Details of the Target

General Information of Target

Target ID LDTP09044
Target Name ATPase family gene 2 protein homolog A (AFG2A)
Gene Name AFG2A
Gene ID 166378
Synonyms
SPAF; SPATA5; ATPase family gene 2 protein homolog A; EC 3.6.4.10; AFG2 AAA ATPase homolog A; Ribosome biogenesis protein SPATA5; Spermatogenesis-associated factor protein; Spermatogenesis-associated protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSKKNRKRLNQSAENGSSLPSAASSCAEARAPSAGSDFAATSGTLTVTNLLEKVDDKIP
KTFQNSLIHLGLNTMKSANICIGRPVLLTSLNGKQEVYTAWPMAGFPGGKVGLSEMAQKN
VGVRPGDAIQVQPLVGAVLQAEEMDVALSDKDMEINEEELTGCILRKLDGKIVLPGNFLY
CTFYGRPYKLQVLRVKGADGMILGGPQSDSDTDAQRMAFEQSSMETSSLELSLQLSQLDL
EDTQIPTSRSTPYKPIDDRITNKASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGN
EQLTEEERLLKFSIGAKCNTDTFYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSS
QLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVING
PEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTL
MDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRV
PHLLTEAELLQLANSAHGYVGADLKVLCNEAGLCALRRILKKQPNLPDVKVAGLVKITLK
DFLQAMNDIRPSAMREIAIDVPNVSWSDIGGLESIKLKLEQAVEWPLKHPESFIRMGIQP
PKGVLLYGPPGCSKTMIAKALANESGLNFLAIKGPELMNKYVGESERAVRETFRKARAVA
PSIIFFDELDALAVERGSSLGAGNVADRVLAQLLTEMDGIEQLKDVTILAATNRPDRIDK
ALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNEVDLDELILQTDAYSGAEIVAVC
REAALLALEEDIQANLIMKRHFTQALSTVTPRIPESLRRFYEDYQEKSGLHTL
Target Bioclass
Enzyme
Family
AAA ATPase family, AFG2 subfamily
Subcellular location
Cytoplasm
Function
ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. Acts together with AFG2B, AIRIM and CINP. May be involved in morphological and functional mitochondrial transformations during spermatogenesis.
Uniprot ID
Q8NB90
Ensemble ID
ENST00000274008.5
HGNC ID
HGNC:18119
ChEMBL ID
CHEMBL2311230

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.N683S DBIA    Probe Info 
KYSE510 SNV: p.G412E DBIA    Probe Info 
MCC26 SNV: p.A40V DBIA    Probe Info 
NCIH2170 SNV: p.E454Ter DBIA    Probe Info 
NCIH2172 SNV: p.D730H DBIA    Probe Info 
NCIH358 SNV: p.Q234H DBIA    Probe Info 
ZR751 Deletion: p.F219LfsTer17 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C81(1.01)  LDD2093  [2]
DA-P3
 Probe Info  		6.52  LDD0179  [3]
AHL-Pu-1
 Probe Info  		C291(2.25)  LDD0171  [4]
HHS-465
 Probe Info  		Y393(1.19)  LDD2237  [5]
DBIA
 Probe Info  		C318(1.22); C291(1.13); C672(1.00); C568(0.97)  LDD0078  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C318(0.00); C459(0.00); C181(0.00); C81(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
Lodoacetamide azide
 Probe Info  		C318(0.00); C672(0.00); C459(0.00); C181(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [10]
NAIA_4
 Probe Info  		C27(0.00); C81(0.00); C318(0.00)  LDD2226  [11]
NAIA_5
 Probe Info  		C181(0.00); C27(0.00); C81(0.00)  LDD2224  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
IPM
 Probe Info  		C574(0.00); C672(0.00); C291(0.00)  LDD0005  [13]
TFBX
 Probe Info  		C459(0.00); C81(0.00); C672(0.00); C291(0.00)  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
AOyne
 Probe Info  		14.90  LDD0443  [15]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C266
 Probe Info  		9.06  LDD1937  [16]
FFF probe11
 Probe Info  		8.63  LDD0472  [17]
FFF probe3
 Probe Info  		15.70  LDD0465  [17]
STS-1
 Probe Info  		N.A.  LDD0136  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C459(4.10)  LDD0371  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C291(2.25)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C163(0.94); C27(0.80); C291(0.74); C318(0.97)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C163(1.20); C27(1.00); C291(1.33); C318(1.16)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C163(0.88); C27(1.07); C291(0.98); C318(0.77)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C163(1.00); C27(1.14); C291(1.11); C318(0.94)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C163(0.84); C27(1.20); C291(1.01); C318(0.83)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C163(0.89); C27(1.26); C291(1.12); C318(0.97)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C163(0.93); C27(1.15); C291(0.91); C318(0.78)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C163(0.85); C27(1.34); C291(1.03); C318(0.84)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C163(0.98); C27(1.19); C291(1.34); C318(0.90)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C163(1.01); C27(1.28); C291(1.22); C318(0.87)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C163(0.72); C27(1.16); C291(1.09); C318(0.75)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C163(0.63); C27(1.16); C291(0.85); C318(0.72)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C163(1.03); C27(1.17); C291(1.22); C318(1.10)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C163(0.60); C27(1.42); C291(0.90); C318(0.84)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C163(0.59); C27(1.32); C291(1.13); C318(0.99)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C163(0.99); C27(1.50); C291(1.08); C318(0.83)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C163(1.00); C27(1.00); C291(0.98); C318(0.77)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C163(1.09); C27(0.90); C291(0.91); C318(0.88)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C163(0.92); C27(1.04); C291(1.18); C318(1.08)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C163(1.11); C27(1.01); C291(1.09); C318(0.95)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C163(0.86); C27(1.27); C291(1.11); C318(1.08)