Details of the Target

General Information of Target

Target ID LDTP08651
Target Name Exocyst complex component 8 (EXOC8)
Gene Name EXOC8
Gene ID 149371
Synonyms
Exocyst complex component 8; Exocyst complex 84 kDa subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAMAMSDSGASRLRRQLESGGFEARLYVKQLSQQSDGDRDLQEHRQRIQALAEETAQNLK
RNVYQNYRQFIETAREISYLESEMYQLSHLLTEQKSSLESIPLTLLPAAAAAGAAAASGG
EEGVGGAGGRDHLRGQAGFFSTPGGASRDGSGPGEEGKQRTLTTLLEKVEGCRHLLETPG
QYLVYNGDLVEYDADHMAQLQRVHGFLMNDCLLVATWLPQRRGMYRYNALYSLDGLAVVN
VKDNPPMKDMFKLLMFPESRIFQAENAKIKREWLEVLEDTKRALSEKRRREQEEAAAPRG
PPQVTSKATNPFEDDEEEEPAVPEVEEEKVDLSMEWIQELPEDLDVCIAQRDFEGAVDLL
DKLNHYLEDKPSPPPVKELRAKVEERVRQLTEVLVFELSPDRSLRGGPKATRRAVSQLIR
LGQCTKACELFLRNRAAAVHTAIRQLRIEGATLLYIHKLCHVFFTSLLETAREFEIDFAG
TDSGCYSAFVVWARSAMGMFVDAFSKQVFDSKESLSTAAECVKVAKEHCQQLGDIGLDLT
FIIHALLVKDIQGALHSYKEIIIEATKHRNSEEMWRRMNLMTPEALGKLKEEMKSCGVSN
FEQYTGDDCWVNLSYTVVAFTKQTMGFLEEALKLYFPELHMVLLESLVEIILVAVQHVDY
SLRCEQDPEKKAFIRQNASFLYETVLPVVEKRFEEGVGKPAKQLQDLRNASRLIRVNPES
TTSVV
Target Bioclass
Transporter and channel
Family
EXO84 family
Subcellular location
Cytoplasm
Function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Uniprot ID
Q8IYI6
Ensemble ID
ENST00000366645.1
HGNC ID
HGNC:24659

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.13  LDD0402  [1]
BTD
 Probe Info  		C428(1.05)  LDD2117  [2]
DA-P3
 Probe Info  		4.40  LDD0183  [3]
DBIA
 Probe Info  		C428(0.99); C664(1.40)  LDD0531  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C428(0.00); C521(0.00); C211(0.00); C664(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C428(0.00); C521(0.00); C664(0.00); C460(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C428(0.00); C521(0.00); C211(0.00); C664(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
ENE
 Probe Info  		C521(0.00); C424(0.00)  LDD0006  [8]
IPM
 Probe Info  		C428(0.00); C521(0.00); C424(0.00)  LDD0005  [8]
STPyne
 Probe Info  		N.A.  LDD0009  [8]
1c-yne
 Probe Info  		N.A.  LDD0228  [9]
AOyne
 Probe Info  		13.10  LDD0443  [10]
NAIA_5
 Probe Info  		C664(0.00); C521(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		16.00  LDD1865  [11]
C191
 Probe Info  		12.73  LDD1868  [11]
C193
 Probe Info  		5.90  LDD1869  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C428(1.05)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C428(0.99); C664(1.40)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C428(1.11)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C428(0.89); C664(0.70)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C428(0.93); C664(0.68)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C428(1.11); C664(0.59)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C428(0.94); C664(0.71)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C428(0.90); C664(0.64)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C428(0.99); C664(0.73)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C428(0.93); C664(0.75)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C428(0.89); C664(0.89)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C428(0.88); C664(0.67)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C428(1.07); C664(0.58)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C428(0.95)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C428(0.97); C664(0.60)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C428(1.17); C664(0.52)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C428(0.94); C664(0.69)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C428(0.97); C664(1.05)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C428(0.89); C664(0.86)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C428(0.77); C664(1.01)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C428(1.02); C664(1.05)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C428(1.00); C664(1.22)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C428(1.07); C664(1.19)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C428(0.79); C664(1.19)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C428(0.96)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C428(0.96); C664(0.90)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C428(0.84); C664(1.08)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C428(0.84); C664(1.10)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C428(0.75); C664(0.98)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C428(0.86); C664(1.16)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C428(1.11); C664(0.95)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C428(1.03); C664(1.17)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C428(0.80); C664(1.30)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C428(1.13); C664(1.65)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C428(0.98); C664(1.33)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C428(1.06); C664(1.31)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C428(1.12); C664(1.39)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C428(0.92); C664(1.51)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C428(1.03); C664(1.35)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C428(0.96); C664(1.58)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C428(1.03); C664(1.71)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C428(0.92); C664(1.24)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C428(1.00); C664(1.35)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C428(1.15); C664(1.35)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C428(1.14); C664(1.56)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C428(0.96)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C428(0.98); C664(1.56)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C428(1.09); C664(1.54)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C428(1.04); C664(1.34)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C428(0.99); C664(1.09)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C428(0.83); C664(0.98)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C428(0.99); C664(1.00)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C428(0.82); C664(1.20)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C428(1.04); C664(1.14)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C428(0.95); C664(1.42)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C428(0.85); C664(1.14)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C428(1.26)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C428(0.95); C664(1.06)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C428(0.83); C664(1.29)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C428(0.76); C664(1.02)