Details of the Target

General Information of Target

Target ID LDTP13955
Target Name Calcium-binding protein 39 (CAB39)
Gene Name CAB39
Gene ID 51719
Synonyms
MO25; Calcium-binding protein 39; MO25alpha; Protein Mo25
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALVHKLLRGTYFLRKFSKPTSALYPFLGIRFAEYSSSLQKPVASPGKASSQRKTEGDLQ
GDHQKEVALDITSSEEKPDVSFDKAIRDEAIYHFRLLKDEIVDHWRGPEGHPLHEVLLEQ
AKVVWQFRGKEDLDKWTVTSDKTIGGRSEVFLKMGKNNQSALLYGTLSSEAPQDGESTRS
GYCAMISRIPRGAFERKMSYDWSQFNTLYLRVRGDGRPWMVNIKEDTDFFQRTNQMYSYF
MFTRGGPYWQEVKIPFSKFFFSNRGRIRDVQHELPLDKISSIGFTLADKVDGPFFLEIDF
IGVFTDPAHTEEFAYENSPELNPRLFK
Target Bioclass
Other
Family
Mo25 family
Subcellular location
Cytoplasm
Function Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Uniprot ID
Q9Y376
Ensemble ID
ENST00000258418.10
HGNC ID
HGNC:20292
ChEMBL ID
CHEMBL3885534

