Details of the Target

General Information of Target

Target ID LDTP01249
Target Name Polycomb protein EED (EED)
Gene Name EED
Gene ID 8726
Synonyms
Polycomb protein EED; hEED; Embryonic ectoderm development protein; WD protein associating with integrin cytoplasmic tails 1; WAIT-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
Target Type
Clinical trial
Target Bioclass
Other
Family
WD repeat ESC family
Subcellular location
Nucleus
Function
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
TTD ID
T44916
Uniprot ID
O75530
DrugMap ID
TTFNJ4R
Ensemble ID
ENST00000263360.11
HGNC ID
HGNC:3188
ChEMBL ID
CHEMBL2189117

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A673 SNV: p.P10S DBIA    Probe Info 
AN3CA SNV: p.R313Ter DBIA    Probe Info 
HT SNV: p.N146S; p.S159G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C126(0.30)  LDD1700  [2]
DBIA
 Probe Info  		C324(1.27)  LDD0531  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C361(0.00); C182(0.00); C126(0.00); C401(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C254(0.00); C311(0.00); C126(0.00); C401(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C361(0.00); C182(0.00); C254(0.00); C311(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		C409(0.00); C311(0.00)  LDD0148  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
W1
 Probe Info  		N.A.  LDD0236  [9]
AOyne
 Probe Info  		14.00  LDD0443  [10]
NAIA_5
 Probe Info  		C401(0.00); C84(0.00); C311(0.00); C182(0.00)  LDD2223  [5]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C378
 Probe Info  		12.82  LDD2037  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C254(1.18)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C126(1.70)  LDD2152  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C254(2.90)  LDD0372  [13]
 LDCM0214  AC1 HCT 116 C324(1.27)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C324(0.91)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C324(0.77); C330(0.77)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C324(0.73); C330(0.73)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C324(0.74); C330(0.74)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C324(0.52); C330(0.52)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C324(0.67); C330(0.67)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C324(0.55); C330(0.55)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C324(0.56); C330(0.56)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C324(1.43); C330(0.70)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C324(1.03); C330(0.63)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C324(0.92); C330(0.64)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C324(0.86)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C324(1.05); C330(0.69)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C324(0.89); C330(0.64)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C324(1.12); C330(0.68)  LDD0546  [3]
 LDCM0230  AC113 HEK-293T C324(0.80); C330(0.86)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C324(1.52); C330(0.95)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C324(0.63); C330(1.08)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C324(1.04); C330(0.78)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C324(1.14); C330(0.74)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C324(1.00); C330(0.65)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C324(1.61); C330(0.65)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C324(0.60)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C324(0.59); C330(0.71)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C324(1.99); C330(0.70)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C324(1.86); C330(0.59)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C324(1.40); C330(0.54)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C324(1.19); C330(0.70)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C324(1.34); C330(0.53)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C324(2.17); C330(0.56)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C324(3.21); C330(0.55)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C330(1.36); C361(1.09)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C330(0.92); C361(0.95)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C330(1.06); C361(1.11)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C330(1.01); C361(1.06)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C330(0.99); C361(0.89)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C330(0.86); C361(0.96)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C330(0.97); C361(1.73)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C330(0.93); C361(0.91)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C330(0.97); C361(1.07)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C330(0.95); C361(1.60)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C330(0.67); C361(1.54)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C330(0.83); C361(1.33)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C324(0.97)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C330(0.77); C361(1.45)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C330(0.84); C361(1.11)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C330(0.70); C361(1.11)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C324(0.99); C330(0.99)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C324(0.79); C330(0.79)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C324(0.94); C330(0.94)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C324(0.97); C330(0.97)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C324(0.68); C330(0.68)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C324(0.35); C330(0.35)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C324(0.75); C330(0.75)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C324(1.09)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C324(0.94); C330(0.94)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C324(1.03); C330(1.03)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C324(0.98); C330(0.98)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C324(0.24); C330(0.24)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C324(0.89); C330(0.89)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C324(0.88); C330(0.88)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C324(0.95); C330(0.95)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C324(1.00); C330(1.00)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C324(2.79)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C324(1.42)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C324(1.01)  LDD0876  [3]
 LDCM0279  AC2 HCT 116 C324(1.33)  LDD0596  [3]
