Details of the Target

General Information of Target

Target ID LDTP03554
Target Name Sorcin (SRI)
Gene Name SRI
Gene ID 6717
Synonyms
Sorcin; 22 kDa protein; CP-22; CP22; V19
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAYPGHPGAGGGYYPGGYGGAPGGPAFPGQTQDPLYGYFAAVAGQDGQIDADELQRCLTQ
SGIAGGYKPFNLETCRLMVSMLDRDMSGTMGFNEFKELWAVLNGWRQHFISFDTDRSGTV
DPQELQKALTTMGFRLSPQAVNSIAKRYSTNGKITFDDYIACCVKLRALTDSFRRRDTAQ
QGVVNFPYDDFIQCVMSV
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
Calcium-binding protein that modulates excitation-contraction coupling in the heart. Contributes to calcium homeostasis in the heart sarcoplasmic reticulum. Modulates the activity of RYR2 calcium channels.
Uniprot ID
P30626
Ensemble ID
ENST00000265729.7
HGNC ID
HGNC:11292

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.A9G .
MFE319 SNV: p.L102P .
MOLM16 SNV: p.R147Ter .
RKO SNV: p.E94D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y67(9.66)  LDD0260  [2]
STPyne
 Probe Info  		K127(5.65); K146(6.19)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K146(4.33)  LDD3494  [4]
THZ1-DTB
 Probe Info  		C194(1.14); C163(1.00)  LDD0460  [5]
BTD
 Probe Info  		C75(0.61)  LDD2096  [6]
DBIA
 Probe Info  		C57(0.92); C75(0.92)  LDD0078  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C194(0.00); C163(0.00); C162(0.00)  LDD0037  [10]
ATP probe
 Probe Info  		N.A.  LDD0035  [12]
JW-RF-010
 Probe Info  		C194(0.00); C162(0.00); C163(0.00); C57(0.00)  LDD0026  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [13]
IPM
 Probe Info  		C162(0.00); C163(0.00)  LDD2156  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		H108(0.00); C163(0.00)  LDD0217  [17]
AOyne
 Probe Info  		6.50  LDD0443  [18]
NAIA_5
 Probe Info  		C57(0.00); C194(0.00); C162(0.00); C75(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		17.15  LDD1865  [19]
C191
 Probe Info  		13.09  LDD1868  [19]
C278
 Probe Info  		51.98  LDD1948  [19]
FFF probe2
 Probe Info  		9.18  LDD0463  [20]
AR-1
 Probe Info  		1.36  LDD0439  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C57(1.05); C75(1.02); C162(0.99); C163(0.97)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C57(1.27); C75(1.50); C162(1.01); C163(0.97)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C57(1.01); C75(0.88); C162(0.85); C163(0.80)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C57(1.13); C75(1.15); C162(0.90); C163(0.89)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C57(1.28); C75(1.53); C162(0.99); C163(0.87)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C57(1.11); C75(1.23); C162(0.88); C163(0.80)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C57(1.49); C75(1.57); C162(0.96); C163(0.88)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C57(1.18); C75(1.24); C162(0.93); C163(0.86)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C57(1.31); C75(1.21); C162(0.87); C163(0.78)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C57(1.17); C75(1.14); C162(0.92); C163(0.83)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C57(1.19); C75(1.02); C162(1.00); C163(0.99)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C57(1.69); C75(1.70); C162(0.91); C163(0.96)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C57(1.36); C75(1.65); C162(0.96); C163(0.91)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C57(1.08); C75(1.08); C162(0.93); C163(0.97)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C57(1.40); C75(1.41); C162(1.01); C163(1.00)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C57(1.40); C75(1.40); C162(0.93); C163(0.90)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C57(0.91); C75(0.88); C162(0.91); C163(1.04)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C57(1.05); C75(1.05); C162(0.77); C163(0.86)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C57(0.93); C75(0.93); C162(0.82); C163(0.76)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C57(1.00); C75(0.97); C162(0.87); C163(0.91)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C57(1.24); C75(1.17); C162(0.83); C163(1.00)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C57(1.03); C75(0.97); C162(0.81); C163(1.00)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C57(0.85); C75(0.80); C162(0.83); C163(0.93)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C57(0.98); C75(1.13); C162(0.98); C163(0.97)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C57(0.93); C75(0.97); C162(0.86); C163(0.89)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C57(0.96); C75(0.90); C162(0.96); C163(1.04)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C57(1.11); C75(1.04); C162(0.86); C163(0.86)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C57(1.07); C75(0.99); C162(0.69); C163(1.10)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C57(1.44); C75(1.35); C162(0.91); C163(0.96)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C57(1.03); C75(0.95); C162(0.98); C163(0.93)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C57(0.86); C75(0.82); C162(0.87); C163(0.82)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C57(0.98); C75(0.86); C162(0.69); C163(0.79)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C57(0.70); C75(0.70); C162(0.78); C163(0.78)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C57(1.00); C75(1.00); C162(0.82); C163(0.82)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C57(0.92); C75(0.92); C162(1.09); C163(1.09)