Details of the Target

General Information of Target

Target ID LDTP05046
Target Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)
Gene Name PPP2R2A
Gene ID 5520
Synonyms
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGAGGGNDIQWCFSQVKGAVDDDVAEADIISTVEFNHSGELLATGDKGGRVVIFQQEQE
NKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIK
LWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHI
NSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCN
TFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYM
MTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTG
SYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKIL
HTAWHPKENIIAVATTNNLYIFQDKVN
Target Bioclass
Enzyme
Family
Phosphatase 2A regulatory subunit B family
Function
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Essential for serine/threonine-protein phosphatase 2A-mediated dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint.
Uniprot ID
P63151
Ensemble ID
ENST00000315985.7
HGNC ID
HGNC:9304
ChEMBL ID
CHEMBL4284

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.R298Ter .
HT115 SNV: p.R298Ter .
Ishikawa (Heraklio) 02 ER Deletion: p.S282PfsTer10 DBIA    Probe Info 
JURKAT SNV: p.R199W .
LS180 Deletion: p.S15LfsTer3 DBIA    Probe Info 
SW620 SNV: p.S276N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K105(10.00); K117(7.14); K123(6.10); K396(4.35)  LDD0277  [2]
BTD
 Probe Info  		C398(9.25)  LDD1699  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [2]
Probe 1
 Probe Info  		Y74(24.20); Y134(111.99); Y143(17.45)  LDD3495  [4]
DBIA
 Probe Info  		C408(1.87)  LDD3312  [5]
Sulforaphane-probe2
 Probe Info  		2.32  LDD0160  [6]
DA-P3
 Probe Info  		8.66  LDD0181  [7]
HHS-475
 Probe Info  		Y86(3.70)  LDD0264  [8]
HHS-465
 Probe Info  		Y134(9.84)  LDD2237  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C262(0.00); C239(0.00); C398(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C239(0.00); C262(0.00); C398(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0147  [14]
PF-06672131
 Probe Info  		N.A.  LDD0152  [15]
Phosphinate-6
 Probe Info  		C398(0.00); C262(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C262(0.00); C398(0.00)  LDD0218  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C262(0.00); C398(0.00); C239(0.00); C13(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.96  LDD0472  [20]
FFF probe13
 Probe Info  		12.71  LDD0475  [20]
FFF probe2
 Probe Info  		5.88  LDD0463  [20]
FFF probe3
 Probe Info  		6.58  LDD0465  [20]
STS-1
 Probe Info  		N.A.  LDD0137  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C398(0.42)  LDD2142  [3]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C398(0.82)  LDD2112  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C398(0.55)  LDD2095  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C398(0.69); C262(0.90)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C398(1.08); C262(1.07)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C398(0.93)  LDD2103  [3]
 LDCM0214  AC1 HEK-293T C262(0.96); C239(1.06); C334(0.91)  LDD1507  [23]
 LDCM0215  AC10 HEK-293T C262(0.95); C239(1.00); C398(1.74); C334(0.94)  LDD1508  [23]
 LDCM0226  AC11 HEK-293T C262(0.96); C239(0.93); C398(1.30); C334(0.85)  LDD1509  [23]
 LDCM0237  AC12 HEK-293T C262(0.92); C239(0.98); C398(1.19); C334(0.98)  LDD1510  [23]
 LDCM0259  AC14 HEK-293T C262(0.98); C239(0.92); C398(1.91); C334(0.94)  LDD1512  [23]
 LDCM0270  AC15 HEK-293T C262(0.93); C239(1.03); C398(1.33); C334(0.94)  LDD1513  [23]
 LDCM0276  AC17 HEK-293T C262(0.97); C239(1.13); C334(1.04)  LDD1515  [23]
 LDCM0277  AC18 HEK-293T C262(0.97); C239(1.03); C398(1.23); C334(0.95)  LDD1516  [23]
