Details of the Target

General Information of Target

Target ID LDTP02161
Target Name Glycogen phosphorylase, liver form (PYGL)
Gene Name PYGL
Gene ID 5836
Synonyms
Glycogen phosphorylase, liver form; EC 2.4.1.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAKPLTDQEKRRQISIRGIVGVENVAELKKSFNRHLHFTLVKDRNVATTRDYYFALAHTV
RDHLVGRWIRTQQHYYDKCPKRVYYLSLEFYMGRTLQNTMINLGLQNACDEAIYQLGLDI
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEYGIFNQKIRDGWQVEEA
DDWLRYGNPWEKSRPEFMLPVHFYGKVEHTNTGTKWIDTQVVLALPYDTPVPGYMNNTVN
TMRLWSARAPNDFNLRDFNVGDYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKASKFGSTRGAGTVFDAFPDQVAIQLNDTHPALAIPELMRIFVDIEKL
PWSKAWELTQKTFAYTNHTVLPEALERWPVDLVEKLLPRHLEIIYEINQKHLDRIVALFP
KDVDRLRRMSLIEEEGSKRINMAHLCIVGSHAVNGVAKIHSDIVKTKVFKDFSELEPDKF
QNKTNGITPRRWLLLCNPGLAELIAEKIGEDYVKDLSQLTKLHSFLGDDVFLRELAKVKQ
ENKLKFSQFLETEYKVKINPSSMFDVQVKRIHEYKRQLLNCLHVITMYNRIKKDPKKLFV
PRTVIIGGKAAPGYHMAKMIIKLITSVADVVNNDPMVGSKLKVIFLENYRVSLAEKVIPA
TDLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENLFIFGMRIDDVA
ALDKKGYEAKEYYEALPELKLVIDQIDNGFFSPKQPDLFKDIINMLFYHDRFKVFADYEA
YVKCQDKVSQLYMNPKAWNTMVLKNIAASGKFSSDRTIKEYAQNIWNVEPSDLKISLSNE
SNKVNGN
Target Bioclass
Enzyme
Family
Glycogen phosphorylase family
Subcellular location
Cytoplasm, cytosol
Function
Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.
Uniprot ID
P06737
Ensemble ID
ENST00000216392.8
HGNC ID
HGNC:9725
ChEMBL ID
CHEMBL2568

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 SNV: p.G187R DBIA    Probe Info 
HCC1954 SNV: p.E665Q .
JHH7 SNV: p.K593R .
MEWO Substitution: p.H63Y DBIA    Probe Info 
NCIH1993 SNV: p.D269Y .
NCIH358 SNV: p.G705W .
REH SNV: p.G213R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.68  LDD0402  [1]
TH211
 Probe Info  		Y732(20.00); Y263(13.03); Y281(12.80); Y204(8.57)  LDD0257  [2]
TH214
 Probe Info  		Y204(10.22)  LDD0258  [2]
TH216
 Probe Info  		Y821(11.29); Y204(8.84)  LDD0259  [2]
Probe 1
 Probe Info  		Y186(36.79); Y574(99.77); Y614(24.15); Y649(28.93)  LDD3495  [3]
DBIA
 Probe Info  		C143(1.16); C496(1.45)  LDD3310  [4]
BTD
 Probe Info  		C79(0.52)  LDD2091  [5]
AHL-Pu-1
 Probe Info  		C143(3.49)  LDD0170  [6]
HHS-482
 Probe Info  		Y204(0.72)  LDD0285  [7]
HHS-475
 Probe Info  		Y204(0.67); Y614(0.83); Y76(0.97); Y298(0.99)  LDD0264  [8]
HHS-465
 Probe Info  		Y186(10.00); Y204(4.75); Y281(10.00); Y574(10.00)  LDD2237  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K438(0.00); K290(0.00); K29(0.00); K30(0.00)  LDD0199  [11]
CY4
 Probe Info  		N.A.  LDD0247  [12]
IA-alkyne
 Probe Info  		C496(0.00); C446(0.00)  LDD0032  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