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C428(0.86); C664(1.31)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C428(0.93); C664(0.98)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C428(0.80); C664(1.05)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C428(1.04); C664(1.05)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C428(0.85); C664(1.21)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C428(0.82); C664(1.27)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C428(0.87); C664(1.16)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C428(0.79); C664(1.28)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C428(1.09); C664(1.12)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C428(0.93); C664(1.18)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C428(0.87); C664(1.32)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C428(0.87); C664(1.12)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C428(0.86); C664(0.98)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C428(0.88); C664(1.23)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C428(0.86)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C428(0.89)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C428(0.80)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C428(0.85)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C428(0.75)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C428(0.97); C664(1.24)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C428(0.79)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C428(0.94)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C428(0.89)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C428(0.78)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C428(0.76)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C664(0.77)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C664(0.85)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C664(0.90)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C664(1.03)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C664(1.06)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C428(1.02); C664(1.15)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C664(0.98)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C664(1.01)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C664(1.07)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C664(1.04)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C664(1.12)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C664(1.20)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C664(1.09); C428(1.26)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C428(1.02); C664(1.26)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C428(1.33); C664(1.56)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C428(1.13); C664(1.17)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C428(1.11); C664(1.26)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C428(1.09); C664(1.35)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C664(1.29); C428(1.30)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C428(1.01); C664(1.09)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C428(1.04); C664(1.27)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C664(1.07); C428(1.23)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C428(1.07); C664(1.41)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C428(1.33); C664(1.63)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C428(0.93); C664(1.19)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C428(0.97); C664(1.42)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C428(1.08); C664(1.20)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C428(0.99)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C428(0.87); C664(1.29)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C428(0.99); C664(1.24)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C428(0.92); C664(1.54)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C428(0.93); C664(1.28)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C428(0.93); C664(1.66)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C428(1.09); C664(2.21)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C428(1.06); C664(1.88)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C428(1.03); C664(1.88)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C428(1.00)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C428(1.02)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C428(1.22)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C428(1.08)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C428(1.04)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C428(1.02)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C428(1.10)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C428(1.18)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C428(1.27)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C428(1.06)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C428(0.98)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C428(1.00)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C428(1.18)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C428(0.87)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C428(1.16)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C428(1.18)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C428(1.37)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C664(0.94); C428(1.06)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C664(0.84); C428(1.04)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C664(0.87); C428(1.01)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C428(1.01); C664(1.03)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C664(1.02); C428(1.12)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C664(0.97); C428(1.17)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C428(1.05); C664(1.18)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C428(1.06); C664(1.06)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C428(1.09); C664(1.18)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C428(1.08); C664(1.16)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C664(0.85); C428(1.04)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C664(1.04); C428(1.51)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C664(0.99); C428(1.17)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C664(1.11); C428(1.27)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C664(0.95); C428(0.96)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C664(0.70); C428(0.90)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C664(0.66); C428(0.85)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C428(1.16)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C428(0.99)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C428(1.03)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C428(1.03)  LDD2171  [4]
