Details of the Target

General Information of Target

Target ID LDTP13439
Target Name A-kinase anchor protein 11 (AKAP11)
Gene Name AKAP11
Gene ID 11215
Synonyms
AKAP220; KIAA0629; A-kinase anchor protein 11; AKAP-11; A-kinase anchor protein 220 kDa; AKAP 220; hAKAP220; Protein kinase A-anchoring protein 11; PRKA11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPVFPMLTVLTMFYYICLRRRARTATRGEMMNTHRAIESNSQTSPLNAEVVQYAKEVVD
FSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFKRTPPN
FQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERP
TKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLEYYTELDAVVLHGVKDKPVLSLKTSL
IDMNDIEDDAYAEKDGCGMDSLNKKFSSAVLGEGPNNGYFDKLPYELIQLILNHLTLPDL
CRLAQTCKLLSQHCCDPLQYIHLNLQPYWAKLDDTSLEFLQSRCTLVQWLNLSWTGNRGF
ISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEVISEMCPNLQALNLSSCDKLPPQAFN
HIAKLCSLKRLVLYRTKVEQTALLSILNFCSELQHLSLGSCVMIEDYDVIASMIGAKCKK
LRTLDLWRCKNITENGIAELASGCPLLEELDLGWCPTLQSSTGCFTRLAHQLPNLQKLFL
TANRSVCDTDIDELACNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDN
RAVLELNASFPKVFIKKSFTQ
Target Bioclass
Other
Family
AKAP110 family
Subcellular location
Cytoplasm
Function Binds to type II regulatory subunits of protein kinase A and anchors/targets them.
Uniprot ID
Q9UKA4
Ensemble ID
ENST00000025301.4
HGNC ID
HGNC:369

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K608(7.77)  LDD0277  [2]
Probe 1
 Probe Info  		Y1367(10.37)  LDD3495  [3]
BTD
 Probe Info  		C1890(0.93)  LDD2109  [4]
DA-P3
 Probe Info  		7.60  LDD0179  [5]
AHL-Pu-1
 Probe Info  		C428(4.55); C1257(4.48)  LDD0169  [6]
DBIA
 Probe Info  		C1290(1.19); C1435(1.14); C1488(1.10); C461(0.92)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C1435(0.00); C1257(0.00); C428(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		C216(0.00); C576(0.00); C1026(0.00); C1257(0.00)  LDD2226  [9]
NAIA_5
 Probe Info  		C497(0.00); C216(0.00); C1488(0.00); C1501(0.00)  LDD2225  [9]
Compound 10
 Probe Info  		C1532(0.00); C497(0.00)  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		C1232(0.00); C1890(0.00); C428(0.00)  LDD0018  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C497(2.04); C1488(12.41)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C428(4.55); C1257(4.48)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C1010(0.88); C1290(0.86); C1006(0.88); C1232(1.11)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C1290(0.79); C1232(1.18); C1435(1.06); C1587(1.06)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C1290(0.71); C1232(1.08); C1435(1.02); C1488(0.89)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C1290(0.83); C1232(1.15); C1435(1.10); C1488(1.06)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C1290(0.60); C1232(0.96); C1435(0.96); C1488(0.89)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C1290(0.95); C1232(1.32); C1435(0.93); C1488(1.01)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C1290(0.75); C1232(1.13); C1435(0.95); C1488(1.02)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C1290(0.92); C1232(1.20); C1435(0.94); C1488(0.95)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C1290(1.08); C1232(1.34); C1435(1.13); C1488(0.94)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C1290(0.97); C1232(0.89); C1435(0.97); C1488(1.22)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C1290(0.90); C1232(0.95); C1435(1.04); C1488(1.01)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C1290(0.76); C1232(0.87); C1435(0.91); C1488(1.21)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C1290(0.93); C1232(1.30); C1435(1.01); C1587(1.11)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C1290(0.63); C1232(1.00); C1435(0.97); C1488(0.90)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C1290(0.74); C1232(0.89); C1435(0.97); C1488(0.91)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C1290(0.85); C1232(0.85); C1435(1.06); C1488(1.01)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C1010(1.00); C1290(1.23); C1006(1.00); C1232(1.20)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C1010(0.84); C1290(1.30); C1006(0.84); C1232(1.44)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C1010(1.11); C1290(1.33); C1006(1.11); C1232(1.59)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C1010(0.86); C1290(1.24); C1006(0.86); C1232(1.86)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C1010(0.92); C1290(1.09); C1006(0.92); C1232(1.51)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C1010(0.79); C1290(1.41); C1006(0.79); C1232(1.50)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C1010(0.90); C1290(1.00); C1006(0.90); C1232(1.34)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C1290(0.97); C1232(1.27); C1435(1.25); C1587(1.00)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C1010(1.13); C1290(0.94); C1006(1.13); C1232(0.72)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C1010(0.78); C1290(1.18); C1006(0.78); C1232(1.33)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C1010(0.82); C1290(1.31); C1006(0.82); C1232(1.60)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C1010(0.89); C1290(1.14); C1006(0.89); C1232(1.20)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C1010(0.87); C1290(1.19); C1006(0.87); C1232(1.18)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C1010(0.77); C1290(1.24); C1006(0.77); C1232(1.69)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C1010(0.83); C1290(