Details of the Target

General Information of Target

Target ID LDTP11260
Target Name Methylthioribose-1-phosphate isomerase (MRI1)
Gene Name MRI1
Gene ID 84245
Synonyms
MRDI; Methylthioribose-1-phosphate isomerase; M1Pi; MTR-1-P isomerase; EC 5.3.1.23; Mediator of RhoA-dependent invasion; S-methyl-5-thioribose-1-phosphate isomerase; Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGKGSSGRRPLLLGLLVAVATVHLVICPYTKVEESFNLQATHDLLYHWQDLEQYDHLEF
PGVVPRTFLGPVVIAVFSSPAVYVLSLLEMSKFYSQLIVRGVLGLGVIFGLWTLQKEVRR
HFGAMVATMFCWVTAMQFHLMFYCTRTLPNVLALPVVLLALAAWLRHEWARFIWLSAFAI
IVFRVELCLFLGLLLLLALGNRKVSVVRALRHAVPAGILCLGLTVAVDSYFWRQLTWPEG
KVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGLVDRRTHAPTVLALGFMA
LYSLLPHKELRFIIYAFPMLNITAARGCSYLLNNYKKSWLYKAGSLLVIGHLVVNAAYSA
TALYVSHFNYPGGVAMQRLHQLVPPQTDVLLHIDVAAAQTGVSRFLQVNSAWRYDKREDV
QPGTGMLAYTHILMEAAPGLLALYRDTHRVLASVVGTTGVSLNLTQLPPFNVHLQTKLVL
LERLPRPS
Target Bioclass
Enzyme
Family
EIF-2B alpha/beta/delta subunits family, MtnA subfamily
Subcellular location
Nucleus
Function
Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {|HAMAP-Rule:MF_03119}.
Uniprot ID
Q9BV20
Ensemble ID
ENST00000040663.8
HGNC ID
HGNC:28469

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.Q64H DBIA    Probe Info 
HCC1395 SNV: p.R138T DBIA    Probe Info 
SUPT1 SNV: p.P275S DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.24  LDD0402  [1]
TH214
 Probe Info  		Y205(11.19)  LDD0258  [2]
BTD
 Probe Info  		C199(1.04)  LDD2107  [3]
HHS-465
 Probe Info  		Y27(1.33)  LDD2237  [4]
DBIA
 Probe Info  		C168(0.97); C285(0.87)  LDD0078  [5]
5E-2FA
 Probe Info  		H196(0.00); H34(0.00)  LDD2235  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C199(0.00); C168(0.00); C285(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C285(0.00); C199(0.00); C168(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C285(0.00); C168(0.00); C199(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
TFBX
 Probe Info  		C128(0.00); C168(0.00); C285(0.00); C199(0.00)  LDD0148  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
1c-yne
 Probe Info  		K259(0.00); K293(0.00)  LDD0228  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
W1
 Probe Info  		R98(0.00); R101(0.00)  LDD0236  [13]
AOyne
 Probe Info  		6.10  LDD0443  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C127(0.90)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C127(1.28)  LDD0813  [5]
 LDCM0216  AC100 HEK-293T C168(0.78)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C168(0.75)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C168(0.76)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C168(0.85)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C168(0.88)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C168(1.43)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C168(0.81)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C168(0.71)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C168(0.73)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C168(0.86)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C127(1.29)  LDD0824  [5]
 LDCM0227  AC110 HEK-293T C168(1.07)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C168(0.79)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C168(0.87)  LDD0827  [5]
 LDCM0230  AC113 PaTu 8988t C168(0.70)  LDD1109  [5]
 LDCM0231  AC114 PaTu 8988t C168(0.79)  LDD1110  [5]
 LDCM0232  AC115 PaTu 8988t C168(0.68)  LDD1111  [5]
 LDCM0233  AC116 PaTu 8988t C168(0.76)  LDD1112  [5]
 LDCM0234  AC117 PaTu 8988t C168(0.84)  LDD1113  [5]
 LDCM0235  AC118 PaTu 8988t C168(0.86)  LDD1114  [5]
 LDCM0236  AC119 PaTu 8988t C168(0.91)  LDD1115  [5]
 LDCM0237  AC12 HEK-293T C127(1.50)  LDD0835  [5]
 LDCM0238  AC120 PaTu 8988t C168(0.65)  LDD1117  [5]
 LDCM0239  AC121 PaTu 8988t C168(0.71)  LDD1118  [5]
 LDCM0240  AC122 PaTu 8988t C168(0.82)  LDD1119  [5]
 LDCM0241  AC123 PaTu 8988t C168(1.25)  LDD1120  [5]
 LDCM0242  AC124 PaTu 8988t C168(1.02)  LDD1121  [5]
 LDCM0243  AC125 PaTu 8988t C168(1.15)  LDD1122  [5]
 LDCM0244  AC126 PaTu 8988t C168(1.14)  LDD1123  [5]
 LDCM0245  AC127 PaTu 8988t C168(0.85)  LDD1124  [5]
 LDCM0246  AC128 HEK-293T C127(1.23); C168(1.04)  LDD0844  [5]
 LDCM0247  AC129 HEK-293T C127(1.28); C168(1.09)  LDD0845  [5]
 LDCM0249  AC130 HEK-293T C127(1.11); C168(0.98)  LDD0847  [5]
 LDCM0250  AC131 HEK-293T C127(1.31); C168(1.04)  LDD0848  [5]
 LDCM0251  AC132 HEK-293T C127(1.39); C168(1.10)  LDD0849  [5]
 LDCM0252  AC133 HEK-293T C127(1.42); C168(0.88)  LDD0850  [5]
 LDCM0253  AC134 HEK-293T C127(1.13); C168(1.07)  LDD0851  [5]
 LDCM0254  AC135 HEK-293T C127(1.09); C168(0.96)  LDD0852  [5]
 LDCM0255  AC136 HEK-293T C127(1.50); C168(0.89)  LDD0853  [5]
 LDCM0256  AC137 HEK-293T C127(1.52); C168(0.97)  LDD0854  [5]
 LDCM0257  AC138 HEK-293T C127(2.17); C168(1.15)  LDD0855  [5]
 LDCM0258  AC139 HEK-293T C127(1.26); C168(1.16)  LDD0856  [5]
 LDCM0259  AC14 HEK-293T C127(1.30)  LDD0857  [5]
 LDCM0260  AC140 HEK-293T C127(1.74); C168(1.17)  LDD0858  [5]
 LDCM0261  AC141 HEK-293T C127(1.63); C168(1.07)  LDD0859  [5]
 LDCM0262  AC142 HEK-293T C127(1.57); C168(1.01)  LDD0860  [5]
 LDCM0263  AC143 HCT 116 C168(1.27)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C168(1.43)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C168(1.54)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C168(1.37)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C168(1.74)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C168(2.26)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C168(1.75)  LDD0586  [5]