IPM
 Probe Info  		N.A.  LDD2156  [15]
NHS
 Probe Info  		K10(0.00); K29(0.00); K290(0.00)  LDD0010  [16]
SF
 Probe Info  		K206(0.00); Y204(0.00); Y76(0.00)  LDD0028  [17]
STPyne
 Probe Info  		N.A.  LDD0009  [16]
Ox-W18
 Probe Info  		W388(0.00); W362(0.00); W175(0.00)  LDD2175  [18]
1c-yne
 Probe Info  		K843(0.00); K545(0.00); K521(0.00); K295(0.00)  LDD0228  [19]
Acrolein
 Probe Info  		H63(0.00); H523(0.00)  LDD0217  [20]
NAIA_5
 Probe Info  		C143(0.00); C446(0.00); C496(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		8.55  LDD0475  [21]
FFF probe14
 Probe Info  		5.44  LDD0477  [21]
FFF probe3
 Probe Info  		6.65  LDD0465  [21]
FFF probe4
 Probe Info  		5.43  LDD0466  [21]
STS-1
 Probe Info  		N.A.  LDD0137  [22]
STS-2
 Probe Info  		N.A.  LDD0139  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]
DA-2
 Probe Info  		N.A.  LDD0071  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C79(1.19)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C79(1.65)  LDD2152  [5]
 LDCM0025  4SU-RNA DM93 C143(3.49)  LDD0170  [6]
 LDCM0214  AC1 PaTu 8988t C496(0.21)  LDD1093  [25]
 LDCM0215  AC10 HEK-293T C446(1.01); C496(0.83); C581(1.02); C143(1.12)  LDD1508  [26]
 LDCM0226  AC11 HEK-293T C446(0.96); C496(0.95); C143(1.00)  LDD1509  [26]
 LDCM0237  AC12 HEK-293T C446(0.94); C496(0.98); C581(1.11); C143(1.10)  LDD1510  [26]
 LDCM0246  AC128 PaTu 8988t C496(1.01)  LDD1125  [25]
 LDCM0247  AC129 PaTu 8988t C496(1.04)  LDD1126  [25]
 LDCM0249  AC130 PaTu 8988t C496(0.88)  LDD1128  [25]
 LDCM0250  AC131 PaTu 8988t C496(1.07)  LDD1129  [25]
 LDCM0251  AC132 PaTu 8988t C496(1.13)  LDD1130  [25]
 LDCM0252  AC133 PaTu 8988t C496(0.67)  LDD1131  [25]
 LDCM0253  AC134 PaTu 8988t C496(0.88)  LDD1132  [25]
 LDCM0254  AC135 PaTu 8988t C496(0.62)  LDD1133  [25]
 LDCM0255  AC136 PaTu 8988t C496(1.01)  LDD1134  [25]
 LDCM0256  AC137 PaTu 8988t C496(0.75)  LDD1135  [25]
 LDCM0257  AC138 PaTu 8988t C496(0.96)  LDD1136  [25]
 LDCM0258  AC139 PaTu 8988t C496(1.17)  LDD1137  [25]
 LDCM0259  AC14 HEK-293T C446(1.04); C496(0.88); C581(1.00); C143(1.10)  LDD1512  [26]
 LDCM0260  AC140 PaTu 8988t C496(1.02)  LDD1139  [25]
 LDCM0261  AC141 PaTu 8988t C496(0.84)  LDD1140  [25]
 LDCM0262  AC142 PaTu 8988t C496(1.11)  LDD1141  [25]
 LDCM0270  AC15 HEK-293T C446(0.88); C496(0.90); C79(1.26); C581(0.93)  LDD1513  [26]
 LDCM0276  AC17 HEK-293T C446(0.97); C496(0.85); C581(0.99)  LDD1515  [26]
 LDCM0277  AC18 HEK-293T C446(1.08); C496(0.86); C581(1.17); C143(0.82)  LDD1516  [26]
 LDCM0278  AC19 HEK-293T C446(0.89); C496(0.95); C143(0.85)  LDD1517  [26]