 LDCM0632  CL-Sc Hep-G2 C664(20.00); C521(1.07)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C664(0.89); C428(1.29)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C664(1.15); C428(1.16)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C428(1.00); C664(1.15)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C428(0.99)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C428(1.04)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C428(0.99)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C428(1.03)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C428(0.80); C664(1.05)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C428(0.81); C664(1.13)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C428(0.86); C664(1.22)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C428(0.85); C664(1.39)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C428(0.81); C664(1.23)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C428(1.18); C664(1.54)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C428(0.88); C664(1.21)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C428(0.85); C664(1.24)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C428(0.84)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C428(0.81)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C428(0.81)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C428(0.83)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C428(0.92)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C664(1.17)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C664(1.06)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C664(1.03)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C428(1.13); C664(1.23)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C664(1.01)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C664(0.99); C428(1.13)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C428(1.02); C664(1.32)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C428(1.01); C664(1.18)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C428(0.99); C664(1.30)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C428(0.98); C664(1.14)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C664(0.94); C428(1.03)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C428(0.96); C664(1.28)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C428(0.98); C664(1.36)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C428(1.11); C664(1.24)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C428(1.07); C664(1.17)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C664(1.00); C428(1.18)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C428(0.74)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C428(0.84)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C428(0.87)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C428(0.90)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C664(1.03); C428(1.04)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C428(0.86)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C428(0.93)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C428(1.01)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C428(0.78)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C428(0.84)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C428(0.85)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C428(0.86)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C428(0.89)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C428(0.92)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C428(0.89)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C428(1.14); C664(1.14)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C428(0.97)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C428(0.90); C664(0.89)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C428(0.77); C664(0.86)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C428(0.82); C664(0.83)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C428(0.87); C664(1.08)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C428(0.85); C664(0.93)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C428(0.91); C664(1.05)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C428(0.82); C664(1.17)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C428(0.84); C664(1.01)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C428(1.10); C664(0.98)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C428(0.89); C664(0.84)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C428(0.79); C664(0.93)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C428(0.99); C664(0.96)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C428(0.90); C664(1.31)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C428(1.00); C664(1.05)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C428(0.92); C664(1.11)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C428(1.17); C664(1.04)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C428(1.08); C664(1.02)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C428(0.97); C664(1.03)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C428(0.91); C664(1.19)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C428(1.04); C664(0.91)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C428(0.93); C664(1.06)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C428(0.97); C664(1.05)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C428(0.83); C664(1.11)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C428(0.90); C664(0.71)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C428(0.93); C664(1.17)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C428(0.84); C664(1.03)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C428(1.04); C664(1.07)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C428(1.07); C664(0.75)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C428(0.96); C664(1.41)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C428(0.94); C664(1.12)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C428(1.02); C664(1.09)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C428(0.81); C664(1.03)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C428(0.84); C664(0.93)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C428(0.76); C664(0.97)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C428(0.91); C664(1.09)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C428(0.86); C664(0.89)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