Details of the Target

General Information of Target

Target ID LDTP12218
Target Name Sentrin-specific protease 2 (SENP2)
Gene Name SENP2
Gene ID 59343
Synonyms
KIAA1331; Sentrin-specific protease 2; EC 3.4.22.-; Axam2; SMT3-specific isopeptidase 2; Smt3ip2; Sentrin/SUMO-specific protease SENP2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPSGDEDRARRRRRRRRRRDLLLSQLCFLASVALLLWSLSSLREQKELDLMDLVGEDRK
WMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYM
FYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV
GTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWE
SLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKK
ANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLIN
SRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNEN
DEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRWEKWFMVTF
ASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDM
AVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVH
LNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH
Target Bioclass
Enzyme
Family
Peptidase C48 family
Subcellular location
Nucleus, nuclear pore complex
Function
Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection.
Uniprot ID
Q9HC62
Ensemble ID
ENST00000296257.10
HGNC ID
HGNC:23116
ChEMBL ID
CHEMBL2176776

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.N61TfsTer16 .
IGROV1 SNV: p.K489R .
MFE319 Deletion: p.E257KfsTer29
SNV: p.L5P		 .
MIAPACA2 SNV: p.Q385Ter .
U118MG SNV: p.T265A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.08  LDD0403  [1]
DBIA
 Probe Info  		C283(2.65)  LDD3312  [2]
DA-P3
 Probe Info  		26.08  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C233(2.79)  LDD0169  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
NAIA_5
 Probe Info  		C233(0.00); C202(0.00)  LDD2224  [6]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
IPM
 Probe Info  		N.A.  LDD0005  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C283(0.00); C202(0.00); C233(0.00)  LDD0018  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [11]
AOyne
 Probe Info  		14.70  LDD0443  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C233(2.79)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C202(0.98); C283(0.96); C505(1.32)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C202(1.15); C505(1.05)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C202(0.97); C283(1.00); C505(1.09)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C283(1.12); C505(1.02); C548(0.98)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C283(1.06); C158(1.16); C505(1.12); C548(1.07)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C202(1.00); C283(0.99); C505(1.00); C548(0.90)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C202(1.05); C283(1.06); C505(1.25)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C202(1.03); C505(1.06)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C202(1.14); C283(1.25); C505(1.05)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C202(1.06); C505(1.11)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C283(0.72); C505(1.01); C548(0.90)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C54(1.12); C283(1.04); C505(1.04)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C283(1.02); C158(0.84); C505(1.14); C548(0.86)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C202(0.97); C283(1.04); C505(1.01); C548(1.03)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C202(1.10); C54(0.99); C283(1.03); C505(1.04)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C202(1.11); C283(1.05); C505(1.26)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C202(1.03); C505(1.01)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C202(0.92); C283(0.99); C505(1.00)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C283(0.86); C505(0.98); C548(0.90)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C54(1.03); C283(1.05); C505(1.02)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C202(0.99); C283(1.00); C505(1.06)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C283(0.99); C158(0.94); C505(1.10); C548(0.97)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C202(0.96); C283(1.02); C505(1.03); C548(0.99)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C202(1.11); C54(0.92); C283(1.04); C505(1.04)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C202(1.19); C283(1.00); C505(1.41)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C202(1.00); C505(1.02)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C202(0.99); C283(0.95); C505(1.03)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C283(0.90); C505(1.01); C548(0.85)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C54(0.99); C283(1.07); C505(1.07)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C283(1.00); C158(0.74); C505(1.14); C548(0.97)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C202(1.04); C283(1.01); C505(1.04); C548(0.95)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C283(0.96); C505(1.05); C548(0.91)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C202(1.05); C54(1.08); C283(1.00); C505(1.03)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C202(1.07); C283(1.09); C505(1.35)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C202(1.00); C505(1.07)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C202(0.99); C283(0.98); C505(1.09)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C283(0.79); C505(1.03); C548(1.04)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C54(1.11); C283(1.11); C505(1.03)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C283(1.06); C158(1.00); C505(1.09); C548(1.04)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C202(1.07); C283(1.07); C505(1.07); C548(1.00)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C202(1.11); C54(0.98); C283(1.09); C505(1.03)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C202(1.13); C283(1.05); C505(1.38)  LDD1550  [13]