 LDCM0279  AC2 PaTu 8988t C496(0.30)  LDD1158  [25]
 LDCM0280  AC20 HEK-293T C446(0.91); C496(0.94); C581(1.19); C143(0.99)  LDD1519  [26]
 LDCM0281  AC21 HEK-293T C446(1.08); C496(0.93); C581(1.04); C143(1.02)  LDD1520  [26]
 LDCM0282  AC22 HEK-293T C446(1.03); C496(0.95); C581(1.06); C143(1.04)  LDD1521  [26]
 LDCM0283  AC23 HEK-293T C446(0.96); C496(0.90); C79(1.19); C581(0.97)  LDD1522  [26]
 LDCM0284  AC24 HEK-293T C446(0.98); C496(0.99); C581(0.97); C143(1.08)  LDD1523  [26]
 LDCM0285  AC25 PaTu 8988t C496(0.85)  LDD1164  [25]
 LDCM0286  AC26 PaTu 8988t C496(0.78)  LDD1165  [25]
 LDCM0287  AC27 PaTu 8988t C496(0.95)  LDD1166  [25]
 LDCM0288  AC28 PaTu 8988t C496(0.86)  LDD1167  [25]
 LDCM0289  AC29 PaTu 8988t C496(0.95)  LDD1168  [25]
 LDCM0290  AC3 PaTu 8988t C496(0.30)  LDD1169  [25]
 LDCM0291  AC30 PaTu 8988t C496(0.81)  LDD1170  [25]
 LDCM0292  AC31 PaTu 8988t C496(1.01)  LDD1171  [25]
 LDCM0293  AC32 PaTu 8988t C496(0.80)  LDD1172  [25]
 LDCM0294  AC33 PaTu 8988t C496(1.05)  LDD1173  [25]
 LDCM0295  AC34 PaTu 8988t C496(0.87)  LDD1174  [25]
 LDCM0296  AC35 PaTu 8988t C496(1.08)  LDD1175  [25]
 LDCM0297  AC36 PaTu 8988t C496(0.95)  LDD1176  [25]
 LDCM0298  AC37 PaTu 8988t C496(1.02)  LDD1177  [25]
 LDCM0299  AC38 PaTu 8988t C496(1.03)  LDD1178  [25]
 LDCM0300  AC39 PaTu 8988t C496(1.06)  LDD1179  [25]
 LDCM0301  AC4 PaTu 8988t C496(0.24)  LDD1180  [25]
 LDCM0302  AC40 PaTu 8988t C496(0.98)  LDD1181  [25]
 LDCM0303  AC41 PaTu 8988t C496(0.82)  LDD1182  [25]
 LDCM0304  AC42 PaTu 8988t C496(0.96)  LDD1183  [25]
 LDCM0305  AC43 PaTu 8988t C496(0.95)  LDD1184  [25]
 LDCM0306  AC44 PaTu 8988t C496(0.90)  LDD1185  [25]
 LDCM0307  AC45 PaTu 8988t C496(0.98)  LDD1186  [25]
 LDCM0308  AC46 HEK-293T C446(0.99); C496(0.89); C581(1.03); C143(1.08)  LDD1547  [26]
 LDCM0309  AC47 HEK-293T C446(0.98); C496(0.89); C79(1.13); C581(1.27)  LDD1548  [26]
 LDCM0310  AC48 HEK-293T C446(1.03); C496(0.92); C581(0.99); C143(1.03)  LDD1549  [26]
 LDCM0311  AC49 HEK-293T C446(0.96); C496(0.91); C581(1.12)  LDD1550  [26]
 LDCM0312  AC5 PaTu 8988t C496(0.23)  LDD1191  [25]
 LDCM0313  AC50 HEK-293T C446(1.00); C496(0.90); C581(1.21); C143(0.95)  LDD1552  [26]
 LDCM0314  AC51 HEK-293T C446(0.95); C496(0.98); C143(1.19)  LDD1553  [26]
 LDCM0315  AC52 HEK-293T C446(0.93); C496(0.98); C581(1.12); C143(1.03)  LDD1554  [26]
 LDCM0316  AC53 HEK-293T C446(1.07); C496(0.89); C581(0.99); C143(1.04)  LDD1555  [26]
 LDCM0317  AC54 HEK-293T C446(1.07); C496(0.94); C581(1.12); C143(1.02)  LDD1556  [26]
 LDCM0318  AC55 HEK-293T C446(0.92); C496(0.93); C79(1.21); C581(1.09)  LDD1557  [26]