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C57(1.13); C75(1.13); C162(1.04); C163(1.04)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C57(0.83); C75(0.83); C162(0.94); C163(0.94)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C57(0.85); C75(0.85); C162(0.90); C163(0.90)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C57(0.90); C75(0.90); C162(0.78); C163(0.78)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C57(0.89); C75(0.89); C162(0.88); C163(0.88)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C57(0.98); C75(0.98); C162(0.93); C163(0.93)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C57(0.88); C75(0.88); C162(1.01); C163(1.01)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C57(1.04); C75(1.04); C162(0.86); C163(0.86)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C57(0.89); C75(0.89); C162(0.91); C163(0.91)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C57(1.87); C75(2.77); C162(0.98); C163(1.01)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C57(0.79); C75(0.79); C162(0.83); C163(0.83)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C57(1.06); C75(1.06); C162(0.86); C163(0.86)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C57(0.98); C75(0.98); C162(0.94); C163(0.94)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C57(0.91); C75(0.94); C162(0.94); C163(0.99)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C163(0.77); C75(0.82); C162(0.86); C57(0.88)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C163(0.91); C162(0.97); C75(1.03); C57(1.15)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C163(0.84); C162(0.85); C75(1.13); C57(1.16)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C163(0.85); C75(0.95); C162(0.96); C57(1.04)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C163(0.75); C75(0.79); C162(0.81); C57(0.97)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C163(0.79); C162(0.82); C75(0.91); C57(1.07)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C162(1.06); C163(1.07); C57(1.22); C75(1.44)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C163(0.95); C162(0.97); C57(1.23); C75(1.35)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C163(0.89); C75(0.98); C162(0.98); C57(1.00)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C163(0.86); C162(0.92); C75(1.34); C57(1.35)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C75(0.70); C163(0.76); C162(0.87); C57(0.87)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C57(1.34); C75(1.31); C162(0.98); C163(0.89)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C57(0.72); C75(0.67); C162(0.87); C163(0.82)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C57(1.22); C75(1.18); C162(1.03); C163(1.00)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C57(1.41); C75(1.42); C162(1.05); C163(0.92)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C75(0.62); C163(0.86); C57(0.90); C162(0.91)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C162(0.83); C163(0.84); C75(0.92); C57(0.95)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C75(0.80); C57(0.90); C163(0.94); C162(0.98)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C194(0.76); C163(0.97); C162(0.98); C75(1.03)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C162(0.91); C57(0.91); C163(0.91); C75(0.94)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C163(0.75); C162(0.79); C57(0.87); C75(0.95)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C75(0.72); C57(0.85); C163(0.88); C162(0.96)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C75(0.70); C57(0.76); C163(0.82); C162(0.87)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C163(0.97); C75(1.05); C57(1.05); C162(1.07)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C57(0.77); C75(0.77); C162(0.93); C163(1.07)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C57(0.47); C75(0.47); C162(0.61); C163(0.74)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C162(0.61); C163(0.81); C57(0.96); C75(0.96)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C57(0.43); C75(0.43); C162(0.55); C163(0.73)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C57(0.67); C75(0.67); C162(0.72); C163(0.82)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C194(0.79); C162(0.96); C75(0.98); C163(0.98)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C57(0.68); C75(0.68); C162(0.74); C163(1.12)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C57(0.55); C75(0.55); C162(0.63); C163(1.05)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C57(0.53); C75(0.53); C162(0.55); C163(1.55)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C57(0.71); C75(0.71); C162(0.74); C163(1.26)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C162(0.96); C163(1.14); C57(1.21); C75(1.21)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C57(0.58); C75(0.58); C162(0.99); C163(0.99)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C57(0.51); C75(0.51); C162(1.03); C163(1.03)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C57(1.02); C75(1.02); C162(1.07); C163(1.07)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C162(0.98); C163(0.98); C57(1.37); C75(1.37)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C57(0.71); C75(0.71); C162(0.96); C163(0.96)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C194(0.85); C163(0.91); C162(0.91); C57(1.02)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C57(0.66); C75(0.66); C162(0.88); C163(0.88)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C57(0.86); C75(0.86); C162(1.00); C163(1.00)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C162(0.89); C163(0.89); C57(1.11); C75(1.11)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C162(0.83); C163(0.83); C57(1.36); C75(1.36)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C162(0.87); C163(0.87); C57(1.25); C75(1.25)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C162(0.88); C163(0.88); C57(0.93); C75(0.93)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C75(0.65); C57(0.82); C163(0.95); C162(0.96)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C75(0.59); C163(0.91); C162(0.91); C57(0.91)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C163(0.98); C162(0.99); C57(1.10); C75(1.12)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C75(0.65); C163(0.82); C162(0.82); C57(0.94)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C194(0.72); C162(0.84); C163(0.90); C57(1.12)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C163(0.82); C162(0.83); C57(1.10); C75(1.13)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C163(0.95); C162(0.95); C57(1.17); C75(1.34)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C75(0.81); C57(0.91); C163(0.93); C162(0.94)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C163(0.87); C162(0.87); C75(1.31); C57(1.31)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C163(0.94); C162(0.96); C57(1.18); C75(1.28)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C75(0.85); C163(0.87); C162(0.89); C57(1.09)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C163(0.73); C162(0.73); C57(1.45); C75(1.59)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C75(0.40); C57(0.50); C163(0.82); C162(0.85)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C57(0.75); C162(0.80); C75(0.83); C163(0.89)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C75(0.56); C57(0.62); C162(0.87); C163(0.88)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C162(0.97); C163(0.98); C57(1.22); C75(1.31)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C57(0.50); C75(0.52); C163(0.74); C162(0.75)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C75(0.57); C57(0.60); C163(0.80); C162(0.81)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C75(0.37); C57(0.45); C163(0.73); C162(0.74)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C75(0.38); C57(0.47); C162(0.78); C163(0.79)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C75(0.34); C57(0.44); C163(0.76); C162(0.79)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C75(0.36); C57(0.43); C163(0.82); C162(0.86)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C75(0.54); C57(0.57); C163(0.87); C162(0.88)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C57(0.48); C75(0.49); C163(0.62); C162(0.69)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C163(0.80); C162(0.81); C57(1.04); C75(1.22)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C163(0.71); C162(0.76); C57(0.98); C75(1.16)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C163(1.02); C162(1.04); C57(1.11); C75(1.17)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C57(0.58); C163(0.61); C162(0.63); C75(0.67)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C163(0.76); C162(0.80); C57(0.92); C75(1.02)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C57(0.77); C163(0.78); C162(0.80); C75(0.86)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C57(0.57); C75(0.65); C163(0.54); C162(0.55)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C163(0.60); C162(0.62); C57(0.66); C75(0.77)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C163(0.49); C57(0.50); C162(0.52); C75(0.56)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C163(0.67); C162(0.69); C57(0.74); C75(0.83)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C163(0.67); C162(0.68); C57(1.00); C75(1.11)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C163(0.76); C162(0.76); C57(0.89); C75(0.96)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C163(0.78); C162(0.80); C57(0.91); C75(1.03)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C162(1.00); C163(1.01); C57(1.05); C75(1.16)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C163(0.78); C162(0.80); C57(1.02); C75(1.11)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C163(0.66); C162(0.69); C57(1.06); C75(1.26)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C162(0.51); C163(0.51); C57(0.52); C75(0.67)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C57(0.52); C163(0.70); C162(0.72); C75(0.79)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C57(0.56); C162(0.63); C75(0.71); C163(0.75)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C57(0.54); C162(0.72); C75(0.72); C163(0.77)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C75(0.69); C57(0.72); C162(0.90); C163(0.91)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C75(0.69); C57(0.73); C162(1.03); C163(1.10)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C57(0.80); C75(0.82); C162(0.92); C163(1.05)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C75(0.66); C162(0.81); C57(0.85); C163(0.94)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C75(0.77); C57(0.78); C162(1.25); C163(1.43)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C162(0.67); C75(0.78); C163(0.78); C57(0.80)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C57(0.61); C162