Details of the Target

General Information of Target

Target ID LDTP07509
Target Name Protein FAM117B (FAM117B)
Gene Name FAM117B
Gene ID 150864
Synonyms
ALS2CR13; Protein FAM117B; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 13 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQRVRRNGSPTPAGSLGGGAVATAGGPGSRLQPMRATVPFQLKQQQQQQHGSPTRSGGG
GGGNNNGGCCGGASGPAGGGGGGGPRTASRSTSPTRGGGNAAARTSPTVATQTGASATST
RGTSPTRSAAPGARGSPPRPPPPPPLLGTVSSPSSSPTHLWTGEVSAAPPPARVRHRRRS
PEQSRSSPEKRSPSAPVCKAGDKTRQPSSSPSSIIRRTSSLDTLAAPYLAGHWPRDSHGQ
AAPCMRDKATQTESAWAEEYSEKKKGSHKRSASWGSTDQLKEIAKLRQQLQRSKHSSRHH
RDKERQSPFHGNHAAINQCQAPVPKSALIPVIPITKSTGSRFRNSVEGLNQEIEIIIKET
GEKEEQLIPQDIPDGHRAPPPLVQRSSSTRSIDTQTPGGADRGSNNSSRSQSVSPTSFLT
ISNEGSEESPCSADDLLVDPRDKENGNNSPLPKYATSPKPNNSYMFKREPPEGCERVKVF
EECSPKQLHEIPAFYCPDKNKVNFIPKSGSAFCLVSILKPLLPTPDLTLKGSGHSLTVTT
GMTTTLLQPIAVASLSTNTEQDRVSRGTSTVMPSASLLPPPEPIEEAEG
Target Bioclass
Other
Uniprot ID
Q6P1L5
Ensemble ID
ENST00000392238.3
HGNC ID
HGNC:14440

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 Deletion: p.K358RfsTer29 .
IGR37 SNV: p.P579S DBIA    Probe Info 
IGR39 SNV: p.P579S .
J82 SNV: p.H534Q DBIA    Probe Info 
KMS27 SNV: p.D371N .
NCIH2170 Substitution: p.G63D .
SNU1 SNV: p.P485R DBIA    Probe Info 
WM115 Substitution: p.G63D .
WM2664 Substitution: p.G63D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-P3
 Probe Info  		8.20  LDD0179  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C474(1.01)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C244(0.00); C513(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C483(0.00); C244(0.00); C198(0.00); C513(0.00)  LDD0037  [4]
TFBX
 Probe Info  		C69(0.00); C70(0.00)  LDD0027  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
IPM
 Probe Info  		N.A.  LDD0147  [5]
Phosphinate-6
 Probe Info  		C513(0.00); C319(0.00)  LDD0018  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C244(1.01); C474(1.01); C198(1.06); C496(1.03)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C244(1.00); C474(1.06); C198(0.93); C496(1.12)  LDD1508  [8]
 LDCM0216  AC100 HEK-293T C244(0.82)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C244(0.68)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C244(0.66)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C244(0.88)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C244(0.90)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C244(1.19)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C244(0.71)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C244(0.72)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C244(0.75)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C244(0.69)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C244(0.98); C474(1.02); C198(0.99); C496(1.04)  LDD1509  [8]
 LDCM0227  AC110 HEK-293T C244(0.66)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C244(0.69)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C244(0.81)  LDD0827  [3]
 LDCM0237  AC12 HEK-293T C244(1.04); C474(1.07); C198(1.02); C496(1.10)  LDD1510  [8]
 LDCM0246  AC128 HEK-293T C244(1.08)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C244(0.90)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C244(0.90)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C244(0.85)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C244(0.89)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C244(0.95)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C244(0.78)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C244(1.11)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C244(1.12)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C244(1.05)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C244(1.00)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C244(0.93)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C244(1.04); C474(0.94); C198(1.03); C496(1.07)  LDD1512  [8]
 LDCM0260  AC140 HEK-293T C244(1.05)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C244(0.97)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C244(0.93)  LDD0860  [3]
 LDCM0270  AC15 HEK-293T C244(1.01); C474(1.08); C198(1.05); C496(1.09)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C244(0.56)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C244(0.65)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C244(0.65)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C244(1.04); C474(1.04); C198(0.99); C496(1.05)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C244(0.55)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C244(0.56)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C244(0.65)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C244(0.71)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C244(0.59)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C244(1.07); C474(0.99); C198(1.16); C496(1.12)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C244(0.99); C474(1.07); C198(0.97); C496(0.96)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C244(1.01); C474(0.96); C198(0.93); C496(0.99)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C244(1.04); C474(0.95); C198(0.97); C496(1.04)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C244(1.01); C474(0.96); C198(1.02); C496(1.01)  LDD1528  [8]
 LDCM0290  AC3 HEK-293T C244(0.98); C474(1.00); C198(1.04); C496(0.97)  LDD1529  [8]
