Details of the Target

General Information of Target

Target ID LDTP08906
Target Name Calcium/calmodulin-dependent protein kinase kinase 1 (CAMKK1)
Gene Name CAMKK1
Gene ID 84254
Synonyms
CAMKKA; Calcium/calmodulin-dependent protein kinase kinase 1; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; EC 2.7.11.17; CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGGPAVCCQDPRAELVERVAAIDVTHLEEADGGPEPTRNGVDPPPRARAASVIPGSTSR
LLPARPSLSARKLSLQERPAGSYLEAQAGPYATGPASHISPRAWRRPTIESHHVAISDAE
DCVQLNQYKLQSEIGKGAYGVVRLAYNESEDRHYAMKVLSKKKLLKQYGFPRRPPPRGSQ
AAQGGPAKQLLPLERVYQEIAILKKLDHVNVVKLIEVLDDPAEDNLYLVFDLLRKGPVME
VPCDKPFSEEQARLYLRDVILGLEYLHCQKIVHRDIKPSNLLLGDDGHVKIADFGVSNQF
EGNDAQLSSTAGTPAFMAPEAISDSGQSFSGKALDVWATGVTLYCFVYGKCPFIDDFILA
LHRKIKNEPVVFPEEPEISEELKDLILKMLDKNPETRIGVPDIKLHPWVTKNGEEPLPSE
EEHCSVVEVTEEEVKNSVRLIPSWTTVILVKSMLRKRSFGNPFEPQARREERSMSAPGNL
LVKEGFGEGGKSPELPGVQEDEAAS
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family
Subcellular location
Cytoplasm
Function
Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
TTD ID
T38134
Uniprot ID
Q8N5S9
DrugMap ID
TTGLQWZ
Ensemble ID
ENST00000158166.5
HGNC ID
HGNC:1469
ChEMBL ID
CHEMBL5256

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LNCaP clone FGC SNV: p.L417I .
MOLT4 SNV: p.G478V IA-alkyne    Probe Info 
NCIH1155 SNV: p.A145G .
TOV21G SNV: p.P101H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P3
 Probe Info  		7.35  LDD0179  [1]
DBIA
 Probe Info  		C243(0.85)  LDD1508  [2]
AMP probe
 Probe Info  		N.A.  LDD0200  [3]
ATP probe
 Probe Info  		K157(0.00); K277(0.00)  LDD0199  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [4]
IPM
 Probe Info  		C122(0.00); C243(0.00)  LDD2156  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C243(0.85)  LDD1508  [2]
 LDCM0226  AC11 HEK-293T C351(1.04); C243(1.11)  LDD1509  [2]
 LDCM0259  AC14 HEK-293T C351(0.95)  LDD1512  [2]
 LDCM0270  AC15 HEK-293T C122(1.16); C243(1.18)  LDD1513  [2]
 LDCM0277  AC18 HEK-293T C243(1.07)  LDD1516  [2]
 LDCM0278  AC19 HEK-293T C351(0.91); C243(0.91)  LDD1517  [2]
 LDCM0279  AC2 HEK-293T C243(1.64)  LDD1518  [2]
 LDCM0282  AC22 HEK-293T C351(1.02)  LDD1521  [2]
 LDCM0283  AC23 HEK-293T C122(1.00); C243(1.14)  LDD1522  [2]
 LDCM0284  AC24 HEK-293T C268(1.07); C243(0.86)  LDD1523  [2]
 LDCM0286  AC26 HEK-293T C243(0.70)  LDD1525  [2]
 LDCM0287  AC27 HEK-293T C351(1.02); C243(1.07)  LDD1526  [2]
