Details of the Target

General Information of Target

Target ID LDTP08136
Target Name YTH domain-containing family protein 3 (YTHDF3)
Gene Name YTHDF3
Gene ID 253943
Synonyms
YTH domain-containing family protein 3; DF3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSATSVDQRPKGQGNKVSVQNGSIHQKDAVNDDDFEPYLSSQTNQSNSYPPMSDPYMPSY
YAPSIGFPYSLGEAAWSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALGNTPPFLG
QHGFNFFPGNADFSTWGTSGSQGQSTQSSAYSSSYGYPPSSLGRAITDGQAGFGNDTLSK
VPGISSIEQGMTGLKIGGDLTAAVTKTVGTALSSSGMTSIATNSVPPVSSAAPKPTSWAA
IARKPAKPQPKLKPKGNVGIGGSAVPPPPIKHNMNIGTWDEKGSVVKAPPTQPVLPPQTI
IQQPQPLIQPPPLVQSQLPQQQPQPPQPQQQQGPQPQAQPHQVQPQQQQLQNRWVAPRNR
GAGFNQNNGAGSENFGLGVVPVSASPSSVEVHPVLEKLKAINNYNPKDFDWNLKNGRVFI
IKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGKGPLYLLFSVNGSGHFCGVAEMK
SVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPL
EKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRRERNRNKQ
Target Bioclass
Other
Family
YTHDF family, YTHDF3 subfamily
Subcellular location
Cytoplasm, cytosol
Function
Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex or PAN3. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. Acts as a negative regulator of type I interferon response by down-regulating interferon-stimulated genes (ISGs) expression: acts by binding to FOXO3 mRNAs. Binds to FOXO3 mRNAs independently of METTL3-mediated m6A modification. Can also act as a regulator of mRNA stability in cooperation with YTHDF2 by binding to m6A-containing mRNA and promoting their degradation. Recognizes and binds m6A-containing circular RNAs (circRNAs); circRNAs are generated through back-splicing of pre-mRNAs, a non-canonical splicing process promoted by dsRNA structures across circularizing exons. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind N1-methyladenosine (m1A)-containing mRNAs: inhibits trophoblast invasion by binding to m1A-methylated transcripts of IGF1R, promoting their degradation.; Has some antiviral activity against HIV-1 virus: incorporated into HIV-1 particles in a nucleocapsid-dependent manner and reduces viral infectivity in the next cycle of infection. May interfere with this early step of the viral life cycle by binding to N6-methyladenosine (m6A) modified sites on the HIV-1 RNA genome.
Uniprot ID
Q7Z739
Ensemble ID
ENST00000539294.6
HGNC ID
HGNC:26465
ChEMBL ID
CHEMBL5169172

