Details of the Target

General Information of Target

Target ID LDTP06620
Target Name Thiosulfate sulfurtransferase (TST)
Gene Name TST
Gene ID 7263
Synonyms
Thiosulfate sulfurtransferase; EC 2.8.1.1; Rhodanese
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFD
IEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFG
HRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLV
DSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDL
SQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
Target Bioclass
Enzyme
Subcellular location
Mitochondrion matrix
Function
Formation of iron-sulfur complexes, cyanide detoxification or modification of sulfur-containing enzymes. Other thiol compounds, besides cyanide, can act as sulfur ion acceptors. Also has weak mercaptopyruvate sulfurtransferase (MST) activity. Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA.
Uniprot ID
Q16762
Ensemble ID
ENST00000249042.8
HGNC ID
HGNC:12388
ChEMBL ID
CHEMBL4295835

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		100.00  LDD0242  [1]
STPyne
 Probe Info  		K14(7.78); K175(3.37); K237(0.83); K24(2.69)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K24(2.33)  LDD3494  [3]
Probe 1
 Probe Info  		Y37(10.83); Y165(96.51)  LDD3495  [4]
DBIA
 Probe Info  		C248(1.44)  LDD3310  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C64(0.00); C248(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C264(0.00); C255(0.00); C248(0.00); C64(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C64(0.00); C248(0.00)  LDD0037  [7]
BTD
 Probe Info  		N.A.  LDD0004  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C187
 Probe Info  		16.11  LDD1865  [12]
C191
 Probe Info  		11.00  LDD1868  [12]
C193
 Probe Info  		5.28  LDD1869  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]
DA-2
 Probe Info  		N.A.  LDD0072  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C248(0.92); C64(1.05); C264(0.98); C255(0.88)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C248(0.96); C264(1.26); C255(0.95)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C248(0.99); C264(0.84)  LDD1509  [15]
 LDCM0230  AC113 HEK-293T C64(0.95)  LDD0828  [16]
 LDCM0231  AC114 HEK-293T C64(1.15)  LDD0829  [16]
 LDCM0232  AC115 HEK-293T C64(1.06)  LDD0830  [16]
 LDCM0233  AC116 HEK-293T C64(1.07)  LDD0831  [16]
 LDCM0234  AC117 HEK-293T C64(1.17)  LDD0832  [16]
 LDCM0235  AC118 HEK-293T C64(1.33)  LDD0833  [16]
 LDCM0236  AC119 HEK-293T C64(1.29)  LDD0834  [16]
 LDCM0237  AC12 HEK-293T C248(0.94); C64(1.06); C264(0.99); C255(1.02)  LDD1510  [15]
 LDCM0238  AC120 HEK-293T C64(1.10)  LDD0836  [16]
 LDCM0239  AC121 HEK-293T C64(1.31)  LDD0837  [16]
 LDCM0240  AC122 HEK-293T C64(1.39)  LDD0838  [16]
 LDCM0241  AC123 HEK-293T C64(1.29)  LDD0839  [16]
 LDCM0242  AC124 HEK-293T C64(1.24)  LDD0840  [16]
 LDCM0243  AC125 HEK-293T C64(1.33)  LDD0841  [16]
 LDCM0244  AC126 HEK-293T C64(1.70)  LDD0842  [16]
 LDCM0245  AC127 HEK-293T C64(2.03)  LDD0843  [16]
 LDCM0259  AC14 HEK-293T C248(1.01); C264(0.90); C255(1.14)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C248(0.97); C64(1.21); C264(0.82); C255(0.85)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C64(1.24)  LDD0874  [16]
 LDCM0277  AC18 HEK-293T C64(1.19)  LDD0875  [16]
 LDCM0278  AC19 HEK-293T C64(1.26)  LDD0876  [16]
 LDCM0279  AC2 HEK-293T C248(1.03); C264(1.35); C255(1.13)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C64(1.18)  LDD0878  [16]
 LDCM0281  AC21 HEK-293T C64(1.22)  LDD0879  [16]
 LDCM0282  AC22 HEK-293T C64(1.40)  LDD0880  [16]
 LDCM0283  AC23 HEK-293T C64(1.36)  LDD0881  [16]
 LDCM0284  AC24 HEK-293T C64(1.11)  LDD0882  [16]
