Details of the Target

General Information of Target

Target ID LDTP01535
Target Name Kinesin-like protein KIF20A (KIF20A)
Gene Name KIF20A
Gene ID 10112
Synonyms
MKLP2; RAB6KIFL; Kinesin-like protein KIF20A; GG10_2; Mitotic kinesin-like protein 2; MKlp2; Rab6-interacting kinesin-like protein; Rabkinesin-6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQGILSPPAGLLSDDDVVVSPMFESTAADLGSVVRKNLLSDCSVVSTSLEDKQQVPSED
SMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSNERGIGQATHR
FTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDGGIL
PRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGGLQEEELSTS
LKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLPVPANIRFS
IWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLK
VGRKNQSFASTHLNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKDQKS
GERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCM
IVNVNPCASTYDETLHVAKFSAIASQLVHAPPMQLGFPSLHSFIKEHSLQVSPSLEKGAK
ADTGLDDDIENEADISMYGKEELLQVVEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQM
QQREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQEARQ
QSVAHQQSGSELALRRSQRLAASASTQQLQEVKAKLQQCKAELNSTTEELHKYQKMLEPP
PSAKPFTIDVDKKLEEGQKNIRLLRTELQKLGESLQSAERACCHSTGAGKLRQALTTCDD
ILIKQDQTLAELQNNMVLVKLDLRKKAACIAEQYHTVLKLQGQVSAKKRLGTNQENQQPN
QQPPGKKPFLRNLLPRTPTCQSSTDCSPYARILRSRRSPLLKSGPFGKKY
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
Subcellular location
Golgi apparatus
Function
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Uniprot ID
O95235
Ensemble ID
ENST00000394894.8
HGNC ID
HGNC:9787
ChEMBL ID
CHEMBL2021753

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.D731N DBIA    Probe Info 
CCFSTTG1 SNV: p.R423W .
HEC1 SNV: p.A701T DBIA    Probe Info 
HEC1B SNV: p.A701T .
LNCaP clone FGC SNV: p.K525N; p.Q793H DBIA    Probe Info 
MFE280 SNV: p.R218Ter DBIA    Probe Info 
NCIH1975 SNV: p.S321N DBIA    Probe Info 
SKN SNV: p.Q656K DBIA    Probe Info 
TOV21G SNV: p.L792Q DBIA    Probe Info 
WM2664 Insertion: p.S124FfsTer40 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.79  LDD0402  [1]
STPyne
 Probe Info  		K142(0.71)  LDD0277  [2]
BTD
 Probe Info  		C763(0.86)  LDD1700  [3]
AHL-Pu-1
 Probe Info  		C809(4.56)  LDD0170  [4]
DBIA
 Probe Info  		C762(1.33); C763(1.33); C860(0.87); C866(0.87)  LDD0078  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C407(0.00); C87(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C407(0.00); C762(0.00); C763(0.00); C87(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C407(0.00); C809(0.00); C87(0.00)  LDD0037  [6]
IPM
 Probe Info  		N.A.  LDD0025  [7]
NAIA_4
 Probe Info  		C270(0.00); C809(0.00)  LDD2226  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C809(0.00); C415(0.00); C762(0.00); C763(0.00)  LDD0018  [10]
Acrolein
 Probe Info  		C43(0.00); C407(0.00); C593(0.00)  LDD0217  [11]
Crotonaldehyde
 Probe Info  		C607(0.00); C407(0.00); C593(0.00)  LDD0219  [11]
Methacrolein
 Probe Info  		C607(0.00); C43(0.00); C763(0.00); C593(0.00)  LDD0218  [11]
AOyne
 Probe Info  		13.90  LDD0443  [12]
NAIA_5
 Probe Info  		C809(0.00); C440(0.00); C407(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		18.77  LDD1865  [13]
C191
 Probe Info  		13.18  LDD1868  [13]
C193
 Probe Info  		6.23  LDD1869  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C762(0.66)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C762(0.69); C763(0.68)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C763(0.95)  LDD2152  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C762(0.56)  LDD2132  [3]
 LDCM0025  4SU-RNA DM93 C809(4.56)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C809(3.15)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C332(1.06); C407(0.94); C479(0.79); C487(0.79)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C407(0.92); C479(0.98); C487(0.98); C607(0.98)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C479(0.57); C487(0.57); C607(0.77); C762(0.85)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C479(0.56); C487(0.56); C607(0.88); C762(0.84)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C479(0.64); C487(0.64); C607(1.01); C762(1.00)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C479(0.49); C487(0.49); C607(0.91); C762(1.04)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C479(0.54); C487(0.54); C607(0.94); C762(1.35)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C479(0.46); C487(0.46); C607(0.86); C762(0.83)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C479(0.44); C487(0.44); C607(0.88); C762(0.82)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C479(0.22); C487(0.55); C607(0.83); C762(0.97)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C479(0.89); C487(0.69); C607(0.71); C762(0.67)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C479(1.05); C487(0.59); C607(0.75); C762(0.78)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C407(1.00); C479(1.23); C487(1.23); C607(1.18)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C479(1.03); C487(0.52); C607(0.89); C762(0.85)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C479(0.81); C487(0.60); C607(0.84); C762(0.86)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C479(0.67); C487(0.50); C607(0.85); C762(1.12)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C407(1.17); C479(1.02); C487(1.02); C762(0.85)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C407(1.11); C479(0.91); C487(0.91); C762(1.01)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C407(1.17); C479(0.97); C487(0.97); C762(1.03)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C407(1.25); C479(0.88); C487(0.88); C762(1.14)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C407(1.14); C479(0.93); C487(0.93); C762(1.01)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C407(1.42); C479(0.