Details of the Target

General Information of Target

Target ID LDTP10147
Target Name Autophagy-related protein 2 homolog B (ATG2B)
Gene Name ATG2B
Gene ID 55102
Synonyms
C14orf103; Autophagy-related protein 2 homolog B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGERTRRFTRSLLRPGQAAELRHSAASAAAVAVSSRQQQRQEKPRLLEPLDYETVIEEL
EKTYRNDPLQDLLFFPSDDFSAATVSWDIRTLYSTVPEDAEHKAENLLVKEACKFYSSQW
HVVNYKYEQYSGDIRQLPRAEYKPEKLPSHSFEIDHEDADKDEDTTSHSSSKGGGGAGGT
GVFKSGWLYKGNFNSTVNNTVTVRSFKKRYFQLTQLPDNSYIMNFYKDEKISKEPKGCIF
LDSCTGVVQNNRLRKYAFELKMNDLTYFVLAAETESDMDEWIHTLNRILQISPEGPLQGR
RSTELTDLGLDSLDNSVTCECTPEETDSSENNLHADFAKYLTETEDTVKTTRNMERLNLF
SLDPDIDTLKLQKKDLLEPESVIKPFEEKAAKRIMIICKALNSNLQGCVTENENDPITNI
EPFFVSVALYDLRDSRKISADFHVDLNHAAVRQMLLGASVALENGNIDTITPRQSEEPHI
KGLPEEWLKFPKQAVFSVSNPHSEIVLVAKIEKVLMGNIASGAEPYIKNPDSNKYAQKIL
KSNRQFCSKLGKYRMPFAWAVRSVFKDNQGNVDRDSRFSPLFRQESSKISTEDLVKLVSD
YRRADRISKMQTIPGSLDIAVDNVPLEHPNCVTSSFIPVKPFNMMAQTEPTVEVEEFVYD
STKYCRPYRVYKNQIYIYPKHLKYDSQKCFNKARNITVCIEFKNSDEESAKPLKCIYGKP
GGPLFTSAAYTAVLHHSQNPDFSDEVKIELPTQLHEKHHILFSFYHVTCDINAKANAKKK
EALETSVGYAWLPLMKHDQIASQEYNIPIATSLPPNYLSFQDSASGKHGGSDIKWVDGGK
PLFKVSTFVVSTVNTQDPHVNAFFQECQKREKDMSQSPTSNFIRSCKNLLNVEKIHAIMS
FLPIILNQLFKVLVQNEEDEITTTVTRVLTDIVAKCHEEQLDHSVQSYIKFVFKTRACKE
RTVHEELAKNVTGLLKSNDSTTVKHVLKHSWFFFAIILKSMAQHLIDTNKIQLPRPQRFP
ESYQNELDNLVMVLSDHVIWKYKDALEETRRANHSVARFLKRCFTFMDRGYVFKMVNNYI
SMFSSGDLKTLCQYKFDFLQEVCQHEHFIPLCLPIRSANIPDPLTPSESTQELHASDMPE
YSVTNEFCRKHFLIGILLREVGFALQEDQDVRHLALAVLKNLMAKHSFDDRYREPRKQAQ
IASLYMPLYGMLLDNMPRIYLKDLYPFTVNTSNQGSRDDLSTNGGFQSQTAIKHANSVDT
SFSKDVLNSIAAFSSIAISTVNHADSRASLASLDSNPSTNEKSSEKTDNCEKIPRPLSLI
GSTLRFDKLDQAETRSLLMCFLHIMKTISYETLIAYWQRAPSPEVSDFFSILDVCLQNFR
YLGKRNIIRKIAAAFKFVQSTQNNGTLKGSNPSCQTSGLLSQWMHSTSSHEGHKQHRSQT
LPIIRGKNALSNPKLLQMLDNTMTSNSNEIDIVHHVDTEANIATEVCLTILDLLSLFTQT
HQRQLQQCDCQNSLMKRVFDTYMLFFQVNQSATALKHVFASLRLFVCKFPSAFFQGPADL
CGSFCYEVLKCCNHRSRSTQTEASALLYFFMRKNFEFNKQKSIVRSHLQLIKAVSQLIAD
AGIGGSRFQHSLAITNNFANGDKQMKNSNFPAEVKDLTKRIRTVLMATAQMKEHEKDPEM
LVDLQYSLANSYASTPELRRTWLESMAKIHARNGDLSEAAMCYIHIAALIAEYLKRKGYW
KVEKICTASLLSEDTHPCDSNSLLTTPSGGSMFSMGWPAFLSITPNIKEEGAMKEDSGMQ
DTPYNENILVEQLYMCVEFLWKSERYELIADVNKPIIAVFEKQRDFKKLSDLYYDIHRSY
LKVAEVVNSEKRLFGRYYRVAFYGQGFFEEEEGKEYIYKEPKLTGLSEISQRLLKLYADK
FGADNVKIIQDSNKVNPKDLDPKYAYIQVTYVTPFFEEKEIEDRKTDFEMHHNINRFVFE
TPFTLSGKKHGGVAEQCKRRTILTTSHLFPYVKKRIQVISQSSTELNPIEVAIDEMSKKV
SELNQLCTMEEVDMIRLQLKLQGSVSVKVNAGPMAYARAFLEETNAKKYPDNQVKLLKEI
FRQFADACGQALDVNERLIKEDQLEYQEELRSHYKDMLSELSTVMNEQITGRDDLSKRGV
DQTCTRVISKATPALPTVSISSSAEV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
ATG2 family
Subcellular location
Preautophagosomal structure membrane
Function
Lipid transfer protein required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion. Lipid transfer activity is enhanced by WDR45/WIPI4, which promotes ATG2B-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes.
TTD ID
T40299
Uniprot ID
Q96BY7
DrugMap ID
TTG6KCU
Ensemble ID
ENST00000359933.6
HGNC ID
HGNC:20187

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.23  LDD0402  [1]
TH211
 Probe Info  		Y649(19.90)  LDD0257  [2]
TH214
 Probe Info  		Y649(17.81)  LDD0258  [2]
TH216
 Probe Info  		Y197(20.00)  LDD0259  [2]
Probe 1
 Probe Info  		Y2012(4.43)  LDD3495  [3]
BTD
 Probe Info  		C1698(1.82)  LDD2118  [4]
AHL-Pu-1
 Probe Info  		C1750(2.53)  LDD0169  [5]
DBIA
 Probe Info  		C1667(1.19)  LDD0078  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
IPM
 Probe Info  		C1597(0.00); C1750(0.00)  LDD0005  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Methacrolein
 Probe Info  		N.A.  LDD0218  [10]
AOyne
 Probe Info  		13.50  LDD0443  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C1750(2.53)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C1597(0.97)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C1597(1.44)  LDD0532  [6]
 LDCM0216  AC100 HEK-293T C1597(0.96); C1667(0.88); C1688(0.95); C1750(1.16)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C1597(0.88); C1667(0.67); C1688(0.99); C1750(0.96)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C1597(1.03); C1667(0.69); C1688(1.12); C1750(1.16)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C1597(0.89); C1667(0.85); C1688(0.91); C1750(1.23)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C1597(0.99); C1667(0.99); C1688(0.84); C1750(1.30)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C1597(1.08); C1667(0.78); C1688(0.85); C1750(1.04)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C1597(1.11); C1667(0.67); C1688(0.77); C1750(0.94)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C1597(1.29); C1667(0.70); C1688(1.11); C1750(1.16)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C1597(1.26); C1667(0.75); C1688(0.75); C1750(0.99)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C1597(1.27); C1667(0.77); C1688(0.87); C1750(1.08)  LDD0823  [6]
 LDCM0226  AC11 HCT 116 C1597(1.21)  LDD0543  [6]
 LDCM0227  AC110 HEK-293T C1597(1.16); C1667(0.68); C1688(0.95); C1750(1.51)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C1597(1.23); C1667(0.79); C1688(0.94); C1750(1.96)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C1597(1.26); C1667(0.77); C1688(1.04); C1750(1.59)  LDD0827  [6]
