Details of the Target

General Information of Target

Target ID LDTP13946
Target Name U6 snRNA-associated Sm-like protein LSm2 (LSM2)
Gene Name LSM2
Gene ID 57819
Synonyms
C6orf28; G7B; U6 snRNA-associated Sm-like protein LSm2; Protein G7b; Small nuclear ribonuclear protein D homolog; snRNP core Sm-like protein Sm-x5
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVKLNSNPSEKGTKPPSVEDGFQTVPLITPLEVNHLQLPAPEKVIVKTRTEYQPEQKNKG
KFRVPKIAEFTVTILVSLALAFLACIVFLVVYKAFTYDHSCPEGFVYKHKRCIPASLDAY
YSSQDPNSRSRFYTVISHYSVAKQSTARAIGPWLSAAAVIHEPKPPKTQGH
Target Bioclass
Other
Family
SnRNP Sm proteins family
Subcellular location
Nucleus
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Uniprot ID
Q9Y333
Ensemble ID
ENST00000375661.6
HGNC ID
HGNC:13940

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y4(16.25)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K88(1.43); K94(1.85)  LDD0277  [4]
DBIA
 Probe Info  		C26(1.33)  LDD3314  [5]
HHS-482
 Probe Info  		Y35(0.99)  LDD0285  [6]
HHS-475
 Probe Info  		Y35(0.87)  LDD0264  [7]
HHS-465
 Probe Info  		Y35(5.06); Y4(10.00)  LDD2237  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD2156  [12]
SF
 Probe Info  		Y4(0.00); Y35(0.00)  LDD0028  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
NAIA_5
 Probe Info  		N.A.  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C174
 Probe Info  		6.06  LDD1854  [18]
C203
 Probe Info  		7.46  LDD1878  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C26(0.86)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C26(1.03)  LDD1508  [19]
 LDCM0237  AC12 HEK-293T C26(1.06)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C26(0.99)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C26(1.07)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C26(0.93)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C26(0.99)  LDD1516  [19]
 LDCM0279  AC2 HEK-293T C26(1.00)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C26(1.12)  LDD1519  [19]
 LDCM0282  AC22 HEK-293T C26(1.02)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C26(1.02)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C26(0.96)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C26(0.92)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C26(0.95)  LDD1525  [19]
 LDCM0288  AC28 HEK-293T C26(1.08)  LDD1527  [19]
 LDCM0291  AC30 HEK-293T C26(1.06)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C26(1.08)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C26(0.91)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C26(0.90)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C26(0.97)  LDD1534  [19]
 LDCM0297  AC36 HEK-293T C26(1.00)  LDD1536  [19]
 LDCM0299  AC38 HEK-293T C26(1.08)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C26(1.13)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C26(1.07)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C26(0.88)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C26(0.99)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C26(0.96)  LDD1543  [19]
 LDCM0306  AC44 HEK-293T C26(1.07)  LDD1545  [19]
 LDCM0308  AC46 HEK-293T C26(1.07)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C26(1.14)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C26(1.06)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C26(0.98)  LDD1550  [19]
 LDCM0313  AC50 HEK-293T C26(1.01)  LDD1552  [19]
 LDCM0315  AC52 HEK-293T C26(1.01)  LDD1554  [19]
 LDCM0317  AC54 HEK-293T C26(1.12)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C26(1.11)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C26(0.88)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C26(0.84)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C26(1.04)  LDD1560  [19]
 LDCM0323  AC6 HEK-293T C26(1.04)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C26(1.02)  LDD1563  [19]
 LDCM0326  AC62 HEK-293T C26(0.99)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C26(0.96)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C26(0.97)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C26(1.14)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C26(0.92)  LDD1569  [19]
 LDCM0356  AKOS034007680 HEK-293T C26(0.97)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C26(0.98)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 12.55  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C26(1.46)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C26(0.90)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C26(1.02)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C26(0.98)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C26(1.02)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C26(0.97)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C26(1.06)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C26(1.09)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C26(1.01)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C26(1.02)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C26(1.13)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C26(1.08)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C26(0.97)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C26(1.12)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C26(0.90)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C26(1.00)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C26(0.98)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C26(1.09)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C26(0.83)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C26(0.89)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C26(1.01)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C26(1.12)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C26(1.05)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C26(0.89)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C26(0.79)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C26(1.07)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C26(1.07)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C26(1.03)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C26(0.96)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C26(1.06)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C26(0.99)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C26(0.94)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C26(0.91)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C26(1.01)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C26(1.01)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C26(0.97)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C26(0.81)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C26(0.96)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C26(0.82)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C26(0.98)  LDD1609  [19]