 LDCM0312  AC5 HEK-293T C54(1.08); C283(1.02); C505(1.13)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C202(1.02); C505(1.04)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C202(1.04); C283(0.98); C505(1.03)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C283(0.92); C505(1.05); C548(0.95)  LDD1554  [13]
 LDCM0316  AC53 HEK-293T C54(1.05); C283(1.10); C505(1.04)  LDD1555  [13]
 LDCM0317  AC54 HEK-293T C283(1.05); C158(0.84); C505(1.04); C548(0.95)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C202(1.02); C283(1.04); C505(1.01); C548(1.04)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C202(0.95); C54(1.02); C283(0.96); C505(1.04)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C202(0.94); C283(1.09); C505(1.21)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C202(1.03); C505(1.07)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C202(1.03); C283(0.99); C505(1.04)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C283(1.10); C158(0.98); C505(1.15); C548(0.95)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C283(0.99); C505(1.03); C548(0.89)  LDD1563  [13]
 LDCM0325  AC61 HEK-293T C54(1.08); C283(1.10); C505(1.04)  LDD1564  [13]
 LDCM0326  AC62 HEK-293T C283(1.07); C158(1.00); C505(1.06); C548(0.93)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C202(1.03); C283(1.09); C505(1.02); C548(0.94)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C202(0.93); C54(0.95); C283(1.01); C505(1.05)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C202(1.05); C283(1.01); C505(1.06); C548(1.03)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C202(1.03); C54(0.91); C283(1.05); C505(1.07)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C54(1.03); C283(1.13); C505(1.01)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C202(1.08); C283(1.06); C505(1.22)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C202(1.10); C54(0.97); C283(0.98); C505(1.03)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 13.08  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C202(0.87); C54(1.59); C283(1.00)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C283(1.03); C158(0.86); C505(0.88); C548(1.23)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C202(0.87); C283(0.99); C505(1.02); C548(0.97)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C202(1.00); C54(1.03); C283(1.07)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C202(1.01); C283(1.05); C158(0.81)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C202(1.03); C283(1.07); C505(1.02)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C202(0.85); C283(1.01); C505(1.02); C548(1.24)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C202(0.98); C54(1.17); C283(0.95)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C202(1.16); C283(1.00); C158(0.82)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C202(0.98); C283(1.02); C505(1.00)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C202(0.97); C283(0.98); C505(0.96); C548(0.83)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C202(0.96); C54(1.09); C283(0.94)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C202(1.06); C283(1.05); C505(0.96); C548(1.60)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C202(1.16); C283(1.01); C158(0.89)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C202(0.99); C283(1.06); C505(0.96)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C202(0.94); C283(1.05); C505(0.91); C548(0.69)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C202(0.98); C54(1.08); C283(0.93)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C202(1.08); C283(1.08); C158(0.56)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C202(0.97); C283(0.90); C505(1.03)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C202(0.94); C283(1.00); C505(1.10); C548(0.82)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C202(0.97); C54(1.07); C283(1.02)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C202(1.03); C283(1.11); C158(0.73)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C202(0.97); C283(1.00); C505(1.02)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C202(0.85); C54(1.03); C283(1.02); C505(0.99)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C202(0.99); C283(1.13); C505(1.07); C548(0.83)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C202(0.94); C54(1.06); C283(1.04)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C202(0.99); C283(1.09); C158(0.98)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C202(0.98); C283(1.04); C505(0.95)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C202(0.86); C283(0.97); C505(0.98); C548(0.81)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C202(0.97); C54