Details of the Target

General Information of Target

Target ID LDTP05545
Target Name TLE family member 5 (TLE5)
Gene Name TLE5
Gene ID 166
Synonyms
AES; GRG; GRG5; TLE family member 5; Amino-terminal enhancer of split; Amino enhancer of split; Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG; TLE family member 5, transcriptional modulator
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRH
YVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELN
SIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDK
NGHDGDTHQEDDGEKSD
Target Bioclass
Other
Family
WD repeat Groucho/TLE family
Subcellular location
Nucleus
Function
Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development.
Uniprot ID
Q08117
Ensemble ID
ENST00000221561.12
HGNC ID
HGNC:307

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ICC108 SNV: p.R7G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C93(2.03)  LDD3323  [1]
HHS-465
 Probe Info  		Y95(10.00)  LDD2237  [2]
Acrolein
 Probe Info  		N.A.  LDD0222  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C26(0.00); C89(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C26(0.00); C47(0.00); C89(0.00)  LDD0036  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [6]
Lodoacetamide azide
 Probe Info  		C26(0.00); C47(0.00); C89(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
Compound 10
 Probe Info  		C26(0.00); C89(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0147  [8]
VSF
 Probe Info  		N.A.  LDD0007  [9]
W1
 Probe Info  		N.A.  LDD0236  [11]
AOyne
 Probe Info  		13.70  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C376
 Probe Info  		6.54  LDD2036  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C26(1.11)  LDD1507  [14]
 LDCM0259  AC14 HEK-293T C26(1.20)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C26(1.21)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C26(1.05)  LDD1515  [14]
 LDCM0281  AC21 HEK-293T C26(0.95)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C26(1.02)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C26(1.11)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C26(1.01)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C26(1.11)  LDD1524  [14]
 LDCM0289  AC29 HEK-293T C26(0.91)  LDD1528  [14]
 LDCM0291  AC30 HEK-293T C26(1.01)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C26(1.02)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C26(1.01)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C26(1.16)  LDD1533  [14]
 LDCM0298  AC37 HEK-293T C26(0.94)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C26(1.27)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C26(0.99)  LDD1539  [14]
 LDCM0302  AC40 HEK-293T C26(1.04)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C26(1.13)  LDD1542  [14]
 LDCM0307  AC45 HEK-293T C26(1.02)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C26(1.11)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C26(1.02)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C26(0.96)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C26(1.05)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C26(0.96)  LDD1551  [14]
 LDCM0316  AC53 HEK-293T C26(1.16)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C26(0.97)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C26(1.07)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C26(0.99)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C26(1.14)  LDD1559  [14]
 LDCM0323  AC6 HEK-293T C26(1.09)  LDD1562  [14]
 LDCM0325  AC61 HEK-293T C26(1.01)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C26(1.10)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C26(1.21)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C26(1.02)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C26(1.19)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C26(0.93)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C26(1.14)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C26(1.09)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C26(0.96)  LDD1514  [14]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [3]
