Details of the Target

General Information of Target

Target ID LDTP08588
Target Name Spindle and kinetochore-associated protein 3 (SKA3)
Gene Name SKA3
Gene ID 221150
Synonyms
C13orf3; RAMA1; Spindle and kinetochore-associated protein 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDPIRSFCGKLRSLASTLDCETARLQRALDGEESDFEDYPMRILYDLHSEVQTLKDDVNI
LLDKARLENQEGIDFIKATKVLMEKNSMDIMKIREYFQKYGYSPRVKKNSVHEQEAINSD
PELSNCENFQKTDVKDDLSDPPVASSCISEKSPRSPQLSDFGLERYIVSQVLPNPPQAVN
NYKEEPVIVTPPTKQSLVKVLKTPKCALKMDDFECVTPKLEHFGISEYTMCLNEDYTMGL
KNARNNKSEEAIDTESRLNDNVFATPSPIIQQLEKSDAEYTNSPLVPTFCTPGLKIPSTK
NSIALVSTNYPLSKTNSSSNDLEVEDRTSLVLNSDTCFENLTDPSSPTISSYENLLRTPT
PPEVTKIPEDILQLLSKYNSNLATPIAIKAVPPSKRFLKHGQNIRDVSNKEN
Target Bioclass
Other
Family
SKA3 family
Subcellular location
Cytoplasm, cytoskeleton, spindle
Function
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules.
Uniprot ID
Q8IX90
Ensemble ID
ENST00000298260.8
HGNC ID
HGNC:20262

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BT549 SNV: p.S34I .
CAL51 Insertion: p.S276KfsTer2 .
KELLY SNV: p.G101Ter .
SKHEP1 Insertion: . .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K92(10.00)  LDD0275  [2]
BTD
 Probe Info  		C20(0.81)  LDD2099  [3]
DA-P3
 Probe Info  		22.45  LDD0179  [4]
AHL-Pu-1
 Probe Info  		C290(20.00)  LDD0169  [5]
DBIA
 Probe Info  		C20(1.83)  LDD0080  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0177  [7]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
NAIA_4
 Probe Info  		C20(0.00); C147(0.00); C290(0.00)  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
Compound 10
 Probe Info  		C147(0.00); C20(0.00); C290(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		C147(0.00); C290(0.00)  LDD2213  [11]
IPM
 Probe Info  		N.A.  LDD0147  [10]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		C20(0.00); C8(0.00)  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C20(1.27)  LDD2117  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C290(20.00)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C147(0.94); C20(1.16)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C147(0.79)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C20(1.24); C290(0.80)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C20(0.97); C290(1.25)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C20(1.68); C290(0.85)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C20(1.57); C290(1.13)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C20(1.00); C290(1.04)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C20(1.62); C290(1.23)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C20(1.52); C290(1.30)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C20(1.74); C290(1.04)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C20(1.65); C290(1.07)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C20(2.06); C290(0.98)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C147(1.38)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C20(1.32); C290(1.16)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C20(1.27); C290(1.24)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C20(1.41); C290(1.09)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C147(1.02); C20(0.97)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C147(1.04); C20(1.37)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C147(1.06); C20(1.38)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C147(0.69); C20(1.45)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C147(0.86); C20(1.61)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C147(0.88); C20(1.19)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C147(0.79); C20(0.99)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C147(1.11)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C147(0.95); C20(1.43)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C147(0.99); C20(1.28)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C147(0.96); C20(1.23)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C147(0.94); C20(1.06)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C147(0.93); C20(1.05)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C147(0.94); C20(1.27)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C147(1.07); C20(1.88)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C147(1.04); C20(2.33)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C290(1.11)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C290(1.22)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C290(1.25)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C290(1.25)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C290(1.42)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C290(1.42)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C290(1.02)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C290(1.11)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C290(1.06)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C290(1.22)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C290(1.12)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C290(1.12)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C147(0.68)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C290(1.14)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C290(1.02)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C290(1.20)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C147(1.02); C290(1.11); C20(1.45)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C147(0.87); C290(1.24); C20(1.85)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C147(0.87); C20(1.02); C290(1.13)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C147(0.88); C290(1.24); C20(1.61)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C290(1.09); C147(1.29); C20(1.69)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C147(0.80); C290(1.04); C20(2.51)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C290(1.01); C147(1.12); C20(2.03)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C147(0.77)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C290(1.02); C147(1.03); C20(1.32)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C147(0.95); C290(1.22); C20(1.67)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C147(0.96); C290(1.05); C20(1.91)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C147(0.69); C290(1.60); C20(2.55)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C147(1.04); C20(1.32); C290(1.17)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C147(0.86); C20(1.84); C290(1.13)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C147(1.00); C20(1.74); C290(1.15)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C147(0.88); C20(1.04); C290(1.14)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C20(0.94)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C20(0.79)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C20(0.88)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C20(0.96); C147(1.04)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C20(0.91)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C20(0.89)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C20(0.87)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C20(0.78)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C20(0.82)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C147(3.14)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C147(2.81)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C147(2.06)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C147(2.17)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C147(1.30)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C147(1.05); C20(1.25)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C147(3.04)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C147(3.73)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C147(6.89)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C147(3.63)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C147(3.40)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C290(0.14)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C290(0.47)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C290(0.39)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C290(0.55)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C290(0.44)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C147(0.96); C20(1.19)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C290(0.35)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C290(0.48)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C290(0.65)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C290(0.50)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C290(0.45)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C290(0.36)  LDD0624  [6]
