Details of the Target

General Information of Target

Target ID LDTP01164
Target Name Gamma-glutamylcyclotransferase (GGCT)
Gene Name GGCT
Gene ID 79017
Synonyms
C7orf24; CRF21; Gamma-glutamylcyclotransferase; EC 4.3.2.9; Cytochrome c-releasing factor 21
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKT
SQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEI
TCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDII
KKGETQTL
Target Bioclass
Enzyme
Family
Gamma-glutamylcyclotransferase family
Function
Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis.
Uniprot ID
O75223
Ensemble ID
ENST00000005374.10
HGNC ID
HGNC:21705

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.D8A DBIA    Probe Info 
HCT116 SNV: p.Q47R .
PANC0403 SNV: p.R123G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
DBIA
 Probe Info  		C50(1.13)  LDD3312  [3]
BTD
 Probe Info  		C144(1.29)  LDD2090  [4]
DA-P3
 Probe Info  		13.81  LDD0179  [5]
Acrolein
 Probe Info  		N.A.  LDD0222  [6]
ATP probe
 Probe Info  		K181(0.00); K182(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C144(0.00); C42(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C144(0.00); C42(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C144(0.00); C42(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
JW-RF-010
 Probe Info  		C42(0.00); C6(0.00)  LDD0026  [9]
PF-06672131
 Probe Info  		N.A.  LDD0017  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
MPP-AC
 Probe Info  		N.A.  LDD0428  [14]
NAIA_5
 Probe Info  		C42(0.00); C144(0.00); C122(0.00); C6(0.00)  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [14]
TPP-AC
 Probe Info  		N.A.  LDD0427  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C42(0.23)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C42(1.15)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C144(0.74); C42(0.96)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C144(0.95)  LDD2152  [4]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C144(3.45)  LDD2103  [4]
 LDCM0025  4SU-RNA HEK-293T C42(10.00)  LDD0371  [16]
 LDCM0026  4SU-RNA+native RNA HEK-293T C42(10.03)  LDD0372  [16]
 LDCM0214  AC1 HEK-293T C144(0.88); C42(1.01)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C144(0.97); C42(1.14)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C144(0.95); C42(1.21)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C144(0.95); C42(1.02)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C144(1.07); C42(0.92)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C144(0.94); C42(1.00)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C144(0.82); C42(1.06)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C144(0.93); C42(1.08)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C144(0.80); C42(0.93)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C144(1.03); C42(1.10)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C144(0.89); C42(1.01)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C144(1.01); C42(1.00)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C144(0.96); C42(1.05)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C144(0.88); C42(1.28)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C144(1.01); C42(1.00)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C144(0.89); C42(1.08)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C144(1.04); C42(1.04)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C144(1.00); C42(1.03)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C144(1.01); C42(1.07)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C144(1.07); C42(1.02)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C144(1.02); C42(1.13)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C144(1.05); C42(1.13)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C144(0.93); C42(1.02)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C144(0.99); C42(1.05)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C144(0.77); C42(1.13)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C144(0.90); C42(1.03)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C144(0.84); C42(0.83)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C144(0.89); C42(1.04)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C144(1.11); C42(1.19)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C144(0.98); C42(1.07)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C144(0.89); C42(0.99)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C144(1.01); C42(0.96)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C144(1.00); C42(1.03)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C144(0.76); C42(1.05)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C144(0.96); C42(0.93)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C144(0.91); C42(1.09)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C144(0.86); C42(1.05)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C144(1.01); C42(0.94)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C144(0.95); C42(1.06)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C144(0.89); C42(1.13)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C144(1.00); C42(1.15)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C144(0.80); C42(1.04)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C144(1.02); C42(1.12)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C144(1.00); C42(1.27)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C144(0.93); C42(1.08)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C144(0.88); C42(1.00)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C144(0.98); C42(1.06)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C144(0.93); C42(1.03)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C144(0.86); C42(1.16)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C144(1.01); C42(0.96)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C144(0.84); C42(0.93)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C144(0.91); C42(1.04)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C144(0.92); C42(1.09)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C144(1.04); C42(1.09)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C144(0.87); C42(1.03)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C144(1.01); C42(0.94)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C144(0.88); C42(0.96)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C144(0.86); C42(0.97)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C144(1.00); C42(1.02)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C144(0.96); C42(1.09)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C144(1.06); C42(0.94)  LDD1569  [17]
 LDCM0545  Acetamide MDA-MB-231 C144(0.40)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C144(0.79); C42(0.66)  LDD2113  [4]
