Details of the Target

General Information of Target

Target ID LDTP13870
Target Name Nischarin (NISCH)
Gene Name NISCH
Gene ID 11188
Synonyms
IRAS; KIAA0975; Nischarin; Imidazoline receptor 1; I-1; IR1; Imidazoline receptor antisera-selected protein; hIRAS; Imidazoline-1 receptor; I1R; Imidazoline-1 receptor candidate protein; I-1 receptor candidate protein; I1R candidate protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSS
PLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQ
LPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNH
VYKERFPKATAQMEEKLRDFTRAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLI
TTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFY
HLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVHLEEQDSGGSNTPEQDDLSEG
RSSKAKKPPGENDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAF
VERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAE
TVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAR
EFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVI
SDDILWPEGDEALPTEAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKA
EFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQ
LSQHEPKTPVAAAGSSKREPSTKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASE
ASFLEGEASPPLGARRRFSALLEPSRFSAPQEDEDEARLRRPPRPSSDPAGSLDARAPKE
ETQGEGTSSAGDSEATDRPRPGDLCPPSKDGDASGPRATNDLVLRRARHQQMSGDVAVEK
RPSRTGGKVIKSASATALSVMIPAVDPHGSSPLASPMSPRSLSSNPSSRDSSPSRDYSPA
VSGLRSPITIQRSGKKYGFTLRAIRVYMGDTDVYSVHHIVWHVEEGGPAQEAGLCAGDLI
THVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRP
SAKEGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHS
YRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAG
NIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPL
LKRVQSAEKLGASLSADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPVEGL
GAPRQVAVRRLGRQESPLSLGADPLLPEGASRPPVSSKEKESPGGAEACTPPRATTPGGR
TLERDVGCTRHQSVQTEDGTGGMARAVAKAALSPVQEHETGRRSSSGEAGTPLVPIVVEP
ARPGAKAVVPQPLGADSKGLQEPAPLAPSVPEAPRGRERWVLEVVEERTTLSGPRSKPAS
PKLSPEPQTPSLAPAKCSAPSSAVTPVPPASLLGSGTKPQVGLTSRCPAEAVPPAGLTKK
GVSSPAPPGP
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Cell membrane
Function
Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity. Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation. Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation. Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells. Inhibits lamellipodia formation, when overexpressed. Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
TTD ID
T78943
Uniprot ID
Q9Y2I1
DrugMap ID
TTUN4L1
Ensemble ID
ENST00000345716.9
HGNC ID
HGNC:18006
ChEMBL ID
CHEMBL3923

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A817V; p.D954E DBIA    Probe Info 
COLO320 SNV: p.S827R DBIA    Probe Info 
EFO27 SNV: p.Q1170R DBIA    Probe Info 
HCT15 SNV: p.L835M .
HEL SNV: p.E663K DBIA    Probe Info 
HEL9217 SNV: p.E663K DBIA    Probe Info 
IGR37 SNV: p.L609Q DBIA    Probe Info 
IGR39 SNV: p.L609Q DBIA    Probe Info 
JURKAT SNV: p.G194S; p.T449I .
KMRC20 Deletion: p.S246CfsTer15 .
LS180 SNV: p.G969D DBIA    Probe Info 
MCC26 SNV: p.S949F .
MFE296 SNV: p.R1036M DBIA    Probe Info 
MOLT4 SNV: p.A148T; p.F725L IA-alkyne    Probe Info 
NALM6 SNV: p.R808C DBIA    Probe Info 
NCIH1793 SNV: p.P1099L .
NCIH1944 SNV: p.E676D .
RH41 SNV: p.Y1169Ter .
