Details of the Target

General Information of Target

Target ID LDTP13841
Target Name Protein canopy homolog 2 (CNPY2)
Gene Name CNPY2
Gene ID 10330
Synonyms
MSAP; TMEM4; ZSIG9; Protein canopy homolog 2; MIR-interacting saposin-like protein; Putative secreted protein Zsig9; Transmembrane protein 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKYLRHRRPNATLILAIGAFTLLLFSLLVSPPTCKVQEQPPAIPEALAWPTPPTRPAPAP
CHANTSMVTHPDFATQPQHVQNFLLYRHCRHFPLLQDVPPSKCAQPVFLLLVIKSSPSNY
VRRELLRRTWGRERKVRGLQLRLLFLVGTASNPHEARKVNRLLELEAQTHGDILQWDFHD
SFFNLTLKQVLFLQWQETRCANASFVLNGDDDVFAHTDNMVFYLQDHDPGRHLFVGQLIQ
NVGPIRAFWSKYYVPEVVTQNERYPPYCGGGGFLLSRFTAAALRRAAHVLDIFPIDDVFL
GMCLELEGLKPASHSGIRTSGVRAPSQRLSSFDPCFYRDLLLVHRFLPYEMLLMWDALNQ
PNLTCGNQTQIY
Target Bioclass
Other
Family
Canopy family
Subcellular location
Endoplasmic reticulum
Function Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.
Uniprot ID
Q9Y2B0
Ensemble ID
ENST00000273308.9
HGNC ID
HGNC:13529

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.Q44E .
NCIH358 SNV: p.S115C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.94  LDD0318  [1]
TH211
 Probe Info  		Y92(5.28)  LDD0260  [2]
TH214
 Probe Info  		Y92(10.36)  LDD0258  [2]
Probe 1
 Probe Info  		Y71(10.03)  LDD3495  [3]
m-APA
 Probe Info  		13.73  LDD0403  [4]
BTD
 Probe Info  		C31(0.95)  LDD2097  [5]
DBIA
 Probe Info  		C28(1.45)  LDD0531  [6]
5E-2FA
 Probe Info  		H101(0.00); H77(0.00); H27(0.00)  LDD2235  [7]
ATP probe
 Probe Info  		K49(0.00); K90(0.00)  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C137(0.00); C86(0.00)  LDD0037  [9]
TFBX
 Probe Info  		C28(0.00); C31(0.00)  LDD0027  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [13]
1d-yne
 Probe Info  		N.A.  LDD0357  [14]
Acrolein
 Probe Info  		H101(0.00); H77(0.00); H179(0.00); C31(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		H27(0.00); C28(0.00); C31(0.00)  LDD0219  [15]
Methacrolein
 Probe Info  		C28(0.00); H27(0.00); C31(0.00); C171(0.00)  LDD0218  [15]
NAIA_5
 Probe Info  		C164(0.00); C137(0.00); C171(0.00); C86(0.00)  LDD2223  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C28(1.45)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C28(0.81); C31(0.81)  LDD0813  [6]
 LDCM0216  AC100 HEK-293T C28(0.93); C31(0.93)  LDD0814  [6]
 LDCM0217  AC101 HEK-293T C28(1.16); C31(1.16)  LDD0815  [6]
 LDCM0218  AC102 HEK-293T C28(1.20); C31(1.20)  LDD0816  [6]
 LDCM0219  AC103 HEK-293T C28(1.00); C31(1.00)  LDD0817  [6]
 LDCM0220  AC104 HEK-293T C28(0.91); C31(0.91)  LDD0818  [6]
 LDCM0221  AC105 HEK-293T C28(0.97); C31(0.97)  LDD0819  [6]
 LDCM0222  AC106 HEK-293T C28(1.18); C31(1.18)  LDD0820  [6]
 LDCM0223  AC107 HEK-293T C28(0.94); C31(0.94)  LDD0821  [6]
 LDCM0224  AC108 HEK-293T C28(1.19); C31(1.19)  LDD0822  [6]
 LDCM0225  AC109 HEK-293T C28(1.29); C31(1.29)  LDD0823  [6]
 LDCM0226  AC11 HEK-293T C28(0.87); C31(0.87)  LDD0824  [6]
 LDCM0227  AC110 HEK-293T C28(0.96); C31(0.96)  LDD0825  [6]
 LDCM0228  AC111 HEK-293T C28(1.29); C31(1.29)  LDD0826  [6]
 LDCM0229  AC112 HEK-293T C28(1.52); C31(1.52)  LDD0827  [6]
 LDCM0237  AC12 HEK-293T C28(0.88); C31(0.88)  LDD0835  [6]
 LDCM0259  AC14 HEK-293T C28(1.04); C31(1.04)  LDD0857  [6]
 LDCM0270  AC15 HEK-293T C28(1.04); C31(1.04)  LDD0868  [6]
 LDCM0276  AC17 HEK-293T C171(1.05); C31(0.86)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C171(0.93); C137(1.15); C31(1.09); C28(1.01)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C171(1.16); C86(0.93); C31(0.85)  LDD1517  [17]
 LDCM0279  AC2 HCT 116 C28(1.49)  LDD0596  [6]
 LDCM0280  AC20 HEK-293T C171(0.97); C31(0.90)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C171(1.03); C31(1.01)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C171(1.08); C137(0.78); C31(0.82)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C171(0.98); C137(1.16); C31(0.89)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C171(0.92); C31(0.94)  LDD1523  [17]
 LDCM0285  AC25 HCT 116 C28(0.70)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C28(0.52)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C28(0.70)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C28(0.54)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C28(0.95)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C28(1.30)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C28(0.96)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C28(0.56)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C28(0.88)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C28(0.83)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C28(1.37)  LDD0612  [6]
