Details of the Target

General Information of Target

Target ID LDTP06054
Target Name Scaffold attachment factor B2 (SAFB2)
Gene Name SAFB2
Gene ID 9667
Synonyms
KIAA0138; Scaffold attachment factor B2; SAF-B2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAETLPGSGDSGPGTASLGPGVAETGTRRLSELRVIDLRAELKKRNLDTGGNKSVLMERL
KKAVKEEGQDPDEIGIELEATSKKSAKRCVKGLKMEEEGTEDNGLEDDSRDGQEDMEASL
ENLQNMGMMDMSVLDETEVANSSAPDFGEDGTDGLLDSFCDSKEYVAAQLRQLPAQPPEH
AVDGEGFKNTLETSSLNFKVTPDIEESLLEPENEKILDILGETCKSEPVKEESSELEQPF
AQDTSSVGPDRKLAEEEDLFDSAHPEEGDLDLASESTAHAQSSKADSLLAVVKREPAEQP
GDGERTDCEPVGLEPAVEQSSAASELAEASSEELAEAPTEAPSPEARDSKEDGRKFDFDA
CNEVPPAPKESSTSEGADQKMSSFKEEKDIKPIIKDEKGRVGSGSGRNLWVSGLSSTTRA
TDLKNLFSKYGKVVGAKVVTNARSPGARCYGFVTMSTSDEATKCISHLHRTELHGRMISV
EKAKNEPAGKKLSDRKECEVKKEKLSSVDRHHSVEIKIEKTVIKKEEKIEKKEEKKPEDI
KKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQD
RKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRLEAFHERKEK
ARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLR
YEQERRPGRRPYDLDRRDDAYWPEGKRVAMEDRYRADFPRPDHRFHDFDHRDRGQYQDHA
IDRREGSRPMMGDHRDGQHYGDDRHGHGGPPERHGRDSRDGWGGYGSDKRLSEGRGLPPP
PRGGRDWGEHNQRLEEHQARAWQGAMDAGAASREHARWQGGERGLSGPSGPGHMASRGGV
AGRGGFAQGGHSQGHVVPGGGLEGGGVASQDRGSRVPHPHPHPPPYPHFTRRY
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Uniprot ID
Q14151
Ensemble ID
ENST00000252542.9
HGNC ID
HGNC:21605

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.P945RfsTer49
SNV: p.R476Ter		 DBIA    Probe Info 
IGROV1 Deletion: p.P945RfsTer49 DBIA    Probe Info 
JURKAT Deletion: p.K536SfsTer15 .
KMCH1 SNV: p.K545E DBIA    Probe Info 
KMRC20 SNV: p.C672F DBIA    Probe Info 
MELHO SNV: p.W862L DBIA    Probe Info 
NCIH23 SNV: p.G489W DBIA    Probe Info 
SKNSH SNV: p.R645L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		4.08  LDD0215  [2]
STPyne
 Probe Info  		K395(10.00); K490(1.39); K53(7.14); K562(1.64)  LDD0277  [3]
ONAyne
 Probe Info  		K391(6.67)  LDD0275  [3]
OPA-S-S-alkyne
 Probe Info  		K829(1.92)  LDD3494  [4]
Probe 1
 Probe Info  		Y732(44.33)  LDD3495  [5]
Alkylaryl probe 3
 Probe Info  		11.59  LDD0384  [6]
BTD
 Probe Info  		C672(1.01); C498(0.88)  LDD1700  [7]
AHL-Pu-1
 Probe Info  		C308(2.14); C224(10.60)  LDD0168  [8]
DBIA
 Probe Info  		C361(1.08); C224(1.04)  LDD0078  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
IPIAA_L
 Probe Info  		C224(0.00); C361(0.00)  LDD0031  [12]
Lodoacetamide azide
 Probe Info  		C672(0.00); C449(0.00)  LDD0037  [10]
ENE
 Probe Info  		C361(0.00); C672(0.00); C224(0.00); C498(0.00)  LDD0006  [13]
IPM
 Probe Info  		C361(0.00); C224(0.00); C672(0.00)  LDD0005  [13]
SF
 Probe Info  		Y732(0.00); K437(0.00)  LDD0028  [14]
TFBX
 Probe Info  		C224(0.00); C672(0.00); C361(0.00)  LDD0148  [15]
Phosphinate-6
 Probe Info  		C672(0.00); C361(0.00); C224(0.00)  LDD0018  [16]
Ox-W18
 Probe Info  		N.A.  LDD2175  [17]
Acrolein
 Probe Info  		H512(0.00); C672(0.00)  LDD0217  [18]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [18]
Crotonaldehyde
 Probe Info  		H850(0.00); C672(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
W1
 Probe Info  		C224(0.00); C361(0.00); C672(0.00)  LDD0236  [19]
AOyne
 Probe Info  		10.50  LDD0443  [20]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		15.43  LDD0475  [22]
FFF probe2
 Probe Info  		20.00  LDD0463  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C464(0.52); C672(0.99)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C464(0.78); C361(0.94); C224(0.97); C672(0.89)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C464(1.16); C361(0.85); C224(0.61)  LDD2095  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C464(0.73); C672(0.63); C498(0.89)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C672(1.05); C498(1.12)  LDD2152  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C672(0.79)  LDD2103  [7]
 LDCM0025  4SU-RNA HEK-293T C308(2.14); C224(10.60)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C361(2.54); C224(5.89)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C224(1.33); C361(0.99); C672(1.03)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C224(1.21); C361(1.24); C672(0.99)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C224(1.02); C361(1.03); C672(0.95)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C224(1.03); C361(1.07); C672(0.96)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C224(1.11); C361(1.10); C672(1.07)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C224(1.01); C361(1.36); C672(1.35)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C224(0.93); C361(1.25); C672(1.47)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C224(0.97); C361(1.28); C672(1.23)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C224(1.02); C361(1.35); C672(1.12)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C224(1.04); C361(1.21); C672(1.20)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C224(0.98); C361(0.99); C672(1.06)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C224(0.96); C361(0.89); C672(1.09)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C224(1.14); C361(1.28); C672(1.16)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C224(1.03); C361(1.08); C672(1.05)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C224(1.06); C361(1.07); C672(0.88)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C224(1.14); C361(1.23); C672(1.20)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C224(1.02); C361(0.99); C672(0.91)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C224(1.24); C361(1.16); C672(0.75)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