SF295 SNV: p.Q538H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K942(10.00)  LDD0277  [1]
BTD
 Probe Info  		C848(0.93)  LDD2109  [2]
DBIA
 Probe Info  		C884(0.95); C887(0.95); C185(0.90)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C436(0.00); C1257(0.00); C403(0.00); C185(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
Lodoacetamide azide
 Probe Info  		C436(0.00); C1267(0.00); C403(0.00); C855(0.00)  LDD0037  [4]
IPM
 Probe Info  		C185(0.00); C959(0.00); C848(0.00)  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
AOyne
 Probe Info  		8.20  LDD0443  [9]
NAIA_5
 Probe Info  		C403(0.00); C227(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		15.03  LDD1865  [11]
C288
 Probe Info  		7.62  LDD1958  [11]
C407
 Probe Info  		11.55  LDD2064  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C848(0.86)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C185(0.93); C848(1.06)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C185(1.13); C848(1.09); C884(1.01); C887(1.01)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C848(1.22)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C848(1.07)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C848(1.08)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C848(1.41)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C848(1.25)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C848(1.30)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C848(1.44)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C848(1.26)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C848(1.14)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C848(1.03)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C185(1.06); C848(0.99); C884(0.80); C887(0.80)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C848(0.91)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C848(0.88)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C848(1.14)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C185(0.94); C848(1.17)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C185(1.09); C848(1.17)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C185(1.33); C848(1.28)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C185(1.39); C848(1.70)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C185(0.93); C848(1.12)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C185(1.16); C848(1.25)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C185(1.06); C848(1.32)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C185(0.94); C848(0.99); C884(0.86); C887(0.86)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C185(0.96); C848(1.28)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C185(1.07); C848(1.08)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C185(0.98); C848(1.14)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C185(0.93); C848(1.10)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C185(1.04); C848(1.31)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C185(1.14); C848(1.07)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C185(1.18); C848(1.36)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C185(1.22); C848(1.32)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C185(1.27); C484(1.22)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C185(1.29); C484(1.23)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C185(1.37); C484(1.03)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C185(1.25); C484(1.17)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C185(1.21); C484(1.26)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C185(1.31); C484(1.12)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C185(1.33); C484(1.17)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C185(1.46); C484(1.24)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C185(1.19); C484(0.98)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C185(1.16); C484(0.80)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C185(1.39); C484(0.98)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C185(1.26); C484(1.40)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C185(1.12); C848(0.74); C884(0.93); C887(0.93)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C185(1.42); C484(1.16)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C185(1.41); C484(1.31)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C185(1.12); C484(1.15)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C484(1.01); C848(1.27)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C848(0.80); C484(0.88)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C848(0.80); C484(0.82)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C848(0.98); C484(1.00)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C848(0.91); C484(1.01)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C484(0.88); C848(0.96)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C484(0.88); C848(1.05)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C848(0.78); C884(1.02); C887(1.02); C185(1.13)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C848(0.78); C484(0.91)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C848(0.95); C484(1.17)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C848(0.93); C484(1.02)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C484(0.87); C848(0.97)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C484(1.14); C848(1.06)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C484(1.30); C848(0.88)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C484(0.95); C848(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C484(1.16); C848(0.84)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C848(0.97); C894(1.07); C895(1.07); C185(1.09)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C185(1.20); C848(1.35); C484(1.52); C894(1.56)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C848(1.00); C185(1.10); C894(1.19); C895(1.19)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C848(0.97); C185(1.01)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C484(0.99); C185(1.09); C894(1.09); C895(1.09)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C185(0.99); C848(1.12); C894(1.13); C895(1.13)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C894(0.94); C895(0.94); C484(0.99); C848(1.01)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C848(0.94); C185(0.97); C484(1.12); C894(1.29)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C484(1.01); C894(1.09); C895(1.09); C185(1.10)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C848(0.87); C185(0.99); C1257(1.38)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C848(1.01); C185(1.11); C1257(1.20)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C848(0.94); C185(1.17); C1257(1.53)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C848(0.81); C185(1.06); C1257(1.40)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C848(1.02); C185(1.18); C1257(1.82)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C848(0.95); C185(1.00)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C848(1.23); C185