1.22); C1006(0.83); C1232(1.74)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C1010(0.76); C1290(1.25); C1006(0.76); C1232(1.86)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C1290(1.10); C1488(0.82); C395(1.32); C461(0.95)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1290(0.61); C1488(0.81); C395(0.85); C461(1.08)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1290(0.83); C1488(0.93); C395(1.13); C461(0.99)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1290(0.76); C1488(0.85); C395(1.08); C461(0.82)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1290(0.81); C1488(0.90); C395(0.96); C461(1.25)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1290(0.73); C1488(0.86); C395(1.06); C461(1.25)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1290(0.87); C1488(0.93); C395(1.16); C461(1.02)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1290(0.87); C1488(0.80); C395(1.10); C461(1.08)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1290(0.83); C1488(0.91); C395(1.09); C461(1.13)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1290(0.67); C1488(0.87); C395(0.96); C461(1.32)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1290(1.04); C1488(1.04); C395(1.12); C461(1.10)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1290(0.82); C1488(1.01); C395(1.05); C461(1.01)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C1290(0.94); C1232(1.03); C1435(0.87); C1587(1.09)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1290(1.08); C1488(1.00); C395(1.20); C461(1.34)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1290(1.17); C1488(1.04); C395(1.09); C461(1.06)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1290(0.74); C1488(0.84); C395(0.90); C461(1.20)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C1010(1.25); C1290(1.09); C1006(1.25); C1232(1.25)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C1232(0.89); C466(1.02); C1290(1.11); C468(1.15)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C466(0.92); C1010(0.96); C921(1.03); C928(1.03)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C1232(1.11); C1010(1.12); C468(1.17); C1006(1.18)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C466(0.80); C1232(0.82); C461(1.05); C921(1.11)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C466(1.21); C468(1.37); C1587(1.40); C461(1.45)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C1587(1.27); C1290(1.27); C468(1.28); C461(1.29)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C466(0.86); C461(0.90); C468(0.90); C1435(0.92)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C466(0.84); C1290(0.94); C461(1.00); C468(1.06)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C921(0.92); C928(0.92); C1587(0.98); C1290(1.04)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C466(0.93); C1290(1.06); C1010(1.20); C468(1.26)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C466(1.04); C1587(1.41); C1232(1.62); C395(1.71)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1010(1.22); C1290(1.25); C1006(1.28); C1232(1.13)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1010(1.24); C1290(1.73); C1006(1.36); C1232(1.83)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1010(1.08); C1290(0.97); C1006(1.15); C1232(1.06)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1010(1.22); C1290(1.19); C1006(1.41); C1232(1.17)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C1587(0.74); C497(0.83); C461(0.86); C468(0.86)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C1587(0.73); C466(0.80); C497(0.85); C1232(0.92)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C461(0.79); C468(0.79); C497(0.83); C466(0.84)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C921(0.85); C928(0.85); C1010(0.93); C1006(0.93)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C497(0.77); C461(0.90); C468(0.90); C1290(0.92)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C497(0.77); C1587(0.81); C1232(0.96); C461(1.06)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C1587(0.75); C497(0.83); C395(0.96); C461(1.04)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C461(0.82); C468(0.82); C1290(0.85); C1587(0.88)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C466(0.68); C1587(0.77); C461(0.80); C468(0.80)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C921(0.97); C928(0.97); C1488(1.00); C1290(1.02)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C1290(0.63); C921(0.99); C928(0.99); C1488(1.04)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C1290(0.83); C921(0.98); C928(0.98); C1488(0.98)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C1290(0.73); C1488(1.00); C921(1.05); C928(1.05)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C1290(0.67); C497(0.87); C1488(0.99); C921(1.19)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C1010(0.80); C1006(0.80); C921(0.83); C928(0.83)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C1290(0.64); C497(0.98); C921(1.02); C928(1.02)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C497(0.98); C1488(1.04); C921(1.08); C928(1.08)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C1290(0.95); C1488(1.09); C497(1.10); C921(1.17)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C1290(0.76); C1488(0.99); C497(1.00); C921(1.25)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C497(0.87); C1488(0.95); C1290(1.03); C921(1.33)