.19)  LDD1554  [15]
 LDCM0317  AC54 HEK-293T C12(1.08); C111(1.06); C192(1.07)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C111(1.08)  LDD1557  [15]
 LDCM0320  AC57 HEK-293T C192(0.84)  LDD0918  [16]
 LDCM0321  AC58 HEK-293T C192(0.96)  LDD0919  [16]
 LDCM0322  AC59 HEK-293T C192(1.14)  LDD0920  [16]
 LDCM0323  AC6 HEK-293T C192(0.77)  LDD0921  [16]
 LDCM0324  AC60 HEK-293T C192(0.99)  LDD0922  [16]
 LDCM0325  AC61 HEK-293T C192(1.08)  LDD0923  [16]
 LDCM0326  AC62 HEK-293T C192(1.06)  LDD0924  [16]
 LDCM0327  AC63 HEK-293T C192(0.70)  LDD0925  [16]
 LDCM0328  AC64 HEK-293T C192(1.04)  LDD0926  [16]
 LDCM0329  AC65 HEK-293T C192(0.95)  LDD0927  [16]
 LDCM0330  AC66 HEK-293T C192(1.03)  LDD0928  [16]
 LDCM0331  AC67 HEK-293T C192(0.91)  LDD0929  [16]
 LDCM0332  AC68 HEK-293T C192(0.80)  LDD0930  [16]
 LDCM0333  AC69 HEK-293T C192(0.78)  LDD0931  [16]
 LDCM0334  AC7 HEK-293T C192(0.70)  LDD0932  [16]
 LDCM0335  AC70 HEK-293T C192(0.93)  LDD0933  [16]
 LDCM0336  AC71 HEK-293T C192(1.02)  LDD0934  [16]
 LDCM0337  AC72 HEK-293T C192(0.55)  LDD0935  [16]
 LDCM0338  AC73 HEK-293T C192(0.93)  LDD0936  [16]
 LDCM0339  AC74 HEK-293T C192(0.65)  LDD0937  [16]
 LDCM0340  AC75 HEK-293T C192(0.47)  LDD0938  [16]
 LDCM0341  AC76 HEK-293T C192(1.02)  LDD0939  [16]
 LDCM0342  AC77 HEK-293T C192(0.78)  LDD0940  [16]
 LDCM0343  AC78 HEK-293T C192(0.56)  LDD0941  [16]
 LDCM0344  AC79 HEK-293T C192(1.38)  LDD0942  [16]
 LDCM0345  AC8 HEK-293T C192(0.68)  LDD0943  [16]
 LDCM0346  AC80 HEK-293T C192(0.99)  LDD0944  [16]
 LDCM0347  AC81 HEK-293T C192(0.49)  LDD0945  [16]
 LDCM0348  AC82 HEK-293T C192(0.45)  LDD0946  [16]
 LDCM0349  AC83 HEK-293T C192(0.72)  LDD0947  [16]
 LDCM0350  AC84 HEK-293T C192(0.87)  LDD0948  [16]
 LDCM0351  AC85 HEK-293T C192(1.26)  LDD0949  [16]
 LDCM0352  AC86 HEK-293T C192(0.69)  LDD0950  [16]
 LDCM0353  AC87 HEK-293T C192(0.89)  LDD0951  [16]
 LDCM0354  AC88 HEK-293T C192(0.91)  LDD0952  [16]
 LDCM0355  AC89 HEK-293T C192(1.10)  LDD0953  [16]
 LDCM0357  AC90 HEK-293T C192(0.94)  LDD0955  [16]
 LDCM0358  AC91 HEK-293T C192(0.70)  LDD0956  [16]
 LDCM0359  AC92 HEK-293T C192(0.58)  LDD0957  [16]
 LDCM0360  AC93 HEK-293T C192(2.32)  LDD0958  [16]
 LDCM0361  AC94 HEK-293T C192(0.60)  LDD0959  [16]
 LDCM0362  AC95 HEK-293T C192(0.68)  LDD0960  [16]
 LDCM0363  AC96 HEK-293T C192(1.22)  LDD0961  [16]
 LDCM0364  AC97 HEK-293T C192(0.62)  LDD0962  [16]
 LDCM0365  AC98 HEK-293T C192(1.05)  LDD0963  [16]
 LDCM0366  AC99 HEK-293T C192(0.95)  LDD0964  [16]
 LDCM0248  AKOS034007472 HEK-293T C192(0.72)  LDD0846  [16]
 LDCM0356  AKOS034007680 HEK-293T C192(0.57)  LDD0954  [16]
 LDCM0275  AKOS034007705 HEK-293T C192(0.72)  LDD0873  [16]
 LDCM0156  Aniline NCI-H1299 11.90  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C12(0.00); C192(0.00)  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C12(1.32)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C12(1.25); C111(1.69); C192(0.88)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C12(1.02); C111(0.99); C192(1.07)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C192(0.51)  LDD0968  [16]
 LDCM0371  CL102 HEK-293T C192(0.52)  LDD0969  [16]
 LDCM0372  CL103 HEK-293T C192(0.72)  LDD0970  [16]
 LDCM0373  CL104 HEK-293T C192(0.52)  LDD0971  [16]
 LDCM0374  CL105 HEK-293T C192(0.54)  LDD0972  [16]
 LDCM0375  CL106 HEK-293T C192(0.80)  LDD0973  [16]
 LDCM0376  CL107 HEK-293T C192(0.84)  LDD0974  [16]
 LDCM0377  CL108 HEK-293T C192(1.03)  LDD0975  [16]
 LDCM0378  CL109 HEK-293T C192(0.53)  LDD0976  [16]
 LDCM0379  CL11 HEK-293T C111(0.95)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C192(0.57)  LDD0978  [16]
 LDCM0381  CL111 HEK-293T C192(0.65)  LDD0979  [16]
 LDCM0382  CL112 HEK-293T C12(1.10); C111(0.82); C192(1.08)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C12(1.22)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C111(1.03)  LDD1588  [15]
