Details of the Target

General Information of Target

Target ID LDTP01564
Target Name Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (PAPSS2)
Gene Name PAPSS2
Gene ID 9060
Synonyms
ATPSK2; Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2; PAPS synthase 2; PAPSS 2; Sulfurylase kinase 2; SK 2; SK2) [Includes: Sulfate adenylyltransferase; EC 2.7.7.4; ATP-sulfurylase; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; EC 2.7.1.25; 3'-phosphoadenosine-5'-phosphosulfate synthase; APS kinase; Adenosine-5'-phosphosulfate 3'-phosphotransferase; Adenylylsulfate 3'-phosphotransferase)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISF
ALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITS
FISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDS
DYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAE
AETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVL
PVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVM
ESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHAL
LMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAI
FPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAP
GLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKA
WKVLTDYYRSLEKN
Target Bioclass
Enzyme
Family
APS kinase family; Sulfate adenylyltransferase family
Function
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases. In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. Plays indirectly an important role in skeletogenesis during postnatal growth.
Uniprot ID
O95340
Ensemble ID
ENST00000361175.8
HGNC ID
HGNC:8604
ChEMBL ID
CHEMBL4105790

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K161(10.00); K173(8.52); K233(8.06); K315(1.10)  LDD0277  [2]
Probe 1
 Probe Info  		Y182(14.20); Y386(17.35); Y565(10.79)  LDD3495  [3]
DBIA
 Probe Info  		C53(1.94); C117(1.42)  LDD3310  [4]
BTD
 Probe Info  		C313(0.55)  LDD2091  [5]
IPM
 Probe Info  		C350(2.34)  LDD1701  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
NAIA_4
 Probe Info  		C117(0.00); C155(0.00); C202(0.00)  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
ENE
 Probe Info  		N.A.  LDD0006  [9]
SF
 Probe Info  		N.A.  LDD0028  [10]
TFBX
 Probe Info  		C313(0.00); C397(0.00)  LDD0148  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		C313(0.00); C350(0.00)  LDD0218  [13]
AOyne
 Probe Info  		11.90  LDD0443  [14]
NAIA_5
 Probe Info  		C117(0.00); C155(0.00); C202(0.00); C73(0.00)  LDD2223  [8]
HHS-465
 Probe Info  		N.A.  LDD2240  [15]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [16]
STS-2
 Probe Info  		5.40  LDD0138  [16]
DA-2
 Probe Info  		N.A.  LDD0071  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C313(0.67)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C313(0.96)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C313(1.14)  LDD2117  [5]
 LDCM0214  AC1 HEK-293T C155(1.10); C202(1.11); C73(1.09)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C350(1.10); C155(1.03); C202(1.00); C73(0.82)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C350(0.99); C155(0.95); C202(0.78); C73(0.99)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C155(0.90); C202(0.76); C73(0.89); C497(0.89)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C350(1.06); C155(1.04); C497(0.74)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C350(1.02); C155(1.02); C202(0.91); C73(0.86)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C155(1.05); C202(0.80); C73(1.11)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C350(1.06); C155(0.96); C202(0.90); C73(0.97)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C350(1.09); C155(0.98); C202(0.97); C73(0.84)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C350(1.04); C155(1.04); C202(0.99); C73(0.95)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C155(0.94); C202(1.03); C73(0.86); C497(1.12)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C155(0.91); C202(0.98); C497(1.23)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C350(1.00); C155(1.15); C497(0.96)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C350(0.97); C155(1.17); C202(0.77); C73(0.95)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C155(1.09); C202(1.00); C73(1.00); C497(0.79)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C155(1.16); C202(0.97); C73(0.99)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C350(1.03); C155(0.88); C202(0.94); C73(1.07)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C350(1.01); C155(0.92); C202(1.02); C73(1.00)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C155(0.99); C202(1.05); C73(1.04); C497(0.97)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C155(0.98); C202(0.94); C497(1.27)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C350(1.02); C155(0.95); C202(0.91); C73(1.03)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C350(0.94); C155(1.21); C497(0.72)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C350(1.02); C155(0.99); C202(1.01); C73(0.96)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C155(1.25); C202(0.96); C73(1.01); C497(1.08)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C155(1.04); C202(0.89); C73(1.11)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C350(1.07); C155(1.08); C202(0.95); C73(1.23)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C350(0.95); C155(1.01); C202(0.85); C73(1.13)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C155(1.08); C202(1.01); C73(1.00); C497(1.06)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C155(0.94); C202(0.86); C497(1.53)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C350(1.10); C155(1.39); C497(1.19)