 LDCM0230  AC113 HCT 116 C1667(0.92)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C1667(1.17)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C1667(1.27)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C1667(1.23)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C1667(1.06)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C1667(1.01)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C1667(1.05)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C1597(1.01)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C1667(1.31)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C1667(0.85)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C1667(0.92)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C1667(0.93)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C1667(1.09)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C1667(1.04)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C1667(1.19)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C1667(1.19)  LDD0562  [6]
 LDCM0246  AC128 HEK-293T C1597(1.11); C1688(1.15); C1750(0.97)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C1597(1.20); C1688(1.19); C1750(1.23)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C1597(0.84); C1688(0.97); C1750(1.07)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C1597(1.01); C1688(0.98); C1750(0.99)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C1597(1.04); C1688(1.44); C1750(1.33)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C1597(0.85); C1688(1.14); C1750(1.16)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C1597(0.99); C1688(1.09); C1750(1.11)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C1597(1.06); C1688(1.16); C1750(1.25)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C1597(1.10); C1688(1.17); C1750(1.30)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C1597(1.13); C1688(0.92); C1750(1.36)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C1597(1.18); C1688(1.17); C1750(1.40)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C1597(1.22); C1688(1.09); C1750(1.70)  LDD0856  [6]
 LDCM0259  AC14 HCT 116 C1597(1.18)  LDD0576  [6]
 LDCM0260  AC140 HEK-293T C1597(1.49); C1688(1.21); C1750(1.18)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C1597(1.17); C1688(1.05); C1750(1.44)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C1597(1.21); C1688(1.21); C1750(1.29)  LDD0860  [6]
 LDCM0263  AC143 HCT 116 C1597(1.45)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C1597(2.03)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C1597(1.74)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C1597(1.61)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C1597(1.87)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C1597(3.38)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C1597(2.14)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C1597(1.14)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C1597(1.45)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C1597(1.64)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C1597(2.36)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C1597(2.98)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C1597(1.31)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C1597(1.44)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C1597(1.35)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C1597(1.27)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C1597(1.22)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C1597(1.21)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C1597(1.04)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C1597(1.13)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C1597(1.15)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C1597(1.06)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C1597(1.09)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C1597(0.96)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C1597(1.00)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C1597(0.95); C1667(1.05)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C1597(1.08); C1667(1.15)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C1597(0.99); C1667(1.35)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C1597(1.16); C1667(1.33)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C1597(1.19); C1667(1.24)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C1597(1.03)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C1597(1.28); C1667(1.32)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C1597(1.11); C1667(1.28)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C1597(1.36); C1667(1.48)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C1597(1.40); C1667(1.45)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C1597(1.24); C1667(1.65)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C1597(0.73); C1667(0.96)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C1597(0.79); C1667(0.82)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C1597(0.81); C1667(0.87)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C1667(0.91); C1597(1.00)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C1597(0.90); C1667(0.99)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C1597(1.35)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C1597(0.77); C1667(1.15)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C1597(0.82); C1667(0.90)