 LDCM0278  AC19 HEK-293T C262(1.03); C239(0.83); C398(1.14); C334(1.07)  LDD1517  [23]
 LDCM0279  AC2 HEK-293T C262(1.04); C239(1.15); C398(1.91); C334(0.97)  LDD1518  [23]
 LDCM0280  AC20 HEK-293T C262(1.00); C239(1.01); C398(1.30); C334(1.00)  LDD1519  [23]
 LDCM0281  AC21 HEK-293T C262(0.98); C239(0.93); C398(1.14); C334(0.96)  LDD1520  [23]
 LDCM0282  AC22 HEK-293T C262(0.89); C239(0.90); C398(1.36); C334(1.05)  LDD1521  [23]
 LDCM0283  AC23 HEK-293T C262(1.04); C239(1.04); C398(1.40); C334(0.96)  LDD1522  [23]
 LDCM0284  AC24 HEK-293T C262(1.09); C239(1.27); C398(0.97); C334(0.95)  LDD1523  [23]
 LDCM0285  AC25 HEK-293T C262(1.03); C239(1.08); C334(1.03)  LDD1524  [23]
 LDCM0286  AC26 HEK-293T C262(0.98); C239(0.97); C398(1.56); C334(0.99)  LDD1525  [23]
 LDCM0287  AC27 HEK-293T C262(0.96); C239(0.95); C398(1.54); C334(0.92)  LDD1526  [23]
 LDCM0288  AC28 HEK-293T C262(0.91); C239(0.92); C398(1.41); C334(0.93)  LDD1527  [23]
 LDCM0289  AC29 HEK-293T C262(0.91); C239(0.87); C398(1.35); C334(1.01)  LDD1528  [23]
 LDCM0290  AC3 HEK-293T C262(0.93); C239(1.09); C398(1.34); C334(0.91)  LDD1529  [23]
 LDCM0291  AC30 HEK-293T C262(0.91); C239(0.84); C398(1.36); C334(1.01)  LDD1530  [23]
 LDCM0292  AC31 HEK-293T C262(0.97); C239(0.95); C398(1.28); C334(0.95)  LDD1531  [23]
 LDCM0293  AC32 HEK-293T C262(0.96); C239(1.15); C398(1.23); C334(0.88)  LDD1532  [23]
 LDCM0294  AC33 HEK-293T C262(1.09); C239(1.13); C334(0.86)  LDD1533  [23]
 LDCM0295  AC34 HEK-293T C262(0.99); C239(1.04); C398(1.64); C334(0.91)  LDD1534  [23]
 LDCM0296  AC35 HEK-293T C262(0.94); C239(0.94); C398(1.49); C334(0.86)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C262(0.92); C239(1.00); C398(1.35); C334(0.93)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C262(1.00); C239(1.22); C398(1.54); C334(0.92)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C262(0.93); C239(0.79); C398(1.70); C334(0.92)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C262(0.89); C239(0.97); C398(1.39); C334(0.94)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C262(0.89); C239(1.12); C398(1.32); C334(0.91)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C262(0.92); C239(1.17); C398(1.41); C334(0.81)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C262(1.08); C239(1.05); C334(0.92)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C262(0.93); C239(1.04); C398(1.79); C334(1.01)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C262(0.93); C239(1.00); C398(1.36); C334(0.88)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C262(0.97); C239(1.03); C398(1.14); C334(0.91)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C262(0.96); C239(1.02); C398(1.17); C334(0.93)  LDD1546  [23]
 LDCM0308  AC46 HEK-293T C262(0.96); C239(1.07); C398(1.20); C334(0.88)  LDD1547  [23]
 LDCM0309  AC47 HEK-293T C262(0.93); C239(1.11); C398(1.17); C334(0.87)  LDD1548  [23]
 LDCM0310  AC48 HEK-293T C262(1.05); C239(1.12); C398(1.46); C334(0.89)  LDD1549  [23]
 LDCM0311  AC49 HEK-293T C262(0.99); C239(1.11); C334(0.86)  LDD1550  [23]
 LDCM0312  AC5 HEK-293T C262(0.91); C239(1.02); C398(1.51); C334(0.84)  LDD1551  [23]
 LDCM0313  AC50 HEK-293T C262(0.95); C239(1.05); C398(1.57); C334(0.91)  LDD1552  [23]
 LDCM0314  AC51 HEK-293T C262(1.00); C239(1.06); C398(1.40); C334(0.83)  LDD1553  [23]
 LDCM0315  AC52 HEK-293T C262(0.91); C239(0.94); C398(1.18); C334(0.92)  LDD1554  [23]
 LDCM0316  AC53 HEK-293T C262(0.99); C239(0.98); C398(1.29); C334(0.87)  LDD1555  [23]
 LDCM0317  AC54 HEK-293T C262(0.96); C239(0.94); C398(1.38); C334(0.85)  LDD1556  [23]
 LDCM0318  AC55 HEK-293T C262(0.92); C239(0.98); C398(1.18); C334(0.91)  LDD1557  [23]