 LDCM0319  AC56 HEK-293T C446(1.04); C496(1.00); C581(1.02); C143(1.02)  LDD1558  [26]
 LDCM0320  AC57 PaTu 8988t C496(1.35)  LDD1199  [25]
 LDCM0321  AC58 PaTu 8988t C496(1.05)  LDD1200  [25]
 LDCM0322  AC59 PaTu 8988t C496(1.42)  LDD1201  [25]
 LDCM0323  AC6 HEK-293T C446(0.96); C496(0.93); C581(1.03); C143(0.94)  LDD1562  [26]
 LDCM0324  AC60 PaTu 8988t C496(1.40)  LDD1203  [25]
 LDCM0325  AC61 PaTu 8988t C496(1.37)  LDD1204  [25]
 LDCM0326  AC62 PaTu 8988t C496(1.41)  LDD1205  [25]
 LDCM0327  AC63 PaTu 8988t C496(1.33)  LDD1206  [25]
 LDCM0328  AC64 PaTu 8988t C496(1.13)  LDD1207  [25]
 LDCM0329  AC65 PaTu 8988t C496(1.09)  LDD1208  [25]
 LDCM0330  AC66 PaTu 8988t C496(0.93)  LDD1209  [25]
 LDCM0331  AC67 PaTu 8988t C496(1.29)  LDD1210  [25]
 LDCM0334  AC7 HEK-293T C446(0.94); C496(0.86); C79(1.02); C581(1.09)  LDD1568  [26]
 LDCM0345  AC8 HEK-293T C446(1.05); C496(0.92); C581(1.01); C143(1.08)  LDD1569  [26]
 LDCM0248  AKOS034007472 HEK-293T C446(1.08); C496(0.89); C581(0.95); C143(1.08)  LDD1511  [26]
 LDCM0356  AKOS034007680 HEK-293T C446(0.94); C496(0.84); C581(1.08)  LDD1570  [26]
 LDCM0275  AKOS034007705 HEK-293T C446(0.97); C496(0.96); C581(1.01); C143(1.12)  LDD1514  [26]
 LDCM0020  ARS-1620 HCC44 C496(0.95)  LDD2171  [25]
 LDCM0498  BS-3668 MDA-MB-231 C79(0.52)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa H523(0.00); H63(0.00); H58(0.00)  LDD0222  [20]
 LDCM0367  CL1 HEK-293T C446(0.99); C496(0.95); C79(0.84); C581(1.10)  LDD1571  [26]
 LDCM0368  CL10 HEK-293T C446(0.80); C496(1.07); C581(0.60); C143(0.95)  LDD1572  [26]
 LDCM0369  CL100 PaTu 8988t C496(0.20)  LDD1248  [25]
 LDCM0370  CL101 HEK-293T C446(0.92); C496(0.89); C79(0.87); C581(1.07)  LDD1574  [26]
 LDCM0371  CL102 HEK-293T C446(0.97); C496(0.91); C581(1.04); C143(1.03)  LDD1575  [26]
 LDCM0372  CL103 HEK-293T C446(0.97); C496(0.95); C581(0.94); C143(1.04)  LDD1576  [26]
 LDCM0373  CL104 HEK-293T C446(1.02); C496(0.98); C581(1.07); C143(1.03)  LDD1577  [26]
 LDCM0374  CL105 HEK-293T C446(0.87); C496(0.94); C79(0.94); C581(1.07)  LDD1578  [26]
 LDCM0375  CL106 HEK-293T C446(0.98); C496(0.93); C581(0.93); C143(0.91)  LDD1579  [26]
 LDCM0376  CL107 HEK-293T C446(1.01); C496(0.96); C581(0.95); C143(1.13)  LDD1580  [26]
 LDCM0377  CL108 HEK-293T C446(1.03); C496(0.92); C581(1.05); C143(1.15)  LDD1581  [26]
 LDCM0378  CL109 HEK-293T C446(0.97); C496(0.98); C79(0.96); C581(1.06)  LDD1582  [26]
 LDCM0379  CL11 HEK-293T C446(0.89); C496(0.77); C79(0.87); C581(0.79)  LDD1583  [26]
 LDCM0380  CL110 HEK-293T C446(0.97); C496(1.08); C581(0.97); C143(0.96)  LDD1584  [26]
