Details of the Target

General Information of Target

Target ID LDTP01085
Target Name Checkpoint protein HUS1 (HUS1)
Gene Name HUS1
Gene ID 3364
Synonyms
Checkpoint protein HUS1; hHUS1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQ
ENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELL
SMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHL
VIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQF
LAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
Target Bioclass
Other
Family
HUS1 family
Subcellular location
Nucleus
Function
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase.
Uniprot ID
O60921
Ensemble ID
ENST00000258774.10
HGNC ID
HGNC:5309

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K25(8.28)  LDD0277  [1]
BTD
 Probe Info  		C253(0.36)  LDD1700  [2]
DBIA
 Probe Info  		C44(6.17); C253(9.30)  LDD0209  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C200(0.00); C12(0.00); C44(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C253(0.00); C200(0.00); C12(0.00); C44(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C253(0.00); C44(0.00); C12(0.00); C200(0.00)  LDD0037  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
IPM
 Probe Info  		C253(0.00); C200(0.00); C12(0.00)  LDD0005  [5]
TFBX
 Probe Info  		C44(0.00); C253(0.00)  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
NAIA_5
 Probe Info  		C12(0.00); C44(0.00)  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C403
 Probe Info  		19.29  LDD2061  [11]
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C253(0.78)  LDD2117  [2]
 LDCM0214  AC1 HCT 116 C200(0.93); C44(1.03)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C200(0.83); C44(1.03)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C44(0.94)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C44(0.90)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C44(0.94)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C44(1.10)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C44(1.03)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C44(1.04)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C44(1.02)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C44(0.73)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C44(0.68)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C44(0.67)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C200(0.90); C44(1.28)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C44(0.68)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C44(0.73)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C44(0.69)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C200(1.09); C44(1.01)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C200(1.26); C44(1.10)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C200(1.31); C44(1.15)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C200(1.23); C44(1.12)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C200(1.02); C44(1.07)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C200(1.04); C44(1.08)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C200(0.99); C44(1.16)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C200(0.87); C44(1.15)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C200(1.00); C44(1.15)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C200(0.96); C44(1.05)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C200(1.03); C44(1.21)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C200(0.92); C44(1.05)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C200(1.03); C44(0.96)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C200(0.98); C44(1.16)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C200(1.10); C44(1.15)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C200(1.10); C44(1.21)  LDD0562  [13]
 LDCM0246  AC128 HEK-293T C200(0.94); C44(1.01)  LDD0844  [13]
 LDCM0247  AC129 HEK-293T C200(1.07); C44(1.08)  LDD0845  [13]
 LDCM0249  AC130 HEK-293T C200(0.92); C44(0.99)  LDD0847  [13]
 LDCM0250  AC131 HEK-293T C200(1.18); C44(1.10)  LDD0848  [13]
 LDCM0251  AC132 HEK-293T C200(1.09); C44(1.14)  LDD0849  [13]
 LDCM0252  AC133 HEK-293T C200(1.12); C44(1.18)  LDD0850  [13]
 LDCM0253  AC134 HEK-293T C200(1.05); C44(1.00)  LDD0851  [13]
 LDCM0254  AC135 HEK-293T C200(1.15); C44(1.14)  LDD0852  [13]
 LDCM0255  AC136 HEK-293T C200(1.10); C44(1.10)  LDD0853  [13]
 LDCM0256  AC137 HEK-293T C200(1.21); C44(1.35)  LDD0854  [13]
 LDCM0257  AC138 HEK-293T C200(1.25); C44(1.32)  LDD0855  [13]
 LDCM0258  AC139 HEK-293T C200(1.25); C44(1.30)  LDD0856  [13]
 LDCM0259  AC14 HCT 116 C200(0.93); C44(0.94)  LDD0576  [13]
 LDCM0260  AC140 HEK-293T C200(1.15); C44(1.16)  LDD0858  [13]
 LDCM0261  AC141 HEK-293T C200(1.16); C44(1.22)  LDD0859  [13]
 LDCM0262  AC142 HEK-293T C200(1.18); C44(1.18)  LDD0860  [13]
 LDCM0263  AC143 HCT 116 C44(1.15)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C44(1.36)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C44(1.13)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C44(1.27)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C44(1.32)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C44(1.75)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C44(1.41)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C44(0.97); C200(1.03)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C44(1.14)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C44(1.13)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C44(1.51)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C44(1.85)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C44(1.24)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C44(1.26)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C44(1.00)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C44(0.94)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C44(1.07); C200(1.13)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C200(1.11); C44(1.34)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C200(1.19); C44(1.28)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C200(0.96); C44(1.03)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C200(1.08); C44(1.23)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C200(1.04); C44(1.16)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C200(0.94); C44(1.39)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C200(0.97); C44(1.29)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C200(1.02); C44(1.08)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C44(1.01); C200(1.11)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C44(1.11); C200(1.20)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C44(1.04); C200(1.38)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C44(1.04); C200(1.14)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C44(1.17); C200(1.36)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C44(0.95); C200(0.96)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C44(1.24); C200(1.30)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C44(1.12); C200(1.19)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C44(1.34); C200(1.40)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C44(1.15); C200(1.40)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C44(1.22); C200(1.32)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C200(0.89); C44(0.92)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C200(0.78); C44(0.98)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C200(0.71); C44(1.05)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C44(0.93); C200(1.02)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C200(0.97); C44(1.03)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C200(0.92); C44(0.93)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C200(1.01); C44(1.17)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C200(0.91); C44(1.20)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C200(1.11); C44(1.13)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C200(1.15); C44(1.16)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C200(1.12); C44(1.18)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C200(1.14); C44(1.29)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C200(0.99); C44(1.09)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C200(1.05); C44(1.08)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C200(1.00); C44(1.13)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