(1.30); C1257(1.91)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C848(1.02); C185(1.15); C1257(1.60)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C848(1.17); C185(1.34); C1257(1.51)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C848(0.96); C185(1.24); C1257(1.66)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C185(1.28); C848(1.28); C1257(1.52)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C484(0.62); C848(0.65); C185(0.83); C894(0.92)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C848(0.73); C484(0.88); C185(0.91); C894(0.94)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C848(0.59); C894(0.87); C895(0.87); C484(0.87)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C484(0.89); C848(0.96); C185(0.97); C894(1.01)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C185(0.91); C848(0.92); C894(1.05); C895(1.05)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C848(0.92); C185(1.13)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C848(0.84); C1257(1.00); C185(1.06); C894(1.08)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C848(0.56); C484(0.88); C185(0.92); C894(0.97)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C848(0.70); C185(1.00); C484(1.04); C1257(1.04)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C1257(0.95); C484(0.98); C848(0.99); C185(1.07)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C848(0.92); C484(0.92); C894(0.96); C895(0.96)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C848(0.57); C894(1.02); C895(1.02); C484(1.13)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C894(0.96); C895(0.96); C848(1.10); C185(1.21)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C848(1.00); C894(1.03); C895(1.03); C185(1.18)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C894(0.93); C895(0.93); C185(1.08); C848(1.09)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C848(1.12); C894(1.31); C895(1.31); C185(1.50)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C848(1.02); C185(1.10)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C848(1.20); C894(1.27); C895(1.27); C185(1.33)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C894(0.82); C895(0.82); C848(1.04); C185(1.06)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C894(0.96); C895(0.96); C848(1.03); C185(1.22)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C185(1.18); C848(1.28); C894(1.33); C895(1.33)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C848(1.10); C894(1.17); C895(1.17); C185(1.28)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C848(1.17); C894(1.34); C895(1.34); C185(1.34)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C848(1.11); C185(1.51); C894(1.70); C895(1.70)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C185(1.01); C895(1.27); C894(1.43); C484(1.51)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C185(1.11); C894(1.27); C895(1.35); C484(1.43)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C185(1.06); C895(1.52); C894(1.54); C484(1.74)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C848(1.23); C185(1.25); C884(1.47); C887(1.47)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C185(0.90); C895(1.25); C894(1.46); C484(1.73)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C185(0.97); C895(1.16); C894(1.24); C484(1.57)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C185(0.93); C895(1.39); C894(1.44); C484(1.58)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C185(0.91); C895(1.26); C894(1.38); C484(1.52)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C185(0.88); C895(1.64); C894(1.68); C484(2.03)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C185(1.13); C895(1.48); C894(1.81); C484(2.44)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C185(1.02); C895(1.39); C894(1.67); C484(2.01)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C185(0.97); C895(1.67); C894(1.96); C484(2.42)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C894(0.92); C895(0.92); C884(1.02); C887(1.02)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C884(0.62); C887(0.62); C894(0.80); C895(0.80)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C884(0.93); C887(0.93); C848(1.09); C185(1.11)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C894(0.79); C895(0.79); C884(1.00); C887(1.00)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C894(0.71); C895(0.71); C884(0.82); C887(0.82)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C894(0.76); C895(0.76); C848(1.00); C884(1.04)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C894(0.82); C895(0.82); C884(0.96); C887(0.96)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C884(0.76); C887(0.76); C894(0.81); C895(0.81)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C894(0.83); C895(0.83); C884(0.92); C887(0.92)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C884(0.94); C887(0.94); C894(0.95); C895(0.95)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C884(0.86); C887(0.86); C894(0.89); C895(0.89)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C894(0.87); C895(0.87); C884(0.88); C887(0.88)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C894(0.78); C895(0.78); C848(0.93); C884(1.29)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C848(0.80); C884(0.91); C887(0.91); C185(1.08)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C884(0.80); C887(0.80); C894(0.84); C895(0.84)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C894(0.70); C895(0.70); C484(1.16); C848(1.17)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C894(0.89); C895(0.89); C884(0.92); C887(0.92)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C884(0.40); C887(0.40); C894(1.09); C895(1.09)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C884(0.40); C887(0.40); C894(1.03); C895(1.03)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C884(0.49); C887(0.49); C894(1.09); C895(1.09)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C884(0.60); C887(0.60); C894(1.33); C895(1.33)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C884(0.50); C887(0.50); C848(1.22); C894(1.24)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C884(0.53); C887(0.53); C848(1.18); C894(1.34)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C884(0.43); C887(0.43); C894(1.30); C895(1.30)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C884(0.60); C887(0.60); C894(1.33); C895(1.33)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C884(0.43); C887(0.43); C894(1.09); C895(1.09)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C884(0.44); C887(0.44); C894(1.10); C895(1.10)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C884(0.46); C887(0.46); C894(1.17); C895(1.17)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C884(0.27); C887(0.27); C894(0.91); C895(0.91)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C884(0.46); C887(0.46); C894(1.41); C895(1.41)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C884(0.38); C887(0.38); C894(0.92); C895(0.92)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C884(0.69); C887(0.69); C894(1.45); C895