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C163(1.04); C27(1.03); C291(1.09); C318(1.00)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C163(1.47); C27(1.15); C291(1.00); C318(0.91)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C163(1.00); C27(0.87); C291(1.08); C318(0.96)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C163(0.89); C27(1.02); C291(1.07); C318(0.73)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C163(0.62); C27(1.43); C291(1.17); C318(1.17)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C163(1.18); C27(0.88); C291(0.92); C318(0.95)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C163(0.62); C27(0.99); C291(0.93); C318(1.04)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C163(0.82); C27(1.56); C291(1.07); C318(1.00)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C163(0.85); C27(0.78); C291(0.96); C318(1.39)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C163(0.68); C27(0.86); C291(0.82); C318(1.16)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C163(1.13); C27(1.07); C291(1.07); C318(1.28)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C163(1.10); C291(1.71); C318(1.46); C568(0.75)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C163(1.35); C291(1.10); C318(1.29); C568(0.90)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C163(1.19); C291(1.71); C318(1.29); C568(0.92)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C163(1.21); C291(1.32); C318(1.48); C568(0.68)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C163(1.33); C291(1.27); C318(1.05); C568(1.18)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C163(1.33); C291(1.58); C318(1.17); C568(1.10)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C163(1.46); C291(1.79); C318(1.79); C568(0.86)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C163(1.32); C291(2.07); C318(1.44); C568(1.13)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C163(1.28); C291(1.13); C318(1.03); C568(1.07)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C163(1.07); C291(1.07); C318(1.06); C568(1.15)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C163(1.37); C291(1.72); C318(1.26); C568(1.01)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C163(1.82); C291(1.51); C318(1.10); C568(0.90)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C163(1.02); C27(0.92); C291(1.19); C318(1.13)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C163(1.48); C291(2.07); C318(1.39); C568(0.91)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C163(1.35); C291(1.89); C318(1.28); C568(1.01)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C163(1.46); C291(1.52); C318(1.07); C568(1.14)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C568(0.81); C163(0.82); C574(0.84); C27(1.09)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C568(0.64); C574(0.85); C672(0.95); C163(1.05)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C568(0.80); C574(0.96); C672(0.96); C163(0.98)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C568(0.75); C574(0.81); C672(0.94); C27(0.94)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C568(0.73); C574(0.82); C672(1.00); C27(1.13)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C568(0.77); C672(0.91); C27(1.19); C574(1.25)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C568(0.65); C574(0.90); C672(1.06); C27(1.38)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C81(0.70); C27(0.97); C574(1.07); C163(1.10)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C568(0.92); C574(0.94); C163(1.03); C318(1.13)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C163(0.84); C568(0.84); C27(1.03); C672(1.04)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C568(0.70); C574(0.91); C672(0.99); C27(1.06)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C568(0.79); C672(0.97); C574(0.97); C27(1.25)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C163(1.12); C27(1.04); C291(1.81); C318(1.73)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C163(1.07); C27(1.10); C291(1.60); C318(1.35)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C163(1.10); C27(1.38); C291(1.03); C318(1.18)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C163(1.31); C27(0.93); C291(1.41); C318(1.03)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C27(0.86); C568(0.90); C163(1.00); C574(1.00)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C568(0.88); C81(0.90); C574(0.90); C163(1.03)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C568(0.84); C574(0.88); C81(1.00); C163(1.01)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C291(0.68); C27(0.78); C568(0.85); C163(0.97)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C81(0.75); C163(0.91); C568(0.91); C574(0.96)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C568(0.89); C163(0.90); C574(0.90); C81(0.99)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C291(0.92); C574(0.97); C81(0.97); C568(0.98)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C81(0.81); C27(0.90); C568(0.94); C574(0.94)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C81(0.93); C163(0.99); C568(1.02); C672(1.05)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C568(0.82); C27(0.89); C81(0.90); C574(0.91)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C568(0.74); C574(0.87); C81(0.89); C27(1.06)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C568(0.84); C574(0.93); C27(1.00); C81(1.03)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C568(1.03); C163(1.04); C318(1.05); C81(1.06)