Details of the Target

General Information of Target

Target ID LDTP02859
Target Name Tyrosine-protein kinase Fer (FER)
Gene Name FER
Gene ID 2241
Synonyms
TYK3; Tyrosine-protein kinase Fer; EC 2.7.10.2; Feline encephalitis virus-related kinase FER; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; Proto-oncogene c-Fer; Tyrosine kinase 3; p94-Fer
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGFGSDLKNSHEAVLKLQDWELRLLETVKKFMALRIKSDKEYASTLQNLCNQVDKESTVQ
MNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYIGVHQQ
IEAEMIKVTKTELEKLKCSYRQLIKEMNSAKEKYKEALAKGKETEKAKERYDKATMKLHM
LHNQYVLALKGAQLHQNQYYDITLPLLLDSLQKMQEEMIKALKGIFDEYSQITSLVTEEI
VNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNL
TAESLQVMLKTLAEELMQTQQMLLNKEEAVLELEKRIEESSETCEKKSDIVLLLSQKQAL
EELKQSVQQLRCTEAKFSAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSK
FESIRHSIAGIIRSPKSALGSSALSDMISISEKPLAEQDWYHGAIPRIEAQELLKKQGDF
LVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVITK
KSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKGTLKDKTSVAVKTCKEDLPQE
LKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKKDELKLKQ
LVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENNVLKISDFGMSRQEDGGVYSSSGLK
QIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMS
APQHCPEDISKIMMKCWDYKPENRPKFSELQKELTIIKRKLT
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, Fes/fps subfamily
Subcellular location
Cytoplasm
Function
Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
TTD ID
T16993
Uniprot ID
P16591
DrugMap ID
TTRA9G0
Ensemble ID
ENST00000281092.9
HGNC ID
HGNC:3655
ChEMBL ID
CHEMBL3982

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.K476NfsTer53 .
HCT15 SNV: p.I240T .
HEC1 SNV: p.R407Ter .
IGR1 SNV: p.R141G .
KMCH1 SNV: p.A668T DBIA    Probe Info 
KYSE180 SNV: p.S542Ter .
LNCaP clone FGC SNV: p.Q599R .
LS180 Deletion: p.K476NfsTer53 .
NCIH82 SNV: p.E345Ter .
SF295 SNV: p.V713M .
SNU1 Deletion: p.N679TfsTer14 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y714(6.82)  LDD0260  [1]
STPyne
 Probe Info  		K420(10.00)  LDD0277  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
BTD
 Probe Info  		C627(0.73)  LDD2109  [4]
DBIA
 Probe Info  		C796(6.89)  LDD0209  [5]
AMP probe
 Probe Info  		K591(0.00); K594(0.00)  LDD0200  [6]
ATP probe
 Probe Info  		K591(0.00); K594(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C796(0.00); C627(0.00); C690(0.00); C785(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C796(0.00); C627(0.00); C785(0.00); C690(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C796(0.00); C627(0.00); C785(0.00); C690(0.00)  LDD0037  [7]
KY-26
 Probe Info  		K591(0.00); Y714(0.00)  LDD0301  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
TFBX
 Probe Info  		C593(0.00); C627(0.00)  LDD0148  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C344(0.99); C627(0.95)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C344(0.95); C627(1.12); C785(1.13); C690(1.03)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C344(0.95); C627(1.06)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C344(1.03); C627(1.05); C785(1.21)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C344(0.88); C627(1.07); C785(0.97)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C344(0.88); C627(1.07)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C344(0.95); C627(1.06)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C344(1.04); C627(0.96); C785(0.96); C690(1.07)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C344(0.90); C627(0.96)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C344(0.97); C627(1.04); C785(0.99); C690(1.00)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C344(0.97); C627(1.00); C785(0.92)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C344(0.90); C627(1.11); C796(1.06)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C344(0.96); C627(0.98); C785(1.12)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C344(0.93); C627(0.96)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C344(0.94); C785(1.01)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C344(0.95); C627(0.99)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C344(1.02); C627(0.99); C785(0.92); C690(1.06)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C344(0.97); C627(1.10)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C344(1.03); C627(1.11); C785(1.04)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C344(0.92); C627(0.87); C796(1.03)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C344(1.00); C627(0.98)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C344(0.92); C627(1.11); C785(1.12)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C344(1.00); C627(0.99)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C344(1.12); C785(0.70)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C344(1.04); C627(0.99)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C344(1.04); C627(0.96); C785(1.03); C690(1.10)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C344(0.98); C627(1.04)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C344(1.02); C627(0.95); C785(1.20)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C344(1.04); C627(0.93); C796(1.01)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C344(0.95); C627(1.05); C785(0.97)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C344(0.90); C627(1.03)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C344(1.21); C627(1.03); C785(1.12)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C344(0.98); C785(0.89)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C344(1.00); C627(1.07)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C344(1.06); C627(0.97); C785(1.18); C690(1.06)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C344(0.95); C627(1.05)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C344(1.04); C627(0.96); C785(1.16)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C344(1.00); C627(1.10); C796(0.97)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C344(0.99); C627(1.07); C785(1.07)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C344(0.92); C627(1.04)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C344(1.04); C785(0.75)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C344(1.04); C627(1.00)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C344(0.96); C627(0.94); C796(1.03)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C344(1.04); C627(0.81); C785(0.97); C690(1.14)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C344(0.95); C627(1.15)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C344(1.03); C627(1.10); C785(0.89)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C344(1.05); C627(0.97); C796(0.99)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C344(0.93); C627(1.07); C785(0.81)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C344(1.00); C627(0.97)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C344(0.91); C785(0.83)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C344(0.94); C627(1.22)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C344(1.16); C627(0.85); C785(0.92); C690(1.11)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C344(0.99); C627(0.93)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C344(1.03); C627(1.04); C785(0.81)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C344(1.08); C627(1.01); C785(0.94)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C344(0.99); C627(1.05); C796(0.97)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C344(1.02); C627(1.01); C785(1.04)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C344(0.96); C627(0.98)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C344(1.16); C785(1.00)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C344(1.08); C627(0.98)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C344(0.92); C785(0.76)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C344(0.96); C627(1.19); C796(0.98)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C344(0.95); C627(1.03)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C344(0.94); C785(0.79)  LDD1514  [12]