(0.68); C75(0.69); C163(0.84)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C57(0.67); C75(0.80); C162(0.81); C163(0.91)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C75(0.71); C162(0.76); C57(0.80); C163(0.81)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C162(0.78); C57(0.82); C163(0.90); C75(0.91)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C162(0.62); C163(0.76); C57(0.91); C75(0.91)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C162(0.72); C57(0.76); C163(0.86); C75(1.14)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C163(0.57); C162(0.63); C75(0.88); C57(0.92)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C163(0.79); C162(0.85); C57(0.86); C75(0.90)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C57(1.14); C75(1.28); C162(1.13); C163(1.09)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C75(1.13); C57(1.13); C163(1.14); C162(1.16)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C163(0.97); C162(0.98); C57(1.24); C75(1.42)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 12.81  LDD0403  [1]
 LDCM0174  Arenobufagin Hep-G2 1.36  LDD0439  [21]
 LDCM0020  ARS-1620 HCC44 C57(0.92); C75(0.92)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa H108(0.00); C163(0.00); C162(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C57(0.89)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C194(0.88); C57(1.13); C75(1.14); C163(1.16)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C162(0.84); C163(0.85); C75(0.99); C194(1.05)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C194(0.80); C75(0.84); C57(0.88); C162(0.95)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C163(0.97); C162(0.98); C57(1.92); C75(2.85)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C163(1.02); C162(1.05); C57(1.60); C75(2.34)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C162(1.06); C163(1.06); C57(1.80); C75(2.62)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C163(1.02); C162(1.08); C57(1.50); C75(2.16)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C75(0.72); C57(0.81); C163(0.94); C162(1.07)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C163(0.77); C162(0.86); C75(0.95); C57(0.99)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C75(0.71); C163(0.80); C57(0.84); C162(0.91)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C75(0.77); C162(0.87); C163(0.88); C57(1.03)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C75(0.71); C163(0.81); C57(0.84); C162(0.89)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C75(0.86); C163(0.95); C57(0.97); C162(1.13)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C75(0.69); C57(0.83); C163(0.85); C162(0.99)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C57(0.83); C163(0.84); C75(0.86); C162(0.98)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C162(0.72); C57(0.78); C75(0.78); C163(1.00)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C162(0.80); C57(0.92); C75(0.92); C163(1.17)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C162(0.71); C57(0.97); C75(0.97); C163(0.97)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C162(0.69); C163(0.93); C57(1.21); C75(1.21)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C162(0.93); C57(1.04); C75(1.04); C163(1.22)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C162(0.77); C163(0.77); C57(6.19); C75(6.19)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C57(0.60); C75(0.60); C162(1.05); C163(1.05)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C57(0.49); C75(0.49); C162(0.93); C163(0.93)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C163(0.92); C162(1.00); C75(1.14); C194(1.23)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C57(0.63); C75(0.63); C162(1.01); C163(1.01)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C75(0.81); C57(0.93); C163(1.22); C162(1.24)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C162(0.93); C163(0.95); C57(1.39); C75(1.69)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C163(0.92); C162(0.93); C57(1.45); C75(1.88)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C163(0.89); C162(0.90); C75(1.03); C57(1.12)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C75(0.46); C57(0.55); C163(0.99); C162(0.99)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C57(0.67); C75(0.76); C162(0.98); C163(1.00)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C75(0.64); C57(0.65); C162(0.94); C163(0.97)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C75(0.51); C57(0.55); C163(0.85); C162(0.90)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C163(0.99); C162(0.99); C75(1.02); C57(1.03)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C163(0.99); C162(1.05); C194(1.20); C57(1.23)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C194(0.81); C162(0.84); C163(0.90); C75(1.01)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C75(0.68); C57(0.81); C163(0.99); C162(1.02)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C163(0.80); C162(0.82); C57(0.97); C75(1.19)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C163(0.84); C162(0.89); C57(0.90); C75(0.94)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C163(0.81); C162(0.85); C57(0.95); C75(1.14)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C194(0.94); C57(1.07); C163(1.14); C75(1.16)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C163(0.87); C57(0.88); C162(0.91); C75(0.93)