 LDCM0291  AC30 HEK-293T C244(1.03); C474(0.88); C198(1.05); C496(1.00)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C244(0.92); C474(1.07); C198(1.05); C496(0.98)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C244(0.95); C474(1.00); C198(0.99); C496(1.01)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C244(1.04); C474(1.08); C198(1.15); C496(1.16)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C244(1.06); C474(1.06); C198(1.03); C496(1.09)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C244(1.94)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C244(2.25)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C244(1.98)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C244(1.58)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C244(1.16)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C244(0.98); C474(0.96); C198(1.01); C496(1.04)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C244(0.99)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C244(0.96)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C244(1.12)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C244(0.88)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C244(1.12)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C244(1.60)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C244(1.13)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C244(1.26)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C244(1.08)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C244(0.97)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C244(1.06); C474(0.91); C198(1.00); C496(1.11)  LDD1551  [8]
 LDCM0313  AC50 HEK-293T C244(1.01)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C244(1.15)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C244(1.03)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C244(0.99)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C244(0.96)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C244(0.95)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C244(1.06)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C244(1.11); C474(1.08); C198(1.16); C496(1.02)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C244(1.05); C474(1.04); C198(0.99); C496(1.11)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C244(1.05); C474(0.94); C198(1.07); C496(1.10)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C244(1.12); C474(1.10); C198(0.96); C496(1.15)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C244(1.10); C474(1.09); C198(1.03); C496(1.06)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C244(1.00); C474(0.99); C198(1.05); C496(1.14)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C244(1.01); C474(1.07); C198(1.01); C496(1.05)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C244(0.97); C474(1.18); C198(1.00); C496(1.23)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C244(1.09); C474(1.13); C198(0.88); C496(1.26)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C244(0.96); C474(0.98); C198(0.97); C496(1.11)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C244(1.03); C474(0.98); C198(0.95); C496(1.03)  LDD1569  [8]
 LDCM0365  AC98 HEK-293T C244(0.63)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C244(0.69)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C244(1.03); C474(1.05); C198(1.00); C496(1.14)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C244(1.01); C474(1.02); C198(1.00); C496(1.10)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C244(1.07); C474(0.96); C198(0.98); C496(1.17)  LDD1514  [8]
 LDCM0020  ARS-1620 HCC44 C474(1.01)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C244(0.70)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C244(1.02)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C244(1.03); C198(0.95); C496(1.06)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C244(1.08); C474(1.00); C198(0.93); C496(1.17)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C244(1.12); C474(0.95); C198(1.06); C496(1.09)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C244(1.04); C474(1.10); C198(1.17); C496(1.19)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C244(1.01); C198(1.01); C496(1.01)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C244(0.68)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C244(0.68)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C244(0.62)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C244(0.59)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C244(0.72)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C244(1.09)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C244(0.60)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C244(0.67)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C244(1.07); C198(1.10); C496(1.08)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C244(1.03); C474(1.00); C198(1.07); C496(1.07)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C244(1.07); C474(0.90); C198(1.06); C496(1.06)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C244(1.06); C474(1.08); C198(1.03); C496(1.07)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C244(1.04); C198(1.06); C496(0.94)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C244(2.01)