93); C487(0.93); C762(1.12)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C407(1.40); C479(0.98); C487(0.98); C762(1.13)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C407(1.24); C479(1.01); C487(1.01); C607(0.88)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C407(1.08); C479(0.99); C487(0.99); C762(2.00)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C407(1.32); C479(1.00); C487(1.00); C762(0.96)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C407(1.16); C479(0.91); C487(0.91); C762(1.04)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C407(1.45); C479(0.96); C487(0.96); C762(1.07)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C407(1.28); C479(0.99); C487(0.99); C762(0.96)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C407(1.37); C479(0.92); C487(0.92); C762(1.02)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C407(1.44); C479(0.87); C487(0.87); C762(1.04)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C407(1.55); C479(0.89); C487(0.89); C762(1.16)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C479(0.85); C487(0.85); C607(1.04); C762(0.69)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C479(0.93); C487(0.93); C607(0.67); C762(0.51)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C479(0.84); C487(0.84); C607(0.83); C762(0.59)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C479(0.89); C487(0.89); C607(0.92); C762(0.63)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C479(0.92); C487(0.92); C607(0.89); C762(0.49)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C479(0.92); C487(0.92); C607(1.03); C762(0.57)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C479(0.80); C487(0.80); C607(0.91); C762(0.66)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C479(0.82); C487(0.82); C607(0.93); C762(0.56)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C479(0.94); C487(0.94); C607(0.83); C762(0.83)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C479(0.80); C487(0.80); C607(0.84); C762(0.74)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C479(0.80); C487(0.80); C607(0.84); C762(0.75)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C479(0.77); C487(0.77); C607(0.97); C762(0.58)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C407(1.14); C479(1.87); C487(1.87); C607(0.98)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C479(0.73); C487(0.73); C607(0.98); C762(0.65)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C479(0.89); C487(0.89); C607(0.93); C762(0.67)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C479(0.86); C487(0.86); C607(0.94); C762(0.59)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C593(0.74); C479(0.79); C487(0.79); C87(0.88)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C479(0.59); C487(0.59); C87(0.73); C593(0.81)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C479(0.61); C487(0.61); C593(0.70); C607(0.88)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C479(0.48); C487(0.48); C87(0.84); C866(0.87)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C479(0.49); C487(0.49); C593(0.79); C87(0.86)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C479(0.57); C487(0.57); C593(0.72); C87(1.04)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C479(0.51); C487(0.51); C593(0.71); C87(0.79)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C762(0.64); C763(0.64); C860(0.72); C866(0.72)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C593(0.61); C479(0.70); C487(0.70); C866(0.99)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C479(0.64); C487(0.64); C593(0.87); C762(1.00)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C479(0.48); C487(0.48); C593(0.76); C87(0.98)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C479(0.59); C487(0.59); C593(0.84); C87(0.99)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C479(0.51); C487(0.51); C593(0.61); C607(1.01)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C479(0.66); C487(0.66); C593(1.16); C607(1.25)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C479(0.71); C487(0.71); C593(0.71); C607(1.09)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C479(0.72); C487(0.72); C593(0.70); C607(1.17)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C762(0.43); C763(0.43); C860(0.68); C866(0.68)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C762(0.48); C763(0.48); C860(0.60); C866(0.60)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C762(0.52); C763(0.52); C860(0.69); C866(0.69)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C479(0.72); C487(0.72); C762(0.73); C763(0.73)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C860(0.77); C866(0.77); C479(0.77); C487(0.77)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C479(0.74); C487(0.74); C762(0.78); C763(0.78)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C479(0.72); C487(0.72); C762(0.80); C763(0.80)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C762(0.62); C763(0.62); C479(0.66); C487(0.66)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C762(0.58); C763(0.58); C860(0.75); C866(0.75)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C860(0.59); C866(0.59); C762(0.66); C763(0.66)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C860(0.51); C866(0.51); C762(0.67); C763(0.67)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C860(0.44); C866(0.44); C607(0.66); C762(0.82)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C860(0.57); C866(0.57); C607(0.87); C762(0.94)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C860(0.47); C866(0.47); C607(0.95); C479(1.03)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C762(0.61); C763(0.61); C860(0.77); C866(0.77)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C860(0.43); C866(0.43); C607(0.77); C479(