 LDCM0319  AC56 HEK-293T C262(0.98); C239(1.10); C398(1.26); C334(0.90)  LDD1558  [23]
 LDCM0320  AC57 HEK-293T C262(1.06); C239(1.03); C334(1.01)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C262(0.94); C239(0.99); C398(1.49); C334(0.94)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C262(0.94); C239(0.93); C398(1.38); C334(0.92)  LDD1561  [23]
 LDCM0323  AC6 HEK-293T C262(0.99); C239(0.97); C398(1.40); C334(0.92)  LDD1562  [23]
 LDCM0324  AC60 HEK-293T C262(0.95); C239(1.06); C398(1.30); C334(0.95)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C262(0.97); C239(1.01); C398(1.48); C334(0.93)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C262(0.95); C239(0.89); C398(1.16); C334(0.92)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C262(0.89); C239(1.07); C398(1.22); C334(0.96)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C262(1.02); C239(1.07); C398(1.11); C334(0.86)  LDD1567  [23]
 LDCM0334  AC7 HEK-293T C262(1.04); C239(1.07); C398(1.56); C334(0.97)  LDD1568  [23]
 LDCM0345  AC8 HEK-293T C262(0.93); C239(1.04); C398(1.45); C334(0.89)  LDD1569  [23]
 LDCM0545  Acetamide MDA-MB-231 C398(0.23)  LDD2138  [3]
 LDCM0520  AKOS000195272 MDA-MB-231 C398(0.69)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C262(0.97); C239(1.02); C398(1.27); C334(0.96)  LDD1511  [23]
 LDCM0356  AKOS034007680 HEK-293T C262(1.08); C239(1.02); C334(1.06)  LDD1570  [23]
 LDCM0275  AKOS034007705 HEK-293T C262(0.95); C239(0.97); C398(1.19); C334(0.85)  LDD1514  [23]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C398(0.22); C262(0.68)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa H295(0.00); C262(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C398(20.00)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C262(0.96); C239(1.05); C334(0.79)  LDD1571  [23]
 LDCM0368  CL10 HEK-293T C262(0.84); C239(1.26); C398(0.43); C334(1.11)  LDD1572  [23]
 LDCM0369  CL100 HEK-293T C262(0.89); C239(1.03); C398(2.45); C334(0.99)  LDD1573  [23]
 LDCM0370  CL101 HEK-293T C262(1.00); C239(1.25); C334(0.94)  LDD1574  [23]
 LDCM0371  CL102 HEK-293T C262(0.88); C239(0.97); C334(0.96)  LDD1575  [23]
 LDCM0372  CL103 HEK-293T C262(0.97); C239(1.04); C334(0.95)  LDD1576  [23]
 LDCM0373  CL104 HEK-293T C262(0.89); C239(0.94); C398(1.65); C334(0.92)  LDD1577  [23]
 LDCM0374  CL105 HEK-293T C262(0.97); C239(0.93); C334(0.95)  LDD1578  [23]
 LDCM0375  CL106 HEK-293T C262(0.92); C239(0.95); C334(0.99)  LDD1579  [23]
 LDCM0376  CL107 HEK-293T C262(0.93); C239(1.01); C334(0.92)  LDD1580  [23]
 LDCM0377  CL108 HEK-293T C262(0.98); C239(0.90); C398(2.04); C334(1.03)  LDD1581  [23]
 LDCM0378  CL109 HEK-293T C262(1.00); C239(0.98); C334(0.98)  LDD1582  [23]
 LDCM0379  CL11 HEK-293T C262(0.88); C239(1.02); C398(0.39); C334(1.11)  LDD1583  [23]
 LDCM0380  CL110 HEK-293T C262(0.84); C239(0.83); C334(1.04)  LDD1584  [23]
 LDCM0381  CL111 HEK-293T C262(0.86); C239(0.92); C334(1.10)  LDD1585  [23]
 LDCM0382  CL112 HEK-293T C262(0.87); C239(0.90); C398(2.27); C334(1.15)  LDD1586  [23]
 LDCM0383  CL113 HEK-293T C262(1.01); C239(1.11); C334(0.83)  LDD1587  [23]
 LDCM0384  CL114 HEK-293T C262(0.90); C239(0.98); C334(0.92)  LDD1588  [23]
 LDCM0385  CL115 HEK-293T C262(0.91); C239(1.01); C334(0.84)  LDD1589  [23]
 LDCM0386  CL116 HEK-293T C262(0.87); C239(0.95); C398(2.07); C334(0.98)  LDD1590  [23]
 LDCM0387  CL117 HEK-293T C262(0.95); C239(1.06); C334(0.93)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C262(1.00); C239(0.94); C334(0.93)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C262(0.92); C239(0.99); C334(0.87)  LDD1593  [23]
 LDCM0390  CL12 HEK-293T C262(0.91); C239(1.32); C398(0.67); C334(1.11)  LDD1594  [23]