 LDCM0290  AC3 HEK-293T C351(1.08); C243(1.07)  LDD1529  [2]
 LDCM0291  AC30 HEK-293T C351(1.11)  LDD1530  [2]
 LDCM0292  AC31 HEK-293T C122(0.92); C243(1.15)  LDD1531  [2]
 LDCM0293  AC32 HEK-293T C268(1.10); C243(1.06)  LDD1532  [2]
 LDCM0295  AC34 HEK-293T C243(0.82)  LDD1534  [2]
 LDCM0296  AC35 HEK-293T C351(1.06); C243(1.12)  LDD1535  [2]
 LDCM0299  AC38 HEK-293T C351(0.85)  LDD1538  [2]
 LDCM0300  AC39 HEK-293T C122(1.14); C243(1.13)  LDD1539  [2]
 LDCM0302  AC40 HEK-293T C268(1.07); C243(1.04)  LDD1541  [2]
 LDCM0304  AC42 HEK-293T C243(0.75)  LDD1543  [2]
 LDCM0305  AC43 HEK-293T C351(1.11); C243(1.07)  LDD1544  [2]
 LDCM0308  AC46 HEK-293T C351(0.98)  LDD1547  [2]
 LDCM0309  AC47 HEK-293T C122(1.40); C243(1.17)  LDD1548  [2]
 LDCM0310  AC48 HEK-293T C268(1.11); C243(1.66)  LDD1549  [2]
 LDCM0313  AC50 HEK-293T C243(0.77)  LDD1552  [2]
 LDCM0314  AC51 HEK-293T C351(1.19); C243(1.09)  LDD1553  [2]
 LDCM0317  AC54 HEK-293T C351(1.19)  LDD1556  [2]
 LDCM0318  AC55 HEK-293T C122(1.03); C243(1.17)  LDD1557  [2]
 LDCM0319  AC56 HEK-293T C268(1.04); C243(1.24)  LDD1558  [2]
 LDCM0321  AC58 HEK-293T C243(0.78)  LDD1560  [2]
 LDCM0322  AC59 HEK-293T C351(1.01); C243(1.07)  LDD1561  [2]
 LDCM0323  AC6 HEK-293T C351(0.99)  LDD1562  [2]
 LDCM0326  AC62 HEK-293T C351(1.44)  LDD1565  [2]
 LDCM0327  AC63 HEK-293T C122(1.13); C243(1.19)  LDD1566  [2]
 LDCM0328  AC64 HEK-293T C268(1.10); C243(1.32)  LDD1567  [2]
 LDCM0334  AC7 HEK-293T C122(1.05); C243(1.22)  LDD1568  [2]
 LDCM0345  AC8 HEK-293T C268(0.94); C243(1.90)  LDD1569  [2]
 LDCM0275  AKOS034007705 HEK-293T C268(1.03); C243(1.19)  LDD1514  [2]
 LDCM0367  CL1 HEK-293T C268(1.15)  LDD1571  [2]
 LDCM0368  CL10 HEK-293T C351(0.55)  LDD1572  [2]
 LDCM0369  CL100 HEK-293T C351(0.87); C122(1.10)  LDD1573  [2]
 LDCM0370  CL101 HEK-293T C268(0.97)  LDD1574  [2]
 LDCM0372  CL103 HEK-293T C268(1.09)  LDD1576  [2]
 LDCM0373  CL104 HEK-293T C351(0.97); C122(0.99)  LDD1577  [2]
 LDCM0374  CL105 HEK-293T C268(1.01)  LDD1578  [2]
 LDCM0376  CL107 HEK-293T C268(1.10)  LDD1580  [2]
 LDCM0377  CL108 HEK-293T C351(1.05); C122(1.06)  LDD1581  [2]
 LDCM0378  CL109 HEK-293T C268(1.10)  LDD1582  [2]
 LDCM0379  CL11 HEK-293T C122(1.33); C243(0.93)  LDD1583  [2]
 LDCM0381  CL111 HEK-293T C268(0.99)  LDD1585  [2]
 LDCM0382  CL112 HEK-293T C351(1.02); C122(1.12)  LDD1586  [2]
 LDCM0383  CL113 HEK-293T C268(1.08)  LDD1587  [2]
