Details of the Target

General Information of Target

Target ID LDTP16166
Target Name Actin-related protein 3B (ACTR3B)
Gene Name ACTR3B
Gene ID 57180
Synonyms
ARP11; ARP4; Actin-related protein 3B; ARP3-beta; Actin-like protein 3B; Actin-related protein ARP4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFG
NLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYY
SFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVF
SEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHA
HAINNLRENQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDAL
TWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE
Target Bioclass
Other
Family
Actin family, ARP3 subfamily
Subcellular location
Cytoplasm, cytoskeleton
Function
Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.
Uniprot ID
Q9P1U1
Ensemble ID
ENST00000256001.13
HGNC ID
HGNC:17256

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MDAMB436 SNV: p.D399V .
NCIH661 SNV: p.V377L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y202(0.79)  LDD0264  [1]
HHS-465
 Probe Info  		Y202(6.76)  LDD2237  [2]
DBIA
 Probe Info  		C232(1.11); C235(1.11)  LDD0532  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
IPM
 Probe Info  		N.A.  LDD2156  [5]
Acrolein
 Probe Info  		H410(0.00); C189(0.00)  LDD0217  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0071  [8]
STS-1
 Probe Info  		N.A.  LDD0068  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C189(1.19); C235(1.02)  LDD1507  [10]
 LDCM0215  AC10 HCT 116 C232(1.11); C235(1.11)  LDD0532  [3]
 LDCM0226  AC11 HCT 116 C232(1.28); C235(1.28)  LDD0543  [3]
 LDCM0237  AC12 HCT 116 C232(1.07); C235(1.07)  LDD0554  [3]
 LDCM0246  AC128 HCT 116 C232(1.36); C235(1.36)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C232(0.97); C235(0.97)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C232(0.97); C235(0.97)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C232(0.94); C235(0.94)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C232(0.94); C235(0.94)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C232(1.02); C235(1.02)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C232(1.12); C235(1.12)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C232(1.26); C235(1.26)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C232(1.12); C235(1.12)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C232(1.03); C235(1.03)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C232(1.04); C235(1.04)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C232(1.06); C235(1.06)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C232(1.14); C235(1.14)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C232(1.04); C235(1.04)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C232(1.22); C235(1.22)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C232(0.97); C235(0.97)  LDD0579  [3]
 LDCM0270  AC15 HCT 116 C232(1.14); C235(1.14)  LDD0587  [3]
 LDCM0276  AC17 HCT 116 C232(1.05); C235(1.05)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C232(1.33); C235(1.33)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C232(1.22); C235(1.22)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C34(0.88); C394(1.02); C235(1.00)  LDD1518  [10]
 LDCM0280  AC20 HCT 116 C232(1.15); C235(1.15)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C232(1.19); C235(1.19)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C232(1.09); C235(1.09)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C232(1.10); C235(1.10)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C232(1.10); C235(1.10)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C232(1.08); C235(1.08)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C232(1.16); C235(1.16)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C232(1.16); C235(1.16)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C232(1.24); C235(1.24)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C232(1.19); C235(1.19)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C189(1.14); C235(1.20)  LDD1529  [10]
 LDCM0291  AC30 HCT 116 C232(1.17); C235(1.17)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C232(1.16); C235(1.16)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C232(1.30); C235(1.30)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C232(1.23); C235(1.23)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C232(1.30); C235(1.30)  LDD0612  [3]
 LDCM0296  AC35 HEK-293T C232(0.84); C235(0.84)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C232(0.79); C235(0.79)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C232(0.87); C235(0.87)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C232(0.97); C235(0.97)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C232(0.94); C235(0.94)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C189(0.97); C235(1.11)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C232(0.97); C235(0.97)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C232(0.86); C235(0.86)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C232(0.86); C235(0.86)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C232(1.02); C235(1.02)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C232(0.90); C235(0.90)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C232(0.90); C235(0.90)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C232(0.99); C235(0.99)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C232(1.08); C235(1.08)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C232(1.13); C235(1.13)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C232(0.93); C235(0.93)  LDD0909  [3]
 LDCM0313  AC50 HEK-293T C232(1.07); C235(1.07)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C232(1.15); C235(1.15)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C232(1.02); C235(1.02)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C232(1.05); C235(1.05)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C232(0.99); C235(0.99)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C232(1.16); C235(1.16)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C232(0.92); C235(0.92)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C189(1.09); C235(1.14)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C34(1.05); C394(1.17); C235(1.08)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C189(1.09); C235(1.31)  LDD1561  [10]