(1.09); C283(0.99)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C202(0.85); C283(1.05); C158(0.68)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C202(0.81); C283(1.04); C505(1.02)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C202(0.83); C283(0.95); C505(0.96); C548(0.86)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C202(0.98); C54(1.48); C283(1.08)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C202(0.91); C283(0.97); C158(0.63)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C202(1.04); C283(0.97); C505(0.94)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C202(0.86); C283(0.95); C505(0.93); C548(1.28)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C202(1.03); C283(0.99); C505(1.24)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C202(0.89); C505(1.05)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C202(0.83); C283(0.98); C505(0.99)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C202(1.07); C283(0.98); C158(1.04)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C283(0.85); C505(0.95); C548(1.38)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C54(1.78); C283(1.08); C505(0.91)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C283(1.05); C158(0.88); C505(1.08); C548(1.70)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C202(1.04); C283(1.02); C505(1.00); C548(2.27)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C202(0.71); C54(1.05); C283(0.96); C505(0.99)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C202(0.96); C54(1.56); C283(0.99)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C202(0.98); C283(1.05); C158(0.69)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C202(0.98); C283(1.02); C505(1.02)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C202(1.04); C283(0.97); C505(1.00); C548(0.96)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C202(1.03); C283(1.04); C505(1.55)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C202(0.97); C283(1.02); C505(0.97)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C202(0.81); C505(1.12)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C202(0.84); C283(1.01); C505(1.02)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C283(0.88); C505(0.99); C548(1.42)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C54(2.39); C283(1.04); C505(0.97)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C283(1.00); C158(0.66); C505(1.14); C548(1.30)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C202(0.96); C283(1.09); C505(1.06); C548(1.67)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C202(0.82); C54(1.05); C283(1.10); C505(1.02)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C202(1.06); C54(1.10); C283(0.96)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C202(1.04); C283(1.00); C505(0.94)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C202(0.94); C283(0.99); C505(0.88); C548(1.08)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C202(1.10); C283(1.07); C505(1.05); C548(0.70)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C202(0.94); C283(0.99); C505(1.36)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C202(0.85); C505(1.07)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C202(0.86); C283(0.97); C505(1.09)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C283(0.84); C505(1.00); C548(1.26)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C54(1.46); C283(1.11); C505(0.90)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C283(1.05); C158(0.97); C505(1.11); C548(1.28)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C202(1.13); C283(1.04); C505(1.01); C548(1.93)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C202(0.68); C54(1.06); C283(1.07); C505(1.11)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C202(1.02); C54(0.98); C283(1.00)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C202(0.91); C283(0.97); C505(1.61)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C202(1.13); C283(1.03); C158(0.67)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C202(1.04); C283(0.99); C505(1.03); C548(1.09)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C202(1.00); C283(1.03); C505(1.36)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C202(0.83); C505(0.99)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C202(0.83); C283(0.99); C505(1.09)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C283(0.88); C505(1.01); C548(1.28)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C54(1.48); C283(1.19); C505(0.98)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C283(1.13); C158(0.80); C505(1.04); C548(1.35)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C202(1.02); C283(1.09); C505(1.05); C548(1.93)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C202(0.85); C505(1.02)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C202(0.68); C54(1.06); C283(1.09); C505(1.07)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C202(1.12); C54(0.96); C283(1.04)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C202(0.95); C283(1.09); C158(0.89)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C202(1.05); C283(1.03); C505(1.10)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C202(0.92); C283(0.98); C505(1.05); C548(0.96)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C202(1.00