Details of the Target

General Information of Target

Target ID LDTP07974
Target Name Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (DHX32)
Gene Name DHX32
Gene ID 55760
Synonyms
DDX32; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32; EC 3.6.4.13; DEAD/H box 32; DEAD/H helicase-like protein 1; DHLP1; DEAH box protein 32; HuDDX32
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEEGLECPNSSSEKRYFPESLDSSDGDEEEVLACEDLELNPFDGLPYSSRYYKLLKERE
DLPIWKEKYSFMENLLQNQIVIVSGDAKCGKSAQVPQWCAEYCLSIHYQHGGVICTQVHK
QTVVQLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLQREMMSNPFLGSYG
VIILDDIHERSIATDVLLGLLKDVLLARPELKLIINSSPHLISKLNSYYGNVPVIEVKNK
HPVEVVYLSEAQKDSFESILRLIFEIHHSGEKGDIVVFLACEQDIEKVCETVYQGSNLNP
DLGELVVVPLYPKEKCSLFKPLDETEKRCQVYQRRVVLTTSSGEFLIWSNSVRFVIDVGV
ERRKVYNPRIRANSLVMQPISQSQAEIRKQILGSSSSGKFFCLYTEEFASKDMTPLKPAE
MQEANLTSMVLFMKRIDIAGLGHCDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGII
MSEFPLDPQLSKSILASCEFDCVDEVLTIAAMVTAPNCFSHVPHGAEEAALTCWKTFLHP
EGDHFTLISIYKAYQDTTLNSSSEYCVEKWCRDYFLNCSALRMADVIRAELLEIIKRIEL
PYAEPAFGSKENTLNIKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSGYSITKK
MPEWVLFHKFSISENNYIRITSEISPELFMQLVPQYYFSNLPPSESKDILQQVVDHLSPV
STMNKEQQMCETCPETEQRCTLQ
Target Bioclass
Enzyme
Family
DEAD box helicase family, DEAH subfamily
Subcellular location
Nucleus
Uniprot ID
Q7L7V1
Ensemble ID
ENST00000284690.4
HGNC ID
HGNC:16717

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.N470S DBIA    Probe Info 
CAL33 SNV: p.G111V .
HCC1395 SNV: p.P209R DBIA    Probe Info 
J82 Deletion: p.K68NfsTer14 .
MOLT4 Insertion: p.R328KfsTer14 .
NCIH2122 SNV: p.G111R .
UMUC3 SNV: p.A580P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.45  LDD0402  [1]
DBIA
 Probe Info  		C730(1.11); C733(1.11)  LDD0078  [2]
IA-alkyne
 Probe Info  		C316(0.00); C161(0.00); C578(0.00)  LDD0162  [3]
NAIA_5
 Probe Info  		C316(0.00); C8(0.00)  LDD2224  [4]
IPM
 Probe Info  		C316(0.00); C329(0.00)  LDD0147  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C403
 Probe Info  		17.75  LDD2061  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C161(0.86); C316(0.84); C566(0.92); C578(0.93)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C161(1.03); C316(1.00); C566(1.08); C578(1.00)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C161(0.67); C316(0.92); C566(1.24); C578(0.92)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C161(0.64); C316(1.04); C566(1.31); C578(0.92)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C161(0.69); C316(0.86); C566(1.13); C578(0.96)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C161(0.63); C316(0.95); C566(1.57); C578(1.00)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C161(0.66); C316(0.83); C566(1.13); C578(0.95)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C161(0.58); C316(0.84); C566(1.25); C578(1.11)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C161(0.60); C316(0.78); C566(1.26); C578(1.03)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C161(0.73); C316(0.77); C566(1.27); C578(0.91)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C161(0.70); C316(0.70); C566(1.10); C578(0.95)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C161(0.82); C316(0.71); C566(1.03); C578(0.99)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C161(1.13); C316(0.88); C566(1.18); C578(0.90)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C161(0.77); C316(0.78); C566(1.13); C578(1.01)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C161(0.71); C316(0.94); C566(1.13); C578(1.11)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C161(0.66); C316(0.84); C566(1.25); C578(1.12)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C316(1.03); C566(1.04); C578(1.03); C730(1.07)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C316(0.91); C566(1.15); C578(0.90); C730(0.91)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C316(0.87); C566(1.15); C578(0.94); C730(0.91)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C316(0.86); C566(1.50); C578(0.84); C730(0.98)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C316(0.89); C566(1.12); C578(1.03); C730(0.97)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C316(0.68); C566(1.13); C578(1.13); C730(0.87)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C316(0.84); C566(1.14); C578(0.98); C730(1.08)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C161(1.56); C316(1.01); C566(0.93); C578(0.92)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C316(0.93); C566(1.27); C578(0.88); C730(0.94)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C316(1.39); C566(1.19); C578(1.16); C730(0.86)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C316(0.91); C566(1.07); C578(0.87); C730(0.97)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C316(0.88); C566(1.08); C578(1.09); C730(1.21)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C316(1.13); C566(1.21); C578(1.02); C730(0.97)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C316(1.17); C566(1.15); C578(0.86); C730(1.02)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C316(0.96); C566(1.39); C578(0.91); C730(1.02)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C316(0.73); C566(1.32); C578(0.95); C730(1.08)  LDD0562  [2]