 LDCM0270  AC15 HEK-293T C127(1.16)  LDD0868  [5]
 LDCM0271  AC150 HCT 116 C168(1.23)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C168(1.85)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C168(1.17)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C168(2.01)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C168(1.18)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C168(1.19)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C168(1.24)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C168(2.36)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C168(1.01)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C168(1.38)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C168(1.33)  LDD0595  [5]
 LDCM0279  AC2 HEK-293T C127(1.32)  LDD0877  [5]
 LDCM0280  AC20 HCT 116 C168(1.33)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C168(1.32)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C168(1.14)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C168(1.14)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C168(1.42)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C168(1.12)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C168(1.13)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C168(1.35)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C168(1.37)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C168(1.30)  LDD0606  [5]
 LDCM0290  AC3 HEK-293T C127(1.11)  LDD0888  [5]
 LDCM0291  AC30 HCT 116 C168(1.19)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C168(1.21)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C168(1.36)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C168(1.65)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C168(1.75)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C168(1.05)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C168(0.67)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C168(0.60)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C168(0.80)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C168(0.67)  LDD0617  [5]
 LDCM0301  AC4 HEK-293T C127(0.90)  LDD0899  [5]
 LDCM0302  AC40 HCT 116 C168(0.94)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C168(0.62)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C168(0.94)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C168(0.61)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C168(1.12)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C168(1.41)  LDD0624  [5]
 LDCM0308  AC46 HEK-293T C127(1.06); C168(1.00)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C127(0.92); C168(0.98)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C127(1.05); C168(1.00)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C127(1.11); C168(0.92)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C127(1.06)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C127(0.78); C168(0.88)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C127(1.12); C168(0.90)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C127(0.88); C168(0.95)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C127(1.19); C168(0.89)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C127(1.11); C168(1.13)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C127(0.99); C168(0.97)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C127(0.91); C168(1.01)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C168(0.91)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C168(1.33)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C168(0.86)  LDD0639  [5]
 LDCM0323  AC6 HEK-293T C127(0.83)  LDD0921  [5]
 LDCM0324  AC60 HCT 116 C168(1.11)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C168(0.94)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C168(1.16)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C168(1.32)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C168(1.42)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C168(0.99)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C168(1.24)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C168(1.01)  LDD0648  [5]
 LDCM0332  AC68 HEK-293T C127(1.06)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C127(1.21)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C127(1.24)  LDD0932  [5]
 LDCM0335  AC70 HEK-293T C127(1.25)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C127(1.15)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C127(1.22)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C127(1.25)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C127(1.40)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C127(0.98)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C127(1.25)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C127(1.35)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C127(1.18)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C127(1.10)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C127(1.05)  LDD0943  [5]
 LDCM0346  AC80 HEK-293T C127(1.13)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C127(1.05)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C127(1.51)  LDD0946  [5]
 LDCM0365  AC98 HEK-293T C168(0.84)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C168(0.91)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C127(1.12)  LDD0846  [5]
 LDCM0356  AKOS034007680 HEK-293T C127(1.37)  LDD0954  [5]
 LDCM0275  AKOS034007705 HEK-293T C127(1.25)  LDD0873  [5]
 LDCM0020  ARS-1620 HCC44 C168(0.97); C285(0.87)  LDD0078  [5]