 LDCM0391  CL120 HEK-293T C262(0.94); C239(1.01); C398(1.78); C334(0.90)  LDD1595  [23]
 LDCM0392  CL121 HEK-293T C262(0.97); C239(0.96); C334(0.88)  LDD1596  [23]
 LDCM0393  CL122 HEK-293T C262(0.95); C239(0.94); C334(0.88)  LDD1597  [23]
 LDCM0394  CL123 HEK-293T C262(0.90); C239(0.84); C334(0.84)  LDD1598  [23]
 LDCM0395  CL124 HEK-293T C262(0.91); C239(0.91); C398(1.70); C334(0.94)  LDD1599  [23]
 LDCM0396  CL125 HEK-293T C262(1.07); C239(1.03); C334(0.90)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C262(1.00); C239(0.94); C334(0.93)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C262(0.94); C239(1.03); C334(0.89)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C262(0.92); C239(0.95); C398(1.86); C334(0.94)  LDD1603  [23]
 LDCM0400  CL13 HEK-293T C262(1.00); C239(0.88); C334(1.26)  LDD1604  [23]
 LDCM0401  CL14 HEK-293T C262(0.99); C239(1.00); C334(0.91)  LDD1605  [23]
 LDCM0402  CL15 HEK-293T C262(0.93); C239(0.88); C334(0.89)  LDD1606  [23]
 LDCM0403  CL16 HEK-293T C262(0.93); C239(1.01); C398(1.51); C334(0.94)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C262(1.12); C239(0.94); C334(0.97)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C262(0.91); C239(0.88); C398(0.96); C334(0.98)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C262(1.02); C239(0.94); C398(0.78); C334(0.92)  LDD1610  [23]
 LDCM0407  CL2 HEK-293T C262(1.02); C239(0.96); C334(0.95)  LDD1611  [23]
 LDCM0408  CL20 HEK-293T C262(0.97); C239(0.92); C398(0.55); C334(1.04)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C262(0.86); C239(0.94); C398(0.39); C334(1.27)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C262(0.97); C239(1.51); C398(0.50); C334(1.03)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C262(0.88); C239(0.99); C398(0.37); C334(1.24)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C262(0.91); C239(1.29); C398(0.71); C334(1.10)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C262(0.96); C239(0.82); C334(0.86)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C262(1.04); C239(0.98); C334(0.89)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C262(0.97); C239(0.94); C334(0.87)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C262(0.93); C239(0.86); C398(1.45); C334(1.01)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C262(1.02); C239(0.91); C334(0.90)  LDD1621  [23]
 LDCM0418  CL3 HEK-293T C262(0.96); C239(1.01); C334(0.91)  LDD1622  [23]
 LDCM0419  CL30 HEK-293T C262(0.94); C239(0.93); C398(0.97); C334(0.92)  LDD1623  [23]
 LDCM0420  CL31 HEK-293T C262(0.99); C239(0.92); C398(0.81); C334(1.03)  LDD1624  [23]
 LDCM0421  CL32 HEK-293T C262(0.97); C239(0.93); C398(0.57); C334(1.03)  LDD1625  [23]
 LDCM0422  CL33 HEK-293T C262(0.83); C239(0.84); C398(0.34); C334(1.09)  LDD1626  [23]
 LDCM0423  CL34 HEK-293T C262(0.91); C239(1.26); C398(0.41); C334(1.02)  LDD1627  [23]
 LDCM0424  CL35 HEK-293T C262(0.96); C239(0.94); C398(0.36); C334(1.27)  LDD1628  [23]
 LDCM0425  CL36 HEK-293T C262(0.92); C239(1.18); C398(0.54); C334(0.98)  LDD1629  [23]
 LDCM0426  CL37 HEK-293T C262(1.00); C239(1.01); C334(0.91)  LDD1630  [23]
 LDCM0428  CL39 HEK-293T C262(0.97); C239(0.92); C334(1.07)  LDD1632  [23]
 LDCM0429  CL4 HEK-293T C262(0.87); C239(0.87); C398(1.95); C334(0.97)  LDD1633  [23]
 LDCM0430  CL40 HEK-293T C262(0.94); C239(1.01); C398(1.38); C334(0.94)  LDD1634  [23]
 LDCM0431  CL41 HEK-293T C262(1.02); C239(0.98); C334(0.97)  LDD1635  [23]
 LDCM0432  CL42 HEK-293T C262(1.02); C239(0.91); C398(0.60); C334(1.06)  LDD1636  [23]
 LDCM0433  CL43 HEK-293T C262(1.04); C239(0.87); C398(0.73); C334(0.93)  LDD1637  [23]
