Details of the Target

General Information of Target

Target ID LDTP11877
Target Name Golgi resident protein GCP60 (ACBD3)
Gene Name ACBD3
Gene ID 64746
Synonyms
GCP60; GOCAP1; GOLPH1; Golgi resident protein GCP60; Acyl-CoA-binding domain-containing protein 3; Golgi complex-associated protein 1; GOCAP1; Golgi phosphoprotein 1; GOLPH1; PBR- and PKA-associated protein 7; Peripheral benzodiazepine receptor-associated protein PAP7) [Cleaved into: Golgi resident protein GCP60, N-terminally processed]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGT
LHLPRRTVDEMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQDI
LGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQ
KSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPKQAPFRSPTAPSVFSPTGNRTP
IPPSRTLLRKERGVKLLDISELDMVGAGREAKRRRKTLDAEVVEKPAKEETVVENATPDY
AAGLVSTQKLGSLNNEPALPSTSYLPSTPSVVPASSYIPSSETPPAPSSREASRPPEEPS
APSPTLPAQFKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQTPPVAMVAPQTQ
APAQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSRENPCQEQGDVIQI
KLSEHTEDLPKADGQGSTTMLVDTVFEMNYATGQWTRFKKYKPMTNVS
Target Bioclass
Transporter and channel
Subcellular location
Golgi apparatus membrane
Function
Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase.; (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.
Uniprot ID
Q9H3P7
Ensemble ID
ENST00000366812.6
HGNC ID
HGNC:15453

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K117(5.56); K95(1.82)  LDD0277  [3]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [4]
THZ1-DTB
 Probe Info  		C129(1.08)  LDD0460  [4]
DA-P3
 Probe Info  		8.52  LDD0179  [5]
AHL-Pu-1
 Probe Info  		C129(4.39)  LDD0168  [6]
HHS-475
 Probe Info  		Y266(0.75); Y483(1.19)  LDD0264  [7]
HHS-465
 Probe Info  		Y483(10.00)  LDD2237  [8]
DBIA
 Probe Info  		C169(1.33)  LDD0080  [9]
5E-2FA
 Probe Info  		H103(0.00); H284(0.00); H341(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K109(0.00); K469(0.00); K473(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
IA-alkyne
 Probe Info  		C129(0.00); C487(0.00)  LDD0032  [13]
Lodoacetamide azide
 Probe Info  		C487(0.00); C129(0.00); C168(0.00); C169(0.00)  LDD0037  [12]
IPM
 Probe Info  		N.A.  LDD0025  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
NAIA_4
 Probe Info  		C129(0.00); C487(0.00)  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		N.A.  LDD0021  [16]
1d-yne
 Probe Info  		N.A.  LDD0356  [17]
NHS
 Probe Info  		N.A.  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [18]
1c-yne
 Probe Info  		K117(0.00); K507(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [19]
AOyne
 Probe Info  		14.90  LDD0443  [20]
NAIA_5
 Probe Info  		C487(0.00); C129(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe2
 Probe Info  		16.94  LDD0463  [21]
FFF probe3
 Probe Info  		5.51  LDD0464  [21]
DA-2
 Probe Info  		N.A.  LDD0072  [22]
STS-1
 Probe Info  		N.A.  LDD0068  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C129(4.39)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C129(4.33)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C129(1.54)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C129(1.31)  LDD0532  [9]
 LDCM0226  AC11 HCT 116 C129(1.21)  LDD0543  [9]
 LDCM0230  AC113 PaTu 8988t C129(1.06)  LDD1109  [9]
 LDCM0231  AC114 PaTu 8988t C129(1.01)  LDD1110  [9]
 LDCM0232  AC115 PaTu 8988t C129(0.84)  LDD1111  [9]
 LDCM0233  AC116 PaTu 8988t C129(1.13)  LDD1112  [9]
 LDCM0234  AC117 PaTu 8988t C129(0.94)  LDD1113  [9]
 LDCM0235  AC118 PaTu 8988t C129(0.99)  LDD1114  [9]
 LDCM0236  AC119 PaTu 8988t C129(0.84)  LDD1115  [9]
 LDCM0237  AC12 HCT 116 C129(1.10)  LDD0554  [9]
 LDCM0238  AC120 PaTu 8988t C129(1.07)  LDD1117  [9]
 LDCM0239  AC121 PaTu 8988t C129(1.08)  LDD1118  [9]
 LDCM0240  AC122 PaTu 8988t C129(1.10)  LDD1119  [9]
 LDCM0241  AC123 PaTu 8988t C129(0.98)  LDD1120  [9]
 LDCM0242  AC124 PaTu 8988t C129(1.13)  LDD1121  [9]
 LDCM0243  AC125 PaTu 8988t C129(1.05)  LDD1122  [9]
 LDCM0244  AC126 PaTu 8988t C129(1.11)  LDD1123  [9]
 LDCM0245  AC127 PaTu 8988t C129(0.95)  LDD1124  [9]
 LDCM0259  AC14 HCT 116 C129(1.36)  LDD0576  [9]