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C163(0.73); C162(0.77); C57(0.79); C75(0.86)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C163(0.71); C162(0.75); C57(1.04); C75(1.97)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C162(0.91); C57(0.92); C163(0.96); C75(1.33)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C75(0.80); C57(0.80); C162(0.83); C163(0.81)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C57(0.78); C75(0.78); C162(0.84); C163(0.85)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C57(0.77); C75(0.66); C162(1.02); C163(1.03)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C57(1.04); C75(1.16); C162(0.87); C163(0.89)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C57(0.84); C75(0.61); C162(0.82); C163(0.83)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C57(0.97); C75(1.02); C162(0.83); C163(0.80)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C57(1.23); C75(0.92); C162(1.39); C163(1.34)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C57(0.97); C75(0.75); C162(0.98); C163(0.99)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C57(0.97); C75(0.85); C162(0.89); C163(0.87)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C57(0.82); C75(0.80); C162(0.92); C163(0.85)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C57(0.71); C75(0.68); C162(0.79); C163(0.75)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C57(0.84); C75(1.03); C162(0.76); C163(0.76)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C57(0.61); C75(0.28); C162(0.83); C163(0.77)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C57(1.11); C75(2.12); C162(0.85); C163(0.85)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C57(0.76); C75(0.76); C162(0.79); C163(0.77)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C57(0.71); C75(0.55); C162(0.83); C163(0.77)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C57(1.10); C75(1.25); C162(2.62); C163(2.07)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C57(0.75); C75(0.82); C162(0.91); C163(0.82)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C57(1.20); C75(2.42); C162(0.89); C163(0.86)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C57(0.77); C75(1.49); C162(0.87); C163(0.80)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C57(0.83); C75(1.20); C162(0.85); C163(0.78)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C57(0.78); C75(0.68); C162(0.82); C163(0.79)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C57(0.69); C75(0.60); C162(0.81); C163(0.81)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C57(1.07); C75(0.59); C162(1.08); C163(1.02)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C57(1.12); C75(0.83); C162(1.13); C163(1.08)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C57(1.16); C75(1.03); C162(1.12); C163(1.04)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C57(1.27); C75(1.00); C162(1.13); C163(1.09)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C57(1.39); C75(1.16); C162(1.28); C163(1.33)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C57(1.18); C75(1.47); C162(1.16); C163(1.10)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C57(1.35); C75(0.98); C162(1.15); C163(1.07)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C57(1.36); C75(1.48); C162(1.17); C163(1.08)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C57(1.02); C75(1.47); C162(1.01); C163(0.94)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C57(1.39); C75(2.11); C162(1.11); C163(1.05)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C57(1.12); C75(0.90); C162(1.07); C163(1.04)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C57(1.15); C75(1.38); C162(1.16); C163(1.12)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C57(1.15); C75(1.40); C162(1.20); C163(1.16)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C57(1.17); C75(1.27); C162(1.15); C163(1.12)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C57(1.10); C75(1.31); C162(1.14); C163(1.13)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C57(1.12); C75(0.93); C162(1.04); C163(1.11)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C57(1.19); C75(1.42); C162(1.10); C163(1.10)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C57(0.75); C75(0.75); C162(0.88); C163(0.79)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C57(0.77); C75(0.77); C162(0.90); C163(0.82)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C57(0.86); C75(0.86); C162(0.75); C163(0.72)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C57(0.89); C75(0.89); C162(0.75); C163(0.66)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C57(0.71); C75(0.71); C162(0.82); C163(0.71)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C57(0.77); C75(0.77); C162(0.69); C163(0.74)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C57(1.15); C75(1.15); C162(0.72); C163(0.74)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C57(1.21); C75(1.21); C162(0.67); C163(0.81)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C57(1.14); C75(1.14); C162(0.72); C163(0.72)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C57(1.13); C75(1.16); C162(0.96); C163(0.90)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C57(1.22); C75(1.22); C162(0.57); C163(0.59)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C57(1.05); C75(1.05); C162(0.70); C163(0.79)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C57(1.22); C75(1.22); C162(0.96); C163(0.96)