 LDCM0381  CL111 HEK-293T C446(0.96); C496(0.88); C581(1.00); C143(0.99)  LDD1585  [26]
 LDCM0382  CL112 PaTu 8988t C496(0.87)  LDD1261  [25]
 LDCM0383  CL113 PaTu 8988t C496(0.77)  LDD1262  [25]
 LDCM0384  CL114 PaTu 8988t C496(0.82)  LDD1263  [25]
 LDCM0385  CL115 PaTu 8988t C496(0.89)  LDD1264  [25]
 LDCM0386  CL116 PaTu 8988t C496(0.89)  LDD1265  [25]
 LDCM0387  CL117 PaTu 8988t C496(0.85)  LDD1266  [25]
 LDCM0388  CL118 PaTu 8988t C496(0.96)  LDD1267  [25]
 LDCM0389  CL119 PaTu 8988t C496(0.96)  LDD1268  [25]
 LDCM0390  CL12 HEK-293T C446(0.95); C496(0.91); C581(0.75); C143(1.05)  LDD1594  [26]
 LDCM0391  CL120 PaTu 8988t C496(0.92)  LDD1270  [25]
 LDCM0392  CL121 HEK-293T C446(0.95); C496(0.99); C79(0.99); C581(1.12)  LDD1596  [26]
 LDCM0393  CL122 HEK-293T C446(0.99); C496(1.07); C581(1.01); C143(1.06)  LDD1597  [26]
 LDCM0394  CL123 HEK-293T C446(1.04); C496(0.77); C581(0.95); C143(1.06)  LDD1598  [26]
 LDCM0395  CL124 HEK-293T C446(1.04); C496(0.94); C581(1.19); C143(1.09)  LDD1599  [26]
 LDCM0396  CL125 PaTu 8988t C496(1.36)  LDD1275  [25]
 LDCM0397  CL126 PaTu 8988t C496(1.21)  LDD1276  [25]
 LDCM0398  CL127 PaTu 8988t C496(1.36)  LDD1277  [25]
 LDCM0399  CL128 PaTu 8988t C496(1.15)  LDD1278  [25]
 LDCM0400  CL13 HEK-293T C446(0.96); C496(0.87); C79(0.93); C581(0.94)  LDD1604  [26]
 LDCM0401  CL14 HEK-293T C446(0.95); C496(0.97); C581(1.08); C143(1.04)  LDD1605  [26]
 LDCM0402  CL15 HEK-293T C446(1.02); C496(0.85); C581(0.88); C143(1.05)  LDD1606  [26]
 LDCM0403  CL16 HEK-293T C446(0.95); C496(0.95); C581(0.91); C143(1.05)  LDD1607  [26]
 LDCM0404  CL17 HEK-293T C446(0.89); C496(0.70); C581(0.91)  LDD1608  [26]
 LDCM0405  CL18 HEK-293T C446(0.96); C496(0.87); C581(0.99); C143(1.08)  LDD1609  [26]
 LDCM0406  CL19 HEK-293T C446(0.95); C496(0.90); C143(0.94)  LDD1610  [26]
 LDCM0407  CL2 HEK-293T C446(0.99); C496(1.01); C581(0.94); C143(1.07)  LDD1611  [26]
 LDCM0408  CL20 HEK-293T C446(0.91); C496(0.95); C581(0.85); C143(1.19)  LDD1612  [26]
 LDCM0409  CL21 HEK-293T C446(1.00); C496(0.87); C581(0.75); C143(0.96)  LDD1613  [26]
 LDCM0410  CL22 HEK-293T C446(0.93); C496(0.91); C581(0.71); C143(1.11)  LDD1614  [26]
 LDCM0411  CL23 HEK-293T C446(0.94); C496(0.91); C79(1.03); C581(0.81)  LDD1615  [26]
 LDCM0412  CL24 HEK-293T C446(0.96); C496(1.05); C581(0.76); C143(1.08)  LDD1616  [26]
 LDCM0413  CL25 HEK-293T C446(1.01); C496(0.98); C79(0.81); C581(1.11)  LDD1617  [26]
 LDCM0414  CL26 HEK-293T C446(1.03); C496(1.12); C581(0.93); C143(0.99)  LDD1618  [26]
 LDCM0415  CL27 HEK-293T C446(1.03); C496(0.93); C581(1.03); C143(1.07)  LDD1619  [26]