 LDCM0323  AC6 HCT 116 C232(0.99); C235(0.99)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C189(0.94); C235(1.14)  LDD1563  [10]
 LDCM0326  AC62 HEK-293T C189(1.02); C235(1.15)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C189(0.93); C235(1.21)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C189(1.05); C34(1.34); C235(1.26)  LDD1567  [10]
 LDCM0332  AC68 HEK-293T C232(1.05); C235(1.05)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C232(1.13); C235(1.13)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C232(0.96); C235(0.96)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C232(0.96); C235(0.96)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C232(1.04); C235(1.04)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C232(1.09); C235(1.09)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C232(0.92); C235(0.92)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C232(0.95); C235(0.95)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C232(0.97); C235(0.97)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C232(1.05); C235(1.05)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C232(0.95); C235(0.95)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C232(0.97); C235(0.97)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C232(1.04); C235(1.04)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C232(1.18); C235(1.18)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C232(1.11); C235(1.11)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C232(0.98); C235(0.98)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C232(1.03); C235(1.03)  LDD0946  [3]
 LDCM0248  AKOS034007472 HCT 116 C232(0.96); C235(0.96)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C232(1.02); C235(1.02)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C232(1.49); C235(1.49)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C232(0.98); C235(0.98)  LDD2171  [3]
 LDCM0108  Chloroacetamide HeLa C189(0.00); H410(0.00); H192(0.00)  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C235(1.09)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C189(1.05); C235(0.83)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C189(0.95)  LDD1573  [10]
 LDCM0370  CL101 HCT 116 C232(1.11); C235(1.11)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C232(1.08); C235(1.08)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C232(1.11); C235(1.11)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C232(0.99); C235(0.99)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C232(1.26); C235(1.26)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C232(1.55); C235(1.55)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C232(1.37); C235(1.37)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C232(1.56); C235(1.56)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C232(1.45); C235(1.45)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C189(1.28); C235(0.90)  LDD1583  [10]
 LDCM0380  CL110 HCT 116 C232(1.61); C235(1.61)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C232(1.44); C235(1.44)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C232(1.20); C235(1.20)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C232(1.24); C235(1.24)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C232(1.12); C235(1.12)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C232(1.22); C235(1.22)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C232(1.18); C235(1.18)  LDD0703  [3]
 LDCM0387  CL117 HEK-293T C232(0.93); C235(0.93)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C232(0.79); C235(0.79)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C232(0.82); C235(0.82)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C189(1.11); C34(0.90); C235(1.26)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C232(0.94); C235(0.94)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C232(1.28); C235(1.28)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C232(1.20); C235(1.20)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C232(1.94); C235(1.94)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C232(1.30); C235(1.30)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C235(1.07)  LDD1600  [10]
 LDCM0398  CL127 HEK-293T C189(1.09)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C189(0.86)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C235(0.94)  LDD1604  [10]
 LDCM0402  CL15 HEK-293T C189(1.03)  LDD1606  [10]
 LDCM0403  CL16 HCT 116 C232(0.95); C235(0.95)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C232(1.21); C235(1.21)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C232(0.96); C235(0.96)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C232(0.99); C235(0.99)  LDD0723  [3]
 LDCM0408  CL20 HCT 116 C232(1.08); C235(1.08)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C232(1.47); C235(1.47)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C232(1.33); C235(1.33)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C232(1.07); C235(1.07)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C232(1.12); C235(1.12)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C232(1.29); C235(1.29)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C232(0.96); C235(0.96)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C232(1.11); C235(1.11)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C232(0.96); C235(0.96)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C232(1.07); C235(1.07)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C189(1.26)  LDD1622  [10]
 LDCM0419  CL30 HCT 116 C232(0.86); C235(0.86)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C189(1.05); C235(1.15)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C189(0.99); C235(0.91)  LDD1625  [10]
 LDCM0423  CL34 HEK-293T C189(1.24); C235(0.89)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C189(1.12); C235(0.95)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C189(0.82); C34(0.97); C235(1.15)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C235(0.97)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C189(0.88)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C189(0.82)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C189(0.83)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C189(1.24); C235(1.07)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C34(0.93); C394(1.11); C235(1.02)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C189(1.09); C235(1.20)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C189(0.85); C235(1.05)  LDD1638  [10]