 LDCM0246  AC128 HCT 116 C161(1.32); C566(1.12); C578(1.59); C730(0.86)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C161(1.56); C566(1.30); C578(1.56); C730(0.81)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C161(0.97); C566(1.34); C578(2.14); C730(0.86)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C161(1.52); C566(1.23); C578(1.62); C730(0.90)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C161(1.59); C566(1.76); C578(2.18); C730(0.91)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C161(0.97); C566(1.27); C578(1.76); C730(0.95)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C161(0.98); C566(1.54); C578(1.45); C730(0.84)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C161(1.09); C566(1.31); C578(1.50); C730(0.81)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C161(1.23); C566(1.50); C578(1.76); C730(0.86)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C161(1.26); C566(1.29); C578(1.33); C730(0.85)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C161(0.99); C566(1.94); C578(0.92); C730(0.82)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C161(1.01); C566(1.66); C578(2.16); C730(0.95)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C161(1.21); C316(1.03); C566(0.91); C578(0.94)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C161(1.09); C566(2.31); C578(1.61); C730(0.86)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C161(1.25); C566(2.32); C578(1.64); C730(0.93)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C161(1.79); C566(1.58); C578(1.27); C730(0.95)  LDD0579  [2]
 LDCM0263  AC143 HCT 116 C161(1.02); C316(1.01); C566(1.55); C578(0.91)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C161(0.53); C316(0.86); C578(0.93); C730(1.04)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C161(0.62); C578(0.89); C316(1.08); C730(1.10)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C161(0.62); C578(0.92); C316(0.95); C566(1.12)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C161(0.54); C733(1.00); C730(1.03); C578(1.03)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C161(0.72); C578(0.88); C316(1.08); C730(1.20)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C161(0.59); C578(0.77); C730(1.06); C733(1.08)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C730(0.92); C733(0.93); C566(0.94); C578(0.98)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C161(0.84); C578(0.92); C730(1.09); C566(1.12)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C161(0.81); C578(0.92); C316(0.95); C566(1.12)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C161(0.57); C578(0.95); C730(0.98); C733(1.02)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C161(0.75); C578(0.88); C316(0.96); C730(1.18)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C161(0.51); C316(0.89); C566(1.05); C578(0.89)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C161(0.48); C316(0.85); C566(1.02); C578(0.88)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C161(0.91); C316(0.98); C566(0.94); C578(0.89)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C161(0.80); C316(0.95); C566(1.07); C578(1.04)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C316(0.74); C578(1.10); C730(1.10); C566(1.12)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C578(1.00); C730(1.12); C733(1.13); C316(1.25)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C578(1.08); C730(1.12); C733(1.12); C566(1.14)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C316(0.79); C161(0.94); C730(0.94); C733(0.94)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C161(1.02); C578(1.06); C566(1.13); C730(1.18)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C578(0.88); C566(1.10); C161(1.12); C733(1.13)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C161(0.82); C730(0.92); C733(0.94); C578(1.00)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C578(0.91); C730(1.13); C733(1.13); C161(1.25)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C161(0.97); C566(1.08); C730(1.10); C733(1.11)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C316(0.82); C730(0.89); C733(0.89); C566(0.94)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C316(0.73); C161(0.85); C730(0.96); C733(0.96)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C316(0.66); C161(0.78); C730(0.91); C733(0.91)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C316(0.59); C161(0.75); C730(0.99); C733(0.99)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C316(0.65); C161(0.78); C730(0.86); C733(0.86)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C316(0.76); C566(0.93); C733(1.03); C161(1.04)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C316(0.66); C161(0.74); C578(0.92); C730(1.00)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C316(0.65); C161(0.76); C730(0.86); C733(0.86)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C316(0.62); C161(0.70); C730(0.77); C733(0.77)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C161(0.74); C730(0.81); C733(0.81); C316(0.85)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