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C57(1.12); C75(1.12); C162(0.74); C163(0.78)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C57(1.09); C75(1.09); C162(0.73); C163(0.73)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C57(0.94); C75(0.88); C162(0.76); C163(0.76)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C57(0.99); C75(0.94); C162(0.85); C163(0.79)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C57(0.84); C75(0.71); C162(0.96); C163(0.97)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C57(0.83); C75(0.78); C162(0.84); C163(0.84)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C57(1.11); C75(1.20); C162(0.83); C163(0.80)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C57(0.87); C75(0.86); C162(0.86); C163(0.82)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C57(0.72); C75(0.63); C162(0.82); C163(0.82)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C57(0.63); C75(0.58); C162(0.79); C163(0.74)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C57(0.72); C75(0.64); C162(0.77); C163(0.73)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C57(0.63); C75(0.58); C162(0.69); C163(0.65)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C57(0.81); C75(0.71); C162(0.85); C163(0.79)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C57(0.90); C75(0.74); C162(0.91); C163(0.88)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C57(0.96); C75(0.85); C162(0.84); C163(0.79)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C57(1.06); C75(0.97); C162(0.79); C163(0.81)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C57(0.83); C75(0.76); C162(0.68); C163(0.70)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C57(1.14); C75(1.11); C162(1.33); C163(1.26)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C57(0.97); C75(0.98); C162(0.88); C163(0.85)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C57(0.95); C75(0.76); C162(1.04); C163(1.02)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C57(0.99); C75(0.93); C162(1.01); C163(1.02)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C57(1.18); C75(1.20); C162(0.97); C163(0.97)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C57(0.99); C75(0.91); C162(0.87); C163(0.87)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C57(1.03); C75(1.12); C162(0.97); C163(0.97)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C57(1.15); C75(1.09); C162(1.04); C163(1.04)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C57(1.26); C75(1.41); C162(1.11); C163(1.13)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C57(0.98); C75(1.05); C162(0.94); C163(0.94)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C57(0.91); C75(0.83); C162(1.02); C163(1.04)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C57(1.09); C75(1.21)  LDD1698  [22]
 LDCM0625  F8 Ramos 0.75  LDD2187  [23]
 LDCM0572  Fragment10 Ramos 0.72  LDD2189  [23]
 LDCM0573  Fragment11 Ramos 0.11; C194(0.36)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos 0.87  LDD2191  [23]
 LDCM0575  Fragment13 Ramos 1.82; C194(0.22)  LDD2192  [23]
 LDCM0576  Fragment14 Ramos 1.31  LDD2193  [23]
 LDCM0579  Fragment20 Ramos 0.90  LDD2194  [23]
 LDCM0580  Fragment21 Ramos 0.99; C194(0.14)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos 0.75; C194(0.21)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos 2.38; C194(0.41)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos 1.17; C194(0.21)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos 1.20; C194(0.37)  LDD2199  [23]
 LDCM0589  Fragment31 Ramos 2.30; C194(0.33)  LDD2200  [23]
 LDCM0590  Fragment32 Ramos 0.64  LDD2201  [23]
 LDCM0468  Fragment33 HCT 116 C57(0.82); C75(0.82); C162(0.77); C163(0.74)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos 1.65; C194(0.10)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos 0.70  LDD2184  [23]
 LDCM0427  Fragment51 HCT 116 C57(0.75); C75(1.10); C162(0.77); C163(0.72)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos 2.34; C194(0.19)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos 1.86; C194(0.16)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos 0.71  LDD2186  [23]
 LDCM0571  Fragment9 Ramos 0.74  LDD2188  [23]
 LDCM0107  IAA HeLa H108(0.00); C163(0.00)  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C162(5.30); C163(5.30)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C162(10.27); C163(10.27)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C162(4.86); C163(4.86)  LDD0082  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C75(0.61)  LDD2096  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C75(0.64)  LDD2151  [6]
 LDCM0131  RA190 MM1.R C194(1.50); C162(1.09); C163(1.09)  LDD0304  [24]
 LDCM0021  THZ1 HeLa S3 C194(1.14); C163(1.00)  LDD0460  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Transcription factor 12 (TCF12) . Q99081
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Annexin A7 (ANXA7) Annexin family P20073
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Proline-rich protein 13 (PRR13) . Q9NZ81

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Calcium Citrate . DB11093

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Affinity-Based Protein Profiling Reveals Cellular Targets of Photoreactive Anticancer Inhibitors. ACS Chem Biol. 2019 Dec 20;14(12):2546-2552. doi: 10.1021/acschembio.9b00784. Epub 2019 Nov 26.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.