 LDCM0308  AC46 PaTu 8988t C20(1.04); C147(1.16)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C20(1.02); C147(1.11)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C20(1.58); C147(1.59)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C20(1.26); C147(1.42)  LDD1190  [6]
 LDCM0312  AC5 HCT 116 C147(1.08); C20(1.13)  LDD0629  [6]
 LDCM0313  AC50 PaTu 8988t C20(1.63); C147(1.46)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C20(1.01); C147(1.18)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C20(2.04); C147(1.36)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C20(2.59); C147(1.82)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C20(2.20); C147(2.09)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C20(1.47); C147(1.39)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C20(1.59); C147(1.65)  LDD1198  [6]
 LDCM0320  AC57 HEK-293T C290(0.85)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C290(1.02)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C290(0.81)  LDD0920  [6]
 LDCM0323  AC6 HCT 116 C147(0.87)  LDD0640  [6]
 LDCM0324  AC60 HEK-293T C290(0.90)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C290(0.60)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C290(0.69)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C290(0.90)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C290(0.72)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C290(0.72)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C290(0.98)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C290(0.78)  LDD0929  [6]
 LDCM0332  AC68 HCT 116 C20(0.88)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C20(1.12)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C147(0.85)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C20(1.14)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C20(1.08)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C20(1.20)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C20(1.18)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C20(1.41)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C20(1.96)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C20(1.04)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C20(1.01)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C20(0.96)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C20(0.91)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C147(0.82)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C20(1.28)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C20(0.92)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C20(1.81)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C290(1.19); C20(2.35)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C290(1.15); C20(1.78)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C290(1.03); C20(1.71)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C20(1.18); C290(1.26)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C290(1.21); C20(1.53)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C290(1.51); C20(1.94)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C290(1.30); C20(1.98)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C20(0.98); C290(1.55)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C290(1.11); C20(2.54)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C290(1.17); C20(1.82)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C290(1.23); C20(1.66)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C290(0.81); C20(1.66)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C290(1.29); C20(1.43)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C290(0.91); C20(2.02)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C290(1.35); C20(2.03)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C20(1.19); C290(1.32)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C290(0.73); C20(1.35)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C147(0.95)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C147(1.00)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C147(0.99)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.94  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C20(20.00)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C290(0.87); C20(1.15)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C290(0.66); C20(1.70)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C147(1.06); C20(1.07)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C147(0.72)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C147(0.62)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C147(0.67)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C147(0.71)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C20(0.81)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C20(0.79)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C20(0.80)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C20(0.96)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C20(0.91)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C290(0.58); C20(1.38)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C20(0.84)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C20(0.91)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C147(3.06)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C147(5.00)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C147(4.50)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C147(4.59)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C147(1.11)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C290(0.35)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C290(0.99)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C290(0.53)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C290(0.69); C20(1.30)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C290(0.45)  LDD0708  [6]
 LDCM0392  CL121 PaTu 8988t C20(1.19); C147(1.28)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C20(1.10); C147(1.72)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C20(1.63); C147(1.44)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C20(2.58); C147(1.51)  LDD1274  [6]
 LDCM0396  CL125 HEK-293T C290(1.06)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C290(0.83)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C290(0.80)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C290(0.98)  LDD0997  [6]
 LDCM0400  CL13 HCT 116 C290(0.56); C20(1.44)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C290(0.75); C20(1.98)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C290(0.75); C20(1.47)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C147(1.15); C290(1.18)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C290(0.79); C147(1.00)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C290(1.08); C147(1.09)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C290(0.90); C147(1.21)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C290(0.71); C20(1.42)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C290(0.96); C147(1.29)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C290(0.83); C147(1.10)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C290(0.83); C147(1.25)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C290(0.97); C147(1.01)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C147(1.25); C290(1.05)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C147(1.13); C290(0.97)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C147(1.33); C290(1.12)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C147(1.29); C290(1.16)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C147(0.93); C290(0.99)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C147(1.12); C290(1.10)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C20(1.39); C290(0.74)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C147(1.40); C290(1.05)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C215(1.06); C20(1.17); C290(1.22)  LDD1624  [13]