C224(1.45); C361(1.29); C672(0.80)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C224(1.32); C361(1.25); C672(0.61)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C224(1.12); C361(1.13); C672(1.01)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C224(1.08); C361(1.10); C672(0.84)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C224(1.21); C361(1.29); C672(0.89)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C224(1.08); C361(1.08); C672(1.01)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C224(1.24); C361(1.20); C672(0.70)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C224(1.12); C361(1.07); C672(1.30)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C224(1.20); C361(1.13); C672(0.86)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C224(1.13); C361(0.93); C672(1.35)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C224(1.06); C361(1.03); C672(1.02)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C224(1.10); C361(1.15); C672(0.86)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C224(1.26); C361(1.27); C672(0.82)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C224(1.21); C361(1.22); C672(0.82)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C224(1.47); C361(0.54); C672(1.09)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C224(0.84); C361(0.60); C672(0.95)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C224(1.15); C361(0.62); C672(0.96)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C224(0.74); C361(0.64); C672(0.85)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C224(0.93); C361(0.72); C672(1.04)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C224(1.07); C361(0.70); C672(1.01)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C224(1.13); C361(0.78); C672(1.48)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C224(1.21); C361(0.65); C672(0.98)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C224(1.06); C361(0.75); C672(1.06)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C224(0.99); C361(0.72); C672(1.05)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C224(1.14); C361(0.92); C672(1.11)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C224(1.01); C361(0.85); C672(1.18)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C224(1.15); C361(1.22); C672(0.84)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C224(1.10); C361(0.99); C672(1.17)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C224(1.10); C361(1.00); C672(1.21)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C224(0.88); C361(0.78); C672(0.92)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C361(1.06); C224(1.12); C672(1.23)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C672(1.17); C361(1.36); C224(1.72)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C672(1.02); C361(1.15); C224(1.32)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C361(1.31); C224(1.43); C672(1.55)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C672(1.22); C361(1.40); C224(1.68)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C672(1.68); C361(1.81); C224(2.43)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C361(1.51); C672(1.60); C224(1.79)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C672(1.11); C224(1.21); C361(1.21)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C361(1.13); C224(1.19); C672(1.39)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C361(1.09); C224(1.19); C672(1.46)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C672(1.25); C361(1.27); C224(1.66)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C672(1.89); C361(1.98); C224(2.47)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C224(1.37); C361(1.25); C672(1.31)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C224(1.49); C361(1.30); C672(1.50)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C224(1.10); C361(1.03); C672(1.53)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C224(0.99); C361(1.08); C672(1.38)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C224(0.97); C361(0.99); C672(1.09)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C224(0.83); C361(1.12); C672(1.20)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C224(1.02); C361(1.05); C672(1.12)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C361(1.05); C672(1.09); C224(1.18)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C224(1.02); C672(1.08); C361(1.13)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C224(0.81); C361(1.20); C672(1.26)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C224(0.87); C672(1.05); C361(1.13)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C224(0.76); C361(1.04); C672(1.19)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C361(1.01); C672(1.05); C224(1.06)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C361(1.05); C224(1.29); C672(1.36)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C361(1.15); C672(1.32); C224(1.42)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C361(1.20); C672(1.29); C224(1.36)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C361(1.26); C224(1.39); C672(1.43)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C224(1.28); C361(1.31); C672(1.33)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C361(0.99); C672(1.05); C224(1.19)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C672(1.23); C361(1.37); C224(1.38)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C361(1.19); C672(1.28); C224(1.37)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C361(1.47); C672(1.50); C224(1.65)