Details of the Target

General Information of Target

Target ID LDTP17811
Target Name Putative protein FAM10A5 (ST13P5)
Gene Name ST13P5
Synonyms
FAM10A5; Putative protein FAM10A5; Suppression of tumorigenicity 13 pseudogene 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAGQEKGYLTQTAAALDKSPSLSPQLAAPIRGRPKKCLVYPHAPKSSRLSRSVLRWLQ
GLDLSFFPRNINRDFSNGFLIAEIFCIYYPWELELSSFENGTSLKVKLDNWAQLEKFLAR
KKFKLPKELIHGTIHCKAGVPEILIEEVYTLLTHREIKSIQDDFVNFTDYSYQMRLPLVS
RSTVSKSIKDNIRLSELLSNPNMLTNELKAEFLILLHMLQRKLGRKLNPEWFDVKPTVGE
VTLNHLPAQASGRRYNLKVKRGRVVPVLPNIGSGGSSHREIHVKQAGQHSYYSAMKPIRN
MDKKP
Target Bioclass
Other
Family
FAM10 family
Subcellular location
Cytoplasm
Uniprot ID
Q8NFI4
HGNC ID
HGNC:18556

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y151(20.00)  LDD0260  [1]
TH214
 Probe Info  		Y213(20.00)  LDD0258  [1]
AZ-9
 Probe Info  		D135(0.92)  LDD2208  [2]
HHS-482
 Probe Info  		Y213(0.87)  LDD0285  [3]
HHS-475
 Probe Info  		Y185(0.67); Y151(0.91); Y213(1.04)  LDD0264  [4]
HHS-465
 Probe Info  		Y213(10.00)  LDD2237  [5]
Acrolein
 Probe Info  		N.A.  LDD0221  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0161  [7]
NAIA_5
 Probe Info  		N.A.  LDD2224  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y185(0.67); Y151(0.91); Y213(1.04)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y185(0.50); Y151(1.03); Y213(8.33)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y185(0.39); Y151(1.03); Y213(1.71)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y185(0.44); Y213(0.87)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y213(0.96); Y151(0.97)  LDD0268  [4]
 LDCM0107  IAA HeLa N.A.  LDD0221  [6]
 LDCM0123  JWB131 DM93 Y213(0.87)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y213(1.34)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y213(0.88)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y213(2.87)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y213(1.78)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y213(1.83)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y213(0.93)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y213(0.72)  LDD0292  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264