Details of the Target

General Information of Target

Target ID LDTP10961
Target Name BRCA1-associated RING domain protein 1 (BARD1)
Gene Name BARD1
Gene ID 580
Synonyms
BRCA1-associated RING domain protein 1; BARD-1; EC 2.3.2.27; RING-type E3 ubiquitin transferase BARD1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
SADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQV
LSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWTD
WLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
Uniprot ID
Q99728
Ensemble ID
ENST00000260947.9
HGNC ID
HGNC:952

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.K596NfsTer9 .
AN3CA SNV: p.K292E .
HCT15 SNV: p.A724T .
IM95 Deletion: p.K208RfsTer4 .
KMCH1 SNV: p.R661T DBIA    Probe Info 
MELJUSO Deletion: p.F242del .
NCIH23 SNV: p.A168T .
OVK18 SNV: p.G32V .
SAOS2 SNV: p.S179L .
TGBC1TKB SNV: p.V154F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C733(1.01); C743(1.01)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD0005  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C174
 Probe Info  		4.92  LDD1854  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C743(1.00)  LDD1507  [6]
 LDCM0215  AC10 HEK-293T C743(0.85)  LDD1508  [6]
 LDCM0226  AC11 HEK-293T C108(1.07); C743(0.99)  LDD1509  [6]
 LDCM0237  AC12 HEK-293T C108(1.05); C743(0.97)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C108(1.06); C743(1.09)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C108(1.07); C743(1.03)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C743(0.99)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C743(0.95)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C108(1.09); C743(1.08)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C743(0.89)  LDD1518  [6]
 LDCM0280  AC20 HEK-293T C108(0.88); C743(1.06)  LDD1519  [6]
 LDCM0282  AC22 HEK-293T C108(0.95); C743(1.11)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C108(1.15); C743(0.86)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C108(1.02); C743(1.00)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C743(0.99)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C743(0.95)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C108(1.07); C743(1.08)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C108(0.91); C743(1.14)  LDD1527  [6]
 LDCM0290  AC3 HEK-293T C108(1.12); C743(1.09)  LDD1529  [6]
 LDCM0291  AC30 HEK-293T C108(1.01); C743(1.11)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C108(1.19); C743(0.90)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C108(0.94); C743(1.00)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C743(0.96)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C743(1.09)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C108(1.09); C743(0.97)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C108(0.94); C743(1.02)  LDD1536  [6]
 LDCM0299  AC38 HEK-293T C108(0.95); C743(1.16)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C108(1.09); C743(0.92)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C108(0.97); C743(0.98)  LDD1540  [6]
 LDCM0302  AC40 HEK-293T C108(1.01); C743(0.90)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C743(1.01)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C743(0.94)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C108(1.07); C743(1.00)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C108(1.09); C743(1.15)  LDD1545  [6]
 LDCM0308  AC46 HEK-293T C108(0.96); C743(1.16)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C108(1.10); C743(1.04)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C108(0.96); C743(1.03)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C743(1.16)  LDD1550  [6]
 LDCM0313  AC50 HEK-293T C743(0.91)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C108(1.08); C743(1.01)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C108(1.06); C743(0.85)  LDD1554  [6]
 LDCM0317  AC54 HEK-293T C108(1.05); C743(1.13)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C108(0.95); C743(0.93)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C108(0.91); C743(1.03)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C743(1.06)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C743(0.94)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C108(1.12); C743(1.18)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C108(1.04); C743(1.02)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C108(1.05); C743(0.99)  LDD1563  [6]
 LDCM0326  AC62 HEK-293T C108(1.11); C743(1.08)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C108(1.00); C743(0.97)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C108(0.94); C743(1.05)  LDD1567  [6]
 LDCM0334  AC7 HEK-293T C108(0.93); C743(1.01)  LDD1568  [6]
 LDCM0345  AC8 HEK-293T C108(0.85); C743(1.01)  LDD1569  [6]
 LDCM0356  AKOS034007680 HEK-293T C743(1.10)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C108(0.90); C743(0.96)  LDD1514  [6]
 LDCM0020  ARS-1620 HCC44 C733(1.01); C743(1.01)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C108(0.96); C557(0.58); C743(0.87)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C108(1.01); C743(0.77)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C743(0.99)  LDD1573  [6]
 LDCM0370  CL101 HEK-293T C108(1.44); C557(0.98); C743(0.98)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C743(0.96)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C743(1.05)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C743(1.01)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C108(0.78); C557(0.80); C743(1.07)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C743(0.88)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C743(1.06)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C743(1.08)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C108(0.90); C557(0.96); C743(1.02)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C108(0.94); C743(0.83)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C743(0.87)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C743(1.08)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C743(1.01)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C108(1.03); C557(0.79); C743(1.07)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C743(1.02)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C743(0.92)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C743(0.99)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C108(0.98); C557(0.77); C743(1.02)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C743(0.90)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C743(1.07)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C108(0.91); C743(0.81)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C743(1.13)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C108(0.99); C557(0.87); C743(1.04)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C743(0.91)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C743(1.13)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C743(1.29)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C108(1.13); C557(0.73); C743(1.01)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C743(0.72)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C743(1.27)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C743(1.02)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C108(1.34); C557(0.91); C743(1.01)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C743(1.21)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C743(1.24)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C743(1.03)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C743(0.92)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C743(0.97)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C108(1.08); C743(0.92)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C743(1.09)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C108(1.04); C743(1.10)  LDD1612  [6]