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C568(0.80); C574(0.97); C27(1.09); C81(1.09)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C27(0.77); C318(0.79); C291(1.03); C672(1.04)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C568(0.73); C574(0.85); C291(1.11); C27(1.13)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C568(0.80); C574(0.83); C27(0.99); C81(1.08)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C568(0.72); C574(0.93); C27(1.12); C163(1.13)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C568(0.68); C574(0.84); C291(0.94); C27(1.05)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C568(0.65); C574(0.78); C291(1.01); C163(1.05)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C318(0.88); C163(0.91); C291(0.92); C672(0.95)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C568(0.81); C163(0.89); C574(0.91); C291(0.91)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C568(0.76); C574(0.88); C672(0.94); C163(0.97)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C291(0.83); C568(0.85); C574(0.88); C672(0.93)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C318(0.87); C568(0.89); C574(0.97); C27(1.00)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C318(0.87); C27(0.93); C568(1.05); C672(1.08)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C568(0.87); C574(0.92); C672(1.09); C291(1.16)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C568(0.81); C574(0.90); C163(1.03); C291(1.05)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C568(0.92); C163(0.94); C574(1.05); C672(1.06)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C568(0.93); C574(1.07); C672(1.12); C163(1.12)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C568(0.85); C574(0.88); C672(1.02); C291(1.03)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C568(0.86); C574(0.96); C163(1.10); C672(1.13)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C568(0.95); C574(0.95); C672(1.04); C291(1.04)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C27(0.88); C672(1.03); C568(1.03); C574(1.03)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C27(1.01); C672(1.09); C163(1.10); C568(1.12)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C568(0.96); C574(0.96); C81(1.03); C291(1.17)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C27(0.74); C291(0.83); C318(0.98); C672(1.17)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C81(0.88); C568(1.00); C574(1.00); C163(1.20)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C672(0.93); C291(0.96); C81(1.03); C163(1.07)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C672(0.99); C81(1.10); C163(1.18); C27(1.25)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C81(0.98); C568(1.01); C574(1.01); C27(1.10)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C81(0.94); C291(1.03); C163(1.08); C672(1.09)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C81(1.01); C163(1.08); C568(1.25); C574(1.25)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C81(1.12); C163(1.21); C568(1.26); C574(1.26)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C568(0.83); C574(0.92); C318(1.10); C27(1.12)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C568(0.79); C574(0.88); C672(1.14); C27(1.21)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C568(0.81); C574(0.95); C672(1.20); C318(1.23)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C81(0.67); C568(1.02); C574(1.02); C27(1.05)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C568(0.72); C574(0.86); C27(1.09); C672(1.17)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C568(0.93); C81(1.00); C574(1.01); C27(1.10)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C568(0.77); C574(0.87); C672(1.26); C163(1.34)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C568(0.79); C574(0.94); C163(1.06); C318(1.17)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C568(0.92); C574(1.02); C672(1.20); C163(1.21)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C568(0.90); C318(1.15); C574(1.16); C27(1.19)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C568(0.98); C318(1.15); C574(1.17); C672(1.20)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C568(0.85); C574(0.95); C27(1.12); C318(1.29)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C163(0.96); C318(1.10); C672(1.11); C291(1.11)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C163(0.97); C318(1.06); C27(1.13); C672(1.14)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C81(0.79); C574(0.98); C568(1.03); C163(1.04)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C318(1.01); C568(1.06); C672(1.12); C291(1.12)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C163(0.94); C318(0.98); C291(1.04); C27(1.04)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C568(0.89); C318(0.99); C291(1.01); C574(1.05)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C568(0.99); C574(1.19); C27(1.24); C163(1.27)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C163(1.04); C574(1.06); C27(1.07); C568(1.13)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C568(0.95); C574(0.98); C163(1.18); C27(1.32)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C568(1.03); C574(1.11); C672(1.13); C27(1.21)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C163(1.07); C574(1.09); C568(1.14); C672(1.27)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C318(0.94); C163(0.96); C672(1.07); C574(1.19)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C318(0.99); C568(1.07); C163(1.12); C672(1.15)