 LDCM0367  CL1 HEK-293T C26(1.10)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C26(1.70)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C26(0.97); C89(1.03)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C26(1.30)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C26(1.32)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C26(0.91); C89(0.90)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C26(1.05); C89(1.16)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C26(1.01)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C26(1.02)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C26(0.93); C89(0.93)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C26(1.04); C89(1.21)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C26(0.98)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C26(1.19)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C26(1.14)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C26(1.09); C89(0.79)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C26(0.96); C89(1.31)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C26(0.90)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C26(1.26)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C26(1.09); C89(0.91)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C26(1.15); C89(1.16)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C26(0.90)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C26(0.97)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C26(0.96); C89(0.91)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C26(1.04)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C26(1.12); C89(1.21)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C26(0.99)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C26(1.12)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C26(1.16); C89(0.98)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C26(1.19); C89(1.26)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C26(1.06)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C26(0.98)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C26(1.01); C89(0.88)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C26(1.03); C89(1.29)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C26(1.00)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C26(0.98)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C26(1.21); C89(0.80)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C26(1.09); C89(1.18)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C26(1.49)  LDD1608  [14]
 LDCM0407  CL2 HEK-293T C26(0.96)  LDD1611  [14]
 LDCM0409  CL21 HEK-293T C26(1.22)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C26(1.22)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C26(1.10)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C26(1.04)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C26(1.12)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C26(0.96)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C26(1.02); C89(0.89)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C26(1.12); C89(1.21)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C26(1.13)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C26(1.03); C89(0.90)  LDD1622  [14]
 LDCM0422  CL33 HEK-293T C26(1.37)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C26(0.99)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C26(1.21)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C26(0.95)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C26(0.95)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C26(1.22); C89(0.92)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C26(1.01); C89(1.43)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C26(1.08); C89(1.21)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C26(1.16)  LDD1635  [14]
 LDCM0435  CL45 HEK-293T C26(1.05)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C26(1.15)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C26(1.27)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C26(0.99)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C26(0.97)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C26(1.17)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C26(1.04)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C26(1.20); C89(1.31)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C26(1.40)  LDD1647  [14]
 LDCM0448  CL57 HEK-293T C26(1.16)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C26(1.23)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C26(1.12)  LDD1653  [14]
 LDCM0452  CL60 HEK-293T C26(0.95)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C26(1.08)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C26(1.06)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C26(1.07); C89(1.01)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C26(1.35); C89(1.24)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C26(1.09)  LDD1660  [14]