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C1667(1.07); C1597(1.12)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C1597(0.89); C1667(1.08)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C1597(0.93); C1667(1.01)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C1667(1.13); C1597(1.14)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C1667(1.13); C1750(0.87)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C1667(1.12); C1750(1.32)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C1667(1.19); C1750(1.31)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C1667(1.07); C1750(0.94)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C1597(1.47)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C1667(1.11); C1750(1.37)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C1667(1.11); C1750(1.52)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C1667(1.27); C1750(1.22)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C1667(1.18); C1750(1.17)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C1667(1.43); C1750(1.28)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C1667(1.45); C1750(1.35)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C1667(1.09); C1750(1.09)  LDD0917  [6]
 LDCM0320  AC57 HCT 116 C1597(1.55)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C1597(1.14)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C1597(2.05)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C1597(1.40)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C1597(1.98)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C1597(1.49)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C1597(1.45)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C1597(1.33)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C1597(1.80)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C1597(1.87)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C1597(1.56)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C1597(1.52)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C1667(1.04); C1597(2.15)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C1667(0.95); C1597(1.61)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C1597(1.05)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C1667(0.85); C1597(3.22)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C1667(0.97); C1597(1.17)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C1667(0.96); C1597(1.75)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C1667(0.96); C1597(2.59)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C1667(1.05); C1597(3.82)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C1667(1.13); C1597(3.68)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C1667(0.92); C1597(2.13)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C1667(1.12); C1597(2.16)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C1667(1.03); C1597(1.59)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C1667(1.01); C1597(2.44)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C1597(1.10)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C1667(1.09); C1597(1.97)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C1667(1.02); C1597(2.06)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C1667(0.92); C1597(3.50)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C1597(1.22); C1667(2.39)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C1597(1.32); C1667(2.08)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C1597(0.87); C1667(1.46)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C1597(1.09); C1667(1.34)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C1667(1.09); C1597(1.19)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C1597(0.92); C1667(1.17)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C1597(0.92); C1667(1.65)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C1597(0.73); C1667(0.92)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C1597(1.40); C1667(1.95)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C1597(1.21); C1667(1.82)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C1597(0.94); C1667(1.37)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C1597(0.89); C1667(1.37)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C1597(0.87); C1667(1.25)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C1597(1.14); C1667(1.66)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C1597(0.99); C1667(1.84)  LDD0681  [6]
 LDCM0365  AC98 HEK-293T C1597(0.91); C1667(0.73); C1688(0.80); C1750(1.03)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C1597(1.15); C1667(0.81); C1688(0.83); C1750(0.86)  LDD0964  [6]
 LDCM0248  AKOS034007472 HCT 116 C1597(1.05)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C1597(1.29)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C1597(1.69)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.81  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1667(1.19)  LDD0078  [6]