 LDCM0385  CL115 HEK-293T C268(1.10)  LDD1589  [2]
 LDCM0386  CL116 HEK-293T C351(0.87); C122(1.13)  LDD1590  [2]
 LDCM0387  CL117 HEK-293T C268(1.05)  LDD1591  [2]
 LDCM0389  CL119 HEK-293T C268(1.19)  LDD1593  [2]
 LDCM0390  CL12 HEK-293T C268(1.10); C243(1.48)  LDD1594  [2]
 LDCM0391  CL120 HEK-293T C351(1.18); C122(1.15)  LDD1595  [2]
 LDCM0392  CL121 HEK-293T C268(1.04)  LDD1596  [2]
 LDCM0394  CL123 HEK-293T C268(1.13)  LDD1598  [2]
 LDCM0395  CL124 HEK-293T C351(0.94); C122(0.97)  LDD1599  [2]
 LDCM0396  CL125 HEK-293T C268(1.01)  LDD1600  [2]
 LDCM0398  CL127 HEK-293T C268(1.14)  LDD1602  [2]
 LDCM0399  CL128 HEK-293T C351(1.05); C122(0.96)  LDD1603  [2]
 LDCM0400  CL13 HEK-293T C268(1.03)  LDD1604  [2]
 LDCM0402  CL15 HEK-293T C268(1.09)  LDD1606  [2]
 LDCM0403  CL16 HEK-293T C351(0.99); C122(1.11)  LDD1607  [2]
 LDCM0405  CL18 HEK-293T C243(0.90)  LDD1609  [2]
 LDCM0406  CL19 HEK-293T C351(0.91); C243(0.95)  LDD1610  [2]
 LDCM0410  CL22 HEK-293T C351(1.33)  LDD1614  [2]
 LDCM0411  CL23 HEK-293T C122(1.03); C243(1.03)  LDD1615  [2]
 LDCM0412  CL24 HEK-293T C268(1.06); C243(1.24)  LDD1616  [2]
 LDCM0413  CL25 HEK-293T C268(0.96)  LDD1617  [2]
 LDCM0415  CL27 HEK-293T C268(1.26)  LDD1619  [2]
 LDCM0416  CL28 HEK-293T C351(1.05); C122(0.99)  LDD1620  [2]
 LDCM0418  CL3 HEK-293T C268(1.02)  LDD1622  [2]
 LDCM0419  CL30 HEK-293T C243(0.75)  LDD1623  [2]
 LDCM0420  CL31 HEK-293T C351(0.98); C243(0.91)  LDD1624  [2]
 LDCM0423  CL34 HEK-293T C351(1.11)  LDD1627  [2]
 LDCM0424  CL35 HEK-293T C122(1.00); C243(0.83)  LDD1628  [2]
 LDCM0425  CL36 HEK-293T C268(0.97); C243(1.38)  LDD1629  [2]
 LDCM0426  CL37 HEK-293T C268(1.21)  LDD1630  [2]
 LDCM0428  CL39 HEK-293T C268(1.08)  LDD1632  [2]
 LDCM0429  CL4 HEK-293T C351(1.01); C122(0.89)  LDD1633  [2]
 LDCM0430  CL40 HEK-293T C351(1.01); C122(1.01)  LDD1634  [2]
 LDCM0432  CL42 HEK-293T C243(0.96)  LDD1636  [2]
 LDCM0433  CL43 HEK-293T C351(0.95); C243(0.88)  LDD1637  [2]
 LDCM0436  CL46 HEK-293T C351(0.92)  LDD1640  [2]
 LDCM0437  CL47 HEK-293T C122(1.16); C243(0.89)  LDD1641  [2]
 LDCM0438  CL48 HEK-293T C268(1.02); C243(1.45)  LDD1642  [2]
 LDCM0439  CL49 HEK-293T C268(1.22)  LDD1643  [2]
 LDCM0443  CL52 HEK-293T C351(0.98); C122(1.07)  LDD1646  [2]
 LDCM0445  CL54 HEK-293T C243(0.74)  LDD1648  [2]
 LDCM0446  CL55 HEK-293T C351(0.88); C243(0.96)  LDD1649  [2]