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C244(1.87)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C244(1.06)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C244(0.87)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C244(0.91)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C244(0.93)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C244(0.85)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C244(0.97)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C244(0.96)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C244(1.00); C474(1.00); C198(0.89); C496(1.17)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C244(1.08); C474(1.32); C198(1.03); C496(1.28)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C244(1.07); C474(1.18); C198(0.87); C496(1.18)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C244(1.08); C198(0.98); C496(0.90)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C244(0.79)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C244(0.82)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C244(0.92)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C244(0.82)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C244(1.03)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C244(0.96)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C244(0.84)  LDD1004  [3]
 LDCM0407  CL2 HEK-293T C244(0.87)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C244(1.12)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C244(1.17)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C244(1.00)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C244(1.25)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C244(1.04)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C244(1.04)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C244(0.96)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C244(1.00)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C244(1.20)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C244(1.33)  LDD1015  [3]
 LDCM0418  CL3 HEK-293T C244(0.82)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C244(1.37)  LDD1017  [3]
 LDCM0420  CL31 HEK-293T C244(0.70)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C244(0.83)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C244(0.72)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C244(0.91)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C244(0.90)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C244(0.89)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C244(0.86)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C244(1.05)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C244(0.87)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C244(0.95)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C244(0.97)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C244(1.02)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C244(1.03)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C244(0.89)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C244(0.98)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C244(0.96); C474(1.23); C198(1.08); C496(1.10)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C244(1.02); C474(1.45); C198(1.09); C496(1.09)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C244(0.98); C474(1.45); C198(0.97); C496(0.96)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C244(1.03); C474(0.98); C198(0.91); C496(1.19)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C244(0.88)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C244(1.10); C474(0.94); C198(1.16); C496(1.23)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C244(1.06); C198(1.05); C496(1.00)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C244(0.98); C474(1.02); C198(1.17); C496(1.12)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C244(1.08); C474(1.04); C198(1.14); C496(1.11)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C244(1.06); C474(1.19); C198(0.95); C496(1.14)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C244(1.12); C474(1.19); C198(1.03); C496(1.00)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C244(1.17); C474(1.18); C198(1.23); C496(1.22)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C244(1.08); C474(1.13); C198(1.13); C496(1.03)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C244(1.03); C474(1.44); C198(1.07); C496(1.22)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C244(0.85)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C244(1.09); C474(1.47); C198(1.08); C496(1.02)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C244(0.84)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C244(0.86)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C244(0.78)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C244(0.78)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C244(0.89)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C244(0.89)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C244(1.03)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C244(1.03)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C244(0.97)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C244(0.85)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C244(0.99)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C244(0.91)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C244(1.11)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C244(1.04)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C244(1.12)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C244(1.03); C198(0.98); C496(1.17)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C244(0.99); C474(1.09); C198(1.22); C496(0.97)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C244(0.98); C474(1.11); C198(0.98); C496(1.06)  LDD1674  [8]
