Details of the Target

General Information of Target

Target ID LDTP14653
Target Name Small ribosomal subunit protein eS4, Y isoform 1 (RPS4Y1)
Gene Name RPS4Y1
Gene ID 6192
Synonyms
RPS4Y; Small ribosomal subunit protein eS4, Y isoform 1; 40S ribosomal protein S4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDAKSLTAWSRTLVTFKDVFVDFTREEWKLLDTAQQIVYRNVMLENYKNLVSLGYQLTKP
DVILRLEKGEEPWLVEREIHQETHPDSETAFEIKSSVSSRSIFKDKQSCDIKMEGMARND
LWYLSLEEVWKCRDQLDKYQENPERHLRQVAFTQKKVLTQERVSESGKYGGNCLLPAQLV
LREYFHKRDSHTKSLKHDLVLNGHQDSCASNSNECGQTFCQNIHLIQFARTHTGDKSYKC
PDNDNSLTHGSSLGISKGIHREKPYECKECGKFFSWRSNLTRHQLIHTGEKPYECKECGK
SFSRSSHLIGHQKTHTGEEPYECKECGKSFSWFSHLVTHQRTHTGDKLYTCNQCGKSFVH
SSRLIRHQRTHTGEKPYECPECGKSFRQSTHLILHQRTHVRVRPYECNECGKSYSQRSHL
VVHHRIHTGLKPFECKDCGKCFSRSSHLYSHQRTHTGEKPYECHDCGKSFSQSSALIVHQ
RIHTGEKPYECCQCGKAFIRKNDLIKHQRIHVGEETYKCNQCGIIFSQNSPFIVHQIAHT
GEQFLTCNQCGTALVNTSNLIGYQTNHIRENAY
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS4 family
Uniprot ID
P22090
Ensemble ID
ENST00000250784.13
HGNC ID
HGNC:10425