 LDCM0461  CL69 HEK-293T C26(1.03)  LDD1664  [14]
 LDCM0463  CL70 HEK-293T C26(1.30)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C26(1.30)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C26(1.06)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C26(1.16)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C26(0.96)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C26(1.16); C89(1.36)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C26(1.22)  LDD1673  [14]
 LDCM0475  CL81 HEK-293T C26(0.95)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C26(1.13)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C26(1.31)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C26(0.99)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C26(0.98)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C26(0.99)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C26(1.10); C89(0.84)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C26(1.01); C89(1.21)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C26(1.10)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C26(1.03)  LDD1687  [14]
 LDCM0488  CL93 HEK-293T C26(1.15)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C26(1.08)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C26(1.78)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C26(1.25)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C26(1.16)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C26(1.05)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C26(1.04); C89(0.76)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C26(1.19); C89(0.87)  LDD1698  [14]
 LDCM0573  Fragment11 Ramos C26(4.25)  LDD2190  [15]
 LDCM0575  Fragment13 Ramos C26(1.09)  LDD2192  [15]
 LDCM0580  Fragment21 Ramos C26(1.22)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C26(1.02)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C26(0.81)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C26(1.03)  LDD2198  [15]
 LDCM0589  Fragment31 Ramos C26(1.67)  LDD2200  [15]
 LDCM0468  Fragment33 HEK-293T C26(1.06); C89(1.03)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C26(2.32)  LDD2203  [15]
 LDCM0427  Fragment51 HEK-293T C26(1.11)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C26(1.46)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C26(1.48)  LDD2205  [15]
 LDCM0022  KB02 HEK-293T C26(0.91)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C26(0.98)  LDD1497  [14]
 LDCM0024  KB05 SKMEL24 C93(2.03)  LDD3323  [1]
 LDCM0628  OTUB2-COV-1 HEK-293T C26(0.62)  LDD2207  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 46 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
DNA-directed RNA polymerases I and III subunit RPAC1 (POLR1C) Archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family O15160
tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) RNA M5U methyltransferase family Q8IZ69
PR domain zinc finger protein 14 (PRDM14) Class V-like SAM-binding methyltransferase superfamily Q9GZV8
Putative histone-lysine N-methyltransferase PRDM6 (PRDM6) Class V-like SAM-binding methyltransferase superfamily Q9NQX0
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7) Complex I NDUFB7 subunit family P17568
Probable ATP-dependent RNA helicase DDX6 (DDX6) DEAD box helicase family P26196
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Glycogen [starch] synthase, muscle (GYS1) Glycosyltransferase 3 family P13807
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) HAD-like hydrolase superfamily Q9BSH5
Cytochrome c oxidase assembly factor 7 (COA7) Hcp beta-lactamase family Q96BR5
Baculoviral IAP repeat-containing protein 7 (BIRC7) IAP family Q96CA5
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (INPP5J) Inositol 1,4,5-trisphosphate 5-phosphatase type II family Q15735
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family Q9UHB4
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Uridine diphosphate glucose pyrophosphatase NUDT22 (NUDT22) Nudix hydrolase family Q9BRQ3
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Ubiquitin thioesterase ZRANB1 (ZRANB1) Peptidase C64 family Q9UGI0
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Proteasome subunit beta type-4 (PSMB4) Peptidase T1B family P28070
Testis-specific serine/threonine-protein kinase 3 (TSSK3) CAMK Ser/Thr protein kinase family Q96PN8
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
Tribbles homolog 3 (TRIB3) CAMK Ser/Thr protein kinase family Q96RU7