 LDCM0472  CL79 HEK-293T C244(1.01); C474(1.06); C198(0.94); C496(1.06)  LDD1675  [8]
 LDCM0473  CL8 HEK-293T C244(0.62)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C244(1.09); C474(1.05); C198(1.01); C496(0.97)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C244(0.98); C474(1.07); C198(1.04); C496(1.16)  LDD1678  [8]
 LDCM0476  CL82 HEK-293T C244(0.99); C474(1.03); C198(1.02); C496(1.03)  LDD1679  [8]
 LDCM0477  CL83 HEK-293T C244(0.97); C474(1.32); C198(0.99); C496(1.09)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C244(1.17); C474(1.01); C198(0.97); C496(1.23)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C244(0.97); C474(1.08); C198(0.69); C496(1.16)  LDD1682  [8]
 LDCM0480  CL86 HEK-293T C244(1.03); C474(0.92); C198(1.11); C496(1.11)  LDD1683  [8]
 LDCM0481  CL87 HEK-293T C244(1.05); C474(0.99); C198(0.82); C496(1.22)  LDD1684  [8]
 LDCM0482  CL88 HEK-293T C244(0.99); C198(0.83); C496(1.02)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C244(0.99); C474(1.10); C198(0.84); C496(1.11)  LDD1686  [8]
 LDCM0484  CL9 HEK-293T C244(0.78)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C244(1.07); C474(1.07); C198(0.91); C496(1.12)  LDD1688  [8]
 LDCM0486  CL91 HEK-293T C244(1.00); C474(1.12); C198(1.00); C496(1.09)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C244(1.07); C474(1.09); C198(0.99); C496(1.09)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C244(1.04); C474(1.06); C198(0.98); C496(1.11)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C244(1.12); C474(1.08); C198(1.08); C496(1.05)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C244(1.08); C474(1.32); C198(1.16); C496(1.04)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C244(1.03); C474(1.28); C198(0.84); C496(1.04)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C244(1.00); C474(1.06); C198(0.89); C496(1.01)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C244(1.09); C474(0.90); C198(1.08); C496(0.99)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C244(1.07); C474(0.95); C198(1.12); C496(1.19)  LDD1697  [8]
 LDCM0027  Dopamine HEK-293T 8.20  LDD0179  [1]
 LDCM0495  E2913 HEK-293T C244(1.04); C474(1.08); C198(1.11); C496(1.40)  LDD1698  [8]
 LDCM0625  F8 Ramos C244(1.53)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C244(1.98)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C244(3.78)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C244(1.04)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C244(1.31)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C244(0.61)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C244(1.05)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C244(1.34)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C244(1.07)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C244(1.13)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C244(0.84)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C244(1.72)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C244(1.20)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C244(2.69)  LDD2201  [9]
 LDCM0468  Fragment33 HEK-293T C244(0.90)  LDD1066  [3]
 LDCM0596  Fragment38 Ramos C244(1.38)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C244(1.22)  LDD2184  [9]
 LDCM0427  Fragment51 HEK-293T C244(0.95)  LDD1025  [3]
 LDCM0610  Fragment52 Ramos C244(1.61)  LDD2204  [9]
 LDCM0614  Fragment56 Ramos C244(1.39)  LDD2205  [9]
 LDCM0569  Fragment7 Ramos C244(1.14)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C244(1.03)  LDD2188  [9]
 LDCM0022  KB02 HCT 116 C69(4.75); C70(4.75); C198(2.73)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C69(1.27); C70(1.27); C198(1.44)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C69(2.67); C70(2.67); C198(2.17)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C69(1.05); C70(1.05); C496(1.12)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
S-adenosylmethionine synthase isoform type-2 (MAT2A) AdoMet synthase family P31153
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) Eukaryotic ATPase B chain family P24539
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Intercellular adhesion molecule 5 (ICAM5) ICAM family Q9UMF0
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Dynein light chain 1, cytoplasmic (DYNLL1) Dynein light chain family P63167
Dynein light chain 2, cytoplasmic (DYNLL2) Dynein light chain family Q96FJ2
Glypican-5 (GPC5) Glypican family P78333
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Protein Dr1 (DR1) NC2 beta/DR1 family Q01658
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
DnaJ homolog subfamily B member 6 (DNAJB6) . O75190
General transcription factor 3C polypeptide 3 (GTF3C3) . Q9Y5Q9
RING finger protein 11 (RNF11) . Q9Y3C5
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578