 LDCM0407  CL2 HEK-293T C26(0.98)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C26(1.06)  LDD1612  [19]
 LDCM0410  CL22 HEK-293T C26(1.28)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C26(1.19)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C26(0.79)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C26(0.97)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C26(1.09)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C26(0.95)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C26(1.04)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C26(1.08)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C26(0.86)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C26(0.98)  LDD1623  [19]
 LDCM0421  CL32 HEK-293T C26(0.98)  LDD1625  [19]
 LDCM0423  CL34 HEK-293T C26(1.21)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C26(1.24)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C26(0.68)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C26(0.99)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C26(0.95)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C26(0.95)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C26(1.04)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C26(0.88)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C26(1.03)  LDD1636  [19]
 LDCM0434  CL44 HEK-293T C26(0.97)  LDD1638  [19]
 LDCM0436  CL46 HEK-293T C26(1.30)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C26(1.16)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C26(0.78)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C26(1.02)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C26(0.84)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C26(0.96)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C26(1.04)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C26(0.81)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C26(0.90)  LDD1648  [19]
 LDCM0447  CL56 HEK-293T C26(1.12)  LDD1650  [19]
 LDCM0449  CL58 HEK-293T C26(1.28)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C26(1.24)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C26(0.81)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C26(0.74)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C26(1.09)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C26(0.98)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C26(1.06)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C26(0.94)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C26(1.01)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C26(0.90)  LDD1661  [19]
 LDCM0460  CL68 HEK-293T C26(0.98)  LDD1663  [19]
 LDCM0463  CL70 HEK-293T C26(1.18)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C26(1.28)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C26(0.76)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C26(0.97)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C26(0.97)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C26(1.07)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C26(0.75)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C26(1.01)  LDD1674  [19]
 LDCM0473  CL8 HEK-293T C26(0.77)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C26(1.05)  LDD1677  [19]
 LDCM0476  CL82 HEK-293T C26(1.18)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C26(1.10)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C26(0.77)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C26(1.08)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C26(0.98)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C26(1.00)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C26(1.01)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C26(0.88)  LDD1686  [19]
 LDCM0485  CL90 HEK-293T C26(0.69)  LDD1688  [19]
 LDCM0487  CL92 HEK-293T C26(0.98)  LDD1690  [19]
 LDCM0489  CL94 HEK-293T C26(1.04)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C26(0.91)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C26(0.92)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C26(0.91)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C26(0.92)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C26(0.97)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C26(0.94)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C26(0.96)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C26(0.90)  LDD1631  [19]
 LDCM0116  HHS-0101 DM93 Y35(0.87)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y35(0.90)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y35(1.15)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y35(1.01)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y35(1.21)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0123  JWB131 DM93 Y35(0.99)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y35(1.64)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y35(1.16)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y35(3.55)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y35(1.27)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y35(0.16)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y35(1.25)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y35(0.97)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C26(1.05)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C26(1.06)  LDD1497  [19]
 LDCM0024  KB05 IGR37 C26(1.33)  LDD3314  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine zipper putative tumor suppressor 1 (LZTS1) LZTS family Q9Y250
Methylosome subunit pICln (CLNS1A) PICln (TC 1.A.47) family P54105
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Proto-oncogene c-Rel (REL) . Q04864
Zinc finger protein 408 (ZNF408) . Q9H9D4
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein BANP (BANP) BANP/SMAR1 family Q8N9N5
Protein LSM12 (LSM12) LSM12 family Q3MHD2
Protein PAT1 homolog 1 (PATL1) PAT1 family Q86TB9
Small nuclear ribonucleoprotein Sm D2 (SNRPD2) SnRNP core protein family P62316
Small nuclear ribonucleoprotein E (SNRPE) SnRNP Sm proteins family P62304
U6 snRNA-associated Sm-like protein LSm1 (LSM1) SnRNP Sm proteins family O15116
U6 snRNA-associated Sm-like protein LSm3 (LSM3) SnRNP Sm proteins family P62310
U6 snRNA-associated Sm-like protein LSm7 (LSM7) SnRNP Sm proteins family Q9UK45
U6 snRNA-associated Sm-like protein LSm8 (LSM8) SnRNP Sm proteins family O95777
U6 snRNA-associated Sm-like protein LSm6 (LSM6) SnRNP Sm proteins family P62312
Dynein axonemal assembly factor 11 (DNAAF11) TilB family Q86X45
TLE family member 5 (TLE5) WD repeat Groucho/TLE family Q08117
Chromobox protein homolog 8 (CBX8) . Q9HC52
Galectin-7 (LGALS7; LGALS7B) . P47929
Melanoma-associated antigen 3 (MAGEA3) . P43357
Melanoma-associated antigen 6 (MAGEA6) . P43360

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402