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C350(1.13); C155(1.15); C202(0.95); C73(0.99)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C155(0.99); C202(1.13); C73(1.10); C497(1.26)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C155(0.88); C202(1.14); C73(0.98); C497(1.15)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C155(1.11); C202(0.88); C73(1.08)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C350(1.18); C155(1.14); C202(0.95); C73(0.93)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C350(1.03); C155(1.00); C202(1.04); C73(1.03)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C155(1.03); C202(1.02); C73(0.87); C497(0.98)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C155(1.02); C202(1.03); C497(1.53)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C350(1.11); C155(1.08); C497(0.86)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C350(1.09); C155(1.03); C202(1.02); C73(1.19)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C155(0.98); C202(1.10); C73(1.01); C497(1.10)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C155(0.99); C202(0.94); C73(1.06)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C155(0.98); C202(1.16); C497(1.31)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C350(1.22); C155(0.92); C202(0.97); C73(1.18)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C350(0.98); C155(1.05); C202(1.03); C73(0.95)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C155(1.04); C202(0.91); C73(1.00); C497(1.01)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C155(0.88); C202(1.05); C497(1.19)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C350(1.17); C155(1.20); C497(0.82)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C350(1.07); C155(0.97); C202(0.83); C73(1.08)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C155(0.97); C202(1.14); C73(0.97); C497(0.96)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C155(1.01); C202(0.80); C73(1.04)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C350(1.13); C155(1.01); C202(1.05); C73(0.82)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C350(0.97); C155(0.93); C202(1.06); C73(0.98)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C350(1.13); C155(1.09); C497(0.83)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C155(0.90); C202(0.91); C73(0.99); C497(1.07)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C155(0.90); C202(1.02); C497(1.06)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C350(1.12); C155(0.96); C497(0.73)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C350(1.16); C155(1.09); C202(1.07); C73(1.02)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C155(1.07); C202(1.15); C73(1.09); C497(1.15)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C350(1.05); C155(0.94); C202(1.07); C73(0.95)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C155(1.00); C202(0.91); C73(0.91); C497(0.81)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C155(0.96); C202(0.99); C497(1.09)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C155(1.00); C202(0.91); C73(0.98)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C155(0.99); C202(0.97); C73(0.86); C497(0.81)  LDD1514  [18]
 LDCM0498  BS-3668 MDA-MB-231 C313(0.55)  LDD2091  [5]
 LDCM0630  CCW28-3 231MFP C155(1.69)  LDD2214  [19]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C350(3.98); C497(1.04); C350(0.12)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C350(1.64); C155(1.05)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C350(5.53); C155(1.24); C497(0.56)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C350(1.05); C155(0.97); C202(1.01); C73(0.97)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C350(1.09); C155(0.93)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C350(1.11); C155(1.12); C202(0.96); C73(0.92)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C155(0.90); C202(0.85); C73(0.94)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C350(1.00); C155(0.95); C202(0.94); C73(1.18)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C350(0.95); C155(0.82)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C350(1.00); C155(1.01); C202(1.04); C73(1.02)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C155(0.87); C202(0.86); C73(1.11)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C350(0.99); C155(0.83); C202(1.14); C73(0.82)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C350(1.13); C155(1.00)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C350(1.38); C155(0.86); C202(0.42); C73(1.10)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C350(1.29); C155(0.98); C202(0.86); C73(0.79)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C155(0.86); C202(0.84); C73(1.03)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C350(1.06); C155(1.01); C202(1.07); C73(0.85)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C350(1.04); C155(0.95)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C350(1.09); C155(0.97); C202(1.03); C73(0.91)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C155(1.10); C202(1.00); C73(0.85)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C350(1.03); C155(1.13); C202(0.95); C73(1.00)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C350(1.11); C155(0.99)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C350(1.03); C155(1.10); C202(1.25); C73(0.95)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C155(0.98); C202(0.94); C73(1.05)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C155(0.94); C202(0.54); C73(1.06); C497(0.51)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C350(1.04); C155(1.06); C202(0.96); C73