 LDCM0248  AKOS034007472 HEK-293T C144(1.03); C42(1.20)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C144(0.83); C42(0.96)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C144(1.02); C42(1.09)  LDD1514  [17]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C144(0.72)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0632  CL-Sc Hep-G2 C42(0.98)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C144(0.83); C42(1.00)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C144(0.76); C42(0.80)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C144(0.91); C42(1.06)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C144(0.92); C42(0.96)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C144(0.89); C42(1.02)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C144(0.86); C42(1.06)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C144(1.02); C42(1.14)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C144(0.88); C42(0.97)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C144(0.87); C42(0.99)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C144(0.92); C42(1.06)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C144(0.96); C42(1.14)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C144(0.90); C42(1.03)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C144(0.91); C42(0.88)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C144(0.86); C42(0.93)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C144(0.89); C42(1.06)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C144(0.97); C42(1.07)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C144(0.90); C42(1.00)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C144(0.85); C42(1.01)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C144(0.96); C42(1.04)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C144(0.91); C42(1.15)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C144(0.97); C42(1.09)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C144(0.90); C42(1.13)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C144(0.96); C42(1.08)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C144(0.90); C42(1.00)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C144(0.93); C42(1.07)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C144(0.91); C42(1.05)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C144(0.89); C42(1.20)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C144(0.84); C42(0.95)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C144(0.88); C42(1.09)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C144(0.93); C42(1.11)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C144(0.86); C42(1.00)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C144(0.93); C42(1.04)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C144(0.94); C42(1.07)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C144(0.78); C42(1.06)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C144(0.81); C42(1.26)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C144(0.82); C42(0.92)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C144(0.89); C42(1.15)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C144(0.68); C42(1.01)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C144(0.92); C42(1.13)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C144(0.96); C42(1.02)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C144(0.92); C42(1.12)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C144(0.98); C42(0.99)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C144(0.76); C42(0.84)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C144(1.02); C42(0.95)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C144(0.93); C42(0.91)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C144(0.97); C42(0.91)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C144(0.80); C42(1.07)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C144(0.91); C42(1.27)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C144(0.86); C42(1.07)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C144(0.96); C42(1.07)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C144(0.83); C42(1.07)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C144(0.94); C42(1.00)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C144(1.01); C42(1.20)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C144(0.93); C42(1.22)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C144(0.97); C42(1.02)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C144(0.83); C42(0.78)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C144(1.01); C42(0.89)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C144(0.95); C42(0.88)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C144(1.01); C42(0.87)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C144(0.83); C42(1.24)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C144(0.81); C42(0.99)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C144(0.89); C42(1.02)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C144(0.96); C42(1.10)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C144(0.85); C42(0.88)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C144(1.04); C42(1.16)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C144(1.03); C42(1.22)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C144(0.94); C42(1.03)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C144(0.95); C42(0.88)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C144(0.98); C42(0.87)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C144(0.94); C42(0.80)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C144(0.93); C42(0.96)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C144(0.90); C42(1.31)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C144(0.85); C42(1.14)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C144(0.81); C42(1.06)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C144(0.94); C42(1.13)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C144(0.70); C42(1.00)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C144(0.91); C42(0.89)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C144(0.99); C42(1.14)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C144(0.92); C42(1.00)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C144(0.90); C42(0.91)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C144(0.95); C42(0.94)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C144(0.91); C42(0.97)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C144(0.81); C42(1.05)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C144(1.01); C42(0.91)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C144(0.85); C42(1.26)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C144(0.92); C42(1.23)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C144(0.89); C42(1.16)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C144(0.63); C42(0.99)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C144(0.82); C42(1.04)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C144(0.90); C42(1.05)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C144(0.94); C42(1.25)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C144(0.90); C42(0.81)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