C428(0.98); C664(0.99)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C428(0.82); C664(1.18)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C428(1.01); C664(0.91)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C428(0.87); C664(1.15)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C428(0.84); C664(0.92)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C428(1.21); C664(1.22)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C428(0.82); C664(1.05)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C428(0.80); C664(0.84)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C428(0.83); C664(0.96)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C428(0.89); C664(0.90)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C428(0.83); C664(0.96)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C428(0.94); C664(0.94)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C428(0.87); C664(0.77)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C428(1.16); C664(1.14)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C428(1.12); C664(1.31)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C428(1.16); C664(1.25)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C428(1.18); C664(1.07)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C428(1.00); C664(1.06)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C428(1.14); C664(1.50)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C428(1.11); C664(1.19)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C428(1.29); C664(1.19)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C428(1.43); C664(1.42)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C428(1.21); C664(1.16)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C428(1.02); C664(1.16)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C428(1.12); C664(1.37)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C428(1.26); C664(1.48)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C428(1.05); C664(1.12)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C428(1.28); C664(1.25)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C428(1.11); C664(1.38)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C428(1.12); C664(0.94)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C428(0.94); C664(1.04)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C428(0.93); C664(1.01)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C428(1.08); C664(0.94)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C428(1.08); C664(1.03)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C428(1.10); C664(1.05)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C428(1.00); C664(1.19)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C428(1.11); C664(1.19)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C664(0.99); C428(0.97); C347(1.03); C521(0.97)  LDD1698  [12]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.40  LDD0183  [3]
 LDCM0625  F8 Ramos C172(1.61)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C172(4.74)  LDD2190  [13]
 LDCM0576  Fragment14 Ramos C172(1.20)  LDD2193  [13]
 LDCM0586  Fragment28 Ramos C172(0.85)  LDD2198  [13]
 LDCM0468  Fragment33 HCT 116 C428(0.89); C664(1.01)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C428(1.08); C664(1.08)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C664(0.89); C521(0.95); C428(0.89); C460(0.85)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C664(1.00); C521(0.98); C428(0.95); C460(1.02)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C460(2.57)  LDD3310  [14]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C424(0.88)  LDD2137  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C521(0.60)  LDD2207  [15]
 LDCM0021  THZ1 HCT 116 C428(1.03)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial inner membrane protease ATP23 homolog (ATP23) Peptidase M76 family Q9Y6H3
E3 ubiquitin-protein ligase TRIM21 (TRIM21) TRIM/RBCC family P19474
Tripartite motif-containing protein 14 (TRIM14) TRIM/RBCC family Q14142
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
E3 ubiquitin-protein ligase MARCHF7 (MARCHF7) . Q9H992
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beclin-1 (BECN1) Beclin family Q14457
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Exocyst complex component 4 (EXOC4) SEC8 family Q96A65
WASH complex subunit 1 (WASHC1) WASH1 family A8K0Z3
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Zinc finger protein 35 (ZNF35) Krueppel C2H2-type zinc-finger protein family P13682
Zinc finger protein 566 (ZNF566) Krueppel C2H2-type zinc-finger protein family Q969W8
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Zinc finger C2HC domain-containing protein 1A (ZC2HC1A) ZC2HC1 family Q96GY0
DNA methyltransferase 1-associated protein 1 (DMAP1) . Q9NPF5
Golgin-45 (BLZF1) . Q9H2G9
Zinc finger and SCAN domain-containing protein 4 (ZSCAN4) . Q8NAM6
Zinc finger protein 628 (ZNF628) . Q5EBL2
Other
Click To Hide/Show 36 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BEX2 (BEX2) BEX family Q9BXY8
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) BLOC1S2 family Q6QNY1
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
CWF19-like protein 2 (CWF19L2) CWF19 family Q2TBE0
RNA polymerase II elongation factor ELL2 (ELL2) ELL/occludin family O00472
Splicing factor ESS-2 homolog (ESS2) ESS2 family Q96DF8
Protein FAM217B (FAM217B) FAM217 family Q9NTX9
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type II cytoskeletal 2 oral (KRT76) Intermediate filament family Q01546
Pre-mRNA-splicing factor ISY1 homolog (ISY1) ISY1 family Q9ULR0
Methyl-CpG-binding domain protein 3-like 1 (MBD3L1) MBD3L family Q8WWY6
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Myozenin-3 (MYOZ3) Myozenin family Q8TDC0
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
Stathmin-3 (STMN3) Stathmin family Q9NZ72
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Synaptotagmin-17 (SYT17) Synaptotagmin family Q9BSW7
Transcription initiation factor IIE subunit beta (GTF2E2) TFIIE beta subunit family P29084
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) . Q13155
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
BRD4-interacting chromatin-remodeling complex-associated protein-like (BICRAL) . Q6AI39
GRAM domain-containing protein 4 (GRAMD4) . Q6IC98
Interactor of HORMAD1 protein 1 (IHO1) . Q8IYA8
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Proline-rich protein 35 (PRR35) . P0CG20
snRNA-activating protein complex subunit 1 (SNAPC1) . Q16533
TBC1 domain family member 22B (TBC1D22B) . Q9NU19
Ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2) . Q9BRT2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.