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C497(0.75); C1232(0.79); C1290(0.82); C1587(0.89)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C921(0.79); C928(0.79); C1587(0.83); C1232(0.90)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C497(0.64); C921(0.81); C928(0.81); C1232(0.89)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C1587(0.80); C497(0.80); C921(0.96); C928(0.96)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1587(0.88); C1488(0.96); C921(0.97); C928(0.97)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C1010(0.71); C1006(0.71); C395(0.74); C921(0.79)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1488(0.92); C1232(0.93); C497(1.04); C921(1.07)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C921(0.86); C928(0.86); C1587(0.97); C1290(1.01)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C497(0.90); C921(0.97); C928(0.97); C1587(1.04)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C497(0.86); C921(0.87); C928(0.87); C1587(0.98)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C921(0.84); C928(0.84); C1587(1.00); C1232(1.01)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1488(1.03); C1232(1.08); C1290(1.16); C921(1.17)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C497(0.87); C1587(0.96); C461(0.98); C468(0.98)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C497(0.97); C921(0.99); C928(0.99); C461(1.04)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C497(0.68); C461(1.02); C468(1.02); C921(1.04)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C1232(1.03); C1290(1.08); C497(1.20); C921(1.34)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C1010(0.76); C1006(0.76); C921(0.79); C928(0.79)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C1232(0.94); C921(1.20); C928(1.20); C1587(1.33)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C497(0.50); C921(0.91); C928(0.91); C1587(0.91)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C497(0.81); C1232(0.93); C461(1.01); C468(1.01)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C1232(1.01); C461(1.20); C468(1.20); C1587(1.21)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C1232(0.94); C1587(1.04); C1290(1.13); C461(1.21)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C1232(1.20); C1587(1.40); C461(1.43); C468(1.43)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C1232(0.94); C921(1.76); C928(1.76); C497(2.03)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C1010(0.94); C1006(0.94); C921(0.95); C928(0.95)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C1010(0.94); C1006(0.94); C921(1.01); C928(1.01)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C921(0.96); C928(0.96); C1010(0.98); C1006(0.98)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1290(0.82); C466(0.96); C461(1.02); C468(1.02)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C921(0.99); C928(0.99); C1587(1.13); C1010(1.29)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C1010(0.86); C1006(0.86); C921(0.99); C928(0.99)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C1010(1.06); C1006(1.06); C921(1.06); C928(1.06)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C921(1.02); C928(1.02); C1587(1.23); C1010(1.25)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C921(1.04); C928(1.04); C1010(1.14); C1006(1.14)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C921(0.73); C928(0.73); C1010(0.83); C1006(0.83)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C921(0.72); C928(0.72); C1010(0.76); C1006(0.76)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C921(0.80); C928(0.80); C1010(1.07); C1006(1.07)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C1010(1.01); C1006(1.01); C466(1.05); C468(1.15)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C1010(0.82); C1006(0.82); C468(1.05); C461(1.07)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C466(0.84); C1290(0.91); C921(0.92); C928(0.92)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C466(1.37); C395(1.39); C1587(1.39); C461(1.39)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C1010(0.81); C1006(0.81); C468(0.97); C466(0.98)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C1010(0.86); C1006(0.86); C466(0.97); C461(1.15)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C1010(1.23); C1006(1.23); C468(1.60); C461(1.65)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C1010(1.21); C1006(1.21); C468(1.45); C466(1.55)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C1010(1.51); C1006(1.51); C468(1.59); C461(1.64)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C1010(1.22); C1006(1.22); C468(1.25); C461(1.30)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C466(1.05); C1010(1.05); C1006(1.05); C468(1.26)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C468(1.05); C461(1.05); C1010(1.14); C1006(1.14)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C1010(1.09); C1006(1.09); C1290(1.14); C466(1.14)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C1290(0.80); C466(0.90); C1435(0.92); C461(1.01)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C468(1.09); C1290(1.11); C461(1.11); C1010(1.22)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C1010(1.08); C1006(1.08); C1232(1.09); C466(1.21)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C468(1.55); C461(1.59); C1010(1.76); C1006(1.76)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C466(0.81); C461