Details of the Target

General Information of Target

Target ID LDTP10037
Target Name Tektin-1 (TEKT1)
Gene Name TEKT1
Gene ID 83659
Synonyms
Tektin-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLEEAGEVLENMLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQP
YGTRNAVLNTEARTMAAEVLSRRCVLMRLLDFSYEQYQKALRQSAGAVVIILPRAMAAVP
QDVVRQFMEIEPEMLAMETAVPVYFAVEDEALLSIYKQTQAASASQGSASAAEVLLRTAT
ANGFQMVTSGVQSKAVSDWLIASVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADS
NGSGVSVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDNLDHTDSSL
LQDNVAFVLCLDTVGRGSSLHLHVSKPPREGTLQHAFLRELETVAAHQFPEVRFSMVHKR
INLAEDVLAWEHERFAIRRLPAFTLSHLESHRDGQRSSIMDVRSRVDSKTLTRNTRIIAE
ALTRVIYNLTEKGTPPDMPVFTEQMQIQQEQLDSVMDWLTNQPRAAQLVDKDSTFLSTLE
HHLSRYLKDVKQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAVFDLLLAVGIAAYLGMAY
VAVQHFSLLYKTVQRLLVKAKTQ
Target Bioclass
Other
Family
Tektin family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules.
Uniprot ID
Q969V4
Ensemble ID
ENST00000338694.7
HGNC ID
HGNC:15534

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
W1
 Probe Info  		D252(7.24)  LDD0238  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0111  W14 Hep-G2 D252(7.24)  LDD0238  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit gamma-1 (PRKAG1) 5'-AMP-activated protein kinase gamma subunit family P54619
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Chromodomain-helicase-DNA-binding protein 2 (CHD2) SNF2/RAD54 helicase family O14647
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Cilia- and flagella-associated protein 206 (CFAP206) CFAP206 family Q8IYR0
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Tektin-4 (TEKT4) Tektin family Q8WW24
UPF0739 protein C1orf74 (C1orf74) UPF0739 family Q96LT6
Vinculin (VCL) Vinculin/alpha-catenin family P18206
EF-hand domain-containing protein 1 (EFHC1) . Q5JVL4
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) . P55795
Kelch-like protein 38 (KLHL38) . Q2WGJ6
Lethal(3)malignant brain tumor-like protein 2 (L3MBTL2) . Q969R5
Placental protein 13-like (LGALS14) . Q8TCE9
Protein unc-45 homolog A (UNC45A) . Q9H3U1
Testis-specific protein 10-interacting protein (TSGA10IP) . Q3SY00

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.