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C361(1.41); C672(1.48); C224(1.55)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C361(1.60); C672(1.71); C224(1.78)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C672(0.83); C361(0.83)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C361(0.81); C672(0.89)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C672(0.79); C361(0.85)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C361(0.93); C672(1.04)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C361(1.00); C672(1.07)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C672(1.05); C361(1.06); C224(1.42)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C672(1.08); C361(1.16)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C672(0.77); C361(0.97)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C672(0.90); C361(0.97)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C672(0.97); C361(1.02)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C672(0.88); C361(1.04)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C672(1.07); C361(1.19)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C672(1.06); C224(1.15); C361(1.26)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C361(1.09); C672(1.15); C224(1.17)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C361(1.15); C672(1.19); C224(1.29)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C672(1.46); C361(1.56); C224(1.60)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C361(1.01); C672(1.10); C224(1.47)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C361(1.38); C224(1.57); C672(1.58)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C672(0.83); C224(0.98); C361(0.99)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C672(0.97); C361(1.14); C224(1.23)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C224(1.19); C361(1.19); C672(1.42)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C672(1.21); C361(1.29); C224(1.30)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C224(1.42); C672(1.55); C361(1.56)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C224(1.80); C361(2.15); C672(2.68)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C224(1.17); C361(1.21); C672(1.47)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C224(1.25); C361(1.40); C672(1.45)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C224(1.25); C361(1.33); C672(1.46)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C672(0.97); C224(1.27); C361(1.29)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C224(1.14); C361(1.29); C672(1.37)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C361(1.05); C224(1.21); C672(1.22)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C224(1.19); C361(1.29); C672(1.35)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C361(1.11); C224(1.12); C672(1.17)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C224(1.20); C361(1.33); C672(1.38)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C361(1.08); C672(1.42); C224(1.54)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C361(1.05); C672(1.23); C224(1.37)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C361(1.27); C672(1.46); C224(1.47)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C672(0.90); C361(1.15); C224(1.17)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C672(1.03); C361(1.11); C224(1.13)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C672(0.94); C361(1.07); C224(1.15)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C224(1.15); C361(1.17); C672(1.36)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C361(1.00); C224(1.00); C672(1.13)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C224(1.16); C361(1.24); C672(1.40)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C672(1.19); C224(1.35); C361(1.59)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C672(0.92); C224(1.30); C361(1.36)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C672(1.00); C224(1.71); C361(1.93)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C672(0.84); C224(1.18); C361(1.28)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C672(1.04); C361(1.16); C224(1.22)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C672(0.83); C224(1.04); C361(1.08)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C672(1.07); C224(1.08); C361(1.14)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C672(1.13); C361(1.26); C224(1.26)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C672(0.73); C224(1.05); C361(1.27)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C224(0.95); C672(0.96); C361(0.99)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C672(0.97); C224(1.66); C361(1.83)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C672(1.65); C361(1.77); C224(1.78)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C672(1.34); C361(1.59); C224(1.68)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C361(1.33); C224(1.39); C672(1.42)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C224(1.19); C361(1.21); C672(1.27)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C672(1.03); C224(1.03); C361(1.08)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C224(1.10); C361(1.23); C672(1.24)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C224(1.30); C672(1.35); C361(1.36)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C224(0.97); C361(1.01); C672(1.08)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C672(1.56); C224(1.69); C361(1.70)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C672(1.40); C224(1.58); C361(1.65)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