 LDCM0434  CL44 HEK-293T C262(1.02); C239(0.92); C398(0.59); C334(1.08)  LDD1638  [23]
 LDCM0435  CL45 HEK-293T C262(0.91); C239(0.88); C398(0.44); C334(1.04)  LDD1639  [23]
 LDCM0436  CL46 HEK-293T C262(0.99); C239(1.48); C398(0.48); C334(1.27)  LDD1640  [23]
 LDCM0437  CL47 HEK-293T C262(1.02); C239(0.97); C398(0.38); C334(1.23)  LDD1641  [23]
 LDCM0438  CL48 HEK-293T C262(1.00); C239(1.20); C398(0.46); C334(1.15)  LDD1642  [23]
 LDCM0439  CL49 HEK-293T C262(0.97); C239(0.94); C334(0.82)  LDD1643  [23]
 LDCM0440  CL5 HEK-293T C262(1.12); C239(1.07); C334(0.97)  LDD1644  [23]
 LDCM0441  CL50 HEK-293T C262(0.98); C239(0.95); C334(0.93)  LDD1645  [23]
 LDCM0443  CL52 HEK-293T C262(0.86); C239(0.89); C398(1.41); C334(1.00)  LDD1646  [23]
 LDCM0444  CL53 HEK-293T C262(0.92); C239(0.85); C334(0.91)  LDD1647  [23]
 LDCM0445  CL54 HEK-293T C262(0.77); C239(0.74); C398(0.84); C334(0.84)  LDD1648  [23]
 LDCM0446  CL55 HEK-293T C262(0.96); C239(0.90); C398(0.63); C334(0.88)  LDD1649  [23]
 LDCM0447  CL56 HEK-293T C262(0.90); C239(0.95); C398(0.48); C334(1.05)  LDD1650  [23]
 LDCM0448  CL57 HEK-293T C262(0.81); C239(0.90); C398(0.46); C334(1.01)  LDD1651  [23]
 LDCM0449  CL58 HEK-293T C262(0.96); C239(1.29); C398(0.43); C334(1.04)  LDD1652  [23]
 LDCM0450  CL59 HEK-293T C262(0.87); C239(0.92); C398(0.36); C334(1.04)  LDD1653  [23]
 LDCM0451  CL6 HEK-293T C262(0.86); C239(0.87); C398(0.90); C334(1.03)  LDD1654  [23]
 LDCM0452  CL60 HEK-293T C262(0.93); C239(1.06); C398(0.65); C334(1.01)  LDD1655  [23]
 LDCM0453  CL61 HEK-293T C262(1.03); C239(1.03); C334(0.89)  LDD1656  [23]
 LDCM0454  CL62 HEK-293T C262(1.02); C239(1.06); C334(0.85)  LDD1657  [23]
 LDCM0455  CL63 HEK-293T C262(0.93); C239(1.04); C334(0.79)  LDD1658  [23]
 LDCM0456  CL64 HEK-293T C262(0.91); C239(0.83); C398(1.23); C334(0.86)  LDD1659  [23]
 LDCM0457  CL65 HEK-293T C262(1.07); C239(1.09); C334(0.92)  LDD1660  [23]
 LDCM0458  CL66 HEK-293T C262(0.97); C239(0.93); C398(0.93); C334(0.99)  LDD1661  [23]
 LDCM0459  CL67 HEK-293T C262(0.94); C239(0.95); C398(0.81); C334(0.93)  LDD1662  [23]
 LDCM0460  CL68 HEK-293T C262(0.98); C239(0.93); C398(0.51); C334(0.95)  LDD1663  [23]
 LDCM0461  CL69 HEK-293T C262(0.90); C239(0.85); C398(0.43); C334(0.98)  LDD1664  [23]
 LDCM0462  CL7 HEK-293T C262(1.02); C239(0.91); C398(0.87); C334(0.88)  LDD1665  [23]
 LDCM0463  CL70 HEK-293T C262(0.99); C239(1.19); C398(0.54); C334(1.03)  LDD1666  [23]
 LDCM0464  CL71 HEK-293T C262(0.94); C239(0.90); C398(0.38); C334(1.12)  LDD1667  [23]
 LDCM0465  CL72 HEK-293T C262(0.95); C239(1.12); C398(0.66); C334(0.96)  LDD1668  [23]
 LDCM0466  CL73 HEK-293T C262(0.94); C239(1.03); C334(0.91)  LDD1669  [23]
 LDCM0467  CL74 HEK-293T C262(1.05); C239(0.96); C334(0.94)  LDD1670  [23]
 LDCM0469  CL76 HEK-293T C262(0.93); C239(0.92); C398(1.49); C334(0.93)  LDD1672  [23]
 LDCM0470  CL77 HEK-293T C262(0.94); C239(1.00); C334(0.92)  LDD1673  [23]
 LDCM0471  CL78 HEK-293T C262(0.97); C239(0.94); C398(1.10); C334(0.98)  LDD1674  [23]
 LDCM0472  CL79 HEK-293T C262(0.94); C239(0.91); C398(0.85); C334(0.93)  LDD1675  [23]
 LDCM0473  CL8 HEK-293T C262(0.72); C239(0.64); C398(0.44); C334(1.04)  LDD1676  [23]
 LDCM0474  CL80 HEK-293T C262(0.91); C239(0.84); C398(0.57); C334(0.99)  LDD1677  [23]
 LDCM0475  CL81 HEK-293T C262(0.93); C239(1.06); C398(0.45); C334(1.01)  LDD1678  [23]
 LDCM0476  CL82 HEK-293T C262(0.92); C239(1.25); C398(0.54); C334(0.98)  LDD1679  [23]
 LDCM0477  CL83 HEK-293T C262(0.91); C239(0.83); C398(0.42); C334(1.03)  LDD1680  [23]
 LDCM0478  CL84 HEK-293T C262(0.86); C239(1.04); C398(0.80); C334(0.96)  LDD1681  [23]
 LDCM0479  CL85 HEK-293T C262(1.02); C239(1.12); C334(0.86)  LDD1682  [23]
