Details of the Target

General Information of Target

Target ID LDTP13455
Target Name Serine/threonine-protein kinase tousled-like 1 (TLK1)
Gene Name TLK1
Gene ID 9874
Synonyms
KIAA0137; Serine/threonine-protein kinase tousled-like 1; EC 2.7.11.1; PKU-beta; Tousled-like kinase 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAKTPIYLKAANNKKGKKFKLRDILSPDMISPPLGDFRHTIHIGKEGQHDVFGDISFLQ
GNYELLPGNQEKAHLGQFPGHNEFFRANSTSDSVFTETPSPVLKNAISLPTIGGSQALML
PLLSPVTFNSKQESFGPAKLPRLSCEPVMEEKAQEKSSLLENGTVHQGDTSWGSSGSASQ
SSQGRDSHSSSLSEQYPDWPAEDMFDHPTPCELIKGKTKSEESLSDLTGSLLSLQLDLGP
SLLDEVLNVMDKNK
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Ser/Thr protein kinase family
Subcellular location
Nucleus
Function
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Uniprot ID
Q9UKI8
Ensemble ID
ENST00000360843.7
HGNC ID
HGNC:11841
ChEMBL ID
CHEMBL5388

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO792 Substitution: p.G102K .
HT115 SNV: p.S743Y .
JURKAT SNV: p.V326A .
MELJUSO SNV: p.T24P .
MFE319 SNV: p.T305I .
MOLT4 SNV: p.H308D .
SKMEL24 SNV: p.P112Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C81(2.72)  LDD3364  [2]
BTD
 Probe Info  		C247(0.95)  LDD2102  [3]
AMP probe
 Probe Info  		K485(0.00); K491(0.00)  LDD0200  [4]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
IA-alkyne
 Probe Info  		C81(0.00); C247(0.00)  LDD0165  [5]
IPM
 Probe Info  		N.A.  LDD0025  [6]
NAIA_5
 Probe Info  		N.A.  LDD2224  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneN
 Probe Info  		C81(0.00); C247(0.00)  LDD0021  [8]
KY-26
 Probe Info  		N.A.  LDD0301  [9]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
Acrolein
 Probe Info  		C81(0.00); C247(0.00)  LDD0217  [11]
Methacrolein
 Probe Info  		N.A.  LDD0218  [11]
AOyne
 Probe Info  		10.40  LDD0443  [12]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C247(1.03)  LDD2117  [3]
 LDCM0214  AC1 HEK-293T C81(1.02); C600(1.19)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C81(0.93); C600(1.07)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C81(0.91); C600(1.08)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C81(1.01); C600(0.98)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C81(1.04)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C81(1.02); C600(0.89)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C81(1.00); C600(1.15)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C81(1.05); C600(1.00)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C81(1.03); C600(0.97)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C81(1.01); C600(1.08)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C81(0.98); C600(0.99)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C81(1.02)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C81(1.06)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C81(0.91); C600(0.81)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C81(0.93); C600(0.90)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C81(0.97); C600(1.25)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C81(1.06); C600(1.05)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C81(0.96); C600(1.08)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C81(0.99); C600(0.99)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C81(0.98)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C81(0.89); C600(1.22)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C81(1.04)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C81(1.10); C600(1.11)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C81(0.95); C600(0.98)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C81(0.99); C600(1.22)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C81(0.88); C600(1.05)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C81(0.97); C600(1.21)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C81(0.96); C600(1.02)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C81(0.89)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C81(1.11)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C81(1.17); C600(1.36)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C81(0.90); C600(1.02)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C81(1.03); C600(1.01)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C81(1.16); C600(1.10)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C81(0.98); C600(1.00)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C81(0.95); C600(1.13)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C81(0.98); C600(1.08)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C81(1.00)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C81(1.13)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C81(1.10); C600(1.27)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C81(0.92); C600(1.08)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C81(1.08); C600(1.05)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C81(0.96)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C81(0.98); C600(0.97)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C81(0.94); C600(1.10)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C81(0.94); C600(0.96)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C81(0.97)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C81(1.14)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C81(1.11); C600(1.06)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C81(1.05); C600(1.01)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C81(1.10); C600(1.17)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C81(0.82); C600(1.08)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C81(0.91); C600(1.13)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C81(1.05)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C81(0.95); C600(0.99)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C81(1.01)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C81(1.04)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C81(1.25); C600(1.22)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C81(1.13); C600(1.01)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C81(1.01); C600(1.10)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C81(1.06); C600(1.10)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C81(0.92)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C81(1.05); C600(1.18)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C81(0.98); C600(1.08)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 12.88  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [11]
 LDCM0367  CL1 HEK-293T C81(0.94); C600(0.89)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C81(0.99)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C81(0.90); C600(1.07)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C81(1.01); C600(1.13)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C81(0.97); C600(1.00)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C81(0.82); C600(0.88)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C81(0.99); C600(0.98)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C81(1.04); C600(1.10)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C81(1.01); C600(0.88)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C81(0.98); C600(0.93)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C81(1.02); C600(0.99)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C81(0.94); C600(1.06)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C81(1.09); C600(1.30)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C81(0.88); C600(0.98)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C81(0.92); C600(0.93)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C81(1.00); C600(0.91)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C81(1.02); C600(1.03)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C81(1.03); C600(0.99)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C81(0.94); C600(0.91)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C81(0.99); C600(1.01)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C81(0.99); C600(1.05)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C81(1.04); C600(1.04)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C81(0.90); C600(1.06)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C81(1.21); C600(1.04)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C81(0.94); C600(1.04)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C81(0.87); C600(1.08)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C81(1.04); C600(1.01)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C81(0.84); C600(1.06)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C81(0.88); C600(1.00)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C81(0.89); C600(1.03)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C81(1.04); C600(1.06)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C81(0.93); C600(0.93)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C81(1.04); C600(1.19)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C81(1.00); C600(1.21)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C81(1.07); C600(1.17)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C81(0.86); C600(0.97)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C81(1