C672(1.14); C224(1.18); C361(1.27)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C672(1.06); C224(1.15); C361(1.24)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C224(1.03); C361(1.12); C672(1.22)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C224(1.28); C361(1.30); C672(1.37)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C224(1.43); C672(1.51); C361(1.55)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C224(1.19); C361(2.03); C672(2.10)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C672(0.91); C361(1.00); C224(1.16)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C224(1.07); C361(1.11); C672(1.03)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C672(1.06); C224(1.12); C361(1.15)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C224(1.47); C672(1.56); C361(1.94)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.43  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C361(1.08); C224(1.04)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa C672(0.00); H511(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C672(2.01)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C224(0.79); C361(0.88); C672(1.23)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C672(0.89); C361(1.07); C224(1.22)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C361(1.05); C672(1.06); C224(1.30)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C672(1.08); C361(1.26); C224(1.30)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C361(0.97); C224(1.00); C672(1.11)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C672(0.99); C224(1.04); C361(1.06)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C672(0.90); C361(1.02); C224(1.11)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C224(0.89); C361(1.16); C672(1.19)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C224(0.74); C361(1.42); C672(1.61)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C224(0.80); C361(1.20); C672(1.33)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C224(0.91); C361(1.32); C672(1.61)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C224(0.93); C361(1.10); C672(1.23)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C672(1.03); C361(1.31); C224(1.49)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C224(0.99); C361(1.12); C672(1.64)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C224(1.07); C361(1.11); C672(1.48)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C361(0.95); C224(1.17); C672(1.37)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C361(1.37); C672(1.39); C224(1.61)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C361(1.10); C224(1.25); C672(1.38)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C361(1.31); C224(1.36); C672(1.38)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C361(1.18); C672(1.21); C224(1.36)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C361(1.57); C672(1.58)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C672(0.83); C361(0.95)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C672(0.87); C361(1.09)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C672(0.85); C224(1.42); C361(1.56)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C672(0.82); C361(0.97)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C672(0.97); C224(1.24); C361(1.31)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C361(1.18); C224(1.21); C672(1.37)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C224(1.25); C361(1.29); C672(1.91)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C361(1.34); C672(1.36); C224(1.41)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C361(0.90); C672(1.05); C224(1.16)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C361(0.89); C224(1.07); C672(1.10)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C361(0.93); C224(1.06); C672(1.28)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C224(1.21); C672(1.31); C361(1.43)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C672(0.95); C361(1.12); C224(1.27)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C361(0.91); C672(0.92); C224(0.92)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C672(1.01); C361(1.17); C224(1.18)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C224(1.12); C672(1.16); C361(1.17)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C361(0.92); C224(1.11); C672(1.51)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C224(1.11); C361(1.19); C672(1.22)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C224(1.04); C672(1.12); C361(1.14)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C361(0.87); C224(0.93); C672(1.11)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C672(1.22); C224(1.29); C361(1.35)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C224(1.25); C361(1.32); C672(1.89)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C224(1.78); C361(2.09); C672(2.78)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C361(1.17); C672(1.19); C224(1.19)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C224(1.38); C361(1.61); C672(1.89)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C224(1.27); C361(1.39); C672(1.86)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C224(1.19); C361(1.28); C672(1.47)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C224(1.24); C361(1.20); C672(1.30)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C224(1.30); C361(1.29); C672(1.38)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C224(1.29); C361(1.35); C672(1.34)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C224(0.97); C361(0.94); C672(0.95)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C224(1.04); C361(1.11); C672(1.15)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C224(1.06); C361(1.03); C672(1.37)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C224(1.17); C361(1.11); C672(1.32)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C224(1.09); C361(1.01); C672(1.30)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C224(1.29); C361(1.38); C672(1.18)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C224(1.32); C361(1.58); C672(1.20)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C224(1.20); C361(1.32); C672(1.36)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C224(1.35); C361(1.42); C672(1.22)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C224(1.31); C361(1.34); C672(1.45)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C224(0.95); C361(0.91); C672(1.33)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C224(1.23); C361(1.38); C672(1.87)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C224(1.09); C361(1.27); C672(1.14)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C224(1.67); C361(2.27); C672(1.06)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C224(1.21); C361(1.47); C672(1.22)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C224(1.19); C361(1.24); C672(1.20)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C224(1.38); C361(1.55); C672(1.29)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C224(0.94); C361(0.83); C672(1.01)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C224(0.94); C361(0.81); C672(1.02)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C224(0.85); C361(0.75); C672(0.98)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C224(0.86); C361(0.82); C672(1.02)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C224(1.11); C361(0.96); C672(0.85)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C224(0.84); C361(0.74); C672(1.06)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C224(0.89); C361(0.85); C672(1.12)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C224(0.98); C361(0.88); C672(1.05)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C224(0.81); C361(0.77); C672(1.10)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C224(0.81); C361(0.78); C672(1.12)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C224(0.84); C361(0.83); C672(0.99)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C224(0.96); C361(0.90); C672(1.10)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C224(0.84); C361(0.75); C672(1.15)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C224(0.91); C361(0.83); C672(1.07)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C224(0.92); C361(0.93); C672(1.08)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C224(1.05); C361(1.12); C672(1.03)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C224(0.90); C361(0.87); C672(1.18)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C224(1.12); C361(1.09); C672(1.17)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C224(1.19); C361(1.08); C672(1.16)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C224(1.37); C361(1.14); C672(1.22)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C224(1.42); C361(1.28); C672(1.29)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C224(1.21); C361(1.08); C672(1.18)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C224(1.76); C361(1.59); C672(1.17)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C224(1.37); C361(1.46); C672(1.28)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C224(1.32); C361(1.31); C672(1.03)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C224(1.02); C361(1.03); C672(1.15)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C224(1.30); C361(1.37); C672(0.97)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C224(1.28); C361(1.29); C672(1.00)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C224(1.42); C361(1.43); C672(1.11)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C224(1.17); C361(1.24); C672(1.41)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C224(1.26); C361(1.28); C672(1.21)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C224(1.27); C361(1.34); C672(1.30)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C224(1.29); C361(1.10); C672(0.96)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C224(1.10); C361(0.95); C672(0.93)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C224(1.26); C361(1.21); C672(1.05)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C224(1.49); C361(1.55); C672(1.02)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C224(1.32); C361(1.35); C672(1.69)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C224(1.14); C361(1.07); C672(0.91)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C224(1.25); C361(1.20); C672(0.94)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C224(1.84); C361(1.89); C672(0.82)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C224(1.76); C361(1.47); C672(1.20)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C224(2.14); C361(1.77); C672(0.96)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C224(1.36); C361(1.13); C672(0.90)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C224(1.32); C361(0.97); C672(0.95)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C224(1.39); C361(1.13); C672(1.18)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C224(1.65); C361(1.55); C672(0.89)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C224(2.43); C361(2.50); C672(0.82)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