); C283(0.98); C505(1.38)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C202(0.94); C505(1.01)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C202(0.89); C283(1.04); C505(1.06)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C283(0.86); C505(1.02); C548(1.14)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C54(1.39); C283(1.09); C505(1.02)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C202(0.86); C283(0.93); C505(1.02)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C283(1.09); C158(1.26); C505(1.04); C548(1.57)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C202(0.93); C283(1.07); C505(1.05); C548(1.70)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C202(0.85); C54(0.95); C283(1.11); C505(1.03)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C202(1.05); C54(1.09); C283(0.98)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C202(0.91); C283(1.05); C158(0.75)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C202(0.97); C283(0.96); C505(1.01); C548(1.15)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C202(0.97); C283(1.04); C505(1.37)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C202(0.90); C505(1.08)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C202(0.85); C283(0.98); C505(1.06)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C283(1.08); C505(0.90); C548(0.85)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C283(0.93); C505(1.06); C548(1.29)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C54(1.04); C283(1.13); C505(1.08)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C283(1.07); C158(0.88); C505(1.10); C548(1.48)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C202(0.95); C283(1.05); C505(1.00); C548(1.53)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C202(0.82); C54(1.25); C283(1.04); C505(0.99)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C202(1.18); C54(1.08); C283(1.07)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C202(0.84); C283(1.06); C158(0.64)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C202(0.77); C283(1.05); C505(0.98)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C202(0.91); C283(1.04); C505(1.08); C548(0.97)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C202(0.82); C283(1.03); C505(1.41)  LDD1686  [13]
 LDCM0484  CL9 HEK-293T C54(1.21); C283(1.03); C505(0.95)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C202(0.92); C505(0.98)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C202(0.87); C283(1.01); C505(1.12)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C283(0.88); C505(1.03); C548(1.16)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C54(2.02); C283(1.14); C505(1.02)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C283(1.08); C158(1.19); C505(1.01); C548(1.46)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C202(1.07); C283(1.16); C505(0.96); C548(1.45)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C202(0.68); C54(1.42); C283(1.07); C505(1.08)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C202(1.00); C54(1.20); C283(1.02)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C202(1.00); C283(1.06); C158(0.59)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C202(1.01); C283(1.02); C505(1.02)  LDD1697  [13]
 LDCM0027  Dopamine HEK-293T 26.08  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C202(1.05); C283(0.99); C505(1.02)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C202(0.36)  LDD1702  [14]
 LDCM0625  F8 Ramos C233(1.43)  LDD2187  [15]
 LDCM0573  Fragment11 Ramos C202(1.74); C233(7.37)  LDD2190  [15]
 LDCM0576  Fragment14 Ramos C202(1.00); C233(0.92)  LDD2193  [15]
 LDCM0586  Fragment28 Ramos C202(0.75); C233(0.31)  LDD2198  [15]
 LDCM0468  Fragment33 HEK-293T C202(0.91); C283(0.97); C505(1.04)  LDD1671  [13]
 LDCM0566  Fragment4 Ramos C202(1.63); C233(1.15)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C202(1.12); C283(1.02); C158(0.71)  LDD1631  [13]
 LDCM0569  Fragment7 Ramos C202(2.18); C233(0.79)  LDD2186  [15]
 LDCM0022  KB02 HEK-293T C505(1.14); C202(1.03); C548(1.01)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C505(0.99); C202(0.96); C548(1.05)  LDD1497  [13]
 LDCM0024  KB05 HMCB C283(2.65)  LDD3312  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) ATP-dependent AMP-binding enzyme family Q96CM8
Holocytochrome c-type synthase (HCCS) Cytochrome c-type heme lyase family P53701
Epidermal retinol dehydrogenase 2 (SDR16C5) Short-chain dehydrogenases/reductases (SDR) family Q8N3Y7
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) . Q9UBN6
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-IV (APOC4) Apolipoprotein C4 family P55056
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
FUN14 domain-containing protein 1 (FUNDC1) FUN14 family Q8IVP5
Nesprin-4 (SYNE4) Nesprin family Q8N205
Protein reprimo (RPRM) Reprimo family Q9NS64
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Small ubiquitin-related modifier 1 (SUMO1) Ubiquitin family P63165
Small ubiquitin-related modifier 2 (SUMO2) Ubiquitin family P61956
Small ubiquitin-related modifier 3 (SUMO3) Ubiquitin family P55854
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Protein KASH5 (KASH5) . Q8N6L0
Transmembrane protein 239 (TMEM239) . Q8WW34
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578