 LDCM0280  AC20 HEK-293T C324(3.29)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C324(3.26)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C324(1.65)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C324(2.55)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C324(0.86)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C324(1.72); C330(0.92); C361(0.67); C401(1.19)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C324(1.72); C330(0.83); C361(0.60); C401(0.85)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C324(1.39); C330(0.84); C361(0.72); C401(0.83)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C324(1.83); C330(0.68); C361(0.56); C401(1.45)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C324(1.49); C330(0.74); C361(0.70); C401(1.08)  LDD0887  [3]
 LDCM0290  AC3 HCT 116 C324(1.32)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C324(1.69); C330(0.91); C361(0.82); C401(1.09)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C324(1.34); C330(1.36); C361(0.97); C401(1.22)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C324(1.36); C330(1.03); C361(0.77); C401(0.98)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C324(1.65); C330(0.79); C361(0.76); C401(0.88)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C324(1.67); C330(1.46); C361(0.97); C401(1.12)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C324(1.03); C330(0.65)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C324(1.14); C330(0.67)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C324(1.10); C330(0.77)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C324(0.99); C330(0.86)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C324(1.15); C330(0.71)  LDD0898  [3]
 LDCM0301  AC4 HCT 116 C324(1.51)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C324(1.30); C330(0.92)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C324(1.57); C330(0.66)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C324(1.33); C330(0.60)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C324(1.27); C330(0.89)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C324(1.51); C330(0.84)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C324(1.16); C330(0.84)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C324(0.97); C330(0.66); C361(0.86); C401(0.89)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C324(0.84); C330(0.59); C361(0.92); C401(0.67)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C324(1.11); C330(0.46); C361(0.90); C401(0.84)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C324(1.27); C330(0.60); C361(0.79); C401(0.71)  LDD0909  [3]
 LDCM0312  AC5 HCT 116 C324(1.13)  LDD0629  [3]
 LDCM0313  AC50 HEK-293T C324(0.92); C330(0.54); C361(0.80); C401(0.86)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C324(1.16); C330(0.38); C361(0.72); C401(0.87)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C324(1.70); C330(0.39); C361(0.74); C401(0.89)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C324(1.35); C330(0.57); C361(0.71); C401(1.05)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C324(1.85); C330(0.39); C361(0.74); C401(0.76)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C324(1.13); C330(0.48); C361(0.75); C401(0.92)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C324(1.03); C330(0.49); C361(0.78); C401(1.05)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C324(0.91); C330(0.91)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C324(1.10); C330(1.10)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C324(0.97); C330(0.97)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C324(0.99)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C324(1.38); C330(1.38)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C324(1.67); C330(1.67)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C324(0.77); C330(0.77)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C324(1.01); C330(1.01)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C324(0.80); C330(0.80)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C324(0.75); C330(0.75)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C324(0.84); C330(0.84)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C324(0.23); C330(0.23)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C324(1.10); C330(1.10)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C324(0.86); C330(0.86)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C324(0.78)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C324(0.57); C330(0.57)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C324(0.99); C330(0.99)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C324(0.81); C330(0.81)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C324(0.45); C330(0.45)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C324(0.54); C330(0.54)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C324(0.40); C330(0.40)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C324(0.77); C330(0.77)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C324(0.67); C330(0.67)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C324(1.01); C330(1.01)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C324(0.83); C330(0.83)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C324(0.90)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C324(0.88); C330(0.88)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C324(1.31); C330(1.31)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C324(0.47); C330(0.47)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C324(0.45); C330(0.45)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C324(0.60); C330(0.60)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C324(0.78); C330(0.78)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C324(0.63); C330(0.63)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C324(0.92); C330(0.92)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C324(0.67); C330(0.67)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C324(0.64); C330(0.64)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C324(0.74); C330(0.74)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C324(0.36); C330(0.36)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C324(0.46); C330(0.46)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C324(0.65); C330(0.65)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C324(0.80); C330(0.80)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C324(1.22); C330(1.22)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C324(0.74); C330(0.74)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C324(0.55); C330(0.55)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C324(0.08); C330(0.08)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C324(0.64); C330(0.64)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C324(0.80)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C324(0.80)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C324(0.86)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 12.63  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C311(1.25)  LDD2171  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C324(1.07); C330(0.91)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C324(2.23); C330(0.48)  LDD0966  [3]
