Details of the Target

General Information of Target

Target ID LDTP01756
Target Name Actin-like protein 6A (ACTL6A)
Gene Name ACTL6A
Gene ID 86
Synonyms
BAF53; BAF53A; INO80K; Actin-like protein 6A; 53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGMVVERDDGSTLMEIDGDK
GKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPV
LMSEAPWNTRAKREKLTELMFEHYNIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAI
PVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELVPPYMIASKEAVREGSPANWKRK
EKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAE
RLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSF
TDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGG
KQCVERKCP
Target Bioclass
Other
Family
Actin family
Subcellular location
Nucleus
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Uniprot ID
O96019
Ensemble ID
ENST00000392662.5
HGNC ID
HGNC:24124

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E300Q DBIA    Probe Info 
CHL1 Insertion: p.N354EfsTer5 DBIA    Probe Info 
HCT116 Deletion: p.N90MfsTer47 DBIA    Probe Info 
RKO SNV: p.V44A DBIA    Probe Info 
SW756 SNV: p.I18V .
TCCSUP SNV: p.Q408H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.35  LDD0402  [1]
TH211
 Probe Info  		Y186(20.00)  LDD0257  [2]
TH214
 Probe Info  		Y186(20.00)  LDD0258  [2]
TH216
 Probe Info  		Y186(20.00)  LDD0259  [2]
STPyne
 Probe Info  		K371(4.31); K379(10.00)  LDD0277  [3]
BTD
 Probe Info  		C32(0.53)  LDD1699  [4]
ONAyne
 Probe Info  		K371(10.00)  LDD0275  [3]
Probe 1
 Probe Info  		Y69(23.93)  LDD3495  [5]
HHS-475
 Probe Info  		Y186(0.44)  LDD0264  [6]
DBIA
 Probe Info  		C32(0.93)  LDD0078  [7]
5E-2FA
 Probe Info  		H327(0.00); H143(0.00); H118(0.00); H176(0.00)  LDD2235  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C32(0.00); C152(0.00); C206(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C206(0.00); C152(0.00)  LDD0032  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		C32(0.00); C152(0.00); C423(0.00); C206(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
Compound 10
 Probe Info  		N.A.  LDD2216  [13]
IPM
 Probe Info  		N.A.  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
PF-06672131
 Probe Info  		N.A.  LDD0017  [15]
TFBX
 Probe Info  		C206(0.00); C32(0.00)  LDD0148  [16]
1c-yne
 Probe Info  		K62(0.00); K34(0.00); K89(0.00)  LDD0228  [17]
1d-yne
 Probe Info  		N.A.  LDD0357  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
NAIA_5
 Probe Info  		C152(0.00); C206(0.00)  LDD2223  [12]
HHS-482
 Probe Info  		Y186(1.09)  LDD2239  [19]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		6.68  LDD0476  [20]
FFF probe3
 Probe Info  		13.97  LDD0464  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C32(1.00); C206(0.63)  LDD2142  [4]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C32(0.76); C206(0.72)  LDD2112  [4]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C206(1.43)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C32(1.58)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C206(1.00); C32(1.18)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C206(1.00)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C32(1.33)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C32(0.59)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C32(0.56)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C32(0.67)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C32(0.93)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C32(0.72)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C32(0.66)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C32(0.80)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C32(0.78)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C32(0.81)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C206(0.91)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C32(0.78)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C32(0.53)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C32(0.71)  LDD0546  [7]
 LDCM0230  AC113 PaTu 8988t C152(0.78); C32(0.73)  LDD1109  [7]
 LDCM0231  AC114 PaTu 8988t C152(0.91); C32(0.97)  LDD1110  [7]
 LDCM0232  AC115 PaTu 8988t C152(0.74); C32(0.95)  LDD1111  [7]
 LDCM0233  AC116 PaTu 8988t C152(0.74); C32(0.86)  LDD1112  [7]
 LDCM0234  AC117 PaTu 8988t C152(0.76); C32(0.87)  LDD1113  [7]
 LDCM0235  AC118 PaTu 8988t C152(0.79); C32(1.06)  LDD1114  [7]
 LDCM0236  AC119 PaTu 8988t C152(0.71); C32(1.07)  LDD1115  [7]
 LDCM0237  AC12 HCT 116 C206(1.10)  LDD0554  [7]
 LDCM0238  AC120 PaTu 8988t C152(0.59); C32(0.90)  LDD1117  [7]
 LDCM0239  AC121 PaTu 8988t C152(0.57); C32(1.06)  LDD1118  [7]
 LDCM0240  AC122 PaTu 8988t C152(0.78); C32(0.94)  LDD1119  [7]
 LDCM0241  AC123 PaTu 8988t C152(0.68); C32(1.09)  LDD1120  [7]
 LDCM0242  AC124 PaTu 8988t C152(0.56); C32(0.98)  LDD1121  [7]
 LDCM0243  AC125 PaTu 8988t C152(0.92); C32(0.92)  LDD1122  [7]
 LDCM0244  AC126 PaTu 8988t C152(0.71); C32(0.96)  LDD1123  [7]
 LDCM0245  AC127 PaTu 8988t C152(0.54); C32(1.11)  LDD1124  [7]
 LDCM0246  AC128 HEK-293T C32(0.95)  LDD0844  [7]
 LDCM0247  AC129 HEK-293T C32(1.16)  LDD0845  [7]
 LDCM0249  AC130 HEK-293T C32(1.02)  LDD0847  [7]
 LDCM0250  AC131 HEK-293T C32(0.79)  LDD0848  [7]
 LDCM0251  AC132 HEK-293T C32(0.95)  LDD0849  [7]
 LDCM0252  AC133 HEK-293T C32(1.07)  LDD0850  [7]
 LDCM0253  AC134 HEK-293T C32(0.98)  LDD0851  [7]
 LDCM0254  AC135 HEK-293T C32(1.07)  LDD0852  [7]
 LDCM0255  AC136 HEK-293T C32(1.07)  LDD0853  [7]
 LDCM0256  AC137 HEK-293T C32(1.33)  LDD0854  [7]
 LDCM0257  AC138 HEK-293T C32(1.56)  LDD0855  [7]
 LDCM0258  AC139 HEK-293T C32(1.56)  LDD0856  [7]
 LDCM0259  AC14 HCT 116 C206(1.10)  LDD0576  [7]
 LDCM0260  AC140 HEK-293T C32(1.15)  LDD0858  [7]
 LDCM0261  AC141 HEK-293T C32(1.28)  LDD0859  [7]
 LDCM0262  AC142 HEK-293T C32(1.40)  LDD0860  [7]
 LDCM0263  AC143 HCT 116 C206(1.31)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C206(0.81)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C206(0.94)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C206(0.99)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C206(0.86)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C206(0.90)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C206(0.98)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C206(0.99)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C206(0.91)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C206(0.87)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C206(0.87)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C206(0.85)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C206(0.97)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C206(0.93)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C206(0.96)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C206(0.87)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C206(0.97); C32(1.69)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C206(0.89); C32(1.24)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C206(0.82); C32(1.39)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C206(0.97); C32(1.07)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C206(0.79); C32(1.14)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