C161(0.68); C316(0.92); C730(1.00); C733(1.00)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C566(0.87); C316(0.91); C578(1.00); C730(1.08)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C730(0.97); C733(0.97); C566(0.97); C578(0.98)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C566(0.82); C578(0.91); C730(0.99); C733(0.99)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C316(0.96); C578(0.99); C730(0.99); C733(0.99)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C316(0.90); C578(0.94); C566(0.94); C730(1.09)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C316(0.78); C161(0.84); C566(0.84); C730(0.95)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C566(0.96); C578(1.03); C730(1.05); C733(1.05)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C578(0.95); C730(1.16); C733(1.16); C566(1.17)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C730(1.02); C733(1.02); C578(1.04); C161(1.07)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C578(0.90); C161(1.01); C730(1.09); C733(1.09)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C566(0.84); C578(0.98); C730(1.01); C733(1.01)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C566(0.81); C578(1.03); C730(1.14); C733(1.14)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C161(0.96); C316(0.96); C566(1.05); C730(1.06)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C316(0.89); C161(0.94); C730(1.03); C733(1.03)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C316(0.95); C578(1.04); C566(1.04); C730(1.05)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C316(0.95); C730(1.13); C733(1.13); C161(1.19)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C316(0.72); C161(0.83); C566(0.88); C730(0.95)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C316(0.93); C578(1.01); C161(1.09); C730(1.09)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C316(0.82); C578(0.85); C566(0.93); C730(1.11)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C316(0.67); C161(0.98); C578(1.00); C566(1.09)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C578(0.92); C161(0.99); C316(1.12); C730(1.15)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C316(0.84); C161(0.86); C730(1.02); C733(1.02)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C161(1.06); C316(1.09); C578(1.13); C730(1.19)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C578(1.26); C316(1.26); C161(1.43); C730(1.52)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C730(0.80); C733(0.80); C161(0.82); C578(0.98)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C730(0.93); C733(0.93); C161(1.11); C578(1.12)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C730(0.86); C733(0.86); C578(0.93); C161(1.09)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C161(0.91); C730(1.01); C733(1.01); C578(1.05)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C578(0.80); C730(0.85); C733(0.85); C402(0.98)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C578(0.80); C730(0.93); C733(0.93); C402(0.94)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C578(0.77); C402(0.99); C730(0.99); C733(0.99)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C730(0.85); C733(0.85); C161(0.92); C578(0.93)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C578(0.87); C730(0.97); C733(0.97); C566(1.03)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C578(0.79); C730(0.96); C733(0.96); C402(1.04)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C578(0.76); C730(0.86); C733(0.86); C402(1.02)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C578(0.78); C730(0.92); C733(0.92); C402(1.02)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C402(0.78); C566(0.80); C161(0.88); C730(1.03)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C402(0.79); C566(0.84); C161(0.84); C730(1.04)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C161(0.86); C578(0.95); C730(0.99); C733(1.01)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C316(0.81); C161(0.81); C402(0.90); C566(1.06)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C566(0.77); C402(0.80); C316(0.95); C161(0.96)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C316(0.69); C402(0.80); C161(0.82); C566(0.94)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C316(0.78); C402(0.92); C566(1.01); C578(1.11)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C402(0.85); C566(0.90); C730(1.12); C733(1.12)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C402(0.87); C316(0.88); C566(1.04); C578(1.27)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C402(0.85); C566(0.88); C316(0.89); C161(1.03)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C402(0.84); C161(0.88); C566(0.95); C730(1.12)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C402(0.80); C566(0.88); C161(0.97); C316(1.02)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C161(0.87); C402(0.89); C566(0.90); C316(0.90)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C578(0.92); C566(1.01); C316(1.02); C730(1.03)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C161(0.75); C566(0.86); C316(0.91); C402(0.92)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