 LDCM0369  CL100 HCT 116 C324(1.31)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C324(0.83)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C324(0.75)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C324(0.84)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C324(0.84)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C324(0.83)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C324(0.98)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C324(1.12)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C324(1.07)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C324(0.90)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C324(2.40); C330(0.44)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C324(1.28)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C324(1.32)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C324(1.45); C330(0.77); C361(0.69); C401(0.99)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C324(1.66); C330(0.95); C361(0.65); C401(1.12)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C324(2.78); C330(0.57); C361(0.63); C401(1.14)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C324(1.81); C330(1.08); C361(0.62); C401(1.21)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C324(1.81); C330(0.77); C361(0.61); C401(1.17)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C324(1.23); C330(0.68)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C324(1.10); C330(0.79)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C324(1.47); C330(0.70)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C324(1.12); C330(0.83)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C324(1.35); C330(0.80)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C324(1.74); C330(0.46); C361(0.69); C401(0.91)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C324(1.28); C330(0.50); C361(0.83); C401(0.87)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C324(0.82); C330(0.56); C361(0.82); C401(0.74)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C324(1.32); C330(0.61); C361(0.79); C401(1.04)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C324(0.99); C330(0.99)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C324(1.06); C330(1.06)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C324(1.00); C330(1.00)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C324(0.83); C330(0.83)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C324(0.89); C330(0.63)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C324(1.33); C330(1.12)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C324(1.79); C330(0.45)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C324(1.49); C330(1.26)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C324(0.97); C330(1.01)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C324(1.38); C330(1.04)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C324(0.83); C330(1.01)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C324(1.04); C330(0.82)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C324(0.82); C330(1.04)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C324(1.32); C330(0.92)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C324(0.93); C330(0.91)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C324(1.14); C330(0.83)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C324(0.99); C330(1.00)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C324(1.23); C330(0.96)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C324(1.30); C330(1.05)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C324(0.82); C330(0.92)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C324(0.92); C330(1.00)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C324(1.08); C330(0.85)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C324(1.18); C330(1.34)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C324(1.97); C330(0.75)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C324(1.00); C330(1.22); C361(0.68); C401(2.07)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C324(1.25); C330(1.03); C361(0.82); C401(1.01)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C324(0.99); C330(0.54); C361(0.56); C401(0.69)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C324(0.86); C330(0.77); C361(0.92); C401(1.36)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C324(1.15); C330(0.76); C361(0.64); C401(1.03)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C324(0.97); C330(0.72); C361(0.89); C401(0.72)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C324(1.01); C330(0.84); C361(0.61); C401(1.52)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C324(1.16); C330(0.48); C361(0.64); C401(0.88)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C324(0.87); C330(0.85)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C324(1.22); C330(0.76); C361(0.65); C401(0.83)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C324(1.13); C330(0.58); C361(0.60); C401(0.98)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C324(1.40); C330(0.74); C361(0.68); C401(1.04)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C324(1.28); C330(0.70); C361(0.68); C401(0.78)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C324(0.98); C330(0.73); C361(0.64); C401(1.11)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C324(0.98); C330(0.53); C361(0.57); C401(0.97)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C324(1.31); C330(0.97)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C324(1.14); C330(0.84)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C324(1.28); C330(1.12)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C324(1.05); C330(0.84)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C324(0.97); C330(0.69)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C324(1.11); C330(0.72)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C324(1.03); C330(0.78)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C324(1.00); C330(1.24)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C324(1.07); C330(1.01)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C324(1.11); C330(0.82)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C324(1.43); C330(1.04)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C324(1.06); C330(0.99)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C324(0.94); C330(0.85)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C324(1.05); C330(0.84)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C324(1.35); C330(1.06)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C324(0.97); C330(0.74)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C324(1.56); C330(0.79)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C324(0.91); C330(0.91)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C324(0.81); C330(0.81)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C324(0.91); C330(0.91)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C324(0.85); C330(0.85)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C324(0.96); C330(0.96)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C324(0.78); C330(0.78)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C324(0.91); C330(0.91)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C324(0.96); C330(0.96)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C324(1.47); C330(1.47)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C324(1.67