Details of the Target

General Information of Target

Target ID LDTP05011
Target Name Small ribosomal subunit protein uS19 (RPS15)
Gene Name RPS15
Gene ID 6209
Synonyms
RIG; Small ribosomal subunit protein uS19; 40S ribosomal protein S15; RIG protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEVEQKKKRTFRKFTYRGVDLDQLLDMSYEQLMQLYSARQRRRLNRGLRRKQHSLLKRL
RKAKKEAPPMEKPEVVKTHLRDMIILPEMVGSMVGVYNGKTFNQVEIKPEMIGHYLGEFS
ITYKPVKHGRPGIGATHSSRFIPLK
Target Bioclass
Other
Family
Universal ribosomal protein uS19 family
Subcellular location
Cytoplasm
Function Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Uniprot ID
P62841
Ensemble ID
ENST00000592588.7
HGNC ID
HGNC:10388

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		5.32  LDD0066  [1]
TH211
 Probe Info  		Y123(10.00); Y97(8.55)  LDD0257  [2]
TH214
 Probe Info  		Y123(20.00); Y115(10.58)  LDD0258  [2]
TH216
 Probe Info  		Y37(15.90); Y115(15.38)  LDD0259  [2]
STPyne
 Probe Info  		K58(10.00); K65(8.98)  LDD0277  [3]
ONAyne
 Probe Info  		K77(0.00); K52(0.00)  LDD0273  [3]
HHS-465
 Probe Info  		Y123(9.25)  LDD2237  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
ATP probe
 Probe Info  		K65(0.00); K124(0.00); K127(0.00); K72(0.00)  LDD0199  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
ATP probe
 Probe Info  		K77(0.00); K124(0.00)  LDD0035  [7]
1d-yne
 Probe Info  		N.A.  LDD0356  [8]
SF
 Probe Info  		N.A.  LDD0028  [9]
1c-yne
 Probe Info  		K65(0.00); K72(0.00); K124(0.00)  LDD0228  [8]
Acrolein
 Probe Info  		H54(0.00); H128(0.00)  LDD0217  [10]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [10]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
HHS-482
 Probe Info  		Y115(1.09); Y123(0.89); Y97(1.22)  LDD2239  [4]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C251
 Probe Info  		40.79  LDD1924  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H128(0.00); H137(0.00)  LDD0222  [10]
 LDCM0107  IAA HeLa H137(0.00); H128(0.00); H54(0.00)  LDD0221  [10]
 LDCM0109  NEM HeLa H137(0.00); H128(0.00); H54(0.00)  LDD0223  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase A (PPIA) Cyclophilin-type PPIase family P62937
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3) . Q7L622

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.