Details of the Target

General Information of Target

Target ID LDTP11021
Target Name Endophilin-A3 (SH3GL3)
Gene Name SH3GL3
Gene ID 6457
Synonyms
CNSA3; SH3D2C; Endophilin-A3; EEN-B2; Endophilin-3; SH3 domain protein 2C; SH3 domain-containing GRB2-like protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQP
NPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEA
MRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPD
EELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRL
EERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYD
FEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
Target Bioclass
Other
Family
Endophilin family
Subcellular location
Cytoplasm
Function Implicated in endocytosis. May recruit other proteins to membranes with high curvature.
Uniprot ID
Q99963
Ensemble ID
ENST00000324537.5
HGNC ID
HGNC:10832

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCSW1 SNV: p.D132V .
COLO792 SNV: p.S18N .
KARPAS422 SNV: p.E116G .
NCIH1792 SNV: p.E19A .
NCIH1793 SNV: p.Q241Ter .
NCIH2052 SNV: p.R291H .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		40.22  LDD1865  [1]
DA-2
 Probe Info  		N.A.  LDD0070  [2]
STS-1
 Probe Info  		N.A.  LDD0068  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-2 (ATXN2) Ataxin-2 family Q99700
Endophilin-A1 (SH3GL2) Endophilin family Q99962
Endophilin-A2 (SH3GL1) Endophilin family Q99961
Endophilin-A3 (SH3GL3) Endophilin family Q99963
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) MRL family Q70E73

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
2 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
3 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.