 LDCM0285  AC25 HEK-293T C248(0.91); C64(1.06); C264(1.05); C255(1.09)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C248(1.01); C264(1.22); C255(0.91)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C248(0.98); C264(0.88)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C248(0.99); C64(1.01); C264(0.79); C255(1.09)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C248(1.00); C264(0.87); C255(1.16)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C248(1.03); C264(0.84)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C248(1.01); C264(0.94); C255(1.06)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C248(1.01); C64(0.91); C264(0.90); C255(0.89)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C248(0.92); C64(0.97); C264(1.08); C255(0.95)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C248(0.89); C64(1.07); C264(1.19); C255(0.86)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C248(0.98); C264(1.37); C255(1.02)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C64(0.78)  LDD0894  [16]
 LDCM0297  AC36 HEK-293T C64(0.82)  LDD0895  [16]
 LDCM0298  AC37 HEK-293T C64(0.75)  LDD0896  [16]
 LDCM0299  AC38 HEK-293T C64(0.89)  LDD0897  [16]
 LDCM0300  AC39 HEK-293T C64(0.97)  LDD0898  [16]
 LDCM0301  AC4 HEK-293T C248(1.11); C64(1.05); C264(0.80); C255(0.94)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C64(1.03)  LDD0900  [16]
 LDCM0303  AC41 HEK-293T C64(1.01)  LDD0901  [16]
 LDCM0304  AC42 HEK-293T C64(0.97)  LDD0902  [16]
 LDCM0305  AC43 HEK-293T C64(1.23)  LDD0903  [16]
 LDCM0306  AC44 HEK-293T C64(1.14)  LDD0904  [16]
 LDCM0307  AC45 HEK-293T C64(0.88)  LDD0905  [16]
 LDCM0308  AC46 HEK-293T C64(0.99)  LDD0906  [16]
 LDCM0309  AC47 HEK-293T C64(1.16)  LDD0907  [16]
 LDCM0310  AC48 HEK-293T C64(1.10)  LDD0908  [16]
 LDCM0311  AC49 HEK-293T C64(1.21)  LDD0909  [16]
 LDCM0312  AC5 HEK-293T C248(1.05); C264(1.41); C255(1.05)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C64(1.13)  LDD0911  [16]
 LDCM0314  AC51 HEK-293T C64(1.16)  LDD0912  [16]
 LDCM0315  AC52 HEK-293T C64(1.22)  LDD0913  [16]
 LDCM0316  AC53 HEK-293T C64(1.14)  LDD0914  [16]
 LDCM0317  AC54 HEK-293T C64(1.20)  LDD0915  [16]
 LDCM0318  AC55 HEK-293T C64(1.20)  LDD0916  [16]
 LDCM0319  AC56 HEK-293T C64(1.18)  LDD0917  [16]
 LDCM0320  AC57 HEK-293T C64(0.88)  LDD0918  [16]
 LDCM0321  AC58 HEK-293T C64(0.84)  LDD0919  [16]
 LDCM0322  AC59 HEK-293T C64(0.91)  LDD0920  [16]
 LDCM0323  AC6 HEK-293T C248(1.02); C264(1.13); C255(0.90)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C64(0.82)  LDD0922  [16]
 LDCM0325  AC61 HEK-293T C64(1.10)  LDD0923  [16]
 LDCM0326  AC62 HEK-293T C64(0.93)  LDD0924  [16]
 LDCM0327  AC63 HEK-293T C64(0.95)  LDD0925  [16]
 LDCM0328  AC64 HEK-293T C64(0.76)  LDD0926  [16]
 LDCM0329  AC65 HEK-293T C64(0.97)  LDD0927  [16]
 LDCM0330  AC66 HEK-293T C64(0.84)  LDD0928  [16]
 LDCM0331  AC67 HEK-293T C64(0.93)  LDD0929  [16]
 LDCM0332  AC68 HEK-293T C64(1.00)  LDD0930  [16]
 LDCM0333  AC69 HEK-293T C64(1.07)  LDD0931  [16]
 LDCM0334  AC7 HEK-293T C248(1.08); C64(1.12); C264(0.68); C255(0.82)  LDD1568  [15]
 LDCM0335  AC70 HEK-293T C64(1.18)  LDD0933  [16]
 LDCM0336  AC71 HEK-293T C64(1.12)  LDD0934  [16]
 LDCM0337  AC72 HEK-293T C64(0.98)  LDD0935  [16]
 LDCM0338  AC73 HEK-293T C64(1.17)  LDD0936  [16]
 LDCM0339  AC74 HEK-293T C64(1.12)  LDD0937  [16]
 LDCM0340  AC75 HEK-293T C64(0.98)  LDD0938  [16]
 LDCM0341  AC76 HEK-293T C64(0.96)  LDD0939  [16]
 LDCM0342  AC77 HEK-293T C64(1.09)  LDD0940  [16]
 LDCM0343  AC78 HEK-293T C64(0.98)  LDD0941  [16]
 LDCM0344  AC79 HEK-293T C64(1.27)  LDD0942  [16]
 LDCM0345  AC8 HEK-293T C248(0.98); C64(0.96); C264(1.06); C255(1.18)  LDD1569  [15]
 LDCM0346  AC80 HEK-293T C64(1.31)  LDD0944  [16]
 LDCM0347  AC81 HEK-293T C64(1.18)  LDD0945  [16]
 LDCM0348  AC82 HEK-293T C64(1.45)  LDD0946  [16]
 LDCM0349  AC83 HEK-293T C64(1.01)  LDD0947  [16]
 LDCM0350  AC84 HEK-293T C64(1.25)  LDD0948  [16]
 LDCM0351  AC85 HEK-293T C64(0.94)  LDD0949  [16]
 LDCM0352  AC86 HEK-293T C64(1.25)  LDD0950  [16]
 LDCM0353  AC87 HEK-293T C64(1.21)  LDD0951  [16]
 LDCM0354  AC88 HEK-293T C64(1.20)  LDD0952  [16]
 LDCM0355  AC89 HEK-293T C64(1.28)  LDD0953  [16]
 LDCM0357  AC90 HEK-293T C64(1.13)  LDD0955  [16]
 LDCM0358  AC91 HEK-293T C64(1.13)  LDD0956  [16]
 LDCM0359  AC92 HEK-293T C64(1.12)  LDD0957  [16]
 LDCM0360  AC93 HEK-293T C64(1.04)  LDD0958  [16]
 LDCM0361  AC94 HEK-293T C64(1.07)  LDD0959  [16]
 LDCM0362  AC95 HEK-293T C64(1.20)  LDD0960  [16]
 LDCM0363  AC96 HEK-293T C64(1.33)  LDD0961  [16]
 LDCM0364  AC97 HEK-293T C64(2.00)  LDD0962  [16]