 LDCM0108  Chloroacetamide HeLa C168(0.00); C127(0.00); C128(0.00)  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C199(1.29)  LDD2227  [15]
 LDCM0367  CL1 PaTu 8988t C127(0.67); C128(0.67)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C127(0.41); C128(0.41)  LDD1247  [5]
 LDCM0369  CL100 HEK-293T C127(1.14)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C127(0.91)  LDD0968  [5]
 LDCM0371  CL102 HEK-293T C127(0.89)  LDD0969  [5]
 LDCM0372  CL103 HEK-293T C127(0.87)  LDD0970  [5]
 LDCM0373  CL104 HEK-293T C127(0.93)  LDD0971  [5]
 LDCM0374  CL105 HCT 116 C168(0.88)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C168(1.51)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C168(1.36)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C168(1.61)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C168(1.25)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C127(0.47); C128(0.47)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C168(1.05)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C168(1.02)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C168(1.00)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C168(1.45)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C168(1.15)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C168(1.35)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C168(1.06)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C168(1.13)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C168(0.81)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C168(0.81)  LDD0706  [5]
 LDCM0390  CL12 PaTu 8988t C127(0.39); C128(0.39)  LDD1269  [5]
 LDCM0391  CL120 HCT 116 C168(0.67)  LDD0708  [5]
 LDCM0392  CL121 HEK-293T C127(1.03); C168(1.00)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C127(0.81); C168(0.89)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C127(0.64); C168(1.06)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C127(1.18); C168(1.02)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C168(0.81)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C168(1.11)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C168(1.17)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C168(1.09)  LDD0716  [5]
 LDCM0400  CL13 PaTu 8988t C127(0.45); C128(0.45)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C127(0.55); C128(0.55)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C127(0.71); C128(0.71)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C127(1.00); C128(1.00)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C127(1.01); C128(1.01)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C127(0.84); C128(0.84)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C127(0.97); C128(0.97)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C127(0.62); C128(0.62)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C127(0.88); C128(0.88)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C127(0.94); C128(0.94)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C127(1.03); C128(1.03)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C127(1.32); C128(1.32)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C127(1.18); C128(1.18)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C127(0.95); C128(0.95)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C127(0.99); C128(0.99)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C127(0.99); C128(0.99)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C127(0.99); C128(0.99)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C127(1.01); C128(1.01)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C127(0.72); C128(0.72)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C127(1.06); C128(1.06)  LDD1298  [5]
 LDCM0420  CL31 HEK-293T C168(1.04)  LDD1018  [5]
 LDCM0421  CL32 HEK-293T C168(0.88)  LDD1019  [5]
 LDCM0422  CL33 HEK-293T C168(1.45)  LDD1020  [5]
 LDCM0423  CL34 HEK-293T C168(1.13)  LDD1021  [5]
 LDCM0424  CL35 HEK-293T C168(1.27)  LDD1022  [5]
 LDCM0425  CL36 HEK-293T C168(1.29)  LDD1023  [5]
 LDCM0426  CL37 HEK-293T C168(1.01)  LDD1024  [5]
 LDCM0428  CL39 HEK-293T C168(0.90)  LDD1026  [5]
 LDCM0429  CL4 PaTu 8988t C127(0.78); C128(0.78)  LDD1308  [5]
 LDCM0430  CL40 HEK-293T C168(0.78)  LDD1028  [5]
 LDCM0431  CL41 HEK-293T C168(1.32)  LDD1029  [5]
 LDCM0432  CL42 HEK-293T C168(1.08)  LDD1030  [5]
 LDCM0433  CL43 HEK-293T C168(0.86)  LDD1031  [5]
 LDCM0434  CL44 HEK-293T C168(1.10)  LDD1032  [5]
 LDCM0435  CL45 HEK-293T C168(1.07)  LDD1033  [5]
 LDCM0436  CL46 HEK-293T C199(0.86); C285(0.88); C168(0.88); C127(0.98)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C199(0.92); C285(0.87); C168(0.94); C127(0.95)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C199(0.79); C285(0.78); C168(1.10); C127(1.18)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C199(0.96); C285(0.96); C168(1.02); C127(0.83)  LDD1643  [17]
 LDCM0440  CL5 PaTu 8988t C127(0.69); C128(0.69)  LDD1319  [5]
 LDCM0441  CL50 HEK-293T C199(1.00); C285(0.99); C168(0.94); C127(0.84)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C199(0.99); C285(0.99); C168(1.02); C127(0.88)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C199(1.03); C285(0.69); C168(0.91); C127(1.05)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C199(1.08); C285(0.81); C168(0.96); C127(0.87)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C199(1.00); C285(0.99); C168(0.87); C127(1.03)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C199(0.66); C285(0.83); C168(1.00); C127(0.91)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C199(0.83); C285(0.93); C168(0.96); C127(0.81)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C199(0.68); C285(0.92); C168(1.07); C127(1.02)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C199(0.94); C285(0.82); C168(0.95); C127(0.87)  LDD1653  [17]