0.95)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C860(0.49); C866(0.49); C607(0.77); C762(0.99)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C860(0.40); C866(0.40); C607(0.53); C479(1.02)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C860(0.46); C866(0.46); C607(0.67); C593(0.88)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C860(0.40); C866(0.40); C607(0.47); C593(0.88)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C762(0.78); C763(0.78); C479(0.98); C487(0.98)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C607(0.91); C762(0.93); C763(0.93); C860(0.94)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C479(0.82); C487(0.82); C860(0.85); C866(0.85)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C607(0.98); C762(1.03); C763(1.03); C479(1.06)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C762(0.87); C763(0.87); C860(0.96); C866(0.96)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C762(0.42); C763(0.42); C479(0.85); C487(0.85)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C607(0.67); C87(0.98); C762(1.02); C763(1.02)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C762(0.70); C763(0.70); C860(0.94); C866(0.94)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C762(0.70); C763(0.70); C860(0.98); C866(0.98)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C762(0.68); C763(0.68); C479(1.00); C487(1.00)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C762(0.68); C763(0.68); C479(0.82); C487(0.82)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C762(0.86); C763(0.86); C607(0.91); C860(1.03)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C762(0.83); C763(0.83); C607(0.86); C593(0.96)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C479(0.84); C487(0.84); C593(0.86); C762(0.89)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C479(0.89); C487(0.89); C860(0.92); C866(0.92)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C607(0.89); C407(1.01); C87(1.02); C860(1.04)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C762(0.49); C763(0.49); C860(0.71); C866(0.71)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C762(0.67); C763(0.67); C607(0.84); C860(1.05)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C762(0.61); C763(0.61); C593(0.76); C607(0.85)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C762(0.84); C763(0.84); C479(0.84); C487(0.84)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C762(0.45); C763(0.45); C479(0.82); C487(0.82)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C762(0.80); C763(0.80); C607(0.87); C407(0.94)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C762(0.47); C763(0.47); C607(0.87); C479(0.95)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C762(0.71); C763(0.71); C607(0.95); C479(1.17)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C866(0.31); C860(0.51); C762(0.79); C763(0.79)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C866(0.28); C860(0.41); C607(0.97); C407(0.99)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C866(0.23); C860(0.31); C762(0.81); C763(0.81)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C860(0.86); C866(0.86); C87(0.93); C607(0.95)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C866(0.30); C860(0.49); C407(0.84); C762(0.95)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C866(0.26); C860(0.37); C762(0.71); C763(0.71)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C866(0.23); C860(0.34); C762(0.69); C763(0.69)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C866(0.31); C860(0.51); C762(0.77); C763(0.77)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C866(0.24); C860(0.39); C762(0.61); C763(0.61)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C866(0.08); C860(0.14); C762(0.65); C763(0.65)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C866(0.08); C860(0.15); C762(0.80); C763(0.80)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C866(0.08); C860(0.14); C407(0.76); C762(0.88)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C860(0.79); C866(0.79); C593(0.79); C479(0.83)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C593(0.65); C479(0.87); C487(0.87); C860(0.94)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C860(0.76); C866(0.76); C87(0.87); C407(0.99)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C479(0.73); C487(0.73); C860(0.76); C866(0.76)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C593(0.84); C860(0.90); C866(0.90); C762(1.01)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C479(0.84); C487(0.84); C87(1.04); C332(1.16)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C479(0.78); C487(0.78); C87(1.05); C332(1.10)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C479(0.75); C487(0.75); C593(0.95); C860(1.08)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C479(0.89); C487(0.89); C593(0.99); C607(1.04)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C479(0.89); C487(0.89); C593(0.92); C860(0.99)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C593(0.71); C332(0.86); C762(0.94); C763(0.94)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C593(0.82); C479(0.89); C487(0.89); C607(0.91)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C860(0.91); C866(0.91); C87(1.01); C593(1.01)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C762(0.80); C763(0.80); C860(0.89); C866(0.89)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C860(0.97); C866(0.97); C479(1.00); C487(1.00)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C860(0.91); C866(0.91); C593(0.98); C479(1.06)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C479(0.79); C487(0.79); C593(1.00); C860(1.05)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C407(0.80); C87(0.92); C860(0.95); C866(0.95)