 LDCM0248  AKOS034007472 HEK-293T C248(1.07); C264(0.93); C255(1.14)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C248(0.88); C64(1.03); C264(1.14); C255(0.96)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C248(0.98); C64(1.08); C264(1.03); C255(1.05)  LDD1514  [15]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C248(0.89); C64(1.08); C264(0.89); C255(0.81)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C248(0.82); C264(0.61); C255(1.03)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C248(0.93); C255(1.03)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C248(0.99); C64(0.96); C264(0.87); C255(0.90)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C248(0.88); C264(0.85)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C248(0.93); C264(0.74); C255(0.96)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C248(0.94); C255(0.94)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C64(1.10)  LDD0972  [16]
 LDCM0375  CL106 HEK-293T C64(1.25)  LDD0973  [16]
 LDCM0376  CL107 HEK-293T C64(1.07)  LDD0974  [16]
 LDCM0377  CL108 HEK-293T C64(1.07)  LDD0975  [16]
 LDCM0378  CL109 HEK-293T C64(1.12)  LDD0976  [16]
 LDCM0379  CL11 HEK-293T C248(0.96); C64(1.04); C264(0.56); C255(0.90)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C64(1.51)  LDD0978  [16]
 LDCM0381  CL111 HEK-293T C64(1.29)  LDD0979  [16]
 LDCM0382  CL112 HEK-293T C248(0.89); C255(0.99)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C248(0.95); C64(1.07); C264(0.79); C255(0.97)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C248(0.93); C264(0.86)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C248(1.02); C264(0.88); C255(0.80)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C248(0.95); C255(1.03)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C64(0.70)  LDD0985  [16]
 LDCM0388  CL118 HEK-293T C64(0.76)  LDD0986  [16]
 LDCM0389  CL119 HEK-293T C64(1.08)  LDD0987  [16]
 LDCM0390  CL12 HEK-293T C248(0.85); C64(1.37); C264(0.81); C255(1.02)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C64(1.02)  LDD0989  [16]
 LDCM0392  CL121 HEK-293T C64(1.28)  LDD0990  [16]
 LDCM0393  CL122 HEK-293T C64(1.32)  LDD0991  [16]
 LDCM0394  CL123 HEK-293T C64(1.31)  LDD0992  [16]
 LDCM0395  CL124 HEK-293T C64(1.19)  LDD0993  [16]
 LDCM0396  CL125 HEK-293T C64(0.94)  LDD0994  [16]
 LDCM0397  CL126 HEK-293T C64(0.93)  LDD0995  [16]
 LDCM0398  CL127 HEK-293T C64(0.82)  LDD0996  [16]
 LDCM0399  CL128 HEK-293T C64(0.83)  LDD0997  [16]
 LDCM0400  CL13 HEK-293T C248(0.83); C64(1.08); C264(0.70); C255(0.79)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C248(0.88); C264(0.97)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C248(0.82); C264(0.85); C255(0.88)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C64(1.00)  LDD1001  [16]
 LDCM0404  CL17 HEK-293T C64(1.18)  LDD1002  [16]
 LDCM0405  CL18 HEK-293T C64(0.99)  LDD1003  [16]
 LDCM0406  CL19 HEK-293T C64(1.11)  LDD1004  [16]
 LDCM0407  CL2 HEK-293T C248(0.97); C264(1.02)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C64(0.98)  LDD1006  [16]
 LDCM0409  CL21 HEK-293T C64(1.59)  LDD1007  [16]
 LDCM0410  CL22 HEK-293T C64(1.06)  LDD1008  [16]
 LDCM0411  CL23 HEK-293T C64(1.02)  LDD1009  [16]
 LDCM0412  CL24 HEK-293T C64(0.89)  LDD1010  [16]
 LDCM0413  CL25 HEK-293T C64(1.10)  LDD1011  [16]
 LDCM0414  CL26 HEK-293T C64(0.98)  LDD1012  [16]
 LDCM0415  CL27 HEK-293T C64(1.03)  LDD1013  [16]
 LDCM0416  CL28 HEK-293T C64(0.99)  LDD1014  [16]
 LDCM0417  CL29 HEK-293T C64(0.90)  LDD1015  [16]
 LDCM0418  CL3 HEK-293T C248(0.91); C264(0.94); C255(1.00)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C64(1.15)  LDD1017  [16]