SRSF protein kinase 2 (SRPK2) CMGC Ser/Thr protein kinase family P78362
Mitogen-activated protein kinase 1 (MAPK1) CMGC Ser/Thr protein kinase family P28482
Serine/threonine-protein kinase Nek6 (NEK6) NEK Ser/Thr protein kinase family Q9HC98
Serine/threonine-protein kinase 16 (STK16) Ser/Thr protein kinase family O75716
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Peptidyl-tRNA hydrolase 2, mitochondrial (PTRH2) PTH2 family Q9Y3E5
Exosome complex component RRP46 (EXOSC5) RNase PH family Q9NQT4
GTP-binding protein GEM (GEM) RGK family P55040
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Tripartite motif-containing protein 26 (TRIM26) TRIM/RBCC family Q12899
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Apoptosis-enhancing nuclease (AEN) . Q8WTP8
Fibronectin type III and SPRY domain-containing protein 2 (FSD2) . A1L4K1
Probable E3 ubiquitin-protein ligase makorin-3 (MKRN3) . Q13064
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Chloride intracellular channel protein 3 (CLIC3) Chloride channel CLIC family O95833
Huntingtin (HTT) Huntingtin family P42858
Low-density lipoprotein receptor (LDLR) LDLR family P01130
MyoD family inhibitor (MDFI) MDFI family Q99750
Melanoma inhibitory activity protein 2 (MIA2) MIA/OTOR family Q96PC5
Protein shisa-6 (SHISA6) Shisa family Q6ZSJ9
Sodium channel modifier 1 (SCNM1) . Q9BWG6
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 66 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C9 (HOXC9) Abd-B homeobox family P31274
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Transcription factor AP-2-delta (TFAP2D) AP-2 family Q7Z6R9
Protein FosB (FOSB) BZIP family P53539
Doublesex- and mab-3-related transcription factor 2 (DMRT2) DMRT family Q9Y5R5
Doublesex- and mab-3-related transcription factor 3 (DMRT3) DMRT family Q9NQL9
Doublesex- and mab-3-related transcription factor B1 (DMRTB1) DMRT family Q96MA1
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
ETS domain-containing transcription factor ERF (ERF) ETS family P50548
Zinc finger protein GLIS2 (GLIS2) GLI C2H2-type zinc-finger protein family Q9BZE0
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Zinc finger protein Aiolos (IKZF3) Ikaros C2H2-type zinc-finger protein family Q9UKT9
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Krueppel-like factor 4 (KLF4) Krueppel C2H2-type zinc-finger protein family O43474
Vascular endothelial zinc finger 1 (VEZF1) Krueppel C2H2-type zinc-finger protein family Q14119
Zinc finger and BTB domain-containing protein 16 (ZBTB16) Krueppel C2H2-type zinc-finger protein family Q05516
Zinc finger and BTB domain-containing protein 24 (ZBTB24) Krueppel C2H2-type zinc-finger protein family O43167
Zinc finger and BTB domain-containing protein 47 (ZBTB47) Krueppel C2H2-type zinc-finger protein family Q9UFB7
Zinc finger protein 383 (ZNF383) Krueppel C2H2-type zinc-finger protein family Q8NA42
Zinc finger protein 414 (ZNF414) Krueppel C2H2-type zinc-finger protein family Q96IQ9
Zinc finger protein 417 (ZNF417) Krueppel C2H2-type zinc-finger protein family Q8TAU3
Zinc finger protein 467 (ZNF467) Krueppel C2H2-type zinc-finger protein family Q7Z7K2
Zinc finger protein 48 (ZNF48) Krueppel C2H2-type zinc-finger protein family Q96MX3
Zinc finger protein 524 (ZNF524) Krueppel C2H2-type zinc-finger protein family Q96C55
Zinc finger protein 576 (ZNF576) Krueppel C2H2-type zinc-finger protein family Q9H609
Zinc finger protein 688 (ZNF688) Krueppel C2H2-type zinc-finger protein family P0C7X2
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Zinc finger protein 835 (ZNF835) Krueppel C2H2-type zinc-finger protein family Q9Y2P0
Zinc finger protein PLAGL1 (PLAGL1) Krueppel C2H2-type zinc-finger protein family Q9UM63
Homeobox protein MSX-2 (MSX2) Msh homeobox family P35548
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Pituitary homeobox 1 (PITX1) Paired homeobox family P78337
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
PHD finger protein 1 (PHF1) Polycomblike family O43189
DNA-binding protein RFX6 (RFX6) RFX family Q8HWS3
Homeobox protein SIX1 (SIX1) SIX/Sine oculis homeobox family Q15475
Homeobox protein SIX2 (SIX2) SIX/Sine oculis homeobox family Q9NPC8
Iroquois-class homeodomain protein IRX-2 (IRX2) TALE/IRO homeobox family Q9BZI1
Iroquois-class homeodomain protein IRX-6 (IRX6) TALE/IRO homeobox family P78412
B-cell lymphoma 6 protein (BCL6) . P41182
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Forkhead box protein D2 (FOXD2) . O60548