 LDCM0480  CL86 HEK-293T C262(0.99); C239(0.96); C334(0.90)  LDD1683  [23]
 LDCM0481  CL87 HEK-293T C262(0.82); C239(1.08); C334(0.74)  LDD1684  [23]
 LDCM0482  CL88 HEK-293T C262(0.90); C239(1.08); C398(2.86); C334(0.99)  LDD1685  [23]
 LDCM0483  CL89 HEK-293T C262(0.99); C239(1.03); C334(0.84)  LDD1686  [23]
 LDCM0484  CL9 HEK-293T C262(0.86); C239(0.99); C398(0.43); C334(1.04)  LDD1687  [23]
 LDCM0485  CL90 HEK-293T C262(0.78); C239(0.78); C398(1.05); C334(0.89)  LDD1688  [23]
 LDCM0486  CL91 HEK-293T C262(0.95); C239(0.84); C398(0.89); C334(0.93)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C262(0.85); C239(0.90); C398(0.71); C334(0.90)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C262(0.85); C239(0.94); C398(0.55); C334(0.92)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C262(0.98); C239(1.11); C398(0.57); C334(0.94)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C262(0.82); C239(0.80); C398(0.43); C334(1.00)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C262(0.89); C239(1.08); C398(0.97); C334(0.91)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C262(0.99); C239(0.99); C334(0.96)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C262(0.92); C239(0.89); C334(0.91)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C262(0.92); C239(1.01); C334(0.89)  LDD1697  [23]
 LDCM0495  E2913 HEK-293T C262(0.92); C239(0.98); C334(0.99)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C262(1.30); C398(0.83)  LDD1702  [3]
 LDCM0625  F8 Ramos C398(1.52); C262(1.15); C239(2.14)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C398(0.99); C262(0.58)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C398(0.56); C239(0.52)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C398(0.94); C262(0.63)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C398(1.04); C262(0.76)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C398(0.45); C262(0.90); C239(0.61)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C398(1.15); C262(0.45)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C398(1.41); C262(0.68)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C398(2.57); C262(0.38)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C398(2.19); C262(0.67)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C398(0.88); C262(0.35)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C398(2.15); C262(0.77)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C398(1.53); C262(0.68)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C398(2.40); C262(0.61)  LDD2201  [24]
 LDCM0468  Fragment33 HEK-293T C262(0.90); C239(0.98); C334(0.79)  LDD1671  [23]
 LDCM0596  Fragment38 Ramos C398(1.48); C262(0.68)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C398(0.84); C262(0.81); C239(1.62)  LDD2184  [24]
 LDCM0427  Fragment51 HEK-293T C262(1.01); C239(0.98); C334(0.98)  LDD1631  [23]
 LDCM0610  Fragment52 Ramos C398(2.10); C262(0.93)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C398(2.26); C262(1.07)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C398(0.51); C262(0.71); C239(1.01)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C398(0.84); C262(0.55)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y86(3.70)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y86(3.47)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y86(3.75)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y86(4.06)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y86(1.76)  LDD0268  [8]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C262(0.90); C239(1.03)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C262(0.92); C239(1.02)  LDD1497  [23]