C206(0.75); C32(1.42)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C206(0.83); C32(1.22)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C206(0.72); C32(1.17)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C32(0.92); C206(1.08)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C206(0.95); C32(1.04)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C206(0.86); C32(1.12)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C206(0.77); C32(1.01)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C206(0.69); C32(1.06)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C32(1.05); C206(1.22)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C206(1.00); C32(1.27)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C206(1.14); C32(1.22)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C206(0.81); C32(1.24)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C206(0.60); C32(1.12)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C206(0.68); C32(1.08)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C206(0.56); C32(0.95)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C206(1.13); C32(1.38)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C206(1.01); C32(1.09)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C206(1.09); C32(1.26)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C206(0.97); C32(1.03)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C206(0.86); C32(1.09)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C206(0.94); C32(1.27)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C206(0.78); C32(1.01)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C206(0.91); C32(1.22)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C206(0.83); C32(1.17)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C206(0.93); C32(1.11)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C206(0.87); C32(1.24)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C206(0.72); C32(1.20)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C206(1.02); C32(1.05)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C206(0.92); C32(0.96)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C206(0.97); C32(1.09)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C206(0.24); C32(0.81)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C206(0.94); C32(1.38)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C206(0.40); C32(0.82)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C32(1.01); C206(1.02)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C32(1.01); C206(1.26)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C32(1.00); C206(1.10)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C206(0.74); C32(1.01)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C206(0.29); C32(0.93)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C206(0.19); C32(0.69)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C32(1.15)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C32(1.02)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C32(1.03)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C206(1.07)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C32(1.12)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C32(1.08)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C32(0.90)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C32(1.00)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C32(1.01)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C32(1.04)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C32(1.05)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C32(0.82)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C32(0.85)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C32(0.99)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C206(1.07)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C32(0.86)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C32(0.97)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C32(1.07)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C32(0.68)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C32(0.73)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C32(0.93)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C32(0.89)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C32(0.86)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C32(0.88)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C32(0.95)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C206(0.92)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C32(0.95)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C32(0.92)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C32(0.74)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C206(0.48); C32(0.59)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C206(0.56); C32(0.79)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C206(0.84); C32(0.99)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C32(0.96); C206(1.05)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C32(0.96); C206(1.08)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C206(0.89); C32(1.11)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C32(0.69); C206(0.80)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C32(0.87); C206(1.14)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C206(0.50); C32(0.70)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C206(0.69); C32(0.83)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C32(0.87); C206(1.05)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C206(0.91); C32(1.00)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C32(1.02); C206(1.16)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C32(0.72); C206(0.80)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C206(0.80); C32(0.92)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C32(0.26)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C32(0.72)  LDD0683  [7]
 LDCM0545  Acetamide MDA-MB-231 C32(0.44)  LDD2138  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C32(0.65); C206(0.70)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C206(0.93)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C206(1.06)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C206(0.73)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.61  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C32(0.93)  LDD0078  [7]
 LDCM0102  BDHI 8 Jurkat C32(6.56)  LDD0204  [22]
 LDCM0498  BS-3668 MDA-MB-231 C32(0.58)  LDD2091  [4]