 LDCM0416  CL28 HEK-293T C446(0.95); C496(0.86); C581(1.08); C143(1.09)  LDD1620  [26]
 LDCM0417  CL29 HEK-293T C446(1.00); C496(0.91); C581(1.03)  LDD1621  [26]
 LDCM0418  CL3 HEK-293T C446(1.05); C496(0.91); C581(0.94); C143(1.13)  LDD1622  [26]
 LDCM0419  CL30 HEK-293T C446(0.99); C496(0.81); C581(0.93); C143(0.87)  LDD1623  [26]
 LDCM0420  CL31 PaTu 8988t C496(1.43)  LDD1299  [25]
 LDCM0421  CL32 PaTu 8988t C496(0.95)  LDD1300  [25]
 LDCM0422  CL33 PaTu 8988t C496(1.12)  LDD1301  [25]
 LDCM0423  CL34 PaTu 8988t C496(1.46)  LDD1302  [25]
 LDCM0424  CL35 PaTu 8988t C496(1.05)  LDD1303  [25]
 LDCM0425  CL36 PaTu 8988t C496(0.43)  LDD1304  [25]
 LDCM0426  CL37 PaTu 8988t C496(0.99)  LDD1305  [25]
 LDCM0428  CL39 PaTu 8988t C496(1.25)  LDD1307  [25]
 LDCM0429  CL4 HEK-293T C446(1.07); C496(0.96); C581(1.02); C143(1.00)  LDD1633  [26]
 LDCM0430  CL40 PaTu 8988t C496(1.02)  LDD1309  [25]
 LDCM0431  CL41 PaTu 8988t C496(1.00)  LDD1310  [25]
 LDCM0432  CL42 PaTu 8988t C496(1.35)  LDD1311  [25]
 LDCM0433  CL43 PaTu 8988t C496(1.37)  LDD1312  [25]
 LDCM0434  CL44 PaTu 8988t C496(1.37)  LDD1313  [25]
 LDCM0435  CL45 PaTu 8988t C496(1.40)  LDD1314  [25]
 LDCM0436  CL46 PaTu 8988t C496(1.03)  LDD1315  [25]
 LDCM0437  CL47 PaTu 8988t C496(1.06)  LDD1316  [25]
 LDCM0438  CL48 PaTu 8988t C496(0.90)  LDD1317  [25]
 LDCM0439  CL49 PaTu 8988t C496(1.13)  LDD1318  [25]
 LDCM0440  CL5 HEK-293T C446(1.02); C496(0.82); C581(0.99)  LDD1644  [26]
 LDCM0441  CL50 PaTu 8988t C496(1.06)  LDD1320  [25]
 LDCM0442  CL51 PaTu 8988t C496(0.92)  LDD1321  [25]
 LDCM0443  CL52 PaTu 8988t C496(1.30)  LDD1322  [25]
 LDCM0444  CL53 PaTu 8988t C496(1.07)  LDD1323  [25]
 LDCM0445  CL54 PaTu 8988t C496(1.04)  LDD1324  [25]
 LDCM0446  CL55 PaTu 8988t C496(1.09)  LDD1325  [25]
 LDCM0447  CL56 PaTu 8988t C496(1.09)  LDD1326  [25]
 LDCM0448  CL57 PaTu 8988t C496(1.16)  LDD1327  [25]
 LDCM0449  CL58 PaTu 8988t C496(1.16)  LDD1328  [25]
 LDCM0450  CL59 PaTu 8988t C496(1.18)  LDD1329  [25]
 LDCM0451  CL6 HEK-293T C446(0.96); C496(0.80); C581(0.88); C143(0.83)  LDD1654  [26]
 LDCM0452  CL60 PaTu 8988t C496(1.12)  LDD1331  [25]
 LDCM0453  CL61 HEK-293T C446(0.99); C496(1.10); C79(0.91); C581(1.17)  LDD1656  [26]
 LDCM0454  CL62 HEK-293T C446(1.01); C496(0.95); C581(1.09); C143(1.16)  LDD1657  [26]
 LDCM0455  CL63 HEK-293T C446(1.01); C496(0.88); C581(1.05); C143(1.00)  LDD1658  [26]
 LDCM0456  CL64 HEK-293T C446(1.01); C496(0.86); C581(1.01); C143(0.70)  LDD1659  [26]
 LDCM0457  CL65 HEK-293T C446(0.93); C496(0.81); C581(1.09)  LDD1660  [26]
 LDCM0458  CL66 HEK-293T C446(1.02); C496(0.73); C581(1.08); C143(0.96)  LDD1661  [26]
