Details of the Target

General Information of Target

Target ID LDTP02186
Target Name Phosphoglycerate kinase 2 (PGK2)
Gene Name PGK2
Gene ID 5232
Synonyms
PGKB; Phosphoglycerate kinase 2; EC 2.7.2.3; Phosphoglycerate kinase, testis specific
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLSKKLTLDKLDVRGKRVIMRVDFNVPMKKNQITNNQRIKASIPSIKYCLDNGAKAVVL
MSHLGRPDGVPMPDKYSLAPVAVELKSLLGKDVLFLKDCVGAEVEKACANPAPGSVILLE
NLRFHVEEEGKGQDPSGKKIKAEPDKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVN
LPHKASGFLMKKELDYFAKALENPVRPFLAILGGAKVADKIQLIKNMLDKVNEMIIGGGM
AYTFLKVLNNMEIGASLFDEEGAKIVKDIMAKAQKNGVRITFPVDFVTGDKFDENAQVGK
ATVASGISPGWMGLDCGPESNKNHAQVVAQARLIVWNGPLGVFEWDAFAKGTKALMDEIV
KATSKGCITVIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKILPGVEALSNM
Target Bioclass
Enzyme
Family
Phosphoglycerate kinase family
Subcellular location
Cytoplasm
Function Essential for sperm motility and male fertility. Not required for the completion of spermatogenesis.
Uniprot ID
P07205
Ensemble ID
ENST00000304801.6
HGNC ID
HGNC:8898
ChEMBL ID
CHEMBL2096677

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HHS-475
 Probe Info  		Y161(0.86)  LDD0264  [1]
HHS-465
 Probe Info  		Y161(8.03)  LDD2237  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		C108(0.00); C50(0.00)  LDD0038  [3]
IA-alkyne
 Probe Info  		C108(0.00); C50(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C108(0.00); C50(0.00)  LDD0037  [3]
1c-yne
 Probe Info  		K30(0.00); K199(0.00)  LDD0228  [4]
Acrolein
 Probe Info  		H125(0.00); H391(0.00)  LDD0217  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		6.64  LDD0465  [7]
STS-2
 Probe Info  		1.33  LDD0139  [8]
DA-2
 Probe Info  		N.A.  LDD0070  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H125(0.00); H391(0.00); H170(0.00)  LDD0222  [5]
 LDCM0116  HHS-0101 DM93 Y161(0.86)  LDD0264  [1]
 LDCM0117  HHS-0201 DM93 Y161(0.83)  LDD0265  [1]
 LDCM0118  HHS-0301 DM93 Y161(0.66)  LDD0266  [1]
 LDCM0119  HHS-0401 DM93 Y161(0.88)  LDD0267  [1]
 LDCM0120  HHS-0701 DM93 Y161(0.97)  LDD0268  [1]
 LDCM0107  IAA HeLa H391(0.00); H125(0.00); H170(0.00)  LDD0221  [5]
 LDCM0109  NEM HeLa H391(0.00); H170(0.00); H125(0.00); K156(0.00)  LDD0223  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acyclovir Small molecular drug DB00787

References

1 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
2 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
8 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
9 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.