 LDCM0367  CL1 HCT 116 C1597(0.90); C1667(1.06)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C1597(0.63); C1667(1.24)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C1597(1.10)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C1597(1.46)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C1597(1.04)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C1597(1.00)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C1597(1.21)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C1597(1.40)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C1597(1.29)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C1597(1.51)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C1597(1.40)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C1597(1.28)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C1597(0.76); C1667(1.18)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C1597(1.40)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C1597(1.10)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C1597(1.01); C1667(1.16)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C1597(1.09); C1667(1.42)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C1667(1.11); C1597(1.36)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C1667(1.24); C1597(1.30)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C1667(1.21); C1597(1.25)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C1597(1.32); C1667(1.44)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C1667(1.00); C1597(1.11)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C1597(1.12); C1667(1.16)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C1597(0.58); C1667(1.10)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C1667(0.84); C1597(0.93)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C1667(1.38); C1750(1.55)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C1667(1.24); C1750(1.13)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C1667(1.68); C1750(1.39)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C1667(1.02); C1750(1.47)  LDD0993  [6]
 LDCM0396  CL125 HCT 116 C1597(1.02)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C1597(0.78)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C1597(1.09)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C1597(1.30)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C1597(0.63); C1667(1.03)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C1597(0.60); C1667(1.07)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C1597(0.83); C1667(1.06)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C1667(0.95); C1688(1.10)  LDD1001  [6]
 LDCM0404  CL17 HCT 116 C1667(1.00)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C1667(0.87)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C1667(1.02)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C1597(0.88); C1667(0.88)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C1667(1.20)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C1667(0.98)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C1667(1.41)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C1667(1.04)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C1667(1.06)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C1667(1.09)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C1667(1.01)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C1667(1.05)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C1667(0.94)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C1667(1.13)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C1597(0.72); C1667(0.85)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C1667(1.19)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C1667(1.00)  LDD0737  [6]
 LDCM0421  CL32 HEK-293T C1667(1.15); C1750(1.05)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C1667(1.60); C1750(2.77)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C1667(1.20); C1750(1.30)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C1667(1.19); C1750(1.24)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C1667(1.13); C1750(1.24)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C1667(1.13); C1750(1.12)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C1667(1.48); C1750(2.03)  LDD1026  [6]
 LDCM0429  CL4 HCT 116 C1597(0.93); C1667(1.52)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C1667(1.15); C1750(1.25)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C1667(1.26); C1750(1.94)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C1667(1.09); C1750(1.48)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C1667(1.13); C1750(1.42)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C1667(1.13); C1750(1.11)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C1667(1.15); C1750(2.27)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C1597(0.73); C1667(0.96); C1698(1.64); C1750(1.44)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C1597(0.99); C1667(1.04); C1698(1.56); C1750(1.07)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C1597(0.90); C1667(0.89); C1698(0.72); C1750(0.92)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C1597(0.80); C1667(0.95); C1698(1.02); C1750(1.08)  LDD1037  [6]
 LDCM0440  CL5 HCT 116 C1597(0.86); C1667(0.83)  LDD0757  [6]