 LDCM0451  CL6 PaTu 8988t C127(0.69); C128(0.69)  LDD1330  [5]
 LDCM0452  CL60 HEK-293T C199(0.73); C285(0.78); C168(1.05); C127(0.94)  LDD1655  [17]
 LDCM0453  CL61 HCT 116 C168(1.09)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C168(1.13)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C168(1.30)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C168(1.22)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C168(1.08)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C168(1.07)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C168(1.32)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C168(1.27)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C168(1.28)  LDD0778  [5]
 LDCM0462  CL7 PaTu 8988t C127(0.58); C128(0.58)  LDD1341  [5]
 LDCM0463  CL70 HCT 116 C168(1.07)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C168(1.19)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C168(1.29)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C168(1.34)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C168(1.31)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C168(0.91)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C168(0.96)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C168(0.98)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C168(1.02)  LDD0789  [5]
 LDCM0473  CL8 PaTu 8988t C127(0.58); C128(0.58)  LDD1352  [5]
 LDCM0474  CL80 HCT 116 C168(0.89)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C168(0.90)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C168(0.88)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C168(0.88)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C168(0.76)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C168(0.79)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C168(0.85)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C168(0.89)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C168(0.97)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C168(0.84)  LDD0800  [5]
 LDCM0484  CL9 PaTu 8988t C127(0.57); C128(0.57)  LDD1363  [5]
 LDCM0485  CL90 HCT 116 C168(0.77)  LDD0802  [5]
 LDCM0486  CL91 HEK-293T C127(0.71)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C127(0.81)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C127(1.04)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C127(1.13)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C127(1.27)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C127(0.85)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C127(0.99)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C127(0.94)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C127(0.88)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C199(1.03); C285(1.06); C168(1.03); C127(0.85)  LDD1698  [17]
 LDCM0625  F8 Ramos C199(1.81); C168(0.73)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C199(0.33)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C199(0.59); C168(0.24)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C199(0.31)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C199(0.64)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C199(1.16); C168(0.98)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C199(0.41)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C199(0.87)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C199(0.31)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C199(1.73); C168(1.23)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C199(0.38); C168(1.63)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C199(0.91); C168(0.19)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C199(0.47); C168(0.50)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C199(0.21); C168(1.03)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C168(1.17)  LDD0785  [5]
 LDCM0596  Fragment38 Ramos C199(0.81); C168(0.47)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C199(1.09); C168(0.35)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C168(0.95)  LDD1025  [5]
 LDCM0610  Fragment52 Ramos C199(0.62); C168(0.24)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C199(0.51); C168(0.14)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C199(0.92); C168(0.24)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C199(0.32)  LDD2188  [18]
 LDCM0022  KB02 HCT 116 C168(1.30); C127(1.13)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C168(1.59); C127(1.16)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C168(1.34); C127(1.18)  LDD0082  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C199(1.04)  LDD2107  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C168(1.14); C199(0.89); C168(0.49)  LDD2206  [19]
 LDCM0628  OTUB2-COV-1 HEK-293T C199(1.00); C168(0.66); C168(0.44)  LDD2207  [19]
 LDCM0131  RA190 MM1.R C168(0.90)  LDD0304  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Methylthioribose-1-phosphate isomerase (MRI1) EIF-2B alpha/beta/delta subunits family Q9BV20
Caspase-6 (CASP6) Peptidase C14A family P55212
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctional adhesion molecule A (F11R) Immunoglobulin superfamily Q9Y624
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 6 (COG6) COG6 family Q9Y2V7
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.