(0.96)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C350(1.08); C155(0.91)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C350(1.14); C155(1.06); C202(1.30); C73(0.88)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C155(0.93); C202(0.89); C73(0.67)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C350(0.94); C155(1.01); C202(1.06); C73(0.89)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C350(1.07); C155(0.84)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C350(1.06); C155(0.95); C202(1.25); C73(0.84)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C155(0.93); C202(1.09); C73(1.11)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C350(1.04); C155(0.97); C202(1.19); C73(0.99)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C350(1.41); C155(0.95)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C350(1.05); C155(1.14); C202(0.97); C73(1.07)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C155(0.92); C202(0.67); C73(0.88)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C350(0.96); C155(0.88); C202(0.83); C73(0.92)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C155(0.95); C202(0.67); C73(1.06)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C350(1.13); C155(1.17); C202(0.61); C73(0.85)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C350(0.98); C155(0.93); C202(0.66); C73(1.05)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C350(1.06); C155(1.05); C202(0.88); C73(1.16)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C155(0.97); C202(0.47); C73(0.99); C497(0.86)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C155(0.81); C202(0.50); C497(0.81)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C350(1.41); C155(1.03); C497(0.54)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C350(1.10); C155(1.14); C202(0.42); C73(1.00)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C155(0.90); C202(0.61); C73(1.02); C497(0.53)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C350(1.05); C155(0.96)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C350(1.03); C155(1.12); C202(1.05); C73(0.84)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C155(1.09); C202(0.84); C73(0.90)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C350(1.07); C155(1.14); C202(0.80); C73(0.98)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C155(1.13); C202(0.73); C73(0.91)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C155(0.93); C202(0.88); C73(0.92)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C350(1.15); C155(1.02); C202(0.75); C73(0.92)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C350(1.09); C155(1.00); C202(0.60); C73(0.99)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C155(0.97); C202(0.45); C73(0.97); C497(0.99)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C155(0.77); C202(0.43); C497(0.61)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C350(1.15); C155(1.40); C497(0.53)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C350(1.12); C155(1.09); C202(0.35); C73(0.97)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C155(1.04); C202(0.49); C73(1.01); C497(0.56)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C350(0.93); C155(0.84)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C155(0.83); C202(0.73); C73(0.90)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C350(0.96); C155(0.95); C202(0.84); C73(1.02)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C350(0.99); C155(1.06); C202(0.82); C73(1.05)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C155(0.99); C202(0.73); C73(0.99)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C350(1.14); C155(0.98); C202(0.73); C73(1.00)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C350(1.39); C155(0.99); C202(0.63); C73(1.00)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C155(0.95); C202(0.43); C73(0.90); C497(0.79)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C155(0.82); C202(0.52); C497(0.75)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C350(1.09); C155(1.06); C497(0.54)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C350(1.59); C155(0.96); C202(0.41); C73(1.09)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C155(0.95); C202(0.54); C73(0.92); C497(0.59)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C350(1.30); C155(0.89)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C155(0.92); C202(0.76); C73(1.04)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C350(1.00); C155(0.90); C202(0.80); C73(1.09)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C350(1.16); C155(1.03); C202(0.80); C73(0.82)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C155(0.96); C202(0.63); C73(0.89)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C350(1.51); C155(1.05); C202(0.71); C73(0.84)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C350(0.97); C155(1.05); C202(0.73); C73(1.06)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C155(0.90); C202(0.44); C73(0.95); C497(0.73)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C155(0.82); C202(0.47); C497(0.56)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C350(1.93); C155(1.06); C497(0.66)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C350(1.33); C155(0.98); C202(0.38); C73(1.02)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C350(1.31); C155(0.96); C202(0.63); C73(1.10)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C155(0.98); C202(0.57); C73(0.93); C497(0.81)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C350(1.11); C155(1.06)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C350(0.98); C155(0.93); C202(1.08); C73(0.92)