 LDCM0296  AC35 HEK-293T C28(0.83); C31(0.83)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C28(0.83); C31(0.83)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C28(1.13); C31(1.13)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C28(0.96); C31(0.96)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C28(0.88); C31(0.88)  LDD0898  [6]
 LDCM0301  AC4 HCT 116 C28(1.44)  LDD0618  [6]
 LDCM0302  AC40 HEK-293T C28(1.31); C31(1.31)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C28(0.94); C31(0.94)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C28(0.80); C31(0.80)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C28(0.94); C31(0.94)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C28(1.06); C31(1.06)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C28(0.95); C31(0.95)  LDD0905  [6]
 LDCM0308  AC46 HEK-293T C28(1.35); C31(1.35)  LDD0906  [6]
 LDCM0309  AC47 HEK-293T C28(1.10); C31(1.10)  LDD0907  [6]
 LDCM0310  AC48 HEK-293T C28(1.58); C31(1.58)  LDD0908  [6]
 LDCM0311  AC49 HEK-293T C28(1.22); C31(1.22)  LDD0909  [6]
 LDCM0312  AC5 HCT 116 C28(1.56)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C28(1.18); C31(1.18)  LDD0911  [6]
 LDCM0314  AC51 HEK-293T C28(1.31); C31(1.31)  LDD0912  [6]
 LDCM0315  AC52 HEK-293T C28(1.21); C31(1.21)  LDD0913  [6]
 LDCM0316  AC53 HEK-293T C28(1.27); C31(1.27)  LDD0914  [6]
 LDCM0317  AC54 HEK-293T C28(1.47); C31(1.47)  LDD0915  [6]
 LDCM0318  AC55 HEK-293T C28(1.43); C31(1.43)  LDD0916  [6]
 LDCM0319  AC56 HEK-293T C28(1.28); C31(1.28)  LDD0917  [6]
 LDCM0320  AC57 HEK-293T C171(0.96); C31(0.81)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C171(0.91); C137(0.75); C31(0.93); C28(1.01)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C171(0.92); C86(0.99); C31(0.89)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C28(0.83); C31(0.83)  LDD0921  [6]
 LDCM0324  AC60 HEK-293T C171(0.96); C31(0.83)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C171(0.92); C31(0.86)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C171(1.05); C137(0.92); C31(0.87)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C171(0.93); C137(1.15); C31(0.86)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C171(0.88); C31(0.91)  LDD1567  [17]
 LDCM0332  AC68 HCT 116 C28(1.02)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C28(0.89)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C28(1.04); C31(1.04)  LDD0932  [6]
 LDCM0335  AC70 HCT 116 C28(0.85)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C28(0.92)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C28(0.86)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C28(1.05)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C28(1.09)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C28(1.03)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C28(0.88)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C28(1.04)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C28(0.95)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C28(0.93)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C28(0.72); C31(0.72)  LDD0943  [6]
 LDCM0346  AC80 HCT 116 C28(1.06)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C28(0.72)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C28(0.99)  LDD0665  [6]
 LDCM0365  AC98 HEK-293T C28(1.08); C31(1.08)  LDD0963  [6]
 LDCM0366  AC99 HEK-293T C28(0.98); C31(0.98)  LDD0964  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C31(0.90); C28(0.94)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C28(1.07); C31(1.07)  LDD0846  [6]
 LDCM0356  AKOS034007680 HEK-293T C28(1.05); C31(1.05)  LDD0954  [6]
 LDCM0275  AKOS034007705 HEK-293T C28(0.90); C31(0.90)  LDD0873  [6]
 LDCM0156  Aniline NCI-H1299 13.73  LDD0403  [4]
 LDCM0020  ARS-1620 HCC44 C28(1.19); C31(1.19)  LDD2171  [6]
 LDCM0108  Chloroacetamide HeLa C86(0.00); C171(0.00); C28(0.00); C31(0.00)  LDD0222  [15]
 LDCM0367  CL1 HCT 116 C28(0.87)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C28(1.37)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C28(0.96)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C28(0.80); C31(0.80)  LDD0968  [6]
 LDCM0371  CL102 HEK-293T C28(0.81); C31(0.81)  LDD0969  [6]
 LDCM0372  CL103 HEK-293T C28(0.96); C31(0.96)  LDD0970  [6]
 LDCM0373  CL104 HEK-293T C28(1.08); C31(1.08)  LDD0971  [6]