 LDCM0441  CL50 HEK-293T C1597(0.70); C1667(0.96); C1698(2.43); C1750(1.69)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C1597(0.96); C1667(1.17); C1698(2.40); C1750(1.47)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C1597(1.17); C1667(0.91); C1698(0.66); C1750(0.96)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C1597(1.34); C1667(1.08); C1698(1.14); C1750(1.68)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C1597(0.87); C1667(1.32); C1698(1.26); C1750(1.49)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C1597(0.88); C1667(1.12); C1698(1.25); C1750(1.09)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C1597(1.00); C1667(1.30); C1698(0.75); C1750(1.43)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C1597(1.01); C1667(1.20); C1698(1.66); C1750(3.23)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C1597(1.05); C1667(0.97); C1698(1.57); C1750(1.37)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C1597(0.92); C1667(1.02); C1698(1.41); C1750(1.32)  LDD1048  [6]
 LDCM0451  CL6 HCT 116 C1597(0.63); C1667(0.96)  LDD0768  [6]
 LDCM0452  CL60 HEK-293T C1597(0.88); C1667(1.02); C1698(1.86); C1750(1.19)  LDD1050  [6]
 LDCM0453  CL61 HCT 116 C1597(1.13); C1667(0.98)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C1597(1.30); C1667(0.93)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C1597(1.16); C1667(1.02)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C1597(1.39); C1667(0.96)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C1597(1.16); C1667(0.93)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C1597(1.53); C1667(0.91)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C1597(1.34); C1667(1.01)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C1597(1.43); C1667(1.38)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C1597(1.22); C1667(1.12)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C1597(0.76); C1667(0.89)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C1597(1.11); C1667(1.01)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C1597(1.21); C1667(1.08)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C1597(1.18); C1667(1.25)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C1597(1.19); C1667(1.08)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C1597(1.46); C1667(1.07)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C1597(1.17); C1667(1.08)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C1597(1.14); C1667(1.24)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C1597(1.01); C1667(0.96)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C1597(1.28); C1667(0.89)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C1597(0.80); C1667(0.74)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C1597(0.88); C1667(0.96)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C1597(1.04); C1667(1.00)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C1597(1.72); C1667(0.94)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C1597(1.29); C1667(0.95)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C1597(1.57); C1667(1.06)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C1597(0.99); C1667(1.09)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C1597(1.23); C1667(0.98)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C1597(1.38); C1667(0.86)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C1597(1.19); C1667(0.80)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C1597(1.80); C1667(0.99)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C1597(0.74); C1667(0.96)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C1597(0.99); C1667(1.32)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C1597(1.50)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C1597(1.49)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C1597(1.45)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C1597(1.19)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C1597(1.53)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C1597(1.17)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C1597(0.92)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C1597(2.02)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C1597(1.68)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C1597(1.03); C1688(0.92); C1750(1.03); C243(1.00)  LDD1698  [12]
 LDCM0625  F8 Ramos C1750(0.35)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C1750(2.28)  LDD2189  [13]
 LDCM0574  Fragment12 Ramos C1750(3.81)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C1750(0.99)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C1750(0.31)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C1750(4.07)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C1750(1.32)  LDD2195  [13]
 LDCM0578  Fragment27 Ramos C1750(1.23)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C1750(0.79)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C1750(3.52)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C1750(1.71)  LDD2200  [13]
 LDCM0468  Fragment33 HCT 116 C1597(1.12); C1667(1.04)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C1750(1.24)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C1750(1.24)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C1667(1.01); C1750(1.23)  LDD1025  [6]
 LDCM0610  Fragment52 Ramos C1750(1.19)  LDD2204  [13]
 LDCM0569  Fragment7 Ramos C1750(1.03)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C1750(2.70)  LDD2188  [13]
 LDCM0022  KB02 HCT 116 C1597(2.46); C1667(1.97)  LDD0080  [6]
 LDCM0023  KB03 HCT 116 C1597(1.40); C1667(1.38)  LDD0081  [6]
 LDCM0024  KB05 HCT 116 C1597(2.14); C1667(1.46)  LDD0082  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C1698(1.82)  LDD2118  [4]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578