 LDCM0263  AC143 HCT 116 C487(0.65)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C487(0.42)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C487(0.56)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C487(0.54)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C487(0.55)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C487(0.47)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C487(0.55)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C129(1.58)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C487(0.65)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C487(0.86)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C487(0.50)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C487(0.38)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C487(0.57)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C487(0.50)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C487(0.64)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C487(0.58)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C487(0.86)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C487(0.89)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C487(0.83)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C129(1.26)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C487(0.95)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C487(0.72)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C487(0.68)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C487(0.79)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C487(1.00)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C487(0.81); C129(1.65)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C487(0.76); C129(1.81)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C487(0.78); C129(2.09)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C487(0.83); C129(2.53)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C487(0.84); C129(2.08)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C129(1.00)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C487(0.73); C129(1.90)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C487(0.75); C129(2.44)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C487(0.75); C129(2.25)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C487(0.74); C129(1.79)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C487(0.73); C129(2.43)  LDD0612  [9]
 LDCM0296  AC35 HEK-293T C487(1.07); C129(1.09); C169(0.98)  LDD1535  [24]
 LDCM0297  AC36 HEK-293T C487(0.95); C129(0.95); C169(1.17)  LDD1536  [24]
 LDCM0298  AC37 HEK-293T C487(0.94); C129(1.00); C169(1.01)  LDD1537  [24]
 LDCM0299  AC38 HEK-293T C487(0.98); C129(1.08); C169(1.01)  LDD1538  [24]
 LDCM0300  AC39 HEK-293T C487(1.00); C129(1.10)  LDD1539  [24]
 LDCM0301  AC4 HCT 116 C129(1.11)  LDD0618  [9]
 LDCM0302  AC40 HEK-293T C487(1.02); C129(1.02); C169(1.00)  LDD1541  [24]
 LDCM0303  AC41 HEK-293T C487(1.03); C129(1.12); C169(1.07)  LDD1542  [24]
 LDCM0304  AC42 HEK-293T C487(0.99); C129(1.09); C169(0.89)  LDD1543  [24]
 LDCM0305  AC43 HEK-293T C487(1.05); C129(1.17); C169(0.88)  LDD1544  [24]
 LDCM0306  AC44 HEK-293T C487(0.95); C129(0.96); C169(1.46)  LDD1545  [24]
 LDCM0307  AC45 HEK-293T C487(1.01); C129(1.15); C169(0.91)  LDD1546  [24]
 LDCM0308  AC46 HCT 116 C487(1.00)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C487(1.01)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C487(1.01)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C487(4.75)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C129(1.30)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C487(1.02)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C487(1.05)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C487(1.67)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C487(0.96)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C487(1.02)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C487(0.93)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C487(0.87)  LDD0636  [9]
 LDCM0320  AC57 HEK-293T C129(1.15); C487(1.15)  LDD0918  [9]
 LDCM0321  AC58 HEK-293T C129(1.05); C487(1.05)  LDD0919  [9]
 LDCM0322  AC59 HEK-293T C129(0.94); C487(0.94)  LDD0920  [9]
 LDCM0323  AC6 HCT 116 C129(1.10)  LDD0640  [9]
 LDCM0324  AC60 HEK-293T C129(1.30); C487(1.30)  LDD0922  [9]
 LDCM0325  AC61 HEK-293T C129(1.73); C487(1.73)  LDD0923  [9]
 LDCM0326  AC62 HEK-293T C129(1.03); C487(1.03)  LDD0924  [9]