 LDCM0374  CL105 HEK-293T C171(1.04); C31(0.89)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C171(1.05); C86(0.96); C31(0.95)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C171(1.08); C31(0.92)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C171(1.05); C31(0.95)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C171(0.94); C31(0.97)  LDD1582  [17]
 LDCM0379  CL11 HCT 116 C28(0.92)  LDD0696  [6]
 LDCM0380  CL110 HEK-293T C171(1.02); C86(0.91); C31(0.96)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C171(0.99); C31(1.03)  LDD1585  [17]
 LDCM0382  CL112 HCT 116 C28(0.75)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C28(0.91)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C28(1.34)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C28(1.27)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C28(0.97)  LDD0703  [6]
 LDCM0387  CL117 HEK-293T C28(1.07); C31(1.07)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C28(0.98); C31(0.98)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C28(1.18); C31(1.18)  LDD0987  [6]
 LDCM0390  CL12 HCT 116 C28(1.10)  LDD0707  [6]
 LDCM0391  CL120 HEK-293T C28(0.80); C31(0.80)  LDD0989  [6]
 LDCM0392  CL121 HEK-293T C28(1.20); C31(1.20)  LDD0990  [6]
 LDCM0393  CL122 HEK-293T C28(1.41); C31(1.41)  LDD0991  [6]
 LDCM0394  CL123 HEK-293T C28(1.55); C31(1.55)  LDD0992  [6]
 LDCM0395  CL124 HEK-293T C28(1.27); C31(1.27)  LDD0993  [6]
 LDCM0396  CL125 HEK-293T C171(0.81); C31(0.81)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C171(0.90); C86(0.95); C31(0.84)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C171(0.92); C31(0.85)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C171(0.92); C31(0.88)  LDD1603  [17]
 LDCM0400  CL13 HCT 116 C28(0.85)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C28(1.06)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C28(0.86)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C28(1.07)  LDD0720  [6]
 LDCM0404  CL17 HEK-293T C171(0.88); C31(0.77)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C171(1.04); C137(1.35); C31(1.30); C28(0.81)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C171(0.88); C86(0.98); C31(0.97)  LDD1610  [17]
 LDCM0407  CL2 HCT 116 C28(0.66)  LDD0724  [6]
 LDCM0408  CL20 HEK-293T C171(0.96); C31(1.07)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C171(1.09); C31(0.88)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C171(1.04); C137(0.85); C31(1.02)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C171(1.16); C137(1.23); C31(1.02)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C171(1.04); C31(0.94)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C171(0.92); C31(0.78)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C171(1.10); C86(0.98); C31(0.96)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C171(1.10); C31(1.05)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C171(1.00); C31(0.96)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C171(0.92); C31(0.82)  LDD1621  [17]
 LDCM0418  CL3 HCT 116 C28(2.00)  LDD0735  [6]
 LDCM0419  CL30 HEK-293T C171(0.96); C137(0.93); C31(0.96); C28(0.96)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C171(0.93); C86(0.87); C31(1.03)  LDD1624  [17]
 LDCM0421  CL32 HCT 116 C28(1.19)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C28(1.12)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C28(1.23)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C28(1.31)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C28(0.99)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C28(1.22)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C28(1.23)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C28(0.87)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C28(1.30)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C28(0.99)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C28(1.08)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C28(1.04)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C28(1.25)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C28(1.02)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C28(1.11)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C28(0.92)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C28(1.00)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C28(0.92)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C28(0.96)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C28(1.01)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C28(1.01)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