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C143(0.70)  LDD0531  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C143(0.00); C121(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C143(0.00); C121(0.00)  LDD0037  [3]
NHS
 Probe Info  		K297(0.00); K301(0.00)  LDD0010  [4]
STPyne
 Probe Info  		N.A.  LDD0009  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
NAIA_5
 Probe Info  		C143(0.00); C121(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C376
 Probe Info  		6.87  LDD2036  [7]
C431
 Probe Info  		15.67  LDD2086  [7]
FFF probe13
 Probe Info  		6.86  LDD0476  [8]
FFF probe2
 Probe Info  		20.00  LDD0463  [8]
VE-P
 Probe Info  		N.A.  LDD0396  [9]
STS-1
 Probe Info  		N.A.  LDD0068  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C143(0.70)  LDD0531  [1]
 LDCM0215  AC10 HEK-293T C121(1.00)  LDD1508  [11]
 LDCM0216  AC100 HCT 116 C143(0.39)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C143(0.48)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C143(0.52)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C143(0.45)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C143(0.38)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C143(0.44)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C143(0.35)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C143(0.62)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C143(0.46)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C143(0.41)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C121(0.96)  LDD1509  [11]
 LDCM0227  AC110 HCT 116 C143(0.40)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C143(0.49)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C143(0.55)  LDD0546  [1]
 LDCM0237  AC12 HEK-293T C121(1.12)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C121(0.71)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C121(0.92)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C121(1.01)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C121(1.28)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C121(1.05)  LDD1517  [11]
 LDCM0279  AC2 HCT 116 C143(0.81)  LDD0596  [1]
 LDCM0280  AC20 HEK-293T C121(1.06)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C121(0.96)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C121(0.79)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C121(0.82)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C121(1.01)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C121(1.02)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C121(1.08)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C121(0.89)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C121(1.24)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C121(1.00)  LDD1528  [11]
 LDCM0290  AC3 HCT 116 C143(0.73)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C121(0.79)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C121(1.28)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C121(1.06)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C121(1.02)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C121(0.93)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C121(0.85)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C121(0.99)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C121(0.97)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C121(1.12)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C121(1.04)  LDD1539  [11]
 LDCM0301  AC4 HCT 116 C143(0.69)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C121(1.13)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C121(1.15)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C121(0.98)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C121(1.11)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C121(0.99)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C121(0.95)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C121(0.83)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C121(1.38)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C121(1.23)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C121(1.08)  LDD1550  [11]
 LDCM0312  AC5 HCT 116 C143(0.71)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C121(1.00)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C121(0.87)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C121(1.21)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C121(1.05)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C121(0.71)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C121(1.05)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C121(1.09)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C121(1.17)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C121(1.05)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C121(1.16)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C121(1.01)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C121(1.15)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C121(1.08)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C121(0.78)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C121(1.32)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C121(1.10)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C121(1.53)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C121(1.05)  LDD1569  [11]
 LDCM0365  AC98 HCT 116 C143(0.31)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C143(0.65)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C121(1.00)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C121(1.09)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C121(1.16)  LDD1514  [11]
 LDCM0108  Chloroacetamide HeLa H276(0.00); H206(0.00)  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C143(0.95)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C143(0.95)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C143(0.60)  LDD0686  [1]
 LDCM0370  CL101 HEK-293T C121(1.03)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C121(0.98); C143(0.98)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C121(0.92)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C121(1.02)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C121(0.85)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C121(0.87); C143(0.81)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C121(0.97)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C121(1.10)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C121(1.00)  LDD1582  [11]
 LDCM0379  CL11 HCT 116 C143(0.59)  LDD0696  [1]
 LDCM0380  CL110 HEK-293T C121(0.70); C143(0.67)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C121(0.78)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C121(0.92)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C121(1.00)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C121(0.71); C143(0.99)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C121(1.00)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C121(0.94)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C121(1.13)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C121(0.76); C143(1.25)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C121(0.92)  LDD1593  [11]
 LDCM0390  CL12 HCT 116 C143(0.73)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C121(1.05)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C121(1.05)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C121(0.93); C143(1.13)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C121(0.82)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C121(1.05)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C121(1.29)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C121(0.86); C143(1.04)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C121(0.95)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C121(1.09)  LDD1603  [11]
 LDCM0400  CL13 HCT 116 C143(0.73)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C143(0.77)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C143(1.10)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C143(0.74)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C143(0.86)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C143(0.49)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C143(0.80)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C143(0.86)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C143(0.68)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C143(0.51)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C143(0.91)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C143(0.76)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C143(0.82)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C143(0.74)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C143(0.85)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C143(0.90)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C143(0.77)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C143(0.94)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C143(0.99)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C143(0.91)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C143(0.80)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C143(0.52)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C143(0.48)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C143(0.48)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C143(0.64)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C143(0.65)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C143(0.62)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C143(0.58)  LDD0745  [1]
 LDCM0429  CL4 HCT 116 C143(0.95)  LDD0746  [1]
 LDCM0430  CL40 HCT 116 C143(0.68)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C143(0.68)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C143(0.58)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C143(0.52)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C143(0.53)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C143(0.55)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C121(0.79)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C121(1.23)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C121(0.97)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C121(1.04)  LDD1643  [11]
 LDCM0440  CL5 HCT 116 C143(0.91)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C121(0.74); C143(1.07)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C121(1.02)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C121(0.95)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C121(0.96)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C121(0.97)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C121(0.94)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C121(0.84)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C121(0.79)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C121(1.24)  LDD1653  [11]
 LDCM0451  CL6 HCT 116 C143(0.72)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C121(0.94)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C121(1.00)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C121(0.91); C143(0.93)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C121(0.97)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C121(0.89)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C121(1.12)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C121(0.94)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C121(1.01)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C121(1.09)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C121(0.94)  LDD1664  [11]
 LDCM0462  CL7 HCT 116 C143(0.94)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C121(0.58)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C121(1.02)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C121(1.01)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C121(0.93)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C121(0.78); C143(1.20)  LDD1670  [11]
 LDCM0469  CL76 HCT 116 C143(0.60)  LDD0786  [1]
 LDCM0470  CL77 HCT 116 C143(0.73)  LDD0787  [1]
 LDCM0471  CL78 HCT 116 C143(0.77)  LDD0788  [1]
 LDCM0472  CL79 HCT 116 C143(0.66)  LDD0789  [1]
 LDCM0473  CL8 HCT 116 C143(1.00)  LDD0790  [1]
 LDCM0474  CL80 HCT 116 C143(0.67)  LDD0791  [1]
 LDCM0475  CL81 HCT 116 C143(0.66)  LDD0792  [1]
 LDCM0476  CL82 HCT 116 C143(0.61)  LDD0793  [1]
 LDCM0477  CL83 HCT 116 C143(0.58)  LDD0794  [1]
 LDCM0478  CL84 HCT 116 C143(0.58)  LDD0795  [1]
 LDCM0479  CL85 HCT 116 C143(0.62)  LDD0796  [1]
 LDCM0480  CL86 HCT 116 C143(0.76)  LDD0797  [1]
 LDCM0481  CL87 HCT 116 C143(0.75)  LDD0798  [1]
 LDCM0482  CL88 HCT 116 C143(0.69)  LDD0799  [1]
 LDCM0483  CL89 HCT 116 C143(0.63)  LDD0800  [1]
 LDCM0484  CL9 HCT 116 C143(1.01)  LDD0801  [1]
 LDCM0485  CL90 HCT 116 C143(0.86)  LDD0802  [1]
 LDCM0486  CL91 HCT 116 C143(0.74)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C143(0.95)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C143(0.76)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C143(0.60)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C143(0.79)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C143(0.71)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C143(0.73)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C143(0.78)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C143(0.88)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C121(0.98)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C121(0.97)  LDD1671  [11]
 LDCM0427  Fragment51 HCT 116 C143(0.53)  LDD0744  [1]
 LDCM0107  IAA HeLa H206(0.00); H276(0.00)  LDD0221  [5]
 LDCM0022  KB02 HEK-293T C143(0.88); C121(1.22)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C143(1.06); C121(1.15)  LDD1497  [11]
 LDCM0024  KB05 MEWO C143(2.98)  LDD3319  [12]
 LDCM0109  NEM HeLa H276(0.00); H206(0.00)  LDD0223  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase STK11 (STK11) CAMK Ser/Thr protein kinase family Q15831
Serine/threonine-protein kinase 25 (STK25) STE Ser/Thr protein kinase family O00506
Serine/threonine-protein kinase 26 (STK26) STE Ser/Thr protein kinase family Q9P289
Serine/threonine-protein kinase OSR1 (OXSR1) STE Ser/Thr protein kinase family O95747
STE20-related kinase adapter protein alpha (STRADA) STE Ser/Thr protein kinase family Q7RTN6
STE20-related kinase adapter protein beta (STRADB) STE Ser/Thr protein kinase family Q9C0K7
STE20/SPS1-related proline-alanine-rich protein kinase (STK39) STE Ser/Thr protein kinase family Q9UEW8
Serine hydroxymethyltransferase, mitochondrial (SHMT2) SHMT family P34897
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Mediator of RNA polymerase II transcription subunit 7 (MED7) Mediator complex subunit 7 family O43513
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Mitochondrial coiled-coil domain protein 1 (MCCD1) . P59942

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840