Details of the Target

General Information of Target

Target ID LDTP02335
Target Name U1 small nuclear ribonucleoprotein C (SNRPC)
Gene Name SNRPC
Gene ID 6631
Synonyms
U1 small nuclear ribonucleoprotein C; U1 snRNP C; U1-C; U1C
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPKFYCDYCDTYLTHDSPSVRKTHCSGRKHKENVKDYYQKWMEEQAQSLIDKTTAAFQQG
KIPPTPFSAPPPAGAMIPPPPSLPGPPRPGMMPAPHMGGPPMMPMMGPPPPGMMPVGPAP
GMRPPMGGHMPMMPGPPMMRPPARPMMVPTRPGMTRPDR
Target Bioclass
Other
Family
U1 small nuclear ribonucleoprotein C family
Subcellular location
Nucleus
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. {|HAMAP-Rule:MF_03153}.
Uniprot ID
P09234
Ensemble ID
ENST00000244520.10
HGNC ID
HGNC:11157

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.60  LDD0402  [1]
TH211
 Probe Info  		Y8(7.06)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K22(7.51); K31(4.27); K35(4.41); K52(5.00)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
DBIA
 Probe Info  		C25(1.92)  LDD3316  [5]
BTD
 Probe Info  		C25(3.47)  LDD1700  [6]
HHS-475
 Probe Info  		Y8(0.93); Y12(1.05)  LDD0264  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C6(0.00); C9(0.00); C25(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C6(0.00); C9(0.00); C25(0.00)  LDD0037  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
IPM
 Probe Info  		N.A.  LDD0147  [14]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		C9(0.00); C6(0.00); C25(0.00)  LDD0018  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		C6(0.00); C9(0.00); H15(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		H15(0.00); C9(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C6(0.00); C9(0.00)  LDD0218  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
HHS-465
 Probe Info  		Y12(0.00); Y8(0.00)  LDD2240  [20]
HHS-482
 Probe Info  		Y12(0.89)  LDD2239  [21]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		21.56  LDD1865  [22]
C191
 Probe Info  		17.88  LDD1868  [22]
C193
 Probe Info  		10.13  LDD1869  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C25(0.35)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C25(0.87)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C25(0.54)  LDD2095  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C25(1.10)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C25(3.22)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C25(1.06)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C25(0.30)  LDD2132  [6]
 LDCM0259  AC14 HEK-293T C6(1.12)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C6(1.04)  LDD1513  [23]
 LDCM0282  AC22 HEK-293T C6(1.55)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C6(1.04)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C6(1.22)  LDD1523  [23]
 LDCM0291  AC30 HEK-293T C6(0.85)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C6(1.09)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C6(1.05)  LDD1532  [23]
 LDCM0299  AC38 HEK-293T C6(0.89)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C6(1.21)  LDD1539  [23]
 LDCM0302  AC40 HEK-293T C6(1.16)  LDD1541  [23]
 LDCM0308  AC46 HEK-293T C6(1.34)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C6(1.39)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C6(1.04)  LDD1549  [23]
 LDCM0317  AC54 HEK-293T C6(0.88)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C6(1.12)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C6(1.09)  LDD1558  [23]
 LDCM0323  AC6 HEK-293T C6(0.80)  LDD1562  [23]
 LDCM0326  AC62 HEK-293T C6(0.85)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C6(0.87)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C6(1.08)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C6(0.99)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C6(1.12)  LDD1569  [23]
 LDCM0545  Acetamide MDA-MB-231 C25(0.37)  LDD2138  [6]
 LDCM0275  AKOS034007705 HEK-293T C6(1.02)  LDD1514  [23]
 LDCM0498  BS-3668 MDA-MB-231 C25(0.39)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C6(0.00); C9(0.00); H15(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C25(20.00); C25(0.52)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C6(0.94)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C6(1.53)  LDD1572  [23]
 LDCM0370  CL101 HEK-293T C6(1.04)  LDD1574  [23]
 LDCM0374  CL105 HEK-293T C6(0.93)  LDD1578  [23]
 LDCM0378  CL109 HEK-293T C6(0.97)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C6(1.40)  LDD1583  [23]
 LDCM0383  CL113 HEK-293T C6(0.94)  LDD1587  [23]
 LDCM0387  CL117 HEK-293T C6(1.12)  LDD1591  [23]
 LDCM0390  CL12 HEK-293T C6(1.27)  LDD1594  [23]
 LDCM0392  CL121 HEK-293T C6(0.99)  LDD1596  [23]
 LDCM0396  CL125 HEK-293T C6(0.82)  LDD1600  [23]
 LDCM0400  CL13 HEK-293T C6(0.66)  LDD1604  [23]
 LDCM0410  CL22 HEK-293T C6(1.17)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C6(1.53)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C6(1.51)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C6(0.69)  LDD1617  [23]
 LDCM0423  CL34 HEK-293T C6(1.06)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C6(1.54)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C6(1.21)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C6(0.87)  LDD1630  [23]
 LDCM0436  CL46 HEK-293T C6(1.45)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C6(1.47)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C6(1.24)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C6(1.07)  LDD1643  [23]
 LDCM0449  CL58 HEK-293T C6(1.01)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C6(1.55)  LDD1653  [23]
 LDCM0452  CL60 HEK-293T C6(1.52)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C6(0.99)  LDD1656  [23]
 LDCM0463  CL70 HEK-293T C6(1.15)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C6(1.37)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C6(1.67)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C6(0.85)  LDD1669  [23]
 LDCM0476  CL82 HEK-293T C6(1.09)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C6(1.31)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C6(1.12)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C6(0.75)  LDD1682  [23]
 LDCM0489  CL94 HEK-293T C6(1.07)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C6(1.07)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C6(1.02)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C6(0.97)  LDD1695  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C25(0.96)  LDD1702  [6]