C28(0.88)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C28(1.27)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C28(0.92)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C28(1.08)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C28(1.18)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C28(1.09)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C28(0.84)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C28(1.03)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C28(0.60)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C28(1.54)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C28(0.87)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C28(0.99)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C28(0.99)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C28(1.10)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C28(1.11)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C28(1.93)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C28(1.42)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C28(1.25)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C28(1.06)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C28(0.64)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C28(1.31)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C28(1.08)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C28(1.02)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C28(0.97)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C28(1.09)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C28(0.88)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C28(1.21)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C28(1.19)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C28(1.31)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C28(0.99)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C28(1.03)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C28(1.10)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C28(1.23)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C28(1.30)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C28(1.16)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C28(0.95)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C28(0.95)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C28(1.05)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C28(1.05)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C28(0.91)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C28(0.66)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C28(1.07)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C28(1.48)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C28(2.22)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C28(1.48)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C28(1.26)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C28(2.43)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C28(1.92)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C28(1.49)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C28(1.10)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C28(1.10)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C171(0.98); C31(0.89)  LDD1698  [17]
 LDCM0468  Fragment33 HCT 116 C28(1.28)  LDD0785  [6]
 LDCM0427  Fragment51 HCT 116 C28(1.07)  LDD0744  [6]
 LDCM0107  IAA HeLa H77(0.00); H27(0.00); C28(0.00); H179(0.00)  LDD0221  [15]
 LDCM0022  KB02 HEK-293T C171(0.97); C31(1.03)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C171(0.91); C31(0.98)  LDD1497  [17]
 LDCM0024  KB05 HEK-293T C171(0.96); C31(1.01)  LDD1502  [17]
 LDCM0109  NEM HeLa H27(0.00); H77(0.00); H101(0.00); H179(0.00)  LDD0223  [15]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C31(0.95)  LDD2097  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C31(0.66)  LDD2098  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C31(1.49)  LDD2101  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C31(0.61)  LDD2115  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C164(0.75)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C164(0.30)  LDD2123  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C164(0.51)  LDD2134  [5]
 LDCM0021  THZ1 HCT 116 C28(1.19); C31(1.19)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase MYLIP (MYLIP) . Q8WY64
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-2C adrenergic receptor (ADRA2C) G-protein coupled receptor 1 family P18825

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402