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C407(0.75); C860(0.89); C866(0.89); C87(1.01)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C407(0.73); C860(0.83); C866(0.83); C87(1.02)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C407(0.79); C860(0.90); C866(0.90); C87(1.02)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C407(0.91); C860(0.95); C866(0.95); C607(1.02)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C407(0.84); C860(0.96); C866(0.96); C607(1.06)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C407(0.79); C860(0.92); C866(0.92); C762(1.05)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C762(0.72); C763(0.72); C607(0.92); C87(1.04)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C407(0.61); C607(1.06); C87(1.07); C860(1.09)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C407(0.76); C860(0.97); C866(0.97); C607(1.06)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C407(0.85); C860(0.95); C866(0.95); C87(1.08)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C407(0.81); C860(1.06); C866(1.06); C87(1.17)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C407(0.89); C607(0.90); C860(0.98); C866(0.98)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C407(0.78); C860(1.03); C866(1.03); C607(1.11)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C407(0.72); C87(1.01); C860(1.13); C866(1.13)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C479(0.49); C487(0.49); C860(0.74); C866(0.74)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C860(0.74); C866(0.74); C479(0.78); C487(0.78)  LDD0683  [5]
 LDCM0545  Acetamide MDA-MB-231 C762(0.49)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C762(0.70)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C407(1.06); C479(0.92); C487(0.92); C607(0.90)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C762(0.73); C763(0.73); C479(0.87); C487(0.87)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C860(0.75); C866(0.75); C762(0.77); C763(0.77)  LDD0592  [5]
 LDCM0020  ARS-1620 HCC44 C762(1.33); C763(1.33); C860(0.87); C866(0.87)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0632  CL-Sc Hep-G2 C809(20.00); C809(1.06)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C593(0.74); C479(0.88); C487(0.88); C762(0.95)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C762(0.60); C763(0.60); C860(0.63); C866(0.63)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C762(0.43); C763(0.43); C860(0.80); C866(0.80)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C860(0.86); C866(0.86); C87(1.01); C407(1.03)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C860(0.94); C866(0.94); C407(0.95); C479(1.04)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C762(0.75); C763(0.75); C407(1.04); C479(1.04)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C762(0.72); C763(0.72); C607(0.86); C860(0.98)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C860(0.54); C866(0.54); C762(0.66); C763(0.66)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C860(0.49); C866(0.49); C762(0.73); C763(0.73)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C860(0.38); C866(0.38); C762(0.58); C763(0.58)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C860(0.42); C866(0.42); C762(0.56); C763(0.56)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C479(0.75); C487(0.75); C860(0.77); C866(0.77)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C762(0.80); C763(0.80); C593(0.87); C332(0.91)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C762(0.62); C763(0.62); C479(0.66); C487(0.66)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C860(0.68); C866(0.68); C479(0.68); C487(0.68)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C860(0.64); C866(0.64); C593(0.92); C762(0.98)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C860(0.47); C866(0.47); C607(0.68); C593(1.16)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C860(0.54); C866(0.54); C479(0.75); C487(0.75)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C860(0.75); C866(0.75); C607(0.93); C479(0.95)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C860(0.41); C866(0.41); C607(0.84); C593(0.94)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C607(0.76); C860(0.81); C866(0.81); C762(0.90)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C762(0.41); C763(0.41); C607(1.06); C87(1.10)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C762(0.40); C763(0.40); C860(1.02); C866(1.02)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C762(0.54); C763(0.54); C860(0.77); C866(0.77)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C762(0.47); C763(0.47); C607(0.87); C87(0.99)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C407(0.95); C762(0.95); C763(0.95); C593(1.16)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C762(0.75); C763(0.75); C479(0.89); C487(0.89)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C407(0.90); C762(1.01); C763(1.01); C479(1.01)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C762(0.82); C763(0.82); C607(0.90); C407(0.93)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C866(0.51); C860(0.57); C762(0.82); C763(0.82)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C866(0.48); C860(0.62); C407(0.77); C87(0.86)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C866(0.31); C860(0.46); C407(0.91); C607(0.95)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C866(0.31); C860(0.46); C607(0.87); C762(0.96)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C762(0.57); C763(0.57); C479(0.71); C487(0.71)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C762(0.59); C763(0.59); C479(0.77); C487(0.77)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C762(0.64); C763(0.64); C87(0.87); C860(0.93)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