 LDCM0625  F8 Ramos C25(0.35); 0.60  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C25(0.42)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C25(1.85)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C25(0.08)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C25(0.07)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C25(0.35)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C25(0.99)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C25(0.22)  LDD2195  [24]
 LDCM0578  Fragment27 Ramos C25(0.16)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C25(0.02)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C25(0.12)  LDD2199  [24]
 LDCM0590  Fragment32 Ramos C25(0.23)  LDD2201  [24]
 LDCM0468  Fragment33 Ramos C25(0.66)  LDD2202  [24]
 LDCM0596  Fragment38 Ramos C25(0.20)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C25(0.35); 0.19  LDD2184  [24]
 LDCM0610  Fragment52 Ramos C25(0.65)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C25(0.21)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C25(0.49); 0.65  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C25(0.66)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y8(0.93); Y12(1.05)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y8(2.51); Y12(4.23)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y8(0.34); Y12(0.59)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y8(2.53); Y12(3.93)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y8(1.44); Y12(2.57)  LDD0268  [7]
 LDCM0107  IAA HeLa C6(0.00); H15(0.00); C9(0.00)  LDD0221  [17]
 LDCM0022  KB02 Ramos C25(0.87); 0.82  LDD2182  [24]
 LDCM0023  KB03 MDA-MB-231 C25(0.92)  LDD1701  [6]
 LDCM0024  KB05 MEL167 C25(1.92)  LDD3316  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C25(1.53)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C25(0.40)  LDD2121  [6]
 LDCM0109  NEM HeLa H15(0.00); C9(0.00)  LDD0223  [17]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C25(0.47)  LDD2089  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C25(1.08)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C25(2.57)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C25(2.81)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C25(0.36)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C25(0.88)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C25(1.36)  LDD2098  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C25(0.32)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C25(1.87)  LDD2101  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C25(2.41)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C25(0.41)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C25(1.39)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C25(0.36)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C25(1.44)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C25(1.62)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C25(1.83)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C25(0.72)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C25(0.68)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C25(1.52)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C25(1.49)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C25(6.76)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C25(0.78)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C25(0.47)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C25(1.39)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C25(1.66)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C25(2.11)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C25(0.76)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C25(2.20)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C25(0.73)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C25(0.65)  LDD2134  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C25(3.47)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C25(1.11)  LDD2140  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C25(1.02)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C25(12.32)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C25(5.61)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C25(1.78)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C25(3.73)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C25(0.78)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C25(0.48)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C25(2.01)  LDD2153  [6]
 LDCM0131  RA190 MM1.R C6(1.02); C9(1.02)  LDD0304  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Integrator complex subunit 11 (INTS11) RNA-metabolizing metallo-beta-lactamase-like family Q5TA45
Inactive Ufm1-specific protease 1 (UFSP1) Peptidase C78 family Q6NVU6
Group 10 secretory phospholipase A2 (PLA2G10) Phospholipase A2 family O15496
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
Exosome complex component RRP43 (EXOSC8) RNase PH family Q96B26
17-beta-hydroxysteroid dehydrogenase 14 (HSD17B14) Short-chain dehydrogenases/reductases (SDR) family Q9BPX1
Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 (JMJD7) . P0C870
Methyltransferase-like protein 27 (METTL27) . Q8N6F8
NEDD4-like E3 ubiquitin-protein ligase WWP2 (WWP2) . O00308
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Arginine-glutamic acid dipeptide repeats protein (RERE) . Q9P2R6
Other
Click To Hide/Show 29 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Keratin-associated protein 19-2 (KRTAP19-2) KRTAP type 19 family Q3LHN2
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-6 (KRTAP19-6) KRTAP type 19 family Q3LI70
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Odontogenic ameloblast-associated protein (ODAM) ODAM family A1E959
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Proline-rich protein 20D (PRR20D) PRR20 family P86480
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
Protein transport protein Sec23B (SEC23B) SEC23/SEC24 family Q15437
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
WD repeat domain-containing protein 83 (WDR83) WD repeat MORG1 family Q9BRX9
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Cytotoxic granule associated RNA binding protein TIA1 (TIA1) . P31483
DAZ-associated protein 2 (DAZAP2) . Q15038
Extracellular matrix protein 1 (ECM1) . Q16610
Four and a half LIM domains protein 3 (FHL3) . Q13643
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) . O14979
Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) . P31943
Keratin-associated protein 21-2 (KRTAP21-2) . Q3LI59
Melanoma-associated antigen D1 (MAGED1) . Q9Y5V3
Rho GTPase-activating protein 9 (ARHGAP9) . Q9BRR9
RNA-binding protein 10 (RBM10) . P98175
Saitohin (STH) . Q8IWL8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.