 LDCM0367  CL1 HEK-293T C344(0.98); C627(1.12)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C344(0.79); C627(1.22); C785(1.03)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C344(1.11); C785(1.18)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C344(0.96); C627(0.97)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C344(0.84); C627(0.81); C785(1.15); C796(1.09)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C344(1.06); C785(0.91)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C344(1.01); C785(1.07)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C344(0.92); C627(1.01)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C344(0.91); C627(1.02); C785(0.77); C796(1.06)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C344(1.03); C785(0.92)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C344(0.92); C785(0.96)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C344(1.02); C627(1.19)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C344(0.88); C627(1.03)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C344(0.85); C627(1.10); C785(1.17); C796(1.10)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C344(1.00); C785(1.23)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C344(0.99); C785(1.36)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C344(0.93); C627(1.25)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C344(0.82); C627(1.32); C785(0.91); C796(1.01)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C344(1.05); C785(0.88)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C344(0.89); C785(1.18)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C344(0.93); C627(1.10)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C344(0.86); C627(0.99); C785(0.93); C796(1.19)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C344(1.01); C785(0.96)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C344(0.91); C785(1.08)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C344(1.06); C785(1.01)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C344(0.91); C627(1.00)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C344(0.92); C627(0.93); C785(0.92); C796(1.16)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C344(0.98); C785(0.78)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C344(0.90); C785(1.23)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C344(1.18); C627(1.07)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C344(1.07); C627(0.92); C785(1.13); C796(1.07)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C344(1.17); C785(0.93)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C344(1.17); C785(0.97)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C344(0.92); C627(0.96)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C344(0.88); C627(0.99); C785(1.09); C796(1.07)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C344(0.91); C785(1.01)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C344(1.10); C785(1.13)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C344(0.77); C627(1.05)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C344(1.03); C627(1.10); C785(1.30); C690(1.12)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C344(0.92); C627(1.02)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C344(0.82); C627(1.03); C785(0.91); C796(1.12)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C344(0.97); C627(1.24); C785(0.99)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C344(0.91); C627(1.38); C796(0.95)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C344(0.89); C627(1.28); C785(1.14)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C344(0.90); C627(0.97)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C344(1.01); C785(1.01)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C344(0.97); C627(1.11)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C344(0.83); C627(1.00); C785(1.13); C796(1.10)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C344(1.03); C785(0.80)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C344(0.93); C785(1.21)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C344(1.00); C627(1.14)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C344(1.15); C785(1.26)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C344(1.00); C627(1.02); C785(0.87); C690(1.08)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C344(0.91); C627(1.10)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C344(0.99); C627(1.14); C785(1.18)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C344(0.97); C627(0.98); C796(0.98)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C344(0.85); C627(1.11); C785(1.13)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C344(0.88); C627(1.11)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C344(0.89); C785(0.99)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C344(1.07); C627(1.28)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C344(1.01); C785(0.76)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C344(0.93); C785(1.28)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C344(1.01); C785(1.14)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C344(0.92); C627(1.09)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C344(1.13); C627(0.95); C785(1.04); C690(0.98)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C344(0.93); C627(0.94)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C344(0.94); C627(1.10); C785(0.90)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C344(1.04); C627(0.98); C796(1.01)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C344(0.91); C627(1.22); C785(0.83)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C344(0.84); C627(1.10)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C344(0.93); C785(0.95)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C344(1.17); C627(1.23)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C344(0.98); C627(1.02)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C344(0.88); C627(1.06); C785(1.17); C796(1.09)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C344(0.94); C785(1.26)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C344(0.93); C627(1.14)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C344(0.88); C627(0.94); C785(1.10); C690(1.12)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C344(1.01); C627(1.09)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C344(1.00); C627(1.07); C785(0.99)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C344(0.83); C627(1.31); C796(1.08)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C344(0.84); C627(1.31); C785(0.86)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C344(0.81); C627(1.05)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C344(1.05); C627(1.07); C785(1.28); C690(1.09)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C344(0.92); C785(0.97)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C344(1.06); C627(1.04)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C344(0.90); C627(1.23); C785(1.16); C796(1.12)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C344(1.09); C785(0.84)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C344(0.90); C785(1.11)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C344(0.88); C627(1.17)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C344(1.05); C627(1.01); C785(1.03); C690(1.06)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C344(1.02); C627(1.09)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C344(0.97); C627(1.18); C785(1.03)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C344(1.07); C627(0.96); C796(0.98)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C344(1.06); C627(1.22)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C344(0.92); C627(1.23); C785(0.96)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C344(0.86); C627(1.01)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C344(1.05); C785(0.82)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C344(0.97); C627(1.07)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C344(0.90); C627(0.97); C785(1.03); C796(1.09)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C344(1.04); C785(1.12)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C344(0.95); C627(1.13)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C344(0.99); C627(0.98); C785(1.01); C690(1.09)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C344(0.98); C627(1.05)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C344(0.77); C627(1.11); C785(0.76)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C344(1.09); C627(1.20); C785(1.02)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C344(1.12); C627(1.03); C796(1.07)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C344(0.90); C627(1.09); C785(1.11)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C344(0.97); C627(1.08)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C344(0.83); C785(1.03)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C344(1.18); C627(1.15)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C344(1.01); C627(1.02); C785(0.89); C796(1.03)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C344(1.31); C785(0.97)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C344(1.22); C785(1.14)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C344(1.00); C627(1.10)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C344(1.02); C627(1.16); C796(1.02)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C344(0.96); C627(0.97); C785(0.93); C690(0.99)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C344(1.08); C627(1.11)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C344(1.06); C627(1.07); C785(0.95)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C344(1.00); C627(1.13); C796(0.95)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C344(0.89); C627(1.25); C785(1.16)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C344(0.83); C627(1.13)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C344(1.16); C785(1.00)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C344(0.96); C627(1.04)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C344(0.79); C627(0.93); C785(1.33); C796(0.99)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C344(1.15); C785(1.03)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C344(1.07); C785(1.16)  LDD1698  [12]
 LDCM0625  F8 Ramos C627(0.76); C690(0.73); C593(1.01); C785(0.78)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C627(0.81); C690(0.51); C593(0.88); C785(1.09)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C627(0.19); C690(0.62); C593(1.23); C785(6.44)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C627(1.35); C690(0.68); C593(0.58); C785(0.99)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C627(0.85); C690(0.72); C593(0.83); C785(1.03)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C627(1.27); C690(1.29); C593(0.62); C785(0.72)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C627(1.11); C690(0.70); C593(0.93); C785(0.77)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C627(0.93); C690(0.58); C593(0.67); C785(0.70)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C627(0.67); C690(0.53); C593(0.55); C785(0.95)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C627(1.07); C690(0.85); C593(0.69); C785(0.98)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C627(0.70); C690(0.69); C593(0.55); C785(0.87)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C627(1.13); C690(0.55); C593(0.92); C785(0.82)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C627(0.94); C690(0.92); C593(0.78); C785(1.24)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C627(1.11); C690(0.71); C593(1.27); C785(20.00)  LDD2201  [13]
 LDCM0468  Fragment33 HEK-293T C344(1.07); C785(0.95)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C627(0.84); C690(0.82); C593(0.77); C785(1.34)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C627(1.43); C690(1.02); C593(0.56)  LDD2184  [13]
 LDCM0427  Fragment51 HEK-293T C344(0.92); C627(0.95); C785(0.88); C796(1.10)  LDD1631  [12]
 LDCM0610  Fragment52 Ramos C627(0.86); C593(0.56)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C627(1.14); C690(0.82); C593(0.56); C785(2.68)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C627(1.04); C690(1.11); C593(1.12); C785(0.88)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C627(1.31); C690(0.81); C593(1.22); C785(8.08)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C344(1.04); C796(1.00); C785(1.02)  LDD1492  [12]
 LDCM0023  KB03 Jurkat C796(6.89)  LDD0209  [5]
 LDCM0024  KB05 NALM-6 C627(2.34); C690(2.41)  LDD3339  [14]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C627(0.73)  LDD2109  [4]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid22564207c25b Small molecular drug D09AID
Pmid24432909c8e Small molecular drug D0K5UF

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Direct Target Site Identification of a Sulfonyl-Triazole Covalent Kinase Probe by LC-MS Chemical Proteomics. Anal Chem. 2021 Sep 7;93(35):11946-11955. doi: 10.1021/acs.analchem.1c01591. Epub 2021 Aug 25.
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Comprehensive identification of staurosporine-binding kinases in the hepatocyte cell line HepG2 using Capture Compound Mass Spectrometry (CCMS). J Proteome Res. 2010 Feb 5;9(2):806-17. doi: 10.1021/pr9007333.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840