C200(1.14); C44(1.40)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C200(0.88); C44(0.95)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C200(1.04); C44(1.31)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C200(0.81); C44(1.00)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C200(0.92); C44(1.17)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C200(1.00); C44(1.18)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C200(0.96); C44(1.21)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C200(1.07); C44(1.34)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C200(1.20); C44(1.68)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C200(0.75); C44(0.97)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C200(0.67); C44(1.00)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C200(0.96); C44(1.00)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C200(1.03); C44(1.08)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C200(0.72); C44(1.00)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C200(0.61); C44(0.96)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C200(0.87); C44(1.06)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C200(0.73); C44(1.13)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C200(0.74); C44(0.97)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C200(0.96); C44(1.06)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C200(0.85); C44(0.99)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C200(0.73); C44(1.10)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C200(0.72); C44(1.12)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C200(0.65); C44(1.16)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C200(0.86); C44(1.09)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C200(1.02); C44(1.19)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C200(0.70); C44(1.05)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C200(0.80); C44(1.14)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C200(0.92); C44(1.61)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C200(0.75); C44(1.56)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C200(0.82); C44(1.73)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C200(0.61); C44(1.21)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C200(0.75); C44(1.21)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C200(0.78); C44(1.08)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C200(0.80); C44(1.11)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C200(0.91); C44(1.04)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C200(0.61); C44(1.17)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C200(0.71); C44(1.04)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C200(0.73); C44(1.79)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C200(1.15); C44(1.70)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C200(1.23); C44(1.70)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C200(1.15); C44(1.41)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C200(1.20); C44(1.21)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C44(1.07); C200(1.13)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C200(1.13); C44(1.19)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C200(1.08); C44(1.31)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C44(1.03); C200(1.32)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C200(0.92); C44(1.58)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C200(1.15); C44(1.58)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C200(1.06); C44(1.30)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C200(0.91); C44(1.22)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C200(1.18); C44(1.20)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C200(0.87); C44(1.31)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C200(1.19); C44(1.51)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C44(1.53)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C44(0.96)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C200(0.85); C44(1.05)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C200(0.86); C44(1.24)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C44(1.01); C200(1.26)  LDD0592  [13]
 LDCM0020  ARS-1620 HCC44 C44(0.86); C200(0.95)  LDD2171  [13]
 LDCM0108  Chloroacetamide HeLa C200(0.00); C253(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C44(20.00)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C200(0.86); C44(0.93)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C200(0.91); C44(1.09)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C200(0.92); C44(0.97)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C44(0.79); C200(0.95)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C200(0.74); C44(0.84)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C200(0.81); C44(0.91)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C200(0.86); C44(0.90)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C200(1.05); C44(1.37)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C200(1.28); C44(1.31)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C200(1.16); C44(1.43)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C44(1.19); C200(1.44)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C200(1.12); C44(1.38)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C200(0.98); C44(1.11)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C200(1.09); C44(1.14)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C200(1.04); C44(1.33)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C44(0.94); C200(1.09)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C44(1.29); C200(1.33)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C200(1.08); C44(1.27)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C44(1.10); C200(1.29)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C44(1.08); C200(1.13)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C200(1.15); C44(1.24)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C200(0.98); C44(1.03)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C200(1.02); C44(1.12)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C44(1.11); C200(1.21)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C200(0.86); C44(1.19)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C200(0.77); C44(0.94)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C200(0.96); C44(1.18)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C200(0.93); C44(1.24)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C200(1.10); C44(1.33)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C200(0.75); C44(1.11)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C200(0.80); C44(1.01)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C200(0.83); C44(1.06)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C44(0.97); C200(0.97)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C200(1.01); C44(1.03)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C200(0.89); C44(1.03)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C44(1.06); C200(1.08)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C200(0.99); C44(1.09)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C200(0.85); C44(1.13)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C200(1.04); C44(1.13)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C44(1.07); C200(1.18)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C44(0.98); C200(0.99)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C44(1.20); C200(1.22)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C200(1.14); C44(1.32)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C44(1.50); C200(1.54)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C200(1.14); C44(1.20)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C200(1.20); C44(1.25)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C200(1.06); C44(1.34)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C200(1.03); C44(1.24)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C200(1.20); C44(1.08)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C200(1.29); C44(1.16)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C200(1.15); C44(1.25)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C200(1.01); C44(0.98)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C200(1.17); C44(1.13)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