C224(1.08); C361(1.13); C672(0.89)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C224(1.03); C361(0.83); C672(1.24)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C224(1.25); C361(1.18); C672(1.03)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C224(1.23); C361(1.03); C672(0.97)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C224(1.16); C361(0.94); C672(0.95)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C224(1.25); C361(1.06); C672(1.08)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C224(1.26); C361(1.05); C672(1.03)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C224(1.24); C361(1.08); C672(1.14)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C224(1.22); C361(1.00); C672(1.31)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C224(1.32); C361(1.14); C672(1.01)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C224(1.39); C361(1.07); C672(1.11)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C672(0.71); C224(0.66); C361(0.35)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C672(0.86); C361(0.96); C224(0.92); C308(1.06)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C672(1.16); C224(0.91); C361(0.91)  LDD1702  [7]
 LDCM0468  Fragment33 HCT 116 C224(1.20); C361(1.42); C672(1.24)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C224(1.52); C361(1.87); C672(1.74)  LDD0744  [9]
 LDCM0022  KB02 HCT 116 C672(4.34); C224(1.49); C361(1.27)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C672(1.57); C224(1.04); C361(1.13)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C672(4.55); C224(1.44); C361(1.18)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C672(1.22); C498(0.69)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C672(0.78)  LDD2121  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C224(1.05); C672(0.34)  LDD2089  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C361(1.16); C498(1.17)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C498(1.06)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C498(0.67)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C498(1.11)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C498(1.01)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C672(0.93)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C498(0.92)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C361(1.03); C672(0.63); C498(0.55)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C464(0.70); C672(0.60); C498(0.95)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C672(0.91); C498(0.78)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C464(0.54); C672(1.01); C498(0.63)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C498(1.07)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C464(0.47); C672(1.50)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C361(1.02); C672(0.95); C498(0.98)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C464(1.06); C672(0.90); C498(0.94)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C361(0.91); C672(0.72)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C672(0.64); C498(0.83)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C464(0.38)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C672(0.38); C498(0.66)  LDD2115  [7]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C498(1.28)  LDD2116  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C498(1.25)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C361(1.06); C672(2.07)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C672(1.03); C498(1.00)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C498(1.01)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C464(0.59); C672(0.55)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C498(1.13)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C361(0.91); C498(0.85)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C672(0.66); C498(0.96)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C672(0.74); C498(0.93)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C672(0.90); C498(0.76)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C498(1.58)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C672(0.46)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C361(0.75); C672(0.91); C498(0.49)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C361(1.24)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C361(0.95)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C672(1.01); C498(0.88)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C361(0.84); C672(0.50)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C464(0.47)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C672(1.08); C498(1.82)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C672(2.76)  LDD2144  [7]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C498(4.32)  LDD2145  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C672(0.68); C498(0.47)  LDD2146  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C498(1.09)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C464(0.81); C498(0.51)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C498(2.04)  LDD2151  [7]
 LDCM0099  Phenelzine MDA-MB-231 11.59  LDD0384  [6]
 LDCM0111  W14 Hep-G2 C224(16.98)  LDD0238  [19]
 LDCM0112  W16 Hep-G2 C672(0.69); C361(1.12)  LDD0239  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) ATG8 family Q9H0R8
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Scaffold attachment factor B1 (SAFB) . Q15424
Scaffold attachment factor B2 (SAFB2) . Q14151

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402