 LDCM0420  CL31 HEK-293T C248(0.94); C264(0.78)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C248(0.96); C64(1.03); C264(0.71); C255(0.91)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C248(0.91); C264(0.69); C255(0.80)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C248(0.93); C264(0.78); C255(0.90)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C248(0.89); C64(1.07); C264(0.52); C255(0.77)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C248(0.82); C64(1.31); C264(0.74); C255(0.81)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C248(1.10); C64(0.95); C264(0.78); C255(0.93)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C248(0.91); C264(0.79); C255(0.92)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C248(0.86); C255(0.88)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C248(0.94); C255(0.94)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C248(0.83); C64(1.03); C264(0.80); C255(0.76)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C248(0.94); C264(1.21); C255(1.02)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C248(0.98); C264(0.86)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C248(0.91); C64(1.01); C264(0.71); C255(0.82)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C248(0.90); C264(0.57); C255(0.97)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C248(0.94); C264(0.73); C255(0.99)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C248(0.91); C64(0.98); C264(0.58); C255(0.87)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C248(0.91); C64(1.29); C264(0.93); C255(0.88)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C248(1.06); C64(1.00); C264(0.83); C255(0.96)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C248(0.91); C64(1.23); C264(0.78); C255(0.69)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C248(0.82); C264(0.94)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C248(0.89); C255(1.02)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C248(0.84); C64(1.01); C264(0.99); C255(0.72)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C248(0.83); C264(1.01); C255(0.88)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C248(0.95); C264(0.85)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C248(0.92); C64(1.05); C264(0.77); C255(0.89)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C248(0.91); C264(0.80); C255(0.93)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C248(0.92); C264(0.97); C255(0.89)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C248(0.93); C64(1.16); C264(0.59); C255(0.69)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C248(0.79); C264(1.15); C255(0.91)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C248(0.85); C64(1.34); C264(0.83); C255(1.03)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C248(1.07); C64(1.02); C264(0.90); C255(0.93)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C248(0.89); C264(0.89)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C248(0.96); C264(0.89); C255(0.87)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C248(0.91); C255(0.99)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C248(0.93); C64(1.08); C264(1.09); C255(0.96)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C248(0.88); C264(0.97); C255(1.02)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C248(0.94); C264(0.91)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C248(0.97); C64(1.09); C264(0.73); C255(0.89)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C248(0.97); C264(0.79); C255(0.95)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C248(0.95); C264(0.75)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C248(0.96); C264(0.79); C255(1.09)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C248(0.95); C64(1.06); C264(0.80); C255(0.93)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C248(0.87); C64(1.29); C264(0.79); C255(0.89)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C248(1.13); C64(0.94); C264(0.74); C255(0.89)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C248(1.08); C264(1.10)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C248(0.93); C255(0.84)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C248(0.84); C64(1.04); C264(0.73); C255(0.87)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C248(0.94); C264(1.16); C255(1.07)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C248(0.99); C264(1.14)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C248(0.87); C64(1.20); C264(0.65); C255(0.73)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C248(0.96); C64(1.11); C264