Forkhead box protein N1 (FOXN1) . O15353
Forkhead box protein P2 (FOXP2) . O15409
Hematopoietically-expressed homeobox protein HHEX (HHEX) . Q03014
Max-like protein X (MLX) . Q9UH92
Myogenic factor 5 (MYF5) . P13349
Myogenin (MYOG) . P15173
Oligodendrocyte transcription factor 3 (OLIG3) . Q7RTU3
Paired box protein Pax-8 (PAX8) . Q06710
Paired box protein Pax-9 (PAX9) . P55771
Protein AF-17 (MLLT6) . P55198
Proto-oncogene c-Rel (REL) . Q04864
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1 (SOHLH1) . Q5JUK2
T-box transcription factor TBX3 (TBX3) . O15119
T-box transcription factor TBX6 (TBX6) . O95947
THAP domain-containing protein 7 (THAP7) . Q9BT49
Transcription factor 4 (TCF4) . P15884
Transcription factor SOX-5 (SOX5) . P35711
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) . Q8N5A5
Zinc finger protein 408 (ZNF408) . Q9H9D4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Other
Click To Hide/Show 157 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Atos homolog protein B (ATOSB) ATOS family Q7L5A3
Ataxin-1 (ATXN1) ATXN1 family P54253
BPI fold-containing family A member 1 (BPIFA1) Plunc family Q9NP55
Bystin (BYSL) Bystin family Q13895
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
Testis-specific gene 10 protein (TSGA10) CEP135/TSGA10 family Q9BZW7
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Cilia- and flagella-associated protein 68 (CFAP68) CFAP68 family Q9H5F2
Cornifelin (CNFN) Cornifelin family Q9BYD5
Cyclin-O (CCNO) Cyclin family P22674
Cyclin-K (CCNK) Cyclin family O75909
Cyclin-J-like protein (CCNJL) Cyclin family, Cyclin J subfamily Q8IV13
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Docking protein 6 (DOK6) DOK family, Type B subfamily Q6PKX4
DPY30 domain-containing protein 1 (DYDC1) Dpy-30 family Q8WWB3
Segment polarity protein dishevelled homolog DVL-2 (DVL2) DSH family O14641
Segment polarity protein dishevelled homolog DVL-3 (DVL3) DSH family Q92997
ELL-associated factor 1 (EAF1) EAF family Q96JC9
EF-hand calcium-binding domain-containing protein 4B (CRACR2A) EFCAB4 family Q9BSW2
Probable RNA-binding protein EIF1AD (EIF1AD) EIF1AD family Q8N9N8
Zinc finger protein 503 (ZNF503) Elbow/Noc family Q96F45
Eukaryotic translation initiation factor 4E type 2 (EIF4E2) Eukaryotic initiation factor 4E family O60573
Protein FAM124A (FAM124A) FAM124 family Q86V42
Protein FAM124B (FAM124B) FAM124 family Q9H5Z6
Protein FAM217B (FAM217B) FAM217 family Q9NTX9
Protein FAM90A1 (FAM90A1) FAM90 family Q86YD7
EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2) Fibulin family O95967
GRB10-interacting GYF protein 1 (GIGYF1) GIGYF family O75420
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8
Progranulin (GRN) Granulin family P28799
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Protein HEXIM2 (HEXIM2) HEXIM family Q96MH2
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cuticular Ha5 (KRT35) Intermediate filament family Q92764
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Vimentin (VIM) Intermediate filament family P08670
Keratin-associated protein 10-11 (KRTAP10-11) KRTAP type 10 family P60412
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Keratin-associated protein 10-9 (KRTAP10-9) KRTAP type 10 family P60411
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 19-5 (KRTAP19-5) KRTAP type 19 family Q3LI72
Keratin-associated protein 19-7 (KRTAP19-7) KRTAP type 19 family Q3SYF9
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 7-1 (KRTAP7-1) KRTAP type 7 family Q8IUC3
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Protein LDOC1 (LDOC1) LDOC1 family O95751
Leucine zipper putative tumor suppressor 2 (LZTS2) LZTS2 family Q9BRK4
Protein mago nashi homolog 2 (MAGOHB) Mago nashi family Q96A72
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Mediator of RNA polymerase II transcription subunit 12-like protein (MED12L) Mediator complex subunit 12 family Q86YW9
Mediator of RNA polymerase II transcription subunit 25 (MED25) Mediator complex subunit 25 family Q71SY5
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
NGFI-A-binding protein 2 (NAB2) NAB family Q15742
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) NAF1 family Q96HR8
Neurochondrin (NCDN) Neurochondrin family Q9UBB6
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Notch homolog 2 N-terminal-like protein A (NOTCH2NLA) NOTCH family Q7Z3S9
Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) NOTCH family P0DPK4