); C330(0.75)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C324(1.11); C330(1.11)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C324(1.11); C330(1.11)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C324(1.21); C330(1.21)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C324(0.84); C330(0.84)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C324(0.87); C330(0.87)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C324(1.17); C330(1.17)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C324(0.89); C330(0.89)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C324(1.01); C330(1.01)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C324(0.88); C330(0.88)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C330(1.07)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C324(1.82); C330(1.82)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C324(0.95); C330(0.95)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C324(0.58); C330(0.58)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C324(0.70); C330(0.70)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C324(0.36); C330(0.36)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C324(0.93); C330(0.93)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C324(0.89); C330(0.89)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C324(0.93); C330(0.93)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C324(0.69); C330(0.69)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C324(0.28); C330(0.28)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C330(0.89)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C324(0.94); C330(0.94)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C324(1.42)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C324(0.61)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C324(0.88)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C324(0.87)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C324(0.91)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C324(1.07)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C324(0.88)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C324(1.84)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C324(1.32)  LDD0811  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C401(1.25); C182(1.00)  LDD1702  [2]
 LDCM0625  F8 Ramos C182(1.44)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C182(0.70)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C182(3.47)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C182(0.66)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C182(1.65)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C182(0.58)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C182(0.51)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C182(1.04)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C182(1.11)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C182(1.12)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C182(0.65)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C182(1.03)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C182(1.12)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C182(0.77)  LDD2201  [14]
 LDCM0468  Fragment33 HCT 116 C324(0.93); C330(0.93)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C182(0.99)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C182(1.33)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C324(0.85); C330(0.64); C361(1.05); C401(0.84)  LDD1025  [3]
 LDCM0610  Fragment52 Ramos C182(0.80)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C182(1.16)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C182(0.68)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C182(0.78)  LDD2188  [14]
 LDCM0022  KB02 Ramos C182(0.62)  LDD2182  [14]
 LDCM0023  KB03 MDA-MB-231 C254(5.60); C126(1.91); C182(0.68)  LDD1701  [2]
 LDCM0024  KB05 G361 C434(2.20); C182(1.23); C254(2.14); C311(2.04)  LDD3311  [15]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C254(0.91)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C182(0.49)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C254(1.25)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C254(1.03)  LDD2099  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C126(0.75)  LDD2104  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C254(1.01)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C126(0.71); C311(0.56)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C126(0.87)  LDD2111  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C126(0.89)  LDD2122  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C126(0.96); C254(1.14)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C311(0.97)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C254(1.50); C311(1.13)  LDD2127  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C126(1.17); C254(0.77)  LDD2129  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C254(1.70)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C126(1.72); C254(1.15)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C126(1.01); C254(0.90)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C126(0.30)  LDD1700  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C254(1.28)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C126(2.05); C311(1.64)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C126(1.11); C254(0.94); C311(1.14)  LDD2146  [2]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C254(0.59)  LDD2150  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C254(2.29)  LDD2153  [2]
 LDCM0021  THZ1 HCT 116 C311(1.25)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA (cytosine-5)-methyltransferase 1 (DNMT1) C5-methyltransferase family P26358
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) C5-methyltransferase family Q9Y6K1
DNA (cytosine-5)-methyltransferase 3B (DNMT3B) C5-methyltransferase family Q9UBC3
Histone-lysine N-methyltransferase EZH1 (EZH1) Histone-lysine methyltransferase family Q92800
Histone-lysine N-methyltransferase EZH2 (EZH2) Histone-lysine methyltransferase family Q15910
Sphingomyelin phosphodiesterase 3 (SMPD3) Neutral sphingomyelinase family Q9NY59
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Alpha-synuclein (SNCA) Synuclein family P37840
Small ribosomal subunit protein RACK1 (RACK1) WD repeat G protein beta family P63244
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Polycomb group protein ASXL1 (ASXL1) Asx family Q8IXJ9
DNA damage-binding protein 1 (DDB1) DDB1 family Q16531
Progranulin (GRN) Granulin family P28799
T-complex protein 1 subunit gamma (CCT3) TCP-1 chaperonin family P49368
Polycomb protein SUZ12 (SUZ12) VEFS (VRN2-EMF2-FIS2-SU(Z)12) family Q15022
Polycomb protein EED (EED) WD repeat ESC family O75530
Merlin (NF2) . P35240
RING finger protein 11 (RNF11) . Q9Y3C5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699
TAR DNA-binding protein 43 (TARDBP) . Q13148

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mak683 . D0UO0C
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
A-395 Small molecular drug DQ0V7Y

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840