C87(0.82); C762(0.90); C763(0.90); C860(0.91)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C479(0.74); C487(0.74); C87(0.85); C407(0.86)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C479(0.74); C487(0.74); C860(0.89); C866(0.89)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C860(0.79); C866(0.79); C87(0.90); C479(0.95)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C479(0.86); C487(0.86); C860(0.90); C866(0.90)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C860(0.73); C866(0.73); C762(0.77); C763(0.77)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C87(0.87); C407(0.93); C860(0.94); C866(0.94)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C860(0.67); C866(0.67); C762(1.01); C763(1.01)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C762(0.81); C763(0.81); C87(0.87); C860(0.89)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C860(0.80); C866(0.80); C762(0.82); C763(0.82)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C407(0.93); C479(0.91); C487(0.91); C607(1.04)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C407(0.85); C479(1.00); C487(1.00); C607(0.86)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C407(1.10); C479(0.84); C487(0.84); C607(1.12)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C407(1.04); C479(0.84); C487(0.84); C607(1.05)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C407(0.93); C479(0.90); C487(0.90); C607(1.02)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C332(0.92); C407(1.00); C479(0.88); C487(0.88)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C407(1.10); C479(0.99); C487(0.99); C607(1.07)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C407(1.05); C479(1.06); C487(1.06); C607(1.20)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C407(1.04); C479(0.89); C487(0.89); C607(1.34)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C407(0.75); C479(0.96); C487(0.96); C607(1.84)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C407(0.88); C479(1.26); C487(1.26); C607(1.40)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C407(0.95); C479(0.74); C487(0.74); C607(1.33)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C407(0.86); C479(0.77); C487(0.77); C607(1.35)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C407(1.01); C479(1.18); C487(1.18); C607(1.38)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C407(1.07); C479(0.81); C487(0.81); C607(1.98)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C332(0.94); C407(0.96); C479(0.95); C487(0.95)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C407(0.99); C479(0.99); C487(0.99); C607(1.73)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C407(1.04); C479(1.07); C487(1.07); C607(1.14)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C407(0.94); C479(1.21); C487(1.21); C607(1.56)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C407(1.05); C479(1.24); C487(1.24); C607(1.19)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C407(1.08); C479(0.97); C487(0.97); C607(1.57)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C407(0.93); C479(1.05); C487(1.05); C607(1.44)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C332(0.98); C407(0.97); C479(0.88); C487(0.88)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C332(0.80); C407(0.80); C479(0.93); C487(0.93)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C332(0.97); C407(1.04); C479(0.97); C487(0.97)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C332(1.08); C407(1.19); C479(0.95); C487(0.95)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C332(1.07); C407(1.03); C479(0.93); C487(0.93)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C332(0.91); C407(1.03); C479(0.91); C487(0.91)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C332(0.85); C407(0.93); C479(0.83); C487(0.83)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C332(1.04); C407(1.07); C479(0.95); C487(0.95)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C332(0.81); C407(0.76); C479(0.79); C487(0.79)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C332(0.87); C407(0.87); C479(0.90); C487(0.90)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C332(1.03); C407(0.83); C479(0.88); C487(0.88)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C332(0.98); C407(0.79); C479(0.98); C487(0.98)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C332(0.96); C407(0.92); C479(0.88); C487(0.88)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C332(1.04); C407(0.91); C479(0.92); C487(0.92)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C332(0.91); C407(0.93); C479(0.95); C487(0.95)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C332(0.90); C407(0.94); C479(0.80); C487(0.80)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C332(0.90); C407(0.88); C479(1.03); C487(1.03)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C479(0.83); C487(0.83); C762(0.63); C763(0.63)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C479(0.86); C487(0.86); C762(0.60); C763(0.60)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C479(0.86); C487(0.86); C762(0.76); C763(0.76)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C479(0.85); C487(0.85); C762(0.58); C763(0.58)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C479(1.00); C487(1.00); C762(0.62); C763(0.62)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C479(0.86); C487(0.86); C762(0.46); C763(0.46)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C479(0.96); C487(0.96); C762(0.82); C763(0.82)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C479(1.07); C487(1.07); C762(1.21); C763(1.21)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C479(0.91); C487(0.91); C762(0.50); C763(0.50)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C332