(1.45)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C848(1.94)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C848(0.98)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C185(1.05); C848(1.08); C884(0.91); C887(0.91)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C884(1.06); C887(1.06); C185(1.08); C848(1.25)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C848(1.07); C884(1.29); C887(1.29); C185(1.39)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C884(0.95); C887(0.95); C185(0.90)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C185(0.39)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C185(0.92); C848(1.18)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C185(1.25); C848(1.63)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C848(1.02); C185(1.03)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C884(0.91); C887(0.91); C848(0.95); C185(1.22)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C884(0.91); C887(0.91); C185(1.08); C848(1.74)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C884(0.70); C887(0.70); C848(0.85); C185(1.01)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C848(1.07); C185(1.08); C884(1.49); C887(1.49)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C185(1.12); C848(1.24); C894(1.46); C895(1.46)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C848(0.97); C185(1.28); C894(1.66); C895(1.66)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C848(0.90); C185(1.28); C894(1.29); C895(1.29)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C848(0.88); C185(1.25); C894(1.58); C895(1.58)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C185(1.17); C484(1.36); C848(1.42); C894(1.67)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C185(1.30); C848(1.47)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C185(1.20); C484(1.55); C848(1.57); C894(2.49)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C185(1.09); C848(1.28); C484(1.38); C894(1.47)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C185(0.92); C848(1.16); C1257(1.18)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C848(1.19); C185(1.26); C1257(1.36)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C185(1.14); C1257(1.30); C848(1.34)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C848(1.01); C185(1.08); C1257(1.47)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C848(0.83); C185(1.11); C1257(1.83)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C1257(1.00); C848(1.03); C185(1.21); C894(1.38)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C848(0.74); C185(1.05); C1257(1.07); C894(1.09)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C848(0.71); C1257(0.98); C185(1.02); C894(1.09)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C848(1.57); C185(1.65)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C484(0.90); C185(0.99); C1257(1.01); C894(1.04)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C185(1.13); C848(1.13); C894(1.80); C895(1.80)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C894(1.19); C895(1.19); C185(1.28); C848(1.33)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C848(1.09); C185(1.32); C894(2.09); C895(2.09)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C848(0.96); C185(1.45); C894(1.51); C895(1.51)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C484(1.09); C185(1.10); C895(1.15); C894(1.15)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C185(1.05); C894(1.22); C895(1.26); C484(1.36)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C894(1.04); C185(1.04); C895(1.08); C484(1.12)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C185(1.04); C895(1.37); C894(1.39); C484(1.56)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C185(1.13); C848(1.27)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C185(1.05); C848(1.52)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C185(1.11); C848(1.73)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C484(0.85); C1257(1.03); C848(1.04)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C484(0.82); C1257(0.87); C848(1.52)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C848(0.95); C484(1.01); C1257(1.08)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C848(0.97); C484(1.13); C1257(1.14)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C185(0.95); C848(1.08)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C484(1.16); C1257(1.20); C848(1.32)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C848(1.35); C1257(1.37); C484(1.45)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C1257(1.28); C848(1.31); C484(2.54)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C1257(0.91); C848(1.25); C484(1.29)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C848(1.07); C1257(1.14); C484(1.43)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C1257(0.98); C484(1.56); C848(1.71)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C1257(0.85); C484(1.05); C848(1.19)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C1257(1.18); C484(1.22); C848(1.06)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C1257(1.09); C484(1.21); C848(1.40)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C1257(0.99); C484(1.21); C848(1.06)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C185(0.96); C848(1.10)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C1257(1.10); C484(1.01); C848(1.29)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C1257(1.01); C185(1.00); C848(1.14); C884(1.62)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C1257(1.00); C185(1.02); C848(1.10); C884(1.12)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C1257(1.04); C185(1.08); C848(1.36); C884(3.46)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C1257(1.12); C185(1.31); C848(1.42); C884(1.90)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C1257(0.90); C185(1.33); C848(1.34); C884(1.71)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C1257(0.92); C185(1.25); C848(1.48); C884(1.12)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C1257(1.02); C185(1.44); C848(1.21); C884(1.56)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C1257(0.94); C185(1.15); C848(1.70); C884(1.78)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C185(1.14); C848(1.23)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C1257(0.95); C185(1.14); C848(1.46); C884(1.42)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C1257(0.91); C185(1.22); C848(1.28); C884(1.19)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C1257(0.82); C185(1.51); C848(1.63); C884(3.50)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C1257(1.03); C185(1.24); C848(1.43); C884(1.44)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C1257(0.88); C185(1.11); C848(1.33); C884(2.14)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C1257(0.92); C185(1.15); C848(1.70); C884(1.84)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C185(0.90); C848(0.96); C884(1.29); C887(1.29)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C185(0.84); C848(1.01); C884(1.05); C887(1.05)