C402(0.80); C566(0.89); C316(0.90); C730(0.98)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C316(0.74); C402(0.87); C566(0.98); C161(1.18)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C161(0.91); C578(0.99); C730(1.02); C733(1.02)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C578(0.77); C161(0.85); C566(1.04); C730(1.09)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C578(0.79); C161(0.95); C730(1.14); C733(1.14)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C161(0.88); C730(0.99); C733(0.99); C578(1.07)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C161(0.74); C578(0.85); C730(1.00); C733(1.00)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C161(0.86); C578(1.13); C730(1.27); C733(1.27)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C161(0.85); C578(0.91); C730(1.01); C733(1.01)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C161(0.70); C578(1.01); C730(1.23); C733(1.23)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C566(0.76); C161(0.90); C316(0.95); C578(0.96)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C161(0.87); C578(0.88); C566(0.92); C730(1.09)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C161(0.76); C730(1.05); C733(1.05); C566(1.07)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C578(0.82); C566(0.86); C730(1.04); C733(1.04)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C578(0.73); C161(0.77); C730(1.05); C733(1.05)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C566(0.79); C578(0.89); C316(1.06); C730(1.11)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C161(0.75); C578(0.76); C730(1.18); C733(1.18)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C161(0.65); C730(0.87); C733(0.87); C578(0.99)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C161(0.80); C730(0.86); C733(0.86); C578(0.89)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C161(1.22); C316(0.91); C566(1.11); C578(1.11)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C578(1.01); C316(1.03); C730(1.05); C733(1.05)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C161(0.95); C316(1.00); C566(1.03); C578(1.06)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C730(1.11); C733(1.11)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C8(1.66); C316(0.30)  LDD2227  [4]
 LDCM0367  CL1 HCT 116 C578(0.93); C316(1.04); C161(1.05); C402(1.07)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C316(0.70); C578(0.90); C161(1.05); C402(1.11)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C161(0.79); C316(0.88); C566(0.94); C730(1.02)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C161(0.98); C578(1.05); C730(1.07); C733(1.08)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C161(0.86); C733(0.98); C730(0.99); C578(1.11)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C578(0.97); C566(0.98); C316(1.12); C730(1.21)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C578(0.98); C566(1.01); C730(1.05); C733(1.05)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C578(0.96); C730(1.08); C733(1.09); C161(1.11)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C578(0.98); C730(1.15); C733(1.17); C316(1.37)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C578(0.86); C316(0.96); C730(1.07); C733(1.09)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C316(1.00); C733(1.04); C730(1.04); C578(1.11)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C316(0.79); C578(0.89); C161(1.06); C733(1.08)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C578(0.94); C316(1.03); C161(1.03); C402(1.24)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C316(0.89); C578(1.11); C730(1.24); C733(1.25)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C578(0.91); C161(1.06); C733(1.25); C730(1.31)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C316(0.67); C161(0.92); C730(1.02); C733(1.02)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C316(0.59); C161(0.67); C730(0.81); C733(0.81)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C316(0.67); C161(0.87); C730(0.92); C733(0.92)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C161(0.70); C316(0.71); C730(0.88); C733(0.88)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C316(0.73); C161(0.85); C730(0.94); C733(0.94)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C578(1.05); C161(1.16); C316(1.22); C566(1.30)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C578(0.96); C730(0.99); C733(0.99); C316(1.08)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C578(0.88); C161(0.99); C316(1.11); C730(1.16)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C316(0.69); C578(0.92); C161(1.16); C402(1.24)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C578(0.96); C316(1.03); C730(1.11); C733(1.11)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C161(0.68); C566(0.83); C578(1.03); C316(1.19)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C578(0.92); C316(1.08); C730(1.11); C733(1.11)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C316(0.89); C578(0.97); C161(1.10); C730(1.28)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C316(0.92); C161(1.10