 LDCM0421  CL32 HCT 116 C147(1.10); C290(1.36)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C147(1.08); C290(1.04)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C147(1.00); C290(0.88)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C147(1.11); C290(1.26)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C147(0.94); C290(0.85)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C147(1.08); C290(1.19)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C147(0.85); C290(1.56)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C20(1.39); C290(0.77)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C147(0.95); C290(1.10)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C147(1.23); C290(0.89)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C147(1.01); C290(0.89)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C147(1.10); C290(1.14)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C147(1.16); C290(1.16)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C147(1.05); C290(1.26)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C20(1.13); C290(0.91)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C20(1.14); C290(0.80)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C20(1.07); C290(0.91)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C20(1.27); C290(0.94)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C20(1.06); C290(0.85)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C20(0.99); C290(0.91)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C20(1.03); C290(1.04)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C20(1.23); C290(0.98)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C20(0.74); C290(0.95)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C20(1.11); C290(1.04)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C20(1.01); C290(0.82)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C20(0.99); C290(0.77)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C20(0.87); C290(0.83)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C20(1.01); C290(0.83)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C20(1.25); C290(1.11)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C20(1.38); C290(0.88)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C20(1.17); C290(1.02)  LDD0769  [6]
 LDCM0453  CL61 HEK-293T C215(1.02); C126(0.95); C20(0.99); C147(1.11)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C215(1.07); C20(1.10); C290(0.95); C231(0.94)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C215(0.98); C290(1.00); C337(1.01)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C215(0.99); C20(1.02); C290(0.80); C231(1.04)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C20(0.97); C290(1.22)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C215(1.01); C20(0.99); C290(1.14)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C215(1.06); C20(1.24); C290(1.04)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C215(1.02); C20(0.90); C290(1.06); C231(0.79)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C215(1.08); C20(0.97); C290(1.07)  LDD1664  [13]
 LDCM0462  CL7 HCT 116 C20(1.75); C290(0.69)  LDD0779  [6]
 LDCM0463  CL70 HEK-293T C215(1.00); C20(1.14); C290(0.99)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C215(0.95); C20(1.00); C290(0.98); C337(0.97)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C215(1.10); C20(0.90); C290(0.85)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C215(0.99); C126(0.82); C20(0.98); C147(0.90)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C215(1.03); C20(1.15); C290(1.00); C231(1.00)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C215(0.97); C20(1.08); C290(1.01); C231(1.10)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C20(0.95); C290(0.94)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C215(1.01); C20(0.97); C290(1.02)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C215(1.05); C20(1.07); C290(1.02)  LDD1675  [13]
 LDCM0473  CL8 HCT 116 C20(1.19); C290(1.04)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C215(0.96); C20(0.97); C290(0.92); C231(0.86)  LDD1677  [13]
 LDCM0475  CL81 HEK-293T C215(1.14); C20(0.98); C290(1.17)  LDD1678  [13]
 LDCM0476  CL82 HEK-293T C215(0.97); C20(0.71); C290(0.91)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C215(0.97); C20(1.03); C290(1.06); C337(0.92)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C215(0.95); C20(1.02); C290(0.81)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C215(0.92); C126(0.77); C20(1.09); C147(0.83)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C215(1.03); C20(1.16); C290(1.21); C231(1.14)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C215(0.95); C290(0.90); C337(0.99)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C215(0.97); C20(1.01); C290(0.96); C231(1.17)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C20(1.20); C290(1.02)  LDD1686  [13]
 LDCM0484  CL9 HCT 116 C20(1.42); C290(0.81)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C215(1.03); C20(1.10); C290(1.18)  LDD1688  [13]
 LDCM0486  CL91 HCT 116 C147(0.98); C20(0.97)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C147(0.87); C20(0.83)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C147(0.95); C20(1.00)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C147(1.07); C20(1.03)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C147(0.97); C20(1.01)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C147(0.94); C20(1.23)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C147(1.07); C20(1.19)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C147(0.90); C20(0.91)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C147(1.02); C20(0.99)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C215(2.38)  LDD2228  [9]
 LDCM0027  Dopamine HEK-293T 22.45  LDD0179  [4]
 LDCM0495  E2913 HEK-293T C215(1.06); C290(1.06); C337(1.16)  LDD1698  [13]
 LDCM0574  Fragment12 Ramos C20(0.85)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C20(0.98)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C20(0.88)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C20(2.02)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C20(1.01)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C20(0.56)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C20(1.63)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C20(0.63)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C20(1.37)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C20(1.12)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C20(1.04)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C215(0.95); C290(0.83); C337(0.97)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C20(0.97)  LDD2203  [14]
 LDCM0427  Fragment51 HCT 116 C147(0.92); C290(1.08)  LDD0744  [6]
 LDCM0610  Fragment52 Ramos C20(1.85)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C20(1.14)  LDD2205  [14]
 LDCM0022  KB02 HCT 116 C20(1.83)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C20(2.23)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C20(2.06)  LDD0082  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C20(0.81)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C20(1.04)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C20(0.71)  LDD2109  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C20(0.63)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C20(1.47)  LDD2127  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C20(0.92)  LDD2137  [3]
 LDCM0628  OTUB2-COV-1 HEK-293T C20(0.07)  LDD2207  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Spindle and kinetochore-associated protein 1 (SKA1) SKA1 family Q96BD8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.