C200(1.06); C44(1.09)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C200(1.25); C44(1.19)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C200(1.08); C44(1.35)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C200(1.38); C44(1.31)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C200(1.36); C44(1.29)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C200(1.08); C44(1.26)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C200(1.18); C44(1.36)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C200(1.31); C44(1.36)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C200(1.08); C44(1.01)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C200(1.17); C44(1.35)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C200(1.10); C44(1.25)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C200(1.43); C44(1.67)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C200(1.37); C44(1.44)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C200(1.14); C44(1.29)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C200(1.20); C44(1.50)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C200(0.98); C44(0.94)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C200(0.77); C44(0.88)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C200(0.85); C44(0.89)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C200(1.11); C44(0.88)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C200(0.90); C44(0.97)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C200(0.82); C44(0.89)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C200(0.87); C44(0.84)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C200(0.98); C44(0.86)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C200(0.90); C44(0.94)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C200(0.77); C44(0.83)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C200(0.86); C44(0.85)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C200(0.87); C44(0.93)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C200(0.81); C44(0.82)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C200(0.85); C44(0.83)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C200(0.85); C44(0.85)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C200(0.99); C44(1.03)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C200(0.95); C44(0.89)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C200(1.11); C44(1.09)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C200(1.04); C44(1.09)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C200(0.98); C44(1.14)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C200(1.11); C44(1.18)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C200(1.04); C44(1.04)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C200(1.22); C44(1.38)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C200(1.08); C44(1.19)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C200(0.99); C44(1.16)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C200(1.02); C44(1.04)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C200(1.08); C44(1.07)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C200(1.04); C44(1.19)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C200(1.15); C44(1.25)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C200(0.99); C44(1.12)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C200(1.15); C44(1.14)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C200(1.07); C44(1.13)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C44(1.07)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C44(1.00)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C44(1.07)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C44(1.23)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C200(1.03); C44(1.22)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C44(1.12)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C44(1.12)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C44(1.43)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C44(1.43)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C44(1.60)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C44(1.17)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C44(1.08)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C44(1.18)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C44(1.36)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C44(1.56)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C200(1.03); C44(1.07)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C44(1.00)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C200(0.94); C44(1.06)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C200(0.92); C44(0.97)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C200(0.85); C44(0.91)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C200(0.88); C44(0.83)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C200(0.86); C44(0.99)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C200(0.88); C44(1.06)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C200(0.95); C44(1.02)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C200(0.88); C44(1.03)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C200(0.90); C44(0.91)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C253(0.82); C44(0.88); C12(1.00); C200(0.89)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C12(10.56)  LDD1702  [2]
 LDCM0625  F8 Ramos C12(0.88); C44(1.27); C253(1.16)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C12(1.31); C44(0.85)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C12(0.19); C44(0.13); C253(0.15)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C12(4.08); C44(1.32); C253(1.76)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C12(1.11); C44(0.91); C253(0.90)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C12(1.79); C44(1.54); C253(2.24)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C12(2.56); C44(1.25); C253(2.11)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C12(1.49); C44(0.95); C253(0.98)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C12(1.63); C44(0.95); C253(0.91)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C12(0.91); C44(0.88); C253(0.67)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C12(0.97); C44(0.76); C253(0.84)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C12(1.35); C44(0.95); C253(0.87)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C12(1.15); C44(0.97); C253(1.04)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C12(2.68); C44(1.09); C253(1.31)  LDD2201  [15]
 LDCM0468  Fragment33 HCT 116 C200(0.98); C44(1.22)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C12(2.52); C44(1.02); C253(1.02)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C12(1.24); C44(1.14); C253(1.55)  LDD2184  [15]
 LDCM0427  Fragment51 HCT 116 C200(1.55); C44(1.62)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C12(1.71); C44(0.98)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C12(1.07); C44(0.95); C253(0.89)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C12(0.65); C44(1.32); C253(1.59)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C12(2.11); C44(0.93)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C12(0.96); C253(0.96); C200(0.93); C44(1.00)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C44(6.17); C253(9.30)  LDD0209  [3]
 LDCM0024  KB05 COLO792 C200(1.04)  LDD3310  [16]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C253(0.61)  LDD2109  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C253(0.61)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C253(0.73)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C253(0.78)  LDD2127  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C253(0.36)  LDD1700  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C253(0.27)  LDD2207  [17]
 LDCM0131  RA190 MM1.R C200(1.06)  LDD0304  [18]
 LDCM0021  THZ1 HCT 116 C44(0.86); C200(0.95)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Cell cycle checkpoint protein RAD1 (RAD1) Rad1 family O60671
Cell cycle checkpoint control protein RAD9A (RAD9A) Rad9 family Q99638
DCN1-like protein 5 (DCUN1D5) . Q9BTE7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Renal cancer differentiation gene 1 protein (C4orf46) . Q504U0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
17 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
18 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.