Details of the Target

General Information of Target

Target ID LDTP03706
Target Name Profilin-2 (PFN2)
Gene Name PFN2
Gene ID 5217
Synonyms
Profilin-2; Profilin II
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF
TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVH
GGGLNKKAYSMAKYLRDSGF
Target Bioclass
Other
Family
Profilin family
Subcellular location
Cytoplasm, cytoskeleton
Function
Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Uniprot ID
P35080
Ensemble ID
ENST00000239940.12
HGNC ID
HGNC:8882

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HS936T SNV: p.E57K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AZ-9
 Probe Info  		E57(0.85)  LDD2208  [2]
Probe 1
 Probe Info  		Y79(47.32); Y99(73.37); Y129(47.22)  LDD3495  [3]
DBIA
 Probe Info  		C84(2.12)  LDD3323  [4]
DA-P3
 Probe Info  		6.80  LDD0182  [5]
HHS-475
 Probe Info  		Y30(0.74); Y99(0.81)  LDD0264  [6]
HHS-465
 Probe Info  		Y99(9.60)  LDD2237  [7]
5E-2FA
 Probe Info  		N.A.  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
IPM
 Probe Info  		N.A.  LDD0025  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
AOyne
 Probe Info  		12.20  LDD0443  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C84(0.80)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C84(1.02)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C84(0.76)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C84(0.97)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C84(1.00)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C84(0.95)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C84(0.96)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C84(1.04)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C84(0.72)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C84(1.15)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C84(1.02)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C84(0.95)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C84(1.07)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C84(0.97)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C84(1.11)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C84(0.91)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C84(1.01)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C84(0.94)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C84(0.98)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C84(1.07)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C84(1.20)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C84(1.00)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C84(0.91)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C84(0.99)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C84(0.94)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C84(1.05)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C84(0.81)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C84(0.99)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C84(1.08)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C84(1.13)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C84(0.92)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C84(0.97)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C84(0.99)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C84(0.91)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C84(0.91)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C84(1.04)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C84(1.07)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C84(0.94)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C84(0.93)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C84(1.08)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C84(1.08)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C84(0.83)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C84(0.96)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C84(1.07)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C84(0.86)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C84(0.99)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C84(1.05)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C84(0.99)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C84(0.95)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C84(0.97)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C84(0.95)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C84(0.97)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C84(0.70)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C84(0.98)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C84(1.03)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C84(0.95)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C84(0.95)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C84(0.96)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C84(1.04)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C84(0.94)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C84(1.06)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C84(1.02)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C84(0.91)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C84(1.06)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 12.58  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C84(1.08)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C84(0.98)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C84(0.94)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C84(0.99)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C84(0.92)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C84(1.03)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C84(1.04)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C84(0.98)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C84(0.98)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C84(0.96)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C84(1.00)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C84(0.85)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C84(1.02)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C84(0.82)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C84(0.98)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C84(0.91)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C84(0.99)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C84(1.07)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C84(0.99)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C84(1.04)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C84(1.05)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C84(0.96)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C84(1.11)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C84(1.10)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C84(1.05)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C84(0.95)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C84(0.91)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C84(0.87)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C84(1.00)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C84(0.93)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C84(0.93)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C84(0.89)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C84(0.96)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C84(1.10)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C84(0.91)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C84(0.93)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C84(0.94)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C84(0.94)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C84(1.11)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C84(1.12)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C84(1.03)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C84(1.09)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C84(1.03)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C84(1.16)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C84(1.05)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C84(1.15)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C84(1.01)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C84(1.01)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C84(1.02)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C84(1.01)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C84(0.94)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C84(0.93)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C84(0.99)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C84(1.13)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C84(1.04)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C84(1.05)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C84(1.06)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C84(0.94)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C84(1.13)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C84(1.06)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C84(1.04)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C84(0.98)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C84(0.97)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C84(0.86)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C84(1.06)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C84(1.07)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C84(1.11)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C84(0.95)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C84(1.05)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C84(0.89)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C84(1.13)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C84(0.93)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C84(0.97)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C84(1.00)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C84(0.99)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C84(0.89)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C84(0.96)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C84(0.89)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C84(1.07)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C84(0.93)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C84(1.07)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C84(1.12)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C84(0.98)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C84(1.13)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C84(0.97)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C84(1.05)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C84(0.99)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C84(0.96)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C84(0.91)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C84(1.07)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C84(0.91)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C84(1.13)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C84(1.07)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C84(0.76)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C84(1.06)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C84(0.92)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C84(1.03)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C84(1.04)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C84(0.98)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C84(1.09)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C84(0.88)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C84(1.04)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C84(0.64)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C84(0.92)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C84(1.08)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C84(0.97)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C84(1.05)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C84(0.98)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C84(1.08)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C84(0.90)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C84(0.92)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C84(0.92)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C84(1.06)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C84(0.98)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C84(1.03)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C84(0.97)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C84(1.12)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C84(1.05)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C84(1.12)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C84(1.06)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C84(0.99)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C84(0.99)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C84(0.96)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C84(0.85)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C84(0.92)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C84(0.95)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C84(1.02)  LDD1702  [18]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.70  LDD0183  [5]
 LDCM0468  Fragment33 HEK-293T C84(1.00)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C84(1.08)  LDD1631  [17]
 LDCM0116  HHS-0101 DM93 Y30(0.74); Y99(0.81)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y30(0.78); Y99(0.79)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y30(0.64); Y99(0.95)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y30(0.94); Y99(1.08)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y30(0.73); Y99(0.84)  LDD0268  [6]
 LDCM0022  KB02 HEK-293T C84(1.02)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C84(1.11)  LDD1497  [17]
 LDCM0024  KB05 SKMEL24 C84(2.12)  LDD3323  [4]
 LDCM0030  Luteolin HEK-293T 6.80  LDD0182  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily B member 1 (GOLGB1) . Q14789

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Triglyme Small molecular drug DB02078
Pentaglyme . DB02580

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761