(1.21); C468(1.21); C1010(1.25)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C466(0.88); C461(1.12); C468(1.12); C1232(1.25)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C466(0.74); C461(0.94); C468(0.94); C1232(1.19)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C466(0.84); C461(0.99); C468(0.99); C921(1.22)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1010(0.93); C1006(0.93); C466(0.97); C461(1.03)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C461(0.93); C468(0.93); C466(0.96); C1010(1.12)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C461(1.14); C468(1.14); C1010(1.15); C1006(1.15)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C461(0.96); C468(0.96); C466(0.98); C1010(1.00)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C466(1.01); C461(1.28); C468(1.28); C1010(1.48)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C466(0.88); C461(1.04); C468(1.04); C1232(1.12)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C466(0.82); C1290(1.08); C461(1.30); C468(1.30)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C466(0.77); C461(0.92); C468(0.92); C1290(1.09)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1010(1.05); C1006(1.05); C1232(1.11); C466(1.18)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C466(0.80); C461(1.01); C468(1.01); C1232(1.11)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C466(1.12); C1232(1.40); C1010(1.46); C1006(1.46)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C1488(1.00); C1587(1.11); C466(1.12); C1435(1.15)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C1290(0.62); C461(0.74); C468(0.74); C466(0.77)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C1290(1.15); C1232(1.04); C1435(1.08); C1587(1.07)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C921(1.00); C928(1.00); C466(1.02); C1290(1.05)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C466(0.91); C1435(0.94); C461(1.09); C468(1.09)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1290(1.19); C1435(1.14); C1488(1.10); C461(0.92)  LDD0078  [7]
 LDCM0632  CL-Sc Hep-G2 C1488(1.68); C216(1.61); C428(1.07); C576(1.03)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C1232(0.82); C461(0.93); C468(0.93); C921(1.00)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C1010(0.91); C1006(0.91); C1488(1.25); C1232(1.41)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C921(0.90); C928(0.90); C1010(0.94); C1006(0.94)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C1232(0.92); C1290(0.93); C1435(0.96); C461(1.06)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1290(0.79); C466(0.94); C1587(0.95); C461(0.95)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C1290(0.80); C395(0.92); C466(0.93); C1587(1.04)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C1290(0.80); C1435(0.89); C466(0.95); C1232(0.98)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C1232(0.79); C1587(0.80); C497(0.81); C461(0.88)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C1232(0.80); C461(0.92); C468(0.92); C1587(0.97)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C466(0.65); C461(0.86); C468(0.86); C1232(0.87)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C1232(0.84); C461(0.87); C468(0.87); C497(0.99)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C497(0.87); C1232(0.96); C1587(0.98); C1290(0.99)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C1010(0.85); C1006(0.85); C1488(1.24); C921(1.37)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C1587(0.93); C1232(0.94); C395(1.00); C497(1.09)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C1587(0.73); C466(0.86); C461(0.88); C468(0.88)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C1290(0.65); C497(0.95); C1488(1.06); C921(1.24)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C1290(0.66); C497(0.98); C1488(1.04); C921(1.19)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C1290(0.78); C497(1.00); C921(1.08); C928(1.08)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C497(1.08); C1488(1.11); C1290(1.15); C921(1.16)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C1290(0.76); C497(1.04); C921(1.05); C928(1.05)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1488(1.07); C1232(1.17); C1587(1.24); C921(1.43)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C921(0.96); C928(0.96); C1290(0.98); C497(1.07)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1488(1.08); C1587(1.09); C1290(1.10); C1232(1.11)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C1010(0.87); C1006(0.87); C921(1.23); C928(1.23)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C921(0.86); C928(0.86); C497(0.93); C1587(0.98)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C497(0.83); C1290(1.04); C1587(1.25); C1232(1.28)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C1232(0.88); C1290(0.94); C1587(1.01); C921(1.05)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C1232(0.85); C1290(1.02); C497(1.11); C1587(1.51)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C1232(0.98); C1587(1.15); C921(1.54); C928(1.54)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C921(0.83); C928(0.83); C1010(0.85); C1006(0.85)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C1010(0.65); C1006(0.65); C921(0.85); C928(0.85)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C1010(0.80); C1006(0.80); C921(0.90); C928(0.90)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