 LDCM0459  CL67 HEK-293T C446(0.94); C496(0.90); C143(0.96)  LDD1662  [26]
 LDCM0460  CL68 HEK-293T C446(0.87); C496(0.98); C581(0.86); C143(0.94)  LDD1663  [26]
 LDCM0461  CL69 HEK-293T C446(0.90); C496(0.89); C581(0.76); C143(1.11)  LDD1664  [26]
 LDCM0462  CL7 HEK-293T C446(0.95); C496(0.90); C143(0.85)  LDD1665  [26]
 LDCM0463  CL70 HEK-293T C446(0.94); C496(0.87); C581(0.87); C143(1.08)  LDD1666  [26]
 LDCM0464  CL71 HEK-293T C446(0.82); C496(0.79); C79(1.05); C581(0.77)  LDD1667  [26]
 LDCM0465  CL72 HEK-293T C446(0.90); C496(0.98); C581(0.79); C143(1.07)  LDD1668  [26]
 LDCM0466  CL73 HEK-293T C446(1.04); C496(1.02); C79(0.84); C581(1.21)  LDD1669  [26]
 LDCM0467  CL74 HEK-293T C446(0.94); C496(1.09); C581(1.10); C143(1.08)  LDD1670  [26]
 LDCM0469  CL76 PaTu 8988t C496(1.18)  LDD1348  [25]
 LDCM0470  CL77 PaTu 8988t C496(1.14)  LDD1349  [25]
 LDCM0471  CL78 PaTu 8988t C496(1.23)  LDD1350  [25]
 LDCM0472  CL79 PaTu 8988t C496(1.12)  LDD1351  [25]
 LDCM0473  CL8 HEK-293T C446(0.91); C496(0.98); C581(0.75); C143(1.03)  LDD1676  [26]
 LDCM0474  CL80 PaTu 8988t C496(1.14)  LDD1353  [25]
 LDCM0475  CL81 PaTu 8988t C496(1.25)  LDD1354  [25]
 LDCM0476  CL82 PaTu 8988t C496(1.34)  LDD1355  [25]
 LDCM0477  CL83 PaTu 8988t C496(1.27)  LDD1356  [25]
 LDCM0478  CL84 PaTu 8988t C496(1.30)  LDD1357  [25]
 LDCM0479  CL85 PaTu 8988t C496(1.17)  LDD1358  [25]
 LDCM0480  CL86 PaTu 8988t C496(1.30)  LDD1359  [25]
 LDCM0481  CL87 PaTu 8988t C496(1.33)  LDD1360  [25]
 LDCM0482  CL88 PaTu 8988t C496(1.32)  LDD1361  [25]
 LDCM0483  CL89 PaTu 8988t C496(1.16)  LDD1362  [25]
 LDCM0484  CL9 HEK-293T C446(1.06); C496(0.99); C581(0.80); C143(1.00)  LDD1687  [26]
 LDCM0485  CL90 PaTu 8988t C496(1.44)  LDD1364  [25]
 LDCM0486  CL91 PaTu 8988t C496(0.21)  LDD1365  [25]
 LDCM0487  CL92 PaTu 8988t C496(0.15)  LDD1366  [25]
 LDCM0488  CL93 PaTu 8988t C496(0.21)  LDD1367  [25]
 LDCM0489  CL94 PaTu 8988t C496(0.20)  LDD1368  [25]
 LDCM0490  CL95 PaTu 8988t C496(0.22)  LDD1369  [25]
 LDCM0491  CL96 PaTu 8988t C496(0.19)  LDD1370  [25]
 LDCM0492  CL97 PaTu 8988t C496(0.15)  LDD1371  [25]
 LDCM0493  CL98 PaTu 8988t C496(0.22)  LDD1372  [25]
 LDCM0494  CL99 PaTu 8988t C496(0.22)  LDD1373  [25]
 LDCM0495  E2913 HEK-293T C446(0.96); C496(1.00); C581(1.05); C143(1.35)  LDD1698  [26]
 LDCM0468  Fragment33 HEK-293T C446(1.01); C496(0.90); C581(0.98); C143(1.10)  LDD1671  [26]
 LDCM0427  Fragment51 PaTu 8988t C496(1.30)  LDD1306  [25]