 LDCM0108  Chloroacetamide HeLa H176(0.00); C206(0.00); H183(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C32(1.02); C206(1.05)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C206(0.57); C32(0.98)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C206(1.01); C32(1.12)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C206(0.90)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C206(1.43)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C206(1.00)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C206(1.31)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C206(0.84); C32(1.57)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C206(0.66); C32(1.42)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C206(0.68); C32(1.28)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C206(0.65); C32(1.19)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C206(0.83); C32(1.19)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C206(0.50); C32(1.06)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C206(0.98); C32(1.15)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C206(1.04); C32(1.25)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C32(0.94); C206(1.29)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C206(0.65); C32(1.03)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C32(0.97); C206(1.07)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C32(1.07); C206(1.08)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C206(0.95); C32(1.17)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C206(0.39); C32(0.80)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C206(0.90); C32(1.20)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C206(0.94); C32(1.12)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C206(0.45); C32(1.03)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C206(1.05); C32(1.14)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C206(0.87); C32(0.98)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C206(0.63); C32(0.98)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C206(0.63); C32(0.86)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C206(0.46); C32(0.86)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C32(1.18)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C32(0.97)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C32(0.95)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C32(1.13)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C206(0.63); C32(1.11)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C32(0.98); C206(1.11)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C206(0.60); C32(1.30)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C206(0.98); C32(1.28)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C32(1.01); C206(1.03)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C206(1.06); C32(1.51)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C206(0.91); C32(1.09)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C32(1.03); C206(1.18)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C206(0.82); C32(1.13)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C206(0.95); C32(1.14)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C206(0.65); C32(0.79)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C206(0.92); C32(1.18)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C206(0.72); C32(1.26)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C206(0.92); C32(1.17)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C206(0.82); C32(1.29)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C206(0.84); C32(1.65)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C206(0.87); C32(1.18)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C206(0.80); C32(1.00)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C206(1.01); C32(1.14)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C206(0.93); C32(1.27)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C206(0.52); C32(1.13)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C206(0.61); C32(1.52)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C206(0.64); C32(1.08)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C206(0.36); C32(1.22)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C206(0.32); C32(1.00)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C206(0.51); C32(0.95)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C206(0.29); C32(1.10)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C206(0.43); C32(1.08)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C206(0.87); C32(1.16)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C206(0.43); C32(1.01)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C206(0.42); C32(0.99)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C206(0.11); C32(1.01)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C206(0.24); C32(1.10)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C206(0.45); C32(1.17)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C206(0.25); C32(1.20)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C32(0.97)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C32(0.90)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C32(0.98)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C32(1.00)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C206(1.07); C32(1.10)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C32(0.81)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C32(0.87)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C32(0.93)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C32(0.96)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C32(0.77)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C32(0.79)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C32(0.77)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C32(0.82)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C32(0.85)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C32(0.77)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C206(0.90); C32(1.09)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C32(0.87)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C206(0.92); C32(1.34)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C206(0.85); C32(1.30)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C206(0.74); C32(1.58)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C206(0.75); C32(1.09)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C206(0.84); C32(1.11)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C206(0.50); C32(1.52)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C206(0.66); C32(1.17)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C206(0.83); C32(0.91)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C206(0.93); C32(0.92)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C206(0.60); C32(1.12)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C206(0.78); C32(0.88)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C206(0.76); C32(0.90)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C206(0.91); C32(1.03)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C206(0.77); C32(0.93)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C206(0.74); C32(0.92)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C206(0.94); C32(0.91)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C206(20.00); C32(0.95)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C206(0.72); C32(1.17)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C206(0.52); C32(1.15)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C206(0.44); C32(0.88)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C206(1.35); C32(0.82)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C206(0.73); C32(1.21)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C206(0.30); C32(0.98)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