 LDCM0386  CL116 HEK-293T C12(1.13); C111(0.79); C192(1.09)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C12(0.96)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C111(1.22)  LDD1592  [15]
 LDCM0391  CL120 HEK-293T C12(0.93); C111(0.62); C192(1.06)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C12(1.10)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C111(1.04)  LDD1597  [15]
 LDCM0395  CL124 HEK-293T C12(0.95); C111(0.76); C192(1.05)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C192(0.74)  LDD0994  [16]
 LDCM0397  CL126 HEK-293T C192(1.13)  LDD0995  [16]
 LDCM0398  CL127 HEK-293T C192(0.53)  LDD0996  [16]
 LDCM0399  CL128 HEK-293T C192(0.76)  LDD0997  [16]
 LDCM0400  CL13 HEK-293T C12(1.24)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C111(1.13)  LDD1605  [15]
 LDCM0403  CL16 HEK-293T C192(0.91)  LDD1001  [16]
 LDCM0404  CL17 HEK-293T C192(0.92)  LDD1002  [16]
 LDCM0405  CL18 HEK-293T C192(0.76)  LDD1003  [16]
 LDCM0406  CL19 HEK-293T C192(0.89)  LDD1004  [16]
 LDCM0407  CL2 HEK-293T C111(1.23)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C192(1.06)  LDD1006  [16]
 LDCM0409  CL21 HEK-293T C192(1.05)  LDD1007  [16]
 LDCM0410  CL22 HEK-293T C192(1.10)  LDD1008  [16]
 LDCM0411  CL23 HEK-293T C192(1.68)  LDD1009  [16]
 LDCM0412  CL24 HEK-293T C192(0.97)  LDD1010  [16]
 LDCM0413  CL25 HEK-293T C192(1.00)  LDD1011  [16]
 LDCM0414  CL26 HEK-293T C192(1.06)  LDD1012  [16]
 LDCM0415  CL27 HEK-293T C192(0.78)  LDD1013  [16]
 LDCM0416  CL28 HEK-293T C192(0.93)  LDD1014  [16]
 LDCM0417  CL29 HEK-293T C192(1.39)  LDD1015  [16]
 LDCM0419  CL30 HEK-293T C192(1.31)  LDD1017  [16]
 LDCM0420  CL31 HEK-293T C12(1.05)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C12(0.99)  LDD1625  [15]
 LDCM0423  CL34 HEK-293T C12(0.98); C111(1.36); C192(0.98)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C111(0.95)  LDD1628  [15]
 LDCM0426  CL37 HEK-293T C12(1.06)  LDD1630  [15]
 LDCM0429  CL4 HEK-293T C12(1.03); C111(0.85); C192(1.00)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C12(0.90); C111(1.40); C192(1.28)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C12(0.85); C111(1.33)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C12(0.94); C111(1.10); C192(1.08)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C12(1.19)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C12(1.31)  LDD1638  [15]
 LDCM0436  CL46 HEK-293T C12(1.12); C111(1.56); C192(0.95)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C111(0.97)  LDD1641  [15]
 LDCM0439  CL49 HEK-293T C12(1.15)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C12(1.00); C111(1.23)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C111(1.12)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C12(1.07); C111(0.92); C192(1.10)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C12(0.95); C111(1.31)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C12(0.86); C111(0.81); C192(0.91)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C12(0.93)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C12(1.16)  LDD1650  [15]
 LDCM0449  CL58 HEK-293T C12(1.09); C111(1.20); C192(0.94)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C111(1.00)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C12(0.88); C111(0.87); C192(0.79)  LDD1654  [15]
 LDCM0453  CL61 HEK-293T C12(1.12)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C111(1.11)  LDD1657  [15]
 LDCM0456  CL64 HEK-293T C12(0.99); C111(0.86); C192(1.23)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C12(0.94); C111(1.12)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C12(0.92); C111(0.94); C192(0.85)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C12(1.08)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C12(1.01)  LDD1663  [15]