 LDCM0410  CL22 HEK-293T C108(1.05); C743(0.98)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C108(0.87); C743(0.99)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C108(0.94); C743(0.90)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C108(1.25); C557(0.68); C743(0.96)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C743(0.92)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C743(1.02)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C743(1.07)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C743(1.06)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C743(1.08)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C743(0.93)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C108(1.08); C743(1.05)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C108(1.18); C743(1.07)  LDD1625  [6]
 LDCM0423  CL34 HEK-293T C108(0.97); C743(0.98)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C108(1.09); C743(0.79)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C108(0.94); C743(0.82)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C108(0.91); C557(1.00); C743(1.04)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C743(1.12)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C743(1.16)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C743(1.15)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C743(0.94)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C743(0.89)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C108(1.18); C743(0.96)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C108(1.09); C743(0.94)  LDD1638  [6]
 LDCM0436  CL46 HEK-293T C108(1.01); C743(0.84)  LDD1640  [6]
 LDCM0437  CL47 HEK-293T C108(0.89); C743(1.01)  LDD1641  [6]
 LDCM0438  CL48 HEK-293T C108(0.96); C743(0.95)  LDD1642  [6]
 LDCM0439  CL49 HEK-293T C108(1.33); C557(0.97); C743(1.14)  LDD1643  [6]
 LDCM0440  CL5 HEK-293T C743(1.03)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C743(0.96)  LDD1645  [6]
 LDCM0443  CL52 HEK-293T C743(1.12)  LDD1646  [6]
 LDCM0444  CL53 HEK-293T C743(1.07)  LDD1647  [6]
 LDCM0445  CL54 HEK-293T C743(0.87)  LDD1648  [6]
 LDCM0446  CL55 HEK-293T C108(1.17); C743(0.52)  LDD1649  [6]
 LDCM0447  CL56 HEK-293T C108(1.09); C743(1.00)  LDD1650  [6]
 LDCM0449  CL58 HEK-293T C108(1.16); C743(1.02)  LDD1652  [6]
 LDCM0450  CL59 HEK-293T C108(1.07); C743(0.97)  LDD1653  [6]
 LDCM0451  CL6 HEK-293T C743(0.86)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C108(1.03); C743(0.86)  LDD1655  [6]
 LDCM0453  CL61 HEK-293T C108(1.21); C557(0.82); C743(1.12)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C743(0.99)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C743(1.11)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C743(0.95)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C743(1.04)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C743(0.81)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C108(1.12); C743(1.02)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C108(1.08); C743(0.96)  LDD1663  [6]
 LDCM0462  CL7 HEK-293T C108(1.07); C743(1.03)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C108(1.08); C743(0.96)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C108(1.26); C743(0.88)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C108(0.93); C743(0.92)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C108(0.99); C557(0.66); C743(1.10)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C743(0.93)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C743(1.11)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C743(1.04)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C743(0.93)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C108(1.08); C743(1.11)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C108(0.94); C743(0.88)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C108(1.10); C743(0.99)  LDD1677  [6]
 LDCM0476  CL82 HEK-293T C108(1.02); C743(1.00)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C108(0.87); C743(1.01)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C108(0.93); C743(0.95)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C108(1.23); C557(0.69); C743(1.07)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C743(0.89)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C743(1.18)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C743(1.39)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C743(1.14)  LDD1686  [6]
 LDCM0485  CL90 HEK-293T C743(0.98)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C108(1.14); C743(1.05)  LDD1689  [6]
 LDCM0487  CL92 HEK-293T C108(1.02); C743(1.01)  LDD1690  [6]
 LDCM0489  CL94 HEK-293T C108(1.06); C743(1.12)  LDD1692  [6]
 LDCM0490  CL95 HEK-293T C108(0.92); C743(0.95)  LDD1693  [6]
 LDCM0491  CL96 HEK-293T C108(1.05); C743(0.96)  LDD1694  [6]
 LDCM0492  CL97 HEK-293T C108(1.14); C557(0.98); C743(1.03)  LDD1695  [6]
 LDCM0493  CL98 HEK-293T C743(0.91)  LDD1696  [6]
 LDCM0494  CL99 HEK-293T C743(1.06)  LDD1697  [6]
 LDCM0495  E2913 HEK-293T C743(1.06)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C743(1.16)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C743(0.85)  LDD1631  [6]
 LDCM0022  KB02 HCT 116 C362(4.08); C368(4.08)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C362(1.74); C368(1.74)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C362(4.07); C368(4.07)  LDD0082  [1]
 LDCM0021  THZ1 HCT 116 C362(1.27); C368(1.27)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poly(A)-specific ribonuclease PARN (PARN) CAF1 family O95453
Histone acetyltransferase KAT7 (KAT7) MYST (SAS/MOZ) family O95251
Chromodomain-helicase-DNA-binding protein 3 (CHD3) SNF2/RAD54 helicase family Q12873
Breast cancer type 1 susceptibility protein (BRCA1) . P38398
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Exocyst complex component 5 (EXOC5) SEC10 family O00471
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Protein LDOC1 (LDOC1) LDOC1 family O95751
Rab GTPase-binding effector protein 1 (RABEP1) Rabaptin family Q15276
ARF GTPase-activating protein GIT1 (GIT1) . Q9Y2X7
Axin-2 (AXIN2) . Q9Y2T1
Centrosomal protein of 126 kDa (CEP126) . Q9P2H0
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Cleavage stimulation factor subunit 1 (CSTF1) . Q05048
Cleavage stimulation factor subunit 2 (CSTF2) . P33240
Heat shock factor 2-binding protein (HSF2BP) . O75031
TNF receptor-associated factor 1 (TRAF1) . Q13077
Transcription elongation regulator 1 (TCERG1) . O14776

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402