C206(0.38); C32(1.18)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C206(0.21); C32(0.73)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C206(1.49); C32(1.41)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C206(1.01); C32(0.96)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C206(1.87); C32(1.14)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C206(0.43); C32(1.04)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C206(0.19); C32(0.65)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C206(0.85); C32(1.07)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C206(1.34); C32(0.94)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C206(0.93); C32(1.19)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C206(1.04); C32(0.99)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C206(1.01); C32(0.99)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C206(1.03); C32(0.98)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C206(1.08); C32(1.02)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C206(1.03); C32(1.07)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C206(1.02); C32(1.04)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C206(1.01); C32(1.10)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C206(1.01); C32(1.21)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C32(0.95)  LDD1698  [23]
 LDCM0625  F8 Ramos C32(0.91); C206(0.90)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C32(0.69); C206(0.77)  LDD2189  [24]
 LDCM0573  Fragment11 Ramos C32(0.37); C206(3.56)  LDD2190  [24]
 LDCM0574  Fragment12 Ramos C32(0.86); C206(0.82)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C32(1.31); C206(1.20)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C32(0.86); C206(0.80)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C32(0.59); C206(0.71)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C32(1.11); C206(1.08)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C32(1.81); C206(1.48)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C32(1.30); C206(1.15)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C32(1.09); C206(0.89)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C32(1.30); C206(1.35)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C32(1.21); C206(1.51)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C32(0.70); C206(0.71)  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C206(0.78); C32(1.05)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C32(1.24); C206(1.24)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C32(0.72); C206(1.02)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C206(0.15); C32(0.67)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C32(1.43); C206(1.33)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C32(1.15); C206(1.32)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C32(0.66); C206(0.73)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C32(0.59); C206(0.72)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y186(0.44)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y186(0.86)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y186(0.45)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y186(4.42)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y186(1.93)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C32(1.09)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C32(1.12)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C32(1.15)  LDD0082  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C32(1.07)  LDD2102  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C32(0.63)  LDD2121  [4]
 LDCM0109  NEM HeLa H176(0.00); H183(0.00)  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C32(0.61)  LDD2089  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C32(1.00)  LDD2090  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C32(1.01)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C206(0.77)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C32(0.68)  LDD2097  [4]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C32(0.59)  LDD2098  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C32(1.26); C206(1.67)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C32(0.49)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C32(0.77)  LDD2101  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C423(0.41); C206(0.47)  LDD2104  [4]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C32(1.10)  LDD2105  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C423(1.55); C32(0.63); C206(0.65)  LDD2106  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C206(1.97)  LDD2107  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C206(1.11)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C32(0.66); C206(1.00)  LDD2109  [4]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C206(0.52)  LDD2110  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C32(1.32)  LDD2111  [4]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C206(0.73)  LDD2114  [4]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C206(0.58)  LDD2118  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C32(2.44)  LDD2119  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C423(1.00)  LDD2120  [4]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C206(0.28)  LDD2122  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C32(0.92); C206(1.35)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C206(0.41)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C32(0.97); C206(1.11)  LDD2125  [4]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C32(2.22); C206(0.35)  LDD2126  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C32(1.09)  LDD2127  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C423(0.77)  LDD2128  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C32(0.44)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C32(0.36); C206(0.57)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C32(1.07)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C32(1.17); C206(1.53)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C206(1.11)  LDD2137  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C32(2.08)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C32(0.82)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C32(0.62); C206(0.56)  LDD2141  [4]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C423(0.85); C32(1.21)  LDD2143  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C32(3.25); C206(1.96)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C423(0.94); C32(0.95)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C32(0.95)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C206(0.50)  LDD2148  [4]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C206(0.56)  LDD2149  [4]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C423(0.69); C32(0.88); C206(1.00)  LDD2150  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C206(0.39)  LDD2151  [4]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C32(1.02)  LDD2153  [4]
 LDCM0131  RA190 MM1.R C206(1.54); C32(0.86)  LDD0304  [25]
 LDCM0021  THZ1 HCT 116 C32(0.97)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.