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C185(0.90); C848(0.86); C884(1.09); C887(1.09)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C185(0.96); C848(1.01); C884(0.82); C887(0.82)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C185(1.09); C848(1.02)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C185(0.94); C848(1.09); C884(0.94); C887(0.94)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C185(0.97); C848(1.16); C884(1.22); C887(1.22)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C185(1.00); C848(1.02); C884(1.13); C887(1.13)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C185(0.92); C848(1.11); C884(1.43); C887(1.43)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C185(0.88); C848(0.91); C884(1.31); C887(1.31)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C185(0.88); C848(0.83); C884(0.98); C887(0.98)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C185(0.93); C848(1.18); C884(1.00); C887(1.00)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C185(0.93); C848(0.87); C884(1.05); C887(1.05)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C185(0.88); C848(0.78); C884(1.72); C887(1.72)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C185(0.90); C848(0.94); C884(1.27); C887(1.27)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C185(0.99); C848(1.78)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C185(0.86); C848(1.26); C884(1.25); C887(1.25)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C1257(1.04); C185(1.06); C848(0.96); C894(0.94)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C1257(0.94); C185(1.05); C848(1.29); C894(1.22)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C1257(0.93); C185(1.13); C848(1.08); C894(1.32)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C1257(1.31); C185(1.17); C848(0.99); C894(1.35)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C1257(0.99); C185(1.07); C848(1.46); C894(1.39)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C1257(1.41); C185(1.24); C848(1.40); C894(1.63)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C1257(1.13); C185(1.06); C848(1.05); C894(1.40)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C1257(1.10); C185(1.23); C848(1.59); C894(1.25)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C1257(0.94); C185(1.09); C848(1.68); C894(1.12)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C185(1.20); C848(1.56)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C1257(0.99); C185(1.07); C848(0.89); C894(1.25)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C1257(1.02); C185(1.12); C848(1.35); C894(2.03)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C1257(0.86); C185(1.13); C848(1.26); C894(1.08)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C1257(1.06); C185(1.07); C848(1.35); C894(1.27)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C1257(0.87); C185(1.15); C848(1.97); C894(1.24)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C185(1.09); C848(1.30); C894(1.00); C895(1.00)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C185(1.00); C848(1.15); C894(1.10); C895(1.10)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C185(1.12); C848(1.65); C894(0.90); C895(0.90)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C185(1.27); C848(1.34); C894(1.11); C895(1.11)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C185(1.48); C848(2.29)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C185(1.07); C848(1.13); C894(1.01); C895(1.01)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C185(1.11); C848(1.31); C894(1.08); C895(1.08)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C185(1.52); C848(1.69); C894(1.05); C895(1.05)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C185(1.40); C848(1.57); C894(1.58); C895(1.58)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C185(1.54); C848(2.13); C894(1.11); C895(1.11)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C185(1.21); C848(1.64); C894(1.09); C895(1.09)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C185(0.98); C848(1.24); C894(1.06); C895(1.06)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C185(1.15); C848(1.51); C894(1.30); C895(1.30)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C185(1.24); C848(1.47); C894(1.27); C895(1.27)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C185(1.55); C848(1.76); C894(1.27); C895(1.27)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C185(1.14); C848(1.62)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C185(0.90); C848(2.11); C894(1.94); C895(1.94)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C185(1.02); C848(1.07)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C185(1.03); C848(1.04)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C185(0.97); C848(0.80)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C185(1.06); C848(1.10)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C185(1.14); C848(1.29)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C185(1.03); C848(0.87)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C185(1.15); C848(1.29)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C185(1.07); C848(1.20)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C185(1.09); C848(1.19)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C848(1.01); C227(0.95); C484(1.09); C855(0.96)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C935(2.48)  LDD1702  [2]
 LDCM0625  F8 Ramos C185(0.83)  LDD2187  [13]
 LDCM0573  Fragment11 Ramos C185(20.00)  LDD2190  [13]
 LDCM0576  Fragment14 Ramos C185(0.71)  LDD2193  [13]
 LDCM0586  Fragment28 Ramos C185(1.20)  LDD2198  [13]
 LDCM0468  Fragment33 HCT 116 C1257(1.05); C185(1.17); C848(1.25); C894(1.94)  LDD0785  [3]
 LDCM0566  Fragment4 Ramos C185(0.73)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C1257(1.27); C185(1.60); C848(1.58); C884(2.52)  LDD0744  [3]
 LDCM0569  Fragment7 Ramos C185(0.60)  LDD2186  [13]
 LDCM0022  KB02 HCT 116 C884(2.58); C887(2.58); C848(7.69); C185(1.29)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C884(5.73); C887(5.73); C848(1.84); C185(1.30)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C884(3.15); C887(3.15); C848(1.68); C185(1.55)  LDD0082  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C848(0.93)  LDD2109  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C848(1.22)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C848(0.99)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C168(2.36)  LDD2140  [2]
 LDCM0021  THZ1 HCT 116 C884(1.12); C887(1.12)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ras-related protein Rab-9A (RAB9A) Rab family P51151
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nischarin (NISCH) . Q9Y2I1

The Drug(s) Related To This Target

Approved
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Moxonidine Small molecular drug DB09242
Tepotinib Small molecular drug DB15133
Tizanidine Small molecular drug DB00697
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Agmatine Small molecular drug DB08838

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578