.02); C600(1.01)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C81(0.99); C600(1.08)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C81(0.96); C600(1.07)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C81(0.95); C600(1.02)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C81(1.11); C600(1.03)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C81(0.96); C600(1.05)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C81(1.01)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C81(1.16)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C81(1.21); C600(1.13)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C81(1.14); C600(1.01)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C81(0.87); C600(0.92)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C81(1.01); C600(1.00)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C81(0.89); C600(1.04)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C81(1.02); C600(0.83)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C81(1.00); C600(1.03)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C81(0.86); C600(1.01)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C81(0.87); C600(1.03)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C81(1.18); C600(0.95)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C81(0.99); C600(1.11)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C81(0.86)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C81(1.07)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C81(1.02); C600(1.28)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C81(1.10); C600(0.98)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C81(0.92); C600(0.98)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C81(0.93); C600(1.02)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C81(0.92); C600(0.99)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C81(0.95); C600(0.93)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C81(0.98); C600(1.15)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C81(0.99); C600(0.97)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C81(1.01); C600(0.92)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C81(0.97); C600(1.04)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C81(1.04)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C81(1.13)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C81(1.11); C600(1.29)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C81(1.06); C600(0.99)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C81(0.99); C600(1.01)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C81(1.10); C600(1.11)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C81(0.99); C600(1.02)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C81(0.95); C600(0.92)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C81(1.04); C600(1.08)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C81(0.81); C600(0.96)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C81(0.89); C600(1.00)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C81(1.08); C600(1.09)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C81(1.08)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C81(1.13)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C81(1.27); C600(1.30)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C81(0.93); C600(1.07)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C81(1.07); C600(1.11)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C81(0.93); C600(0.96)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C81(0.96); C600(1.00)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C81(0.96); C600(0.91)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C81(0.91); C600(1.13)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C81(1.15); C600(1.14)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C81(1.09); C600(0.94)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C81(0.95); C600(1.04)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C81(1.00); C600(1.11)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C81(0.97)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C81(1.03); C600(0.94)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C81(1.16)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C81(1.14); C600(1.53)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C81(1.15); C600(0.95)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C81(0.86); C600(1.00)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C81(1.02); C600(1.10)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C81(0.87); C600(0.99)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C81(1.04); C600(1.12)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C81(0.91); C600(1.00)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C81(0.85); C600(0.96)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C81(0.80); C600(1.13)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C81(0.93); C600(1.02)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C81(0.95)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C81(1.06)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C81(1.01); C600(0.91)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C81(0.96); C600(1.04)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C81(0.97); C600(1.02)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C81(1.08); C600(1.11)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C81(0.89); C600(1.09)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C81(0.94); C600(0.98)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C81(1.00); C600(1.08)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C81(1.01)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C81(0.75); C600(1.02)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C81(0.98); C600(0.91)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C81(0.93); C600(1.11)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C81(0.89)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C81(1.20)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C81(1.08); C600(1.24)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C81(1.01); C600(1.16)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C81(0.98); C600(1.10)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C81(1.05); C600(1.03)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C81(0.97); C600(0.99)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C81(0.90); C600(1.02)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C247(1.31); C81(1.04)  LDD1702  [3]
 LDCM0625  F8 Ramos C81(0.68)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C81(1.54)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C81(2.10)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C81(0.90)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C81(0.77)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C81(0.58)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C81(0.64)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C81(0.73)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C81(1.12)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C81(0.75)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C81(1.32)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C81(1.32)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C81(0.88)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C81(1.36)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C81(0.88); C600(0.95)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C81(0.93)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C81(0.81)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C81(0.97); C600(0.98)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C81(1.20)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C81(1.16)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C81(1.32)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C81(0.98)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C81(1.00)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C81(1.14)  LDD1497  [14]
 LDCM0024  KB05 NCI-N87 C81(2.72)  LDD3364  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C247(0.95)  LDD2102  [3]
 LDCM0109  NEM HeLa N.A.  LDD0225  [11]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C247(1.99)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C247(0.81)  LDD2107  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C247(1.02)  LDD2125  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C247(0.76)  LDD2129  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
Alpha-globin transcription factor CP2 (TFCP2) Grh/CP2 family Q12800
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Zinc finger protein 773 (ZNF773) Krueppel C2H2-type zinc-finger protein family Q6PK81
Paired box protein Pax-6 (PAX6) Paired homeobox family P26367
LIM/homeobox protein Lhx2 (LHX2) . P50458
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein light chain 2, cytoplasmic (DYNLL2) Dynein light chain family Q96FJ2
PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) PINX1 family Q96BK5
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190
Leucine zipper protein 4 (LUZP4) . Q9P127

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578