 LDCM0436  CL46 HCT 116 C232(0.92); C235(0.92)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C232(1.03); C235(1.03)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C232(0.99); C235(0.99)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C232(1.06); C235(1.06)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C189(1.00); C235(0.94)  LDD1644  [10]
 LDCM0441  CL50 HCT 116 C232(0.84); C235(0.84)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C232(0.93); C235(0.93)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C232(1.07); C235(1.07)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C232(1.10); C235(1.10)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C232(1.01); C235(1.01)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C232(1.07); C235(1.07)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C232(0.93); C235(0.93)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C232(0.99); C235(0.99)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C232(1.14); C235(1.14)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C232(1.02); C235(1.02)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C34(1.06); C394(0.96); C235(0.95)  LDD1654  [10]
 LDCM0452  CL60 HCT 116 C232(1.18); C235(1.18)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C232(1.04); C235(1.04)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C232(1.03); C235(1.03)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C232(1.16); C235(1.16)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C232(1.60); C235(1.60)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C232(1.08); C235(1.08)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C232(1.51); C235(1.51)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C232(1.35); C235(1.35)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C232(1.36); C235(1.36)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C232(1.47); C235(1.47)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C189(1.08); C235(1.11)  LDD1665  [10]
 LDCM0463  CL70 HCT 116 C232(1.23); C235(1.23)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C232(1.16); C235(1.16)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C232(1.16); C235(1.16)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C232(1.34); C235(1.34)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C232(1.29); C235(1.29)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C189(0.90)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C189(1.33); C235(1.13)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C34(1.05); C394(1.00); C235(1.01)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C189(1.04); C235(1.36)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C189(0.84); C235(1.27)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C189(0.96); C235(1.11)  LDD1677  [10]
 LDCM0476  CL82 HEK-293T C189(1.27); C235(1.08)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C189(1.27); C235(1.10)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C189(1.05); C34(0.91); C235(1.41)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C235(0.99)  LDD1682  [10]
 LDCM0481  CL87 HEK-293T C189(1.34)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C189(1.00)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C189(0.97); C235(1.07)  LDD1686  [10]
 LDCM0485  CL90 HEK-293T C34(0.99); C394(0.99); C235(1.23)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C189(0.93); C235(1.19)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C189(0.86); C235(1.10)  LDD1690  [10]
 LDCM0489  CL94 HEK-293T C189(0.98); C235(1.11)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C189(1.29); C235(1.02)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C189(1.42); C34(1.05); C235(1.37)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C235(0.99)  LDD1695  [10]
 LDCM0494  CL99 HEK-293T C189(1.05)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C189(1.06)  LDD1698  [10]
 LDCM0625  F8 Ramos C34(0.54)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C34(0.69)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C34(0.60)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C34(0.43)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C34(0.41)  LDD2192  [11]
 LDCM0579  Fragment20 Ramos C34(0.58)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C34(1.51)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C34(0.74)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C34(0.81)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C34(0.15)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C34(0.75)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C34(0.98)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C34(0.46)  LDD2201  [11]
 LDCM0468  Fragment33 HCT 116 C232(1.34); C235(1.34)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C34(1.06)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C34(0.51)  LDD2184  [11]
 LDCM0610  Fragment52 Ramos C34(0.52)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C34(0.69)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C34(0.45)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C34(0.54)  LDD2188  [11]
 LDCM0116  HHS-0101 DM93 Y202(0.79)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y202(0.69)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y202(0.71)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y202(0.69)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y202(0.68)  LDD0268  [1]
 LDCM0107  IAA HeLa H410(0.00); H192(0.00)  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C408(1.02)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C408(1.07)  LDD1497  [10]
 LDCM0024  KB05 OE33 C34(1.80)  LDD3375  [12]
 LDCM0109  NEM HeLa H410(0.00); H192(0.00)  LDD0223  [6]
 LDCM0021  THZ1 HCT 116 C232(0.98); C235(0.98)  LDD2173  [3]

References

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2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
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4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
9 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840