C921(0.96); C928(0.96); C1587(1.17); C1010(1.26)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C1010(0.86); C1006(0.86); C921(1.08); C928(1.08)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C461(0.96); C468(0.96); C921(1.10); C928(1.10)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C461(1.08); C468(1.08); C921(1.15); C928(1.15)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C1587(0.82); C461(0.97); C468(1.00); C1232(1.02)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C1232(0.73); C1587(0.76); C1290(0.82); C466(1.06)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C466(0.96); C461(1.00); C468(1.02); C1587(1.03)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C466(0.96); C1587(0.97); C461(1.03); C921(1.04)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C461(0.60); C468(0.60); C1232(0.88); C921(0.97)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C468(0.98); C461(0.98); C921(1.02); C928(1.02)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C1290(1.10); C1587(1.22); C921(1.45); C928(1.45)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C1290(0.81); C1232(0.88); C1587(1.11); C466(1.45)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C461(0.99); C1232(1.01); C468(1.05); C466(1.16)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C461(1.15); C468(1.16); C1232(1.17); C466(1.21)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C1290(1.11); C1232(2.19); C1587(0.71); C461(1.55)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C1290(1.16); C1232(1.03); C1587(1.28); C461(0.97)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C1290(1.43); C1232(1.53); C1587(0.99); C461(0.98)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C1290(1.36); C1232(2.54); C1587(1.45); C461(1.15)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C1290(1.68); C1232(1.13); C1587(1.00); C461(1.02)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C1010(1.72); C1006(1.72); C1232(0.82); C1488(1.07)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C1290(1.48); C1232(1.34); C1587(1.74); C461(1.08)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C1232(1.12); C1587(1.05); C461(0.68); C468(0.68)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C1290(1.02); C1232(0.95); C1435(1.05); C1587(1.15)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C1290(0.80); C1232(0.95); C1435(1.10); C1587(1.30)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C1290(0.83); C1232(1.08); C1435(1.03); C1587(1.28)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C1290(0.91); C1232(1.28); C1435(1.31); C1587(1.34)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C1290(0.77); C1232(1.02); C1435(1.09); C1587(1.28)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C1290(0.93); C1232(1.25); C1435(0.73); C1587(1.30)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C1290(1.02); C1232(1.13); C1435(1.24); C1587(1.17)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C1010(1.20); C1006(1.20); C1232(1.42); C1488(1.27)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C1290(0.79); C1232(1.15); C1435(1.09); C1587(1.16)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C1290(1.04); C1232(1.16); C1435(1.04); C1587(1.15)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C1290(0.84); C1232(0.98); C1435(0.69); C1587(1.28)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C1290(0.94); C1232(1.23); C1435(0.92); C1587(1.52)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C1290(0.96); C1232(1.18); C1435(0.96); C1587(1.35)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C1290(0.83); C1232(1.24); C1435(1.05); C1587(1.40)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C1290(0.88); C1232(0.85); C1435(1.13); C1587(0.82)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C1290(0.78); C1232(0.84); C1435(1.29); C1587(0.72)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C1290(1.10); C1232(0.86); C1435(1.18); C1587(0.82)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C1290(0.79); C1232(0.99); C1435(1.07); C1587(0.91)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C1010(1.47); C1006(1.47); C1232(1.12); C1488(1.27)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C1290(0.93); C1232(0.99); C1435(1.40); C1587(0.87)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C1290(1.04); C1232(1.00); C1435(1.46); C1587(0.86)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C1290(1.15); C1232(1.20); C1435(1.00); C1587(0.78)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C1290(0.90); C1232(0.95); C1435(0.90); C1587(0.81)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C1290(0.81); C1232(0.90); C1435(0.87); C1587(0.81)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C1290(0.82); C1232(0.75); C1435(1.10); C1587(0.79)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C1290(0.94); C1232(0.78); C1435(0.73); C1587(0.83)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C1290(1.13); C1232(0.89); C1435(0.64); C1587(0.82)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C1290(0.81); C1232(1.24); C1435(0.94); C1587(0.80)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C1290(1.09); C1232(0.93); C1435(0.89); C1587(0.81)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C1010(1.58); C1006(1.58); C1232(1.27); C1488(1.04)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C1290(0.92); C1232(1.00); C1435(0.86); C1587(0.90)