 LDCM0449  CL58 HEK-293T C351(0.97)  LDD1652  [2]
 LDCM0450  CL59 HEK-293T C122(1.31); C243(0.98)  LDD1653  [2]
 LDCM0451  CL6 HEK-293T C243(0.89)  LDD1654  [2]
 LDCM0452  CL60 HEK-293T C268(1.08); C243(1.16)  LDD1655  [2]
 LDCM0453  CL61 HEK-293T C268(1.16)  LDD1656  [2]
 LDCM0455  CL63 HEK-293T C268(1.24)  LDD1658  [2]
 LDCM0456  CL64 HEK-293T C351(1.02); C122(0.98)  LDD1659  [2]
 LDCM0458  CL66 HEK-293T C243(1.19)  LDD1661  [2]
 LDCM0459  CL67 HEK-293T C351(0.96); C243(1.03)  LDD1662  [2]
 LDCM0462  CL7 HEK-293T C351(0.94); C243(0.96)  LDD1665  [2]
 LDCM0463  CL70 HEK-293T C351(1.17)  LDD1666  [2]
 LDCM0464  CL71 HEK-293T C122(0.90); C243(1.03)  LDD1667  [2]
 LDCM0465  CL72 HEK-293T C268(1.00); C243(0.93)  LDD1668  [2]
 LDCM0466  CL73 HEK-293T C268(1.01)  LDD1669  [2]
 LDCM0469  CL76 HEK-293T C351(1.09); C122(1.02)  LDD1672  [2]
 LDCM0471  CL78 HEK-293T C243(1.11)  LDD1674  [2]
 LDCM0472  CL79 HEK-293T C351(1.09); C243(1.00)  LDD1675  [2]
 LDCM0476  CL82 HEK-293T C351(0.73)  LDD1679  [2]
 LDCM0477  CL83 HEK-293T C122(1.08); C243(1.06)  LDD1680  [2]
 LDCM0478  CL84 HEK-293T C268(0.99); C243(0.82)  LDD1681  [2]
 LDCM0479  CL85 HEK-293T C268(1.13)  LDD1682  [2]
 LDCM0481  CL87 HEK-293T C268(1.17)  LDD1684  [2]
 LDCM0482  CL88 HEK-293T C351(1.11); C122(0.83)  LDD1685  [2]
 LDCM0485  CL90 HEK-293T C243(0.72)  LDD1688  [2]
 LDCM0486  CL91 HEK-293T C351(1.00); C243(1.04)  LDD1689  [2]
 LDCM0489  CL94 HEK-293T C351(0.91)  LDD1692  [2]
 LDCM0490  CL95 HEK-293T C122(0.88); C243(1.02)  LDD1693  [2]
 LDCM0491  CL96 HEK-293T C268(1.09); C243(1.28)  LDD1694  [2]
 LDCM0492  CL97 HEK-293T C268(1.09)  LDD1695  [2]
 LDCM0494  CL99 HEK-293T C268(1.06)  LDD1697  [2]
 LDCM0027  Dopamine HEK-293T 7.35  LDD0179  [1]
 LDCM0495  E2913 HEK-293T C268(1.07)  LDD1698  [2]
 LDCM0468  Fragment33 HEK-293T C268(1.23)  LDD1671  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Alpha-synuclein (SNCA) Synuclein family P37840
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein eta (YWHAH) 14-3-3 family Q04917
Neurofilament light polypeptide (NEFL) Intermediate filament family P07196
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
RING finger protein 11 (RNF11) . Q9Y3C5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sto609 Small molecular drug D0HZ8U

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
3 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.