 LDCM0116  HHS-0101 DM93 Y204(0.67); Y614(0.83); Y76(0.97); Y298(0.99)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y204(0.67); Y76(0.72); Y186(0.80); Y614(0.80)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y204(0.70); Y614(0.70); Y76(0.71); Y298(0.72)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y614(0.78); Y204(0.82); Y298(0.82); Y186(0.87)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y614(0.46); Y298(0.55); Y186(0.68); Y76(0.69)  LDD0268  [8]
 LDCM0107  IAA HeLa H523(0.00); H58(0.00); H63(0.00)  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y204(0.72)  LDD0285  [7]
 LDCM0124  JWB142 DM93 Y204(0.47)  LDD0286  [7]
 LDCM0125  JWB146 DM93 Y204(0.98)  LDD0287  [7]
 LDCM0126  JWB150 DM93 Y204(2.86)  LDD0288  [7]
 LDCM0127  JWB152 DM93 Y204(3.64)  LDD0289  [7]
 LDCM0128  JWB198 DM93 Y204(0.98)  LDD0290  [7]
 LDCM0130  JWB211 DM93 Y204(0.83)  LDD0292  [7]
 LDCM0022  KB02 HEK-293T C446(1.00); C581(1.07); C496(0.99); C143(0.93)  LDD1492  [26]
 LDCM0023  KB03 HEK-293T C446(1.05); C581(0.97); C496(0.96); C143(0.92)  LDD1497  [26]
 LDCM0024  KB05 COLO792 C143(1.16); C496(1.45)  LDD3310  [4]
 LDCM0109  NEM HeLa H523(0.00); H58(0.00); H769(0.00); H63(0.00)  LDD0223  [20]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C79(1.01)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C784(0.57)  LDD2096  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C79(1.18)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C79(0.70)  LDD2109  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C446(0.48)  LDD2116  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C79(1.35)  LDD2119  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C446(0.29)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C79(1.19); C784(1.09)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C446(0.23)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C79(0.83)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C79(1.82)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C79(0.84)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C79(0.95)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C79(1.63)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C79(1.05)  LDD2137  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C79(0.78)  LDD2146  [5]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C446(0.33)  LDD2149  [5]
 LDCM0021  THZ1 HCT 116 C496(0.95)  LDD2173  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen phosphorylase, brain form (PYGB) Glycogen phosphorylase family P11216
Glycogen phosphorylase, muscle form (PYGM) Glycogen phosphorylase family P11217

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
25 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402