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y54(61.02)  LDD3495  [1]
DBIA
 Probe Info  		C41(7.91)  LDD0209  [2]
HHS-482
 Probe Info  		Y54(0.82)  LDD0285  [3]
HHS-465
 Probe Info  		Y54(4.43)  LDD2237  [4]
W1
 Probe Info  		C181(0.77)  LDD0238  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C41(0.00); C181(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C41(0.00); C181(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C41(0.00); C181(0.00)  LDD0037  [6]
Acrolein
 Probe Info  		H138(0.00); H201(0.00); H209(0.00); H142(0.00)  LDD0217  [7]
Crotonaldehyde
 Probe Info  		H201(0.00); H142(0.00)  LDD0219  [7]
Methacrolein
 Probe Info  		H138(0.00); C65(0.00); H17(0.00); H201(0.00)  LDD0218  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
TPP-AC
 Probe Info  		N.A.  LDD0427  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C41(1.03)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C41(0.81)  LDD0532  [10]
 LDCM0226  AC11 HCT 116 C41(0.62)  LDD0543  [10]
 LDCM0237  AC12 HCT 116 C41(0.71)  LDD0554  [10]
 LDCM0259  AC14 HCT 116 C41(0.76)  LDD0576  [10]
 LDCM0263  AC143 HCT 116 C41(0.90)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C41(1.24)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C41(0.85)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C41(0.99)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C41(0.92)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C41(1.28)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C41(1.06)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C41(0.79)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C41(0.85)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C41(1.23)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C41(1.27)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C41(1.77)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C41(1.34)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C41(1.29)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C41(1.18)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C41(1.92)  LDD2161  [10]
 LDCM0279  AC2 HCT 116 C41(0.99)  LDD0596  [10]
 LDCM0285  AC25 HCT 116 C41(0.80); C181(0.99)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C181(0.81); C41(1.44)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C181(0.75); C41(1.32)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C181(0.74); C41(1.13)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C181(0.83); C41(1.00)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C41(0.85)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C181(0.62); C41(0.95)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C181(0.88); C41(1.24)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C181(0.42); C41(0.89)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C181(0.60); C41(1.73)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C181(0.39); C41(1.39)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C41(0.64); C181(1.45)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C41(0.69); C181(2.06)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C41(0.83); C181(1.62)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C41(1.01); C181(1.87)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C41(0.61); C181(1.22)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C41(1.07)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C181(0.67); C41(0.96)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C41(0.70); C181(1.49)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C41(0.89); C181(1.12)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C41(0.83); C181(1.23)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C41(0.72); C181(0.93)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C181(0.77); C41(0.91)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C41(0.68)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C41(0.82)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C41(0.97)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C41(0.74)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C41(0.79)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C41(1.02)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C41(0.75)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C41(1.13)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C41(0.86)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C41(0.89)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C41(1.04)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C41(1.33)  LDD0636  [10]
 LDCM0323  AC6 HCT 116 C41(0.93)  LDD0640  [10]
 LDCM0332  AC68 HCT 116 C181(0.83); C41(1.06)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C181(0.62); C41(1.40)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C41(0.65)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C181(0.32); C41(0.94)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C181(0.89); C41(0.98)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C181(0.54); C41(1.49)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C181(0.38); C41(1.55)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C181(0.41); C41(1.51)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C181(0.41); C41(1.64)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C181(0.48); C41(1.32)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C181(0.44); C41(1.33)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C181(0.91); C41(1.24)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C181(0.85); C41(1.20)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C41(0.60)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C181(0.50); C41(1.25)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C181(0.54); C41(0.89)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C181(0.35); C41(1.22)  LDD0665  [10]
 LDCM0248  AKOS034007472 HCT 116 C41(0.67)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C41(0.70)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C41(0.90)  LDD0592  [10]
 LDCM0108  Chloroacetamide HeLa H209(0.00); H138(0.00); H17(0.00); H201(0.00)  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C41(0.93)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C41(1.34)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C41(1.03)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C41(0.74)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C41(0.89)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C41(0.80)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C41(1.16)  LDD0690  [10]
 LDCM0379  CL11 HCT 116 C41(1.24)  LDD0696  [10]
 LDCM0382  CL112 HCT 116 C41(0.59); C181(1.15)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C181(0.51); C41(1.32)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C181(1.09); C41(1.19)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C41(0.92); C181(1.07)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C41(0.71); C181(0.93)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C181(0.56); C41(1.09)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C41(0.73); C181(1.16)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C181(0.71); C41(0.83)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C41(1.45)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C41(0.67); C181(1.33)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C41(0.56)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C41(1.01)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C41(0.88)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C41(0.93)  LDD0712  [10]
 LDCM0400  CL13 HCT 116 C41(1.59)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C41(1.24)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C41(1.11)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C41(1.01)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C41(1.16)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C41(1.61)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C41(1.31)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C41(0.90)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C41(1.70)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C41(1.51)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C41(1.78)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C41(1.57)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C41(1.52)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C41(1.26)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C41(1.32)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C41(1.01)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C41(1.38)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C41(1.23)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C41(0.93)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C41(1.11)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C41(0.75)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C41(1.00)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C41(0.90)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C41(1.09)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C41(0.97)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C41(1.63)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C41(1.62)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C41(0.75)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C41(1.16)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C41(1.22)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C41(0.82)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C41(1.26)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C41(1.56)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C41(1.84)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C41(1.52)  LDD0752  [10]
 LDCM0440  CL5 HCT 116 C41(1.27)  LDD0757  [10]
 LDCM0451  CL6 HCT 116 C41(0.94)  LDD0768  [10]
 LDCM0453  CL61 HCT 116 C41(0.99)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C41(0.90)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C41(0.81)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C41(0.96)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C41(1.07)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C41(1.02)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C41(1.10)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C41(0.70)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C41(0.97)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C41(1.07)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C41(1.13)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C41(0.75)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C41(0.69)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C41(0.92)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C41(0.99)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C181(0.78)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C181(0.71)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C181(0.80)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C181(0.55)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C41(1.49)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C181(0.99)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C181(0.66)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C181(0.69)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C181(0.64)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C181(0.73)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C181(0.70)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C181(0.80)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C181(0.71)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C181(0.65)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C181(0.83)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C41(1.47)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C181(1.03)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C41(0.86)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C41(0.75)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C41(0.97)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C41(1.02)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C41(0.84)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C41(0.80)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C41(1.02)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C41(0.94)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C41(0.96)  LDD0811  [10]
 LDCM0468  Fragment33 HCT 116 C41(0.73)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C41(1.34)  LDD0744  [10]
 LDCM0107  IAA HeLa H201(0.00); H138(0.00); H142(0.00); H17(0.00)  LDD0221  [7]
 LDCM0123  JWB131 DM93 Y54(0.82)  LDD0285  [3]
 LDCM0124  JWB142 DM93 Y54(0.78)  LDD0286  [3]
 LDCM0125  JWB146 DM93 Y54(1.04)  LDD0287  [3]
 LDCM0126  JWB150 DM93 Y54(1.73)  LDD0288  [3]
 LDCM0127  JWB152 DM93 Y54(1.45)  LDD0289  [3]
 LDCM0128  JWB198 DM93 Y54(1.22)  LDD0290  [3]
 LDCM0129  JWB202 DM93 Y54(0.48)  LDD0291  [3]
 LDCM0130  JWB211 DM93 Y54(1.05)  LDD0292  [3]
 LDCM0022  KB02 22RV1 C181(1.10)  LDD2243  [11]
 LDCM0023  KB03 Jurkat C41(7.91)  LDD0209  [2]
 LDCM0024  KB05 MKN45 C181(1.34)  LDD3332  [11]
 LDCM0109  NEM HeLa H138(0.00); H209(0.00); H142(0.00); H201(0.00)  LDD0223  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C65(1.26)  LDD2206  [12]
 LDCM0628  OTUB2-COV-1 HEK-293T C65(0.52)  LDD2207  [12]
 LDCM0111  W14 Hep-G2 C181(0.77)  LDD0238  [5]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
12 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.