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C568(0.80); C81(0.81); C574(0.90); C27(1.04)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C318(1.03); C574(1.05); C163(1.07); C27(1.07)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C318(0.82); C291(0.93); C672(0.96); C163(1.09)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C27(1.12); C574(1.12); C568(1.16); C163(1.21)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C568(0.68); C574(0.75); C163(1.12); C318(1.12)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C568(0.69); C574(0.73); C163(0.88); C318(1.06)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C568(0.76); C574(0.79); C163(0.89); C318(1.04)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C568(0.81); C574(0.87); C163(1.02); C318(1.04)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C318(0.88); C163(0.95); C672(1.04); C574(1.05)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C574(0.89); C568(0.89); C318(0.96); C163(1.03)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C568(0.74); C574(0.78); C163(1.04); C27(1.15)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C163(0.93); C27(0.96); C672(1.00); C81(1.08)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C568(0.67); C574(0.73); C27(1.05); C163(1.15)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C568(0.78); C574(0.82); C27(0.96); C163(1.10)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C574(0.80); C568(0.82); C318(0.89); C163(0.96)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C291(0.91); C163(0.92); C318(0.94); C568(0.94)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C568(0.81); C574(0.82); C318(0.98); C163(1.02)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C568(0.78); C574(0.80); C163(1.03); C81(1.04)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C568(0.72); C574(0.76); C318(1.07); C163(1.09)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C318(0.85); C163(0.99); C672(1.16); C27(1.22)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C318(0.72); C163(0.77); C291(0.94); C672(1.00)  LDD0683  [6]
 LDCM0248  AKOS034007472 HCT 116 C163(1.07); C27(1.07); C291(1.25); C318(0.94)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C81(0.82); C568(0.94); C27(0.97); C672(1.07)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C81(0.82); C568(1.05); C574(1.09); C163(1.22)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 10.09  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C318(1.22); C291(1.13); C672(1.00); C568(0.97)  LDD0078  [6]
 LDCM0630  CCW28-3 231MFP C672(1.77)  LDD2214  [19]
 LDCM0632  CL-Sc Hep-G2 C81(1.33); C181(0.55)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C163(0.59); C81(0.65); C318(0.91); C672(0.93)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C163(0.76); C27(0.82); C568(0.99); C574(1.01)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C291(0.80); C27(0.86); C318(0.91); C568(1.06)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C81(0.66); C574(1.00); C672(1.01); C568(1.01)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C81(0.57); C672(0.89); C163(0.92); C568(0.95)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C81(0.66); C574(0.87); C568(0.90); C672(0.91)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C81(0.71); C163(0.98); C672(0.99); C574(1.05)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C568(0.83); C27(0.86); C574(0.93); C81(1.05)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C27(0.78); C568(0.80); C574(0.90); C81(0.94)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C568(0.80); C27(0.88); C81(0.91); C574(0.94)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C27(0.78); C568(0.81); C574(0.98); C81(1.12)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C568(0.82); C574(0.87); C27(0.96); C81(1.07)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C81(0.85); C163(0.89); C27(0.89); C291(1.00)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C27(0.82); C568(0.95); C81(0.95); C574(0.99)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C568(0.74); C574(0.79); C81(0.95); C27(1.01)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C568(0.89); C318(0.89); C27(0.98); C163(0.98)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C568(0.65); C574(0.80); C81(0.96); C291(1.13)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C568(0.73); C574(0.92); C318(1.14); C291(1.19)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C568(0.67); C574(0.83); C81(0.96); C318(1.16)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C568(0.82); C574(0.93); C81(1.08); C318(1.18)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C574(0.80); C568(0.81); C163(1.06); C672(1.27)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C568(0.89); C574(0.95); C672(1.01); C27(1.07)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C568(0.88); C574(0.98); C27(1.06); C672(1.09)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C163(0.87); C27(0.94); C568(1.04); C81(1.11)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C568(0.83); C318(0.95); C574(1.01); C672(1.08)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C672(0.80); C163(0.94); C291(0.96); C81(0.99)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C81(0.95); C163(0.96); C568(1.10); C574(1.10)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C568(0.93); C574(0.93); C163(1.07); C81(1.09)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C568(1.17); C574(1.17); C291(1.22); C163(1.22)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C318(0.81); C27