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y424(13.07); Y452(63.71)  LDD3495  [1]
DBIA
 Probe Info  		C439(1.35)  LDD0531  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
SF
 Probe Info  		N.A.  LDD0028  [5]
1c-yne
 Probe Info  		N.A.  LDD0228  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
HHS-465
 Probe Info  		N.A.  LDD2240  [9]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		19.97  LDD1865  [10]
C191
 Probe Info  		18.00  LDD1868  [10]
C193
 Probe Info  		6.45  LDD1869  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C439(1.35)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C439(0.78)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C439(0.77)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C439(0.72)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C439(0.78)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C439(0.72)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C439(0.76)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C439(0.68)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C439(0.63)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C439(0.67)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C439(0.72)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C439(0.75)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C439(0.69)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C439(0.73)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C439(0.63)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C439(0.67)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C439(0.87)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C439(0.76)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C439(0.74)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C439(0.77)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C439(0.84)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C439(0.83)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C439(0.91)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C439(0.83)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C439(1.06)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C439(0.86)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C439(0.89)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C439(1.05)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C439(0.89)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C439(0.85)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C439(0.84)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C439(0.74)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C439(0.83)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C439(0.79)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C439(0.67)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C439(0.86)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C439(0.92)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C439(0.82)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C439(0.77)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C439(0.75)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C439(0.82)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C439(0.89)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C439(0.79)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C439(0.80)  LDD0575  [2]
 LDCM0259  AC14 HEK-293T C439(0.76)  LDD0857  [2]
 LDCM0260  AC140 HCT 116 C439(0.78)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C439(0.71)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C439(0.90)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C439(0.78)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C439(0.48)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C439(0.68)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C439(0.56)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C439(0.54)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C439(0.55)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C439(0.52)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C439(0.89)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C439(0.72)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C439(0.75)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C439(0.60)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C439(0.55)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C439(0.59)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C439(0.55)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C439(0.68)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C439(0.66)  LDD2161  [2]
 LDCM0277  AC18 HEK-293T C439(0.98)  LDD1516  [11]
 LDCM0279  AC2 HCT 116 C439(1.02)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C439(1.01)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C439(0.97)  LDD1520  [11]
 LDCM0284  AC24 HEK-293T C439(0.94)  LDD1523  [11]
 LDCM0285  AC25 HCT 116 C439(0.89)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C439(0.77)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C439(0.81)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C439(0.93)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C439(0.84)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C439(1.20)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C439(0.80)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C439(0.78)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C439(0.73)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C439(0.74)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C439(0.84)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C439(0.96)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C439(0.89)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C439(0.97)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C439(0.98)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C439(0.95)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C439(1.22)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C439(0.84)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C439(0.69)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C439(0.84)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C439(0.65)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C439(0.83)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C439(0.87)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C439(0.82)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C439(0.91)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C439(0.78)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C439(1.08)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C439(1.31)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C439(0.90)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C439(0.94)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C439(0.91)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C439(0.94)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C439(1.11)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C439(0.93)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C439(0.93)  LDD0636  [2]
 LDCM0321  AC58 HEK-293T C439(0.99)  LDD1560  [11]
 LDCM0323  AC6 HEK-293T C439(0.72)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C439(0.98)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C439(0.86)  LDD1564  [11]
 LDCM0328  AC64 HEK-293T C439(0.85)  LDD1567  [11]
 LDCM0332  AC68 HEK-293T C439(1.21)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C439(1.34)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C439(0.75)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C439(1.61)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C439(1.39)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C439(1.17)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C439(1.67)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C439(1.56)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C439(1.73)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C439(1.60)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C439(1.53)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C439(1.75)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C439(1.06)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C439(0.90)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C439(1.19)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C439(1.21)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C439(1.60)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C439(1.15)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C439(1.23)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C439(1.06)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C439(1.05)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C439(1.40)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C439(1.52)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C439(1.07)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C439(1.22)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C439(0.95)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C439(1.16)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C439(1.31)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C439(1.16)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C439(1.42)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C439(1.43)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C439(2.14)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C439(0.69)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C439(0.88)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C439(0.80)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C439(1.01)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C439(0.73)  LDD0873  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 PaTu 8988t C439(0.97)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C439(0.64)  LDD1247  [2]
 LDCM0369  CL100 HCT 116 C439(0.98)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C439(0.93)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C439(1.17)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C439(1.05)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C439(0.94)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C439(1.11)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C439(1.07)  LDD1579  [11]
 LDCM0378  CL109 HEK-293T C439(1.15)  LDD1582  [11]
 LDCM0379  CL11 PaTu 8988t C439(0.82)  LDD1258  [2]
 LDCM0380  CL110 HEK-293T C439(1.22)  LDD1584  [11]
 LDCM0382  CL112 HCT 116 C439(1.19)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C439(0.93)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C439(0.84)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C439(0.94)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C439(0.89)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C439(0.73)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C439(0.78)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C439(0.74)  LDD0706  [2]
 LDCM0390  CL12 PaTu 8988t C439(0.90)  LDD1269  [2]
 LDCM0391  CL120 HCT 116 C439(0.67)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C439(1.21)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C439(0.85)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C439(0.80)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C439(0.90)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C439(0.82)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C439(0.98)  LDD1601  [11]
 LDCM0400  CL13 PaTu 8988t C439(0.85)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C439(0.85)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C439(0.81)  LDD1281  [2]
 LDCM0403  CL16 HCT 116 C439(0.96)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C439(0.69)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C439(0.60)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C439(0.78)  LDD0723  [2]
 LDCM0407  CL2 PaTu 8988t C439(0.80)  LDD1286  [2]
 LDCM0408  CL20 HCT 116 C439(0.71)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C439(0.67)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C439(0.77)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C439(0.74)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C439(0.78)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C439(0.71)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C439(0.79)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C439(0.72)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C439(0.68)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C439(0.66)  LDD0734  [2]
 LDCM0418  CL3 PaTu 8988t C439(0.62)  LDD1297  [2]
 LDCM0419  CL30 HCT 116 C439(0.74)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C439(0.77)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C439(0.57)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C439(0.67)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C439(0.62)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C439(0.66)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C439(0.68)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C439(0.60)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C439(0.73)  LDD0745  [2]
 LDCM0429  CL4 PaTu 8988t C439(0.70)  LDD1308  [2]
 LDCM0430  CL40 HCT 116 C439(0.56)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C439(0.76)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C439(0.79)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C439(0.76)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C439(0.56)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C439(0.69)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C439(1.10)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C439(0.98)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C439(0.93)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C439(0.84)  LDD0756  [2]
 LDCM0440  CL5 PaTu 8988t C439(0.74)  LDD1319  [2]
 LDCM0441  CL50 HCT 116 C439(0.85)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C439(0.89)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C439(1.11)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C439(1.15)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C439(0.92)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C439(0.96)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C439(0.97)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C439(1.03)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C439(1.36)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C439(1.15)  LDD0767  [2]
 LDCM0451  CL6 PaTu 8988t C439(0.74)  LDD1330  [2]
 LDCM0452  CL60 HCT 116 C439(1.01)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C439(1.15)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C439(1.84)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C439(1.40)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C439(1.54)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C439(1.31)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C439(1.84)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C439(1.21)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C439(1.61)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C439(1.64)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C439(0.76)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C439(1.15)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C439(1.54)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C439(1.55)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C439(1.77)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C439(3.31)  LDD1065  [2]
 LDCM0469  CL76 PaTu 8988t C439(0.75)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C439(0.86)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C439(0.69)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C439(1.08)  LDD1351  [2]
 LDCM0473  CL8 PaTu 8988t C439(0.64)  LDD1352  [2]
 LDCM0474  CL80 PaTu 8988t C439(0.68)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C439(0.84)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C439(0.88)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C439(0.69)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C439(0.83)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C439(0.90)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C439(0.74)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C439(0.90)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C439(0.77)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C439(0.84)  LDD1362  [2]
 LDCM0484  CL9 PaTu 8988t C439(0.78)  LDD1363  [2]
 LDCM0485  CL90 PaTu 8988t C439(0.94)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C439(0.83)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C439(0.91)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C439(0.95)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C439(1.36)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C439(1.03)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C439(1.12)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C439(0.98)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C439(0.80)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C439(0.91)  LDD0811  [2]
 LDCM0468  Fragment33 HEK-293T C439(3.03)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C439(0.82)  LDD0744  [2]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C439(0.91)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C439(0.91)  LDD1497  [11]
 LDCM0024  KB05 MOLM-13 C439(2.80)  LDD3333  [12]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FAS-associated factor 1 (FAF1) . Q9UNN5

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840