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C155(1.03); C202(0.99); C73(1.39)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C350(1.43); C155(1.01); C202(0.97); C73(0.79)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C155(1.12); C202(0.74); C73(1.14)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C350(1.19); C155(0.87); C202(0.78); C73(0.93)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C350(1.00); C155(1.08); C202(0.64); C73(0.99)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C155(0.94); C202(0.46); C73(0.97); C497(0.92)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C155(0.82); C202(0.60); C497(0.82)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C350(1.04); C155(0.99); C202(0.63); C73(0.94)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C350(1.13); C155(1.01); C497(0.46)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C350(1.15); C155(0.89); C202(0.42); C73(0.82)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C155(1.04); C202(0.68); C73(0.95); C497(0.66)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C350(1.29); C155(0.95)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C350(1.02); C155(1.19); C202(1.51); C73(0.82)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C350(1.02); C155(0.99); C202(1.03); C73(1.10)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C155(1.03); C202(0.77); C73(0.95)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C350(1.19); C155(1.01); C202(0.80); C73(1.07)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C350(0.97); C155(0.87); C202(0.69); C73(1.07)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C155(0.92); C202(0.41); C73(0.80); C497(0.88)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C155(0.87); C202(0.58); C73(1.02); C497(1.17)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C155(0.93); C202(0.58); C497(0.76)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C350(1.13); C155(1.20); C497(0.61)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C350(1.16); C155(0.94); C202(0.52); C73(0.93)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C155(0.87); C202(0.64); C73(0.93); C497(0.57)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C350(1.07); C155(0.88)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C350(0.98); C155(1.06); C202(1.18); C73(0.83)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C155(1.20); C202(0.99); C73(0.90)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C350(1.03); C155(0.97); C202(1.17); C73(1.24)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C155(1.06); C202(0.79); C73(1.19)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C155(0.83); C202(0.57); C497(0.81)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C350(1.73); C155(0.95); C202(0.61); C73(0.60)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C350(1.00); C155(0.84); C202(0.81); C73(1.05)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C155(0.85); C202(0.61); C73(0.89); C497(0.79)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C155(0.91); C202(0.80); C497(0.90)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C350(1.26); C155(1.19); C497(0.79)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C350(1.39); C155(0.96); C202(0.41); C73(0.78)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C155(0.86); C202(0.72); C73(0.53); C497(0.79)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C350(1.12); C155(0.92)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C350(1.08); C155(1.20); C202(1.15); C73(0.86)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C155(1.06); C202(1.08); C73(1.12)  LDD1697  [18]
 LDCM0634  CY-0357 Hep-G2 C350(1.59)  LDD2228  [8]
 LDCM0495  E2913 HEK-293T C155(0.96); C202(0.88); C73(0.97)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C350(1.55)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C155(0.96); C202(0.88); C73(1.21)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C350(1.00); C155(1.01); C202(1.24); C73(0.86)  LDD1631  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C350(0.98); C155(0.90); C202(1.19)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C350(1.03); C155(1.12); C202(1.05)  LDD1497  [18]
 LDCM0024  KB05 COLO792 C53(1.94); C117(1.42)  LDD3310  [4]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C313(0.39)  LDD2121  [5]
 LDCM0109  NEM HeLa H570(0.00); H225(0.00)  LDD0223  [13]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C313(0.81)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C313(0.86)  LDD2099  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C313(1.22)  LDD2105  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C313(0.63)  LDD2109  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C313(0.94)  LDD2114  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C313(0.70)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C313(0.71)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C313(1.02)  LDD2127  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C313(0.99)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C313(0.98)  LDD2137  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C313(0.81)  LDD2141  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C313(0.87)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C313(0.78)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C342(0.30)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C313(1.18)  LDD2153  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 19 kDa (CEP19) CEP19 family Q96LK0
Heat shock factor 2-binding protein (HSF2BP) . O75031

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.