 LDCM0327  AC63 HEK-293T C129(1.36); C487(1.36)  LDD0925  [9]
 LDCM0328  AC64 HEK-293T C129(1.12); C487(1.12)  LDD0926  [9]
 LDCM0329  AC65 HEK-293T C129(1.64); C487(1.64)  LDD0927  [9]
 LDCM0330  AC66 HEK-293T C129(1.05); C487(1.05)  LDD0928  [9]
 LDCM0331  AC67 HEK-293T C129(1.11); C487(1.11)  LDD0929  [9]
 LDCM0332  AC68 HEK-293T C487(0.90)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C487(0.94)  LDD0931  [9]
 LDCM0334  AC7 HCT 116 C129(1.26)  LDD0651  [9]
 LDCM0335  AC70 HEK-293T C487(1.09)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C487(1.06)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C487(1.41)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C487(1.28)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C487(1.54)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C487(1.10)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C487(1.15)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C487(1.06)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C487(1.21)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C487(1.13)  LDD0942  [9]
 LDCM0345  AC8 HCT 116 C129(1.15)  LDD0662  [9]
 LDCM0346  AC80 HEK-293T C487(1.33)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C487(1.08)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C487(1.29)  LDD0946  [9]
 LDCM0349  AC83 HEK-293T C129(1.01); C487(1.01)  LDD0947  [9]
 LDCM0350  AC84 HEK-293T C129(1.63); C487(1.63)  LDD0948  [9]
 LDCM0351  AC85 HEK-293T C129(1.47); C487(1.47)  LDD0949  [9]
 LDCM0352  AC86 HEK-293T C129(1.07); C487(1.07)  LDD0950  [9]
 LDCM0353  AC87 HEK-293T C129(1.34); C487(1.34)  LDD0951  [9]
 LDCM0354  AC88 HEK-293T C129(1.30); C487(1.30)  LDD0952  [9]
 LDCM0355  AC89 HEK-293T C129(1.35); C487(1.35)  LDD0953  [9]
 LDCM0357  AC90 HEK-293T C129(1.64); C487(1.64)  LDD0955  [9]
 LDCM0358  AC91 HEK-293T C129(1.51); C487(1.51)  LDD0956  [9]
 LDCM0359  AC92 HEK-293T C129(1.36); C487(1.36)  LDD0957  [9]
 LDCM0360  AC93 HEK-293T C129(1.50); C487(1.50)  LDD0958  [9]
 LDCM0361  AC94 HEK-293T C129(1.60); C487(1.60)  LDD0959  [9]
 LDCM0362  AC95 HEK-293T C129(1.29); C487(1.29)  LDD0960  [9]
 LDCM0363  AC96 HEK-293T C129(1.34); C487(1.34)  LDD0961  [9]
 LDCM0364  AC97 HEK-293T C129(2.84); C487(2.84)  LDD0962  [9]
 LDCM0248  AKOS034007472 HCT 116 C129(1.00)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C129(0.96)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C129(2.23)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.50  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [19]
 LDCM0632  CL-Sc Hep-G2 C487(1.09); C168(0.48)  LDD2227  [15]
 LDCM0367  CL1 PaTu 8988t C129(0.67)  LDD1246  [9]
 LDCM0368  CL10 PaTu 8988t C129(0.98)  LDD1247  [9]
 LDCM0369  CL100 HCT 116 C129(1.20)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C129(1.60)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C129(1.12)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C129(1.37)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C129(1.41)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C487(0.72)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C487(0.65)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C487(0.95)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C487(3.01)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C487(0.69)  LDD0695  [9]
 LDCM0379  CL11 PaTu 8988t C129(0.98)  LDD1258  [9]
 LDCM0380  CL110 HCT 116 C487(0.64)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C487(0.76)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C487(0.81); C129(1.47)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C487(0.68); C129(2.57)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C487(0.70); C129(1.56)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C487(0.73); C129(1.76)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C487(0.77); C129(2.10)  LDD0703  [9]
 LDCM0387  CL117 HEK-293T C487(0.99); C129(1.09); C169(1.00)  LDD1591  [24]
 LDCM0388  CL118 HEK-293T C487(0.94); C129(1.06); C169(0.95)  LDD1592  [24]
 LDCM0389  CL119 HEK-293T C487(1.09); C129(1.05); C169(0.91)  LDD1593  [24]
 LDCM0390  CL12 PaTu 8988t C129(1.26)  LDD1269  [9]
 LDCM0391  CL120 HEK-293T C487(1.02); C129(1.07)  LDD1595  [24]