C144(0.96); C42(0.88)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C144(0.90); C42(1.17)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C144(0.99); C42(0.96)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C144(0.94); C42(1.06)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C144(0.97); C42(0.91)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C144(0.93); C42(1.00)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C144(1.03); C42(1.17)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C144(1.00); C42(1.20)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C144(0.77); C42(1.07)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C144(1.06); C42(1.12)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C144(1.02); C42(1.11)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C144(0.64); C42(0.74)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C144(1.12); C42(1.09)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C144(0.98); C42(1.00)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C144(1.08); C42(1.17)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C144(1.04); C42(1.02)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C144(0.95); C42(0.96)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C144(0.89); C42(1.22)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C144(0.84); C42(1.31)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C144(0.82); C42(1.28)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C144(0.93); C42(1.23)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C144(0.84); C42(1.12)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C144(1.04); C42(0.98)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C144(0.82); C42(0.93)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C144(0.98); C42(0.94)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C144(0.83); C42(0.93)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C144(0.90); C42(1.04)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C144(0.97); C42(0.96)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C144(0.70); C42(0.87)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C144(0.84); C42(1.04)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C144(0.90); C42(1.05)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C144(0.92); C42(1.03)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C144(0.92); C42(0.97)  LDD1697  [17]
 LDCM0027  Dopamine HEK-293T 13.81  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C144(0.82); C42(1.08)  LDD1698  [17]
 LDCM0625  F8 Ramos C42(0.62); C122(0.87)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C42(0.60); C122(0.54)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C42(3.13); C122(1.22)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C42(0.67); C122(0.45)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C42(1.11); C122(0.97)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C42(0.78); C122(0.76)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C42(0.68); C122(0.32)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C42(1.19); C122(0.84)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C42(1.70); C122(1.10)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C42(1.36); C122(0.89)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C42(0.92); C122(0.55)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C42(0.99); C122(1.23)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C42(2.32); C122(1.19)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C42(0.56); C122(0.63)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C144(0.91); C42(1.07)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C42(1.18); C122(0.93)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C42(1.16); C122(0.64)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C144(0.93); C42(1.08)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C42(1.14); C122(0.97)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C42(1.23); C122(1.49)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C42(0.53); C122(0.39)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C42(0.63); C122(0.46)  LDD2188  [18]
 LDCM0022  KB02 HEK-293T C144(0.94); C42(0.85)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C144(0.92); C42(1.05)  LDD1497  [17]
 LDCM0024  KB05 HMCB C50(1.13)  LDD3312  [3]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C144(1.29)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C144(1.10)  LDD2093  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C144(0.75)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C144(1.14)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C144(0.30)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C144(0.98)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C144(0.27); C42(0.45)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C144(0.88)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C42(0.52)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C144(0.68); C42(0.86)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C144(0.39)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C144(0.47)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C42(0.37)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C144(1.03)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C42(0.68)  LDD2114  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C144(0.42); C42(0.48)  LDD2115  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C144(2.41)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C144(0.75)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C144(0.66)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C144(0.77); C42(0.83)  LDD2123  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C144(0.80); C42(0.97)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C144(0.98); C42(1.05)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C144(0.76)  LDD2128  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C144(0.98)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C144(0.55)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C144(0.44); C42(0.43)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C144(1.06)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C144(0.85); C42(1.12)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C144(0.95); C42(0.89)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C144(0.64)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C42(0.55)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C144(0.90)  LDD2143  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C144(0.72)  LDD2146  [4]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C144(1.78)  LDD2147  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C144(0.40)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C144(0.49)  LDD2149  [4]
 LDCM0131  RA190 MM1.R C42(1.37)  LDD0304  [19]

References

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2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.