(0.96); C672(1.02); C568(1.03)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C318(0.86); C568(0.97); C672(1.03); C574(1.08)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C568(0.90); C163(1.04); C574(1.04); C318(1.05)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C568(0.80); C574(0.87); C672(1.11); C318(1.31)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C163(0.75); C81(0.81); C568(0.96); C27(0.99)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C163(0.74); C81(0.78); C672(0.93); C574(0.94)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C163(0.73); C81(0.80); C574(0.93); C568(0.97)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C291(0.94); C568(0.95); C574(0.95); C672(0.96)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C568(0.88); C574(0.88); C672(0.95); C81(0.96)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C568(0.76); C574(0.76); C163(0.98); C672(1.00)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C568(0.84); C574(0.84); C672(0.98); C163(1.00)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C163(0.60); C81(0.65); C574(0.92); C318(0.98)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C568(0.76); C574(0.76); C672(0.98); C81(1.02)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C568(0.78); C574(0.78); C163(0.88); C81(0.94)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C568(0.79); C574(0.79); C163(0.84); C81(0.96)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C291(0.64); C568(0.79); C574(0.79); C81(1.01)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C163(1.29); C27(1.51); C291(0.89); C318(1.72)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C163(1.22); C27(1.44); C291(1.12); C318(1.24)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C163(1.11); C27(1.30); C291(1.58); C318(1.25)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C163(1.09); C27(1.23); C291(0.93); C318(1.28)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C163(1.27); C27(1.26); C291(1.31); C318(1.32)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C163(1.17); C27(1.24); C291(1.03); C318(1.39)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C163(0.84); C27(1.04); C291(1.27); C318(1.13)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C163(1.26); C27(1.11); C291(0.86); C318(1.28)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C163(0.99); C27(1.09); C291(1.02); C318(1.26)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C163(1.02); C27(1.12); C291(1.14); C318(1.36)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C163(1.03); C27(1.10); C291(1.19); C318(1.66)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C163(1.34); C27(1.35); C291(0.97); C318(1.74)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C163(1.43); C27(1.61); C291(1.08); C318(2.20)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C163(1.28); C27(1.37); C291(1.05); C318(2.06)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C163(1.36); C27(1.61); C291(1.08); C318(2.52)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C163(1.51); C27(1.42); C291(1.44); C318(1.69)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C163(0.88); C27(0.94); C291(1.04); C318(1.06)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C163(1.17); C27(1.72); C291(1.17); C318(1.83)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C163(1.33); C27(1.29); C291(1.03); C318(1.54)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C163(1.48); C27(2.01); C291(1.00); C318(2.47)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C163(1.25); C27(1.36); C291(1.08); C318(2.03)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C163(1.22); C27(1.38); C291(1.13); C318(1.71)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C163(1.29); C27(1.39); C291(1.11); C318(1.96)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C163(0.91); C27(0.99); C291(1.05); C318(0.96)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C163(0.78); C27(0.99); C291(0.97); C318(0.79)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C163(0.90); C27(0.92); C291(0.95); C318(1.05)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C163(0.94); C27(1.18); C291(0.92); C318(1.30)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C163(0.72); C27(0.90); C291(1.18); C318(1.04)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C163(0.91); C27(1.11); C291(0.91); C318(1.10)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C163(0.93); C27(0.88); C291(1.04); C318(1.04)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C163(0.98); C27(1.05); C291(1.06); C318(1.23)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C163(0.87); C27(1.24); C291(1.14); C318(1.38)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C163(0.95); C27(1.07); C291(0.88); C318(1.24)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C163(0.85); C27(1.23); C291(1.04); C318(1.16)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C163(0.86); C27(1.10); C291(0.96); C318(0.91)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C163(0.88); C27(1.06); C291(0.89); C318(1.30)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C163(0.87); C27(1.02); C291(1.05); C318(0.99)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C163(0.90); C27(1.02); C291(1.00); C318(0.87)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C163(0.69); C27(0.97); C291(1.29); C318(1.17)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C163(0.92); C27(1.24); C291(1.05); C318(1.02)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C163(1.23); C27(0.98); C291(0.96); C318(0.94)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C163(0.97); C27(1.03); C291(1.09); C318(0.89)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C163(1.07); C27(1.01); C291(1.29); C318(1.01)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C163(1.17); C27(1.02); C291(0.92); C318(1.04)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C163(1.29); C27(1.22); C291(0.96); C318(0.88)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C163(1.55); C27(1.30); C291(1.01); C318(1.04)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C163(0.99); C27(1.16); C291(0.89); C318(1.16)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C163(1.11); C27(1.07); C291(0.86); C318(1.35)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C163(1.20); C27(1.42); C291(1.09); C318(1.12)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C163(0.78); C27(0.76); C291(1.35); C318(1.09)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C163(1.09); C27(1.10); C291(0.92); C318(0.98)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C163(1.16); C27(0.99); C291(1.07); C318(0.96)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C163(1.07); C27(1.15); C291(0.96); C318(0.97)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C163(1.25); C27(1.11); C291(0.87); C318(2.01)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C163(1.17); C27(1.29); C291(1.04); C318(1.55)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C163(0.81); C27(1.12); C291(1.15); C318(1.29)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C163(0.94); C27(1.07); C291(1.00); C318(2.31)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C163(1.01); C27(1.30); C291(1.18); C318(1.22)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C163(0.93); C27(1.09); C291(1.38); C318(1.63)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C163(0.75); C27(0.96); C291(1.08); C318(1.34)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C163(0.82); C27(1.03); C291(1.09); C318(1.49)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C163(1.05); C27(1.04); C291(1.24); C318(1.13)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C163(1.04); C27(0.97); C291(1.55); C318(1.30)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C163(1.04); C27(1.18); C291(1.47); C318(2.05)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C163(0.96); C27(1.44); C291(1.61); C318(2.36)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C163(0.97); C27(1.53); C291(1.23); C318(1.15)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C163(0.87); C27(1.23); C291(1.10); C318(1.13)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C163(0.82); C27(1.25); C291(1.29); C318(1.19)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C163(0.79); C27(1.30); C291(1.48); C318(1.64)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C163(1.06); C27(1.07); C291(1.60); C318(1.72)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C163(0.75); C27(0.90); C291(1.30); C318(1.22)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C163(0.83); C27(1.29); C291(1.03); C318(0.97)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C163(0.99); C27(0.95); C291(0.70); C318(0.92)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C163(0.79); C27(0.94); C291(0.65); C318(1.00)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C163(1.15); C27(0.85); C291(0.79); C318(1.12)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C163(0.98); C27(1.06); C291(0.94); C318(1.27)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C163(1.11); C27(0.97); C291(0.79); C318(1.24)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C163(0.99); C27(0.81); C291(0.92); C318(0.86)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C163(0.98); C27(0.96); C291(1.06); C318(1.06)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C163(1.39); C27(0.78); C291(0.80); C318(0.91)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C163(1.18); C27(0.97); C291(0.81); C318(0.87)  LDD0811  [6]
 LDCM0027  Dopamine HEK-293T 6.52  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C291(1.04); C81(1.00); C27(1.07); C318(0.98)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C459(4.85); C291(1.60); C81(1.28); C574(1.00)  LDD1702  [2]
 LDCM0576  Fragment14 Ramos C318(3.01)  LDD2193  [21]
 LDCM0468  Fragment33 HCT 116 C163(0.94); C27(1.16); C291(0.92); C318(1.00)  LDD0785  [6]
 LDCM0566  Fragment4 Ramos C318(0.61)  LDD2184  [21]
 LDCM0427  Fragment51 HCT 116 C163(1.30); C27(1.77); C291(1.19); C318(2.01)  LDD0744  [6]
 LDCM0022  KB02 HCT 116 C672(13.38); C291(2.38); C318(1.15)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C672(9.74); C291(1.81); C318(1.14)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C672(3.66); C291(2.26); C318(1.23)  LDD0082  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C81(1.01)  LDD2093  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C81(0.94)  LDD2109  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C81(0.98)  LDD2127  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C81(1.25)  LDD2136  [2]
 LDCM0029  Quercetin HEK-293T 6.62  LDD0181  [3]
 LDCM0021  THZ1 HCT 116 C318(1.11); C291(1.13); C672(1.07); C568(1.18)  LDD2173  [6]

References

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Mass spectrometry data entry: PXD039908 , PXD029761
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Mass spectrometry data entry: PXD043348
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Mass spectrometry data entry: PXD044625
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578