(0.89); C255(1.04)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C248(1.02); C264(0.83); C255(1.03)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C248(1.03); C264(0.84); C255(1.07)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C248(0.99); C64(0.90); C264(0.57); C255(0.84)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C248(0.91); C64(1.05); C264(0.87); C255(1.00)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C248(1.21); C64(1.01); C264(0.94); C255(1.08)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C248(1.06); C264(0.84)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C248(0.97); C264(0.70); C255(0.89)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C248(1.00); C255(1.09)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C248(0.98); C64(1.20); C264(0.91); C255(1.16)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C248(0.94); C264(0.73); C255(1.05)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C248(0.86); C264(0.83); C255(0.96)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C248(1.04); C264(1.00)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C248(0.94); C64(1.05); C264(0.83); C255(0.92)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C248(1.00); C264(0.77); C255(1.21)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C248(0.95); C264(0.81); C255(1.02)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C248(0.88); C64(1.08); C264(0.73); C255(0.71)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C248(1.03); C64(1.13); C264(0.96); C255(0.79)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C248(0.93); C64(0.99); C264(0.78); C255(0.97)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C248(0.94); C264(0.90)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C248(0.90); C264(0.95); C255(0.79)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C248(0.90); C264(0.78); C255(0.78)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C248(2.13); C64(1.63)  LDD1702  [17]
 LDCM0468  Fragment33 HEK-293T C248(0.89); C264(0.72); C255(1.08)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C248(0.93); C264(0.88)  LDD1631  [15]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C248(1.08); C64(1.04); C264(1.03)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C248(1.03); C64(1.05); C264(1.00)  LDD1497  [15]
 LDCM0024  KB05 COLO792 C248(1.44)  LDD3310  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C248(0.82)  LDD2102  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [10]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C248(1.06)  LDD2090  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C248(0.83)  LDD2092  [17]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C248(0.32)  LDD2096  [17]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C64(0.98)  LDD2098  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C248(0.80)  LDD2099  [17]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C64(1.06)  LDD2105  [17]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C248(1.04)  LDD2107  [17]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C248(0.46)  LDD2116  [17]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C248(1.00)  LDD2118  [17]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C248(0.93)  LDD2122  [17]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C248(0.76)  LDD2124  [17]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C248(0.71)  LDD2125  [17]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C248(1.25)  LDD2126  [17]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C248(0.41)  LDD2135  [17]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C248(0.57)  LDD2137  [17]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C248(0.60)  LDD2140  [17]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C248(1.03)  LDD2149  [17]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C248(1.85)  LDD2153  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C264(1.58)  LDD2207  [18]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
S-mercaptocysteine . DB02761

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.