); C730(1.20); C733(1.20)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C730(0.77); C733(0.77); C578(0.84); C161(0.95)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C161(0.72); C730(0.83); C733(0.83); C578(0.87)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C730(0.80); C733(0.80); C578(0.83); C161(0.92)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C161(0.81); C730(0.85); C733(0.85); C578(0.88)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C316(0.80); C578(0.91); C402(1.02); C161(1.07)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C402(0.87); C578(0.88); C316(0.88); C161(1.02)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C578(0.99); C161(1.04); C402(1.06); C316(1.26)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C402(0.76); C578(0.81); C161(0.84); C316(1.01)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C402(0.77); C578(0.83); C161(0.84); C730(0.96)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C402(0.67); C161(0.81); C730(0.83); C733(0.83)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C161(0.75); C402(0.88); C730(0.92); C733(0.92)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C578(0.79); C316(0.85); C402(1.12); C161(1.17)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C161(0.63); C402(0.77); C578(0.81); C566(0.82)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C578(0.83); C402(0.85); C161(0.91); C730(1.13)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C161(1.02); C578(1.02); C566(1.25); C730(1.32)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C161(0.63); C402(0.73); C578(0.90); C730(1.03)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C161(0.72); C402(0.86); C578(0.87); C566(1.03)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C161(0.67); C402(0.75); C566(1.14); C578(0.84)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C161(0.66); C402(0.64); C566(1.14); C578(0.92)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C161(0.64); C402(0.67); C566(1.05); C578(0.95)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C161(0.66); C402(0.76); C566(1.22); C578(0.84)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C161(0.73); C402(0.77); C566(1.04); C578(0.78)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C161(1.03); C316(0.81); C402(0.99); C566(1.07)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C161(0.73); C402(0.80); C566(1.04); C578(0.97)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C566(1.37); C578(1.15); C730(0.78); C733(0.78)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C316(1.08); C566(1.31); C578(0.98); C730(0.87)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C316(2.03); C566(2.37); C578(0.92); C730(0.95)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C316(1.06); C566(1.61); C578(1.11); C730(1.17)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C316(0.91); C566(1.40); C578(0.95); C730(0.93)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C316(1.02); C566(1.45); C578(0.97); C730(0.87)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C316(0.96); C566(1.70); C578(1.11); C730(0.85)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C316(1.07); C566(2.44); C578(1.17); C730(0.98)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C161(0.93); C316(0.88); C402(0.87); C566(1.77)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C316(1.45); C566(2.22); C578(1.15); C730(0.89)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C316(1.24); C566(1.51); C578(1.01); C730(0.79)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C316(1.23); C566(2.30); C578(1.11); C730(1.20)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C316(1.03); C566(1.93); C578(0.92); C730(0.91)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C316(0.83); C566(1.81); C578(1.11); C730(0.84)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C316(0.78); C566(2.28); C578(0.95); C730(1.01)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C161(1.48); C316(0.93); C566(1.04); C578(1.04)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C161(1.23); C316(0.91); C566(1.23); C578(1.06)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C161(0.93); C316(0.87); C566(0.97); C578(0.89)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C161(0.76); C316(0.86); C566(1.01); C578(1.46)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C161(1.03); C316(0.66); C402(0.84); C566(1.04)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C161(1.07); C316(0.86); C566(1.07); C578(1.20)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C161(0.98); C316(0.89); C566(1.18); C578(1.33)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C161(0.99); C316(0.86); C566(1.09); C578(1.11)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C161(0.91); C316(1.66); C566(1.17); C578(1.32)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C161(0.89); C316(0.79); C566(1.04); C578(0.98)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C161(1.02); C316(0.71); C566(1.02); C578(1.18)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C161(0.85); C316(0.85); C566(1.32); C578(1.10)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C