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C1010(1.23); C1290(0.44); C1006(1.23); C1232(1.04)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C1010(1.66); C1290(0.44); C1006(1.66); C1232(1.05)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C1010(1.12); C1290(0.50); C1006(1.12); C1232(1.22)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C1010(1.07); C1290(0.52); C1006(1.07); C1232(1.08)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C1010(1.17); C1290(0.62); C1006(1.17); C1232(1.05)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C1010(1.03); C1290(0.76); C1006(1.03); C1232(1.30)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C1010(1.11); C1290(0.56); C1006(1.11); C1232(1.07)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C1010(1.14); C1290(0.45); C1006(1.14); C1232(1.07)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C1010(1.43); C1290(0.52); C1006(1.43); C1232(1.16)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C1010(1.00); C1006(1.00); C1232(1.65); C1488(1.19)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C1010(1.14); C1290(0.46); C1006(1.14); C1232(1.14)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C1010(1.24); C1290(0.40); C1006(1.24); C1232(1.11)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C1010(1.28); C1290(0.76); C1006(1.28); C1232(1.06)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C1010(1.18); C1290(0.67); C1006(1.18); C1232(1.09)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C1010(1.27); C1290(0.58); C1006(1.27); C1232(1.27)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C1290(0.89); C1232(0.99); C1435(0.66); C1587(1.42)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C1290(0.77); C1232(0.87); C1435(0.65); C1587(0.94)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C1290(1.07); C1232(1.00); C1435(0.79); C1587(1.17)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C1290(0.92); C1232(1.24); C1435(1.01); C1587(1.42)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C1010(1.54); C1006(1.54); C1232(1.76); C1488(1.10)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C1290(0.98); C1232(1.05); C1435(0.85); C1587(1.16)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C1290(0.84); C1232(1.09); C1435(0.95); C1587(1.37)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C1290(0.78); C1232(1.35); C1435(0.85); C1587(1.75)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C1290(0.74); C1232(1.26); C1435(0.71); C1587(1.35)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C1290(0.95); C1232(1.29); C1435(0.79); C1587(1.96)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C1290(1.01); C1232(1.10); C1435(0.61); C1587(1.15)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C1290(0.79); C1232(0.89); C1435(0.77); C1587(1.05)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C1290(0.75); C1232(1.09); C1435(0.69); C1587(1.27)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C1290(0.86); C1232(1.33); C1435(0.71); C1587(1.50)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C1290(1.03); C1232(1.28); C1435(0.71); C1587(2.16)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C1010(0.99); C1006(0.99); C1232(1.12); C1488(1.30)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C1290(0.82); C1232(0.94); C1435(0.59); C1587(1.14)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C1010(0.67); C1290(0.90); C1006(0.67); C1232(0.86)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C1010(0.81); C1290(0.92); C1006(0.81); C1232(0.95)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C1010(0.71); C1290(0.92); C1006(0.71); C1232(1.03)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C1010(0.75); C1290(0.98); C1006(0.75); C1232(1.07)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C1010(0.86); C1290(0.94); C1006(0.86); C1232(1.10)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C1010(0.94); C1290(0.91); C1006(0.94); C1232(1.09)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C1010(0.87); C1290(1.02); C1006(0.87); C1232(1.12)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C1010(0.86); C1290(1.18); C1006(0.86); C1232(1.09)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C1010(0.69); C1290(1.01); C1006(0.69); C1232(1.12)  LDD0811  [7]
 LDCM0027  Dopamine HEK-293T 7.60  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C1598(0.98); C395(0.98); C1232(1.09); C428(1.07)  LDD1698  [15]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C395(2.16); C1280(1.68); C1391(1.65); C1026(1.16)  LDD1702  [4]
 LDCM0031  Epigallocatechin gallate HEK-293T 29.36  LDD0183  [5]
 LDCM0468  Fragment33 HCT 116 C1010(1.01); C1290(0.42); C1006(1.01); C1232(1.01)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C1290(0.80); C1232(0.98); C1435(0.96); C1587(1.24)  LDD0744  [7]
 LDCM0022  KB02 HCT 116 C395(3.01); C921(5.50); C928(5.50); C1290(4.00)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C395(2.04); C921(2.11); C928(2.11); C1290(3.03)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C395(4.72); C921(4.38); C928(4.38); C1290(3.18)  LDD0082  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1890(0.93)  LDD2109  [4]
 LDCM0029  Quercetin HEK-293T 11.91  LDD0181  [5]
 LDCM0021  THZ1 HCT 116 C461(0.99); C466(0.99); C468(0.99); C1006(1.06)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) CDIP1/LITAF family Q99732

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402