 LDCM0462  CL7 HEK-293T C12(0.98)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C12(1.21); C111(1.25); C192(1.19)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C111(1.09)  LDD1667  [15]
 LDCM0466  CL73 HEK-293T C12(1.04)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C111(1.26)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C12(1.33); C111(1.09); C192(1.14)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C12(1.01); C111(1.27)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C12(1.13); C111(0.89); C192(1.09)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C12(0.92)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C12(0.78)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C12(1.05)  LDD1677  [15]
 LDCM0476  CL82 HEK-293T C12(1.12); C111(1.23); C192(1.00)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C111(1.03)  LDD1680  [15]
 LDCM0479  CL85 HEK-293T C12(1.14)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C111(1.14)  LDD1683  [15]
 LDCM0482  CL88 HEK-293T C12(1.10); C111(0.88); C192(1.09)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C12(0.98); C111(1.08)  LDD1686  [15]
 LDCM0485  CL90 HEK-293T C12(0.93); C111(0.85); C192(0.86)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C12(0.92)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C12(0.90)  LDD1690  [15]
 LDCM0489  CL94 HEK-293T C12(1.05); C111(1.30); C192(0.87)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C111(0.81)  LDD1693  [15]
 LDCM0492  CL97 HEK-293T C12(1.08)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C111(1.02)  LDD1696  [15]
 LDCM0625  F8 Ramos C12(0.92)  LDD2187  [17]
 LDCM0572  Fragment10 Ramos C12(0.43); C192(1.29)  LDD2189  [17]
 LDCM0573  Fragment11 Ramos C12(0.24)  LDD2190  [17]
 LDCM0574  Fragment12 Ramos C12(0.46); C192(1.09)  LDD2191  [17]
 LDCM0575  Fragment13 Ramos C12(0.74); C192(0.96)  LDD2192  [17]
 LDCM0576  Fragment14 Ramos C12(0.74)  LDD2193  [17]
 LDCM0579  Fragment20 Ramos C12(0.31); C192(1.48)  LDD2194  [17]
 LDCM0580  Fragment21 Ramos C12(0.75); C192(1.56)  LDD2195  [17]
 LDCM0582  Fragment23 Ramos C12(0.13); C192(0.46)  LDD2196  [17]
 LDCM0578  Fragment27 Ramos C12(0.71)  LDD2197  [17]
 LDCM0586  Fragment28 Ramos C12(0.61)  LDD2198  [17]
 LDCM0588  Fragment30 Ramos C12(0.84); C192(1.63)  LDD2199  [17]
 LDCM0589  Fragment31 Ramos C12(0.80)  LDD2200  [17]
 LDCM0590  Fragment32 Ramos C12(0.33); C192(1.05)  LDD2201  [17]
 LDCM0468  Fragment33 Ramos C12(0.80); C192(1.54)  LDD2202  [17]
 LDCM0596  Fragment38 Ramos C12(0.77)  LDD2203  [17]
 LDCM0566  Fragment4 Ramos C12(0.75)  LDD2184  [17]
 LDCM0427  Fragment51 HEK-293T C111(1.18)  LDD1631  [15]
 LDCM0610  Fragment52 Ramos C12(0.90)  LDD2204  [17]
 LDCM0614  Fragment56 Ramos C12(1.20); C192(0.78)  LDD2205  [17]
 LDCM0569  Fragment7 Ramos C12(0.54)  LDD2186  [17]
 LDCM0571  Fragment9 Ramos C12(0.41); C192(1.32)  LDD2188  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HEK-293T C12(1.02); C111(0.96)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C12(1.16); C111(1.14)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C192(1.55); C12(1.23)  LDD3310  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [11]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C12(0.95)  LDD2093  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C12(0.67)  LDD2111  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C12(1.00)  LDD2127  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C12(0.77)  LDD2136  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C12(1.02)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C12(0.56)  LDD2148  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Double-strand-break repair protein rad21 homolog (RAD21) Rad21 family O60216
Cohesin subunit SA-2 (STAG2) SCC3 family Q8N3U4
Symplekin (SYMPK) Symplekin family Q92797

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578