 LDCM0024  KB05 HMCB C408(1.87)  LDD3312  [5]
 LDCM0030  Luteolin HEK-293T 14.46  LDD0182  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C398(0.95)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C398(0.33); C262(1.12)  LDD2121  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C398(1.42)  LDD2090  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C398(0.87); C334(0.86)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C398(0.93); C262(0.97)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C398(1.19)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C398(0.64)  LDD2096  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C398(0.84)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C398(0.54)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C398(0.91); C262(0.75)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C398(0.42)  LDD2100  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C398(0.96)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C398(0.75); C262(0.83)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C398(0.78)  LDD2108  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C398(1.09); C262(0.56)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C262(0.88)  LDD2111  [3]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C398(0.81)  LDD2114  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C398(0.81)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C398(2.75); C262(3.03)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C398(0.86)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C398(0.87)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C398(0.57)  LDD2123  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C398(0.80)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C398(0.78); C262(0.65)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C398(0.68)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C398(1.00); C262(1.00)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C398(0.89)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C398(0.86); C262(0.85)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C398(0.45)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C398(0.75); C262(0.96)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C398(0.76); C262(1.00)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C398(0.72); C262(0.83)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C262(0.62)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C398(1.14)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C398(2.54)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C398(0.89); C262(0.71)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C398(4.08)  LDD2147  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C398(0.27)  LDD2150  [3]
 LDCM0029  Quercetin HEK-293T 8.66  LDD0181  [7]
 LDCM0003  Sulforaphane MDA-MB-231 2.32  LDD0160  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) Phosphatase 2A regulatory subunit A family P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) Phosphatase 2A regulatory subunit A family P30154
Death-associated protein kinase 1 (DAPK1) CAMK Ser/Thr protein kinase family P53355
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Low-density lipoprotein receptor-related protein 1B (LRP1B) LDLR family Q9NZR2
NEDD8 (NEDD8) Ubiquitin family Q15843

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
268-trimethyl-3-amino-9-benzyl-9-methoxynonanoic Acid . DB02506

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
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Mass spectrometry data entry: PXD041264
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578