161(0.96); C316(1.04); C566(1.27); C578(1.13)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C161(0.99); C316(0.78); C566(0.90); C578(1.36)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C161(0.93); C316(0.68); C566(1.01); C578(1.38)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C161(1.02); C316(0.83); C402(1.01); C566(1.52)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C161(0.86); C316(0.69); C566(1.14); C578(1.09)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C161(0.94); C402(0.98); C566(1.14); C730(0.84)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C161(0.90); C402(0.96); C566(1.20); C730(0.97)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C161(0.79); C402(0.78); C566(1.24); C730(0.98)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C161(0.73); C402(0.74); C566(1.36); C730(0.90)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C161(1.12); C402(0.85); C566(1.16); C730(0.96)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C161(0.71); C402(0.98); C566(1.43); C730(1.03)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C161(0.81); C402(0.86); C566(1.30); C730(0.95)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C161(0.79); C402(0.84); C566(1.19); C730(0.86)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C161(0.70); C402(0.78); C566(1.28); C730(0.97)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C161(1.11); C316(0.60); C402(1.08); C566(1.33)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C161(0.90); C402(0.89); C566(1.17); C730(0.92)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C161(0.83); C402(0.83); C566(1.54); C730(0.93)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C161(0.91); C402(0.95); C566(1.12); C730(1.06)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C161(0.61); C402(1.09); C566(1.45); C730(0.96)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C161(0.76); C402(0.89); C566(1.49); C730(0.91)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C161(0.91); C316(1.23); C566(1.11); C578(0.89)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C161(0.56); C316(1.36); C566(1.31); C578(1.04)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C161(0.68); C316(1.23); C566(0.96); C578(1.05)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C161(0.60); C316(1.49); C566(1.14); C578(1.02)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C161(1.15); C316(2.16); C402(1.33); C566(2.49)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C161(0.79); C316(1.24); C566(1.06); C578(0.83)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C161(0.61); C316(1.02); C566(1.33); C578(1.03)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C161(0.78); C316(1.33); C566(1.05); C578(1.08)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C161(0.77); C316(1.46); C566(1.28); C578(1.00)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C161(0.89); C316(1.52); C566(1.02); C578(1.11)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C161(0.58); C316(1.09); C566(1.15); C578(1.03)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C161(0.70); C316(1.11); C566(0.92); C578(1.03)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C161(0.61); C316(1.30); C566(1.09); C578(0.99)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C161(0.63); C316(1.29); C566(0.96); C578(0.99)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C161(0.87); C316(1.65); C566(0.89); C578(1.11)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C161(0.98); C316(0.87); C402(0.87); C566(1.50)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C161(1.15); C316(2.44); C566(2.59); C578(1.19)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C161(0.90); C316(1.00); C566(1.28); C578(0.95)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C161(0.85); C316(0.99); C566(1.12); C578(0.86)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C161(0.88); C316(0.74); C566(0.99); C578(0.88)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C161(0.84); C316(0.93); C566(0.96); C578(0.75)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C161(0.85); C316(1.24); C566(1.23); C578(0.87)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C161(0.83); C316(0.86); C566(1.05); C578(1.04)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C161(0.78); C316(0.89); C566(1.47); C578(0.97)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C161(0.90); C316(0.92); C566(1.07); C578(0.94)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C161(0.72); C316(0.92); C566(0.77); C578(1.01)  LDD0811  [2]
 LDCM0634  CY-0357 Hep-G2 C329(1.55); C566(0.64)  LDD2228  [4]
 LDCM0468  Fragment33 HCT 116 C161(0.72); C402(0.81); C566(1.30); C730(0.85)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C316(1.13); C566(3.13); C578(1.03); C730(1.29)  LDD0744  [2]
 LDCM0022  KB02 T cell-activated C566(11.91)  LDD1704  [7]
 LDCM0023  KB03 42-MG-BA C289(1.74)  LDD2661  [8]
 LDCM0024  KB05 NALM-6 C289(1.73)  LDD3339  [8]
 LDCM0021  THZ1 HCT 116 C730(1.07); C733(1.07)  LDD2173  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM161A (FAM161A) FAM161 family Q3B820

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840