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OKL38 family Q9UJX0
Gamma-parvin (PARVG) Parvin family Q9HBI0
Keratin-associated protein 11-1 (KRTAP11-1) PMG family Q8IUC1
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 13-3 (KRTAP13-3) PMG family Q3SY46
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
Rho GTPase-activating protein 32 (ARHGAP32) PX domain-containing GAP family A7KAX9
DNA repair protein RAD51 homolog 4 (RAD51D) RecA family O75771
RIB43A-like with coiled-coils protein 1 (RIBC1) RIB43A family Q8N443
RIMS-binding protein 3A (RIMBP3) RIMBP family Q9UFD9
Protein ripply1 (RIPPLY1) Ripply family Q0D2K3
Cleavage and polyadenylation specificity factor subunit 7 (CPSF7) RRM CPSF6/7 family Q8N684
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
tRNA-splicing endonuclease subunit Sen15 (TSEN15) SEN15 family Q8WW01
Splicing factor 3B subunit 4 (SF3B4) SF3B4 family Q15427
Ski-like protein (SKIL) SKI family P12757
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
U6 snRNA-associated Sm-like protein LSm2 (LSM2) SnRNP Sm proteins family Q9Y333
Spermatogenesis-associated protein 25 (SPATA25) SPATA25 family Q9BR10
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
Suppressor of fused homolog (SUFU) SUFU family Q9UMX1
Syntaxin-11 (STX11) Syntaxin family O75558
Tigger transposable element-derived protein 3 (TIGD3) Tigger transposable element derived protein family Q6B0B8
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
Transcription cofactor vestigial-like protein 1 (VGLL1) Vestigial family Q99990
Vacuolar protein sorting-associated protein 37B (VPS37B) VPS37 family Q9H9H4
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
YTH domain-containing family protein 1 (YTHDF1) YTHDF family Q9BYJ9
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
AFG2-interacting ribosome maturation factor (AIRIM) . Q9NX04
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Bromo adjacent homology domain-containing 1 protein (BAHD1) . Q8TBE0
Calcium and integrin-binding family member 3 (CIB3) . Q96Q77
Calcium-binding protein 2 (CABP2) . Q9NPB3
Calcium-binding protein 5 (CABP5) . Q9NP86
Cancer/testis antigen 55 (CT55) . Q8WUE5
CAP-Gly domain-containing linker protein 3 (CLIP3) . Q96DZ5
Caspase recruitment domain-containing protein 9 (CARD9) . Q9H257
Cation channel sperm-associated targeting subunit tau (C2CD6) . Q53TS8
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Cleavage stimulation factor subunit 2 tau variant (CSTF2T) . Q9H0L4
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
DAZ-associated protein 2 (DAZAP2) . Q15038
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Fibroblast growth factor receptor substrate 3 (FRS3) . O43559
Four and a half LIM domains protein 3 (FHL3) . Q13643
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
GRIP and coiled-coil domain-containing protein 1 (GCC1) . Q96CN9
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
INO80 complex subunit B (INO80B) . Q9C086
INO80 complex subunit E (INO80E) . Q8NBZ0
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
Keratin-associated protein 17-1 (KRTAP17-1) . Q9BYP8
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
LIM domain transcription factor LMO4 (LMO4) . P61968
Microspherule protein 1 (MCRS1) . Q96EZ8
Migration and invasion-inhibitory protein (MIIP) . Q5JXC2
Mortality factor 4-like protein 2 (MORF4L2) . Q15014
Nuclear transport factor 2 (NUTF2) . P61970
Poly(rC)-binding protein 1 (PCBP1) . Q15365
PRKCA-binding protein (PICK1) . Q9NRD5
Proline-rich protein 3 (PRR3) . P79522
Proline-rich protein 35 (PRR35) . P0CG20
Protein phosphatase 1 regulatory subunit 16A (PPP1R16A) . Q96I34
Protein SPMIP9 (SPMIP9) . Q96LM6
Putative protein MSS51 homolog, mitochondrial (MSS51) . Q4VC12
Putative uncharacterized protein encoded by LINC00526 (LINC00526) . Q96FQ7
Rhombotin-1 (LMO1) . P25800
Rhombotin-2 (LMO2) . P25791
RNA-binding protein 10 (RBM10) . P98175
RNA-binding protein with multiple splicing (RBPMS) . Q93062
SERTA domain-containing protein 3 (SERTAD3) . Q9UJW9
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00
TNF receptor-associated factor 1 (TRAF1) . Q13077
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
Ubiquitin-like protein 5 (UBL5) . Q9BZL1
UBX domain-containing protein 11 (UBXN11) . Q5T124
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7
Uncharacterized protein C14orf119 (C14orf119) . Q9NWQ9
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.