(1.15); C407(1.11); C479(0.72); C487(0.72)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C479(1.01); C487(1.01); C762(0.68); C763(0.68)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C479(0.93); C487(0.93); C762(0.56); C763(0.56)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C479(1.06); C487(1.06); C762(0.68); C763(0.68)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C479(0.78); C487(0.78); C762(0.47); C763(0.47)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C479(0.89); C487(0.89); C762(0.59); C763(0.59)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C607(1.09); C762(1.49); C763(1.49); C860(0.65)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C607(1.42); C762(1.98); C763(1.98); C860(0.75)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C607(0.89); C762(0.88); C763(0.88); C860(0.78)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C607(1.05); C762(1.43); C763(1.43); C860(0.71)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C332(0.94); C407(0.99); C479(1.05); C487(1.05)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C607(0.96); C762(1.05); C763(1.05); C860(0.72)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C607(0.94); C762(0.82); C763(0.82); C860(0.66)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C607(0.91); C762(0.94); C763(0.94); C860(0.53)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C607(1.11); C762(1.29); C763(1.29); C860(0.69)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C607(1.05); C762(0.98); C763(0.98); C860(0.92)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C607(1.28); C762(2.39); C763(2.39); C860(0.79)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C607(1.03); C762(1.66); C763(1.66); C860(0.70)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C607(1.47); C762(1.70); C763(1.70); C860(0.60)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C607(1.23); C762(3.42); C763(3.42); C860(0.65)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C607(0.95); C762(1.66); C763(1.66); C860(0.67)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C332(0.98); C407(1.08); C479(0.81); C487(0.81)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C607(1.46); C762(3.03); C763(3.03); C860(0.69)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C332(0.98); C407(0.89); C479(0.66); C487(0.66)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C332(0.89); C407(0.86); C479(0.76); C487(0.76)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C332(0.93); C407(0.86); C479(0.64); C487(0.64)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C332(0.91); C407(0.87); C479(0.56); C487(0.56)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C332(0.83); C407(0.88); C479(0.60); C487(0.60)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C332(0.90); C407(0.88); C479(0.85); C487(0.85)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C332(0.92); C407(0.85); C479(0.79); C487(0.79)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C332(0.97); C407(0.94); C479(0.79); C487(0.79)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C332(0.89); C407(0.91); C479(0.87); C487(0.87)  LDD0811  [5]
 LDCM0495  E2913 HEK-293T C332(1.20); C809(1.04); C487(0.78)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C762(3.85); C809(1.28)  LDD1702  [3]
 LDCM0468  Fragment33 HCT 116 C479(0.95); C487(0.95); C762(0.40); C763(0.40)  LDD0785  [5]
 LDCM0427  Fragment51 HCT 116 C407(0.89); C479(1.10); C487(1.10); C607(1.69)  LDD0744  [5]
 LDCM0107  IAA HeLa N.A.  LDD0221  [11]
 LDCM0022  KB02 HCT 116 C607(2.02)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C607(2.12)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C607(2.84)  LDD0082  [5]
 LDCM0109  NEM HeLa H527(0.00); H168(0.00)  LDD0223  [11]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C763(1.08)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C763(0.88)  LDD2093  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C762(0.95); C763(0.70)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C763(0.74)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C762(0.71)  LDD2101  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C762(0.40); C763(0.65)  LDD2104  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C762(1.06); C763(0.64)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C762(0.72); C763(0.75)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C762(1.11); C763(0.97)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C762(0.56); C763(0.94)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C762(0.45)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C762(1.56)  LDD2119  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C762(0.56); C763(0.69)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C762(0.98); C763(0.56)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C762(0.51)  LDD2127  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C762(0.73); C763(0.71)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C762(0.99)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C762(0.55)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C763(1.11)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C762(0.74); C763(0.71)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C763(0.86)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C762(0.73); C763(0.64)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C762(0.59)  LDD2141  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C763(0.63)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C762(0.41)  LDD2148  [3]
 LDCM0021  THZ1 HCT 116 C87(1.15); C762(1.04); C763(1.04); C860(0.96)  LDD2173  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Atos homolog protein B (ATOSB) ATOS family Q7L5A3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402