 LDCM0392  CL121 HCT 116 C487(1.00)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C487(0.98)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C487(0.79)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C487(1.01)  LDD0712  [9]
 LDCM0396  CL125 HEK-293T C129(1.11); C487(1.11)  LDD0994  [9]
 LDCM0397  CL126 HEK-293T C129(1.22); C487(1.22)  LDD0995  [9]
 LDCM0398  CL127 HEK-293T C129(1.15); C487(1.15)  LDD0996  [9]
 LDCM0399  CL128 HEK-293T C129(0.91); C487(0.91)  LDD0997  [9]
 LDCM0400  CL13 PaTu 8988t C129(1.40)  LDD1279  [9]
 LDCM0401  CL14 PaTu 8988t C129(1.33)  LDD1280  [9]
 LDCM0402  CL15 PaTu 8988t C129(1.15)  LDD1281  [9]
 LDCM0403  CL16 PaTu 8988t C129(1.05)  LDD1282  [9]
 LDCM0404  CL17 PaTu 8988t C129(1.31)  LDD1283  [9]
 LDCM0405  CL18 PaTu 8988t C129(1.15)  LDD1284  [9]
 LDCM0406  CL19 PaTu 8988t C129(1.01)  LDD1285  [9]
 LDCM0407  CL2 PaTu 8988t C129(0.96)  LDD1286  [9]
 LDCM0408  CL20 PaTu 8988t C129(1.21)  LDD1287  [9]
 LDCM0409  CL21 PaTu 8988t C129(1.09)  LDD1288  [9]
 LDCM0410  CL22 PaTu 8988t C129(1.92)  LDD1289  [9]
 LDCM0411  CL23 PaTu 8988t C129(1.19)  LDD1290  [9]
 LDCM0412  CL24 PaTu 8988t C129(1.34)  LDD1291  [9]
 LDCM0413  CL25 PaTu 8988t C129(1.30)  LDD1292  [9]
 LDCM0414  CL26 PaTu 8988t C129(1.21)  LDD1293  [9]
 LDCM0415  CL27 PaTu 8988t C129(1.13)  LDD1294  [9]
 LDCM0416  CL28 PaTu 8988t C129(1.35)  LDD1295  [9]
 LDCM0417  CL29 PaTu 8988t C129(1.10)  LDD1296  [9]
 LDCM0418  CL3 PaTu 8988t C129(1.80)  LDD1297  [9]
 LDCM0419  CL30 PaTu 8988t C129(1.27)  LDD1298  [9]
 LDCM0420  CL31 PaTu 8988t C129(1.06)  LDD1299  [9]
 LDCM0421  CL32 PaTu 8988t C129(1.51)  LDD1300  [9]
 LDCM0422  CL33 PaTu 8988t C129(1.29)  LDD1301  [9]
 LDCM0423  CL34 PaTu 8988t C129(1.47)  LDD1302  [9]
 LDCM0424  CL35 PaTu 8988t C129(1.46)  LDD1303  [9]
 LDCM0425  CL36 PaTu 8988t C129(1.16)  LDD1304  [9]
 LDCM0426  CL37 PaTu 8988t C129(1.75)  LDD1305  [9]
 LDCM0428  CL39 PaTu 8988t C129(1.03)  LDD1307  [9]
 LDCM0429  CL4 PaTu 8988t C129(1.05)  LDD1308  [9]
 LDCM0430  CL40 PaTu 8988t C129(1.10)  LDD1309  [9]
 LDCM0431  CL41 PaTu 8988t C129(1.54)  LDD1310  [9]
 LDCM0432  CL42 PaTu 8988t C129(1.53)  LDD1311  [9]
 LDCM0433  CL43 PaTu 8988t C129(1.66)  LDD1312  [9]
 LDCM0434  CL44 PaTu 8988t C129(1.78)  LDD1313  [9]
 LDCM0435  CL45 PaTu 8988t C129(1.56)  LDD1314  [9]
 LDCM0436  CL46 HEK-293T C487(1.01)  LDD1034  [9]
 LDCM0437  CL47 HEK-293T C487(1.18)  LDD1035  [9]
 LDCM0438  CL48 HEK-293T C487(1.25)  LDD1036  [9]
 LDCM0439  CL49 HEK-293T C487(0.99)  LDD1037  [9]
 LDCM0440  CL5 PaTu 8988t C129(0.82)  LDD1319  [9]
 LDCM0441  CL50 HEK-293T C487(1.55)  LDD1039  [9]
 LDCM0442  CL51 HEK-293T C487(0.95)  LDD1040  [9]
 LDCM0443  CL52 HEK-293T C487(1.02)  LDD1041  [9]
 LDCM0444  CL53 HEK-293T C487(0.95)  LDD1042  [9]
 LDCM0445  CL54 HEK-293T C487(0.78)  LDD1043  [9]
 LDCM0446  CL55 HEK-293T C487(0.89)  LDD1044  [9]
 LDCM0447  CL56 HEK-293T C487(0.95)  LDD1045  [9]
 LDCM0448  CL57 HEK-293T C487(1.09)  LDD1046  [9]
 LDCM0449  CL58 HEK-293T C487(1.01)  LDD1047  [9]
 LDCM0450  CL59 HEK-293T C487(0.96)  LDD1048  [9]
 LDCM0451  CL6 PaTu 8988t C129(1.36)  LDD1330  [9]
 LDCM0452  CL60 HEK-293T C487(1.05)  LDD1050  [9]
 LDCM0453  CL61 HCT 116 C129(0.97)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C129(0.80)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C129(1.01)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C129(1.13)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C129(0.86)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C129(1.32)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C129(1.25)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C129(1.06)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C129(0.82)  LDD0778  [9]
 LDCM0462  CL7 PaTu 8988t C129(1.83)  LDD1341  [9]
 LDCM0463  CL70 HCT 116 C129(1.01)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C129(0.95)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C129(0.97)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C129(0.96)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C129(0.96)  LDD0784  [9]
 LDCM0469  CL76 PaTu 8988t C129(0.95)  LDD1348  [9]
 LDCM0470  CL77 PaTu 8988t C129(1.09)  LDD1349  [9]
 LDCM0471  CL78 PaTu 8988t C129(1.23)  LDD1350  [9]
 LDCM0472  CL79 PaTu 8988t C129(1.12)  LDD1351  [9]
 LDCM0473  CL8 PaTu 8988t C129(1.13)  LDD1352  [9]
 LDCM0474  CL80 PaTu 8988t C129(1.37)  LDD1353  [9]
 LDCM0475  CL81 PaTu 8988t C129(1.06)  LDD1354  [9]
 LDCM0476  CL82 PaTu 8988t C129(1.28)  LDD1355  [9]
 LDCM0477  CL83 PaTu 8988t C129(1.27)  LDD1356  [9]
 LDCM0478  CL84 PaTu 8988t C129(0.87)  LDD1357  [9]
 LDCM0479  CL85 PaTu 8988t C129(1.10)  LDD1358  [9]
 LDCM0480  CL86 PaTu 8988t C129(1.29)  LDD1359  [9]
 LDCM0481  CL87 PaTu 8988t C129(1.32)  LDD1360  [9]
 LDCM0482  CL88 PaTu 8988t C129(1.42)  LDD1361  [9]
 LDCM0483  CL89 PaTu 8988t C129(0.89)  LDD1362  [9]
 LDCM0484  CL9 PaTu 8988t C129(1.13)  LDD1363  [9]
 LDCM0485  CL90 PaTu 8988t C129(1.17)  LDD1364  [9]
 LDCM0486  CL91 HCT 116 C129(0.90)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C129(0.95)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C129(0.95)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C129(0.96)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C129(1.12)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C129(1.03)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C129(0.95)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C129(1.11)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C129(1.11)  LDD0811  [9]
 LDCM0027  Dopamine HEK-293T 8.52  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C487(1.14); C129(1.06); C169(1.03)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C487(1.31)  LDD1702  [25]
 LDCM0625  F8 Ramos C487(1.89)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C487(0.79); C129(1.92)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C487(1.96)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C487(0.84); C129(2.08)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C487(0.67)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C487(1.30); C129(0.26)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C487(0.73); C129(0.38)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C487(0.76); C129(0.85)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C487(0.97)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C487(0.74); C129(0.87)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C487(0.58)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C487(1.01); C129(0.59)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C487(1.03); C129(0.53)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C487(0.90)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C129(0.99)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C487(1.41); C129(0.51)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C487(0.71)  LDD2184  [26]
 LDCM0427  Fragment51 PaTu 8988t C129(2.01)  LDD1306  [9]
 LDCM0610  Fragment52 Ramos C487(1.40); C129(0.48)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C487(1.09); C129(0.85)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C487(0.82)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C487(0.66)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y266(0.75); Y483(1.19)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y266(0.54); Y483(1.02); Y293(14.71)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y483(0.74); Y266(1.09); Y293(7.70)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y483(0.76); Y266(1.31); Y293(4.77)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y483(0.90); Y266(0.91)  LDD0268  [7]
 LDCM0107  IAA HeLa H103(0.00); H116(0.00)  LDD0221  [19]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [4]
 LDCM0022  KB02 HCT 116 C169(1.33)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C169(1.27)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C169(1.29)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C129(0.61)  LDD2207  [27]
 LDCM0131  RA190 MM1.R C129(1.08)  LDD0304  [28]
 LDCM0021  THZ1 HeLa S3 C129(1.08)  LDD0460  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidylinositol 4-kinase beta (PI4KB) PI3/PI4-kinase family Q9UBF8
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TBC1 domain family member 22A (TBC1D22A) . Q8WUA7
TBC1 domain family member 22B (TBC1D22B) . Q9NU19

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
23 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
28 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.