Details of the Target

General Information of Target

Target ID LDTP12788
Target Name BRISC and BRCA1-A complex member 2 (BABAM2)
Gene Name BABAM2
Gene ID 9577
Synonyms
BRCC45; BRE; BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSAAGAGAGVEAGFSSEELLSLRFPLHRACRDGDLATLCSLLQQTPHAHLASEDSFYGWT
PVHWAAHFGKLECLVQLVRAGATLNVSTTRYAQTPAHIAAFGGHPQCLVWLIQAGANINK
PDCEGETPIHKAARSGSLECISALVANGAHVDLRNASGLTAADIAQTQGFQECAQFLLNL
QNCHLNHFYNNGILNGGHQNVFPNHISVGTNRKRCLEDSEDFGVKKARTEAQSLDSAVPL
TNGDTEDDADKMHVDREFAVVTDMKNSSSVSNTLTNGCVINGHLDFPSTTPLSGMESRNG
QCLTGTNGISSGLAPGQPFPSSQGSLCISGTEEPEKTLRANPELCGSLHLNGSPSSCIAS
RPSWVEDIGDNLYYGHYHGFGDTAESIPELNSVVEHSKSVKVQERYDSAVLGTMHLHHGS
Target Bioclass
Other
Family
BABAM2 family
Subcellular location
Cytoplasm
Function
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect.
Uniprot ID
Q9NXR7
Ensemble ID
ENST00000342045.6
HGNC ID
HGNC:1106

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.01  LDD0403  [1]
DBIA
 Probe Info  		C129(2.99); C34(3.66)  LDD3310  [2]
BTD
 Probe Info  		C34(0.73)  LDD2099  [3]
AHL-Pu-1
 Probe Info  		C34(3.04)  LDD0171  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C129(0.00); C34(0.00); C245(0.00); C254(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C129(0.00); C34(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C34(0.00); C129(0.00); C245(0.00); C254(0.00)  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD0025  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [10]
Compound 11
 Probe Info  		N.A.  LDD2213  [10]
PF-06672131
 Probe Info  		N.A.  LDD0017  [11]
1c-yne
 Probe Info  		N.A.  LDD0228  [12]
Acrolein
 Probe Info  		N.A.  LDD0217  [13]
Methacrolein
 Probe Info  		C44(0.00); C34(0.00); C53(0.00)  LDD0218  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
AOyne
 Probe Info  		13.40  LDD0443  [15]
NAIA_5
 Probe Info  		C129(0.00); C34(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		48.17  LDD1948  [16]
C399
 Probe Info  		6.92  LDD2058  [16]
C403
 Probe Info  		14.12  LDD2061  [16]
STS-2
 Probe Info  		N.A.  LDD0138  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C34(3.04)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C129(1.04); C34(0.95); C245(0.89)  LDD1507  [19]
 LDCM0215  AC10 HEK-293T C129(1.00); C34(0.92); C245(1.07); C53(0.83)  LDD1508  [19]
 LDCM0226  AC11 HEK-293T C129(0.94); C34(0.94); C245(0.90); C53(0.91)  LDD1509  [19]
 LDCM0237  AC12 HEK-293T C129(0.87); C34(0.94); C53(1.04)  LDD1510  [19]
 LDCM0259  AC14 HEK-293T C129(1.06); C34(1.00); C245(1.17); C53(1.01)  LDD1512  [19]
 LDCM0270  AC15 HEK-293T C129(0.96); C34(0.94); C245(1.07); C53(0.67)  LDD1513  [19]
 LDCM0276  AC17 HEK-293T C129(0.97); C34(1.01); C245(0.99)  LDD1515  [19]
 LDCM0277  AC18 HEK-293T C129(1.01); C34(0.92); C245(0.92); C53(0.97)  LDD1516  [19]
 LDCM0278  AC19 HEK-293T C129(0.91); C34(0.91); C245(0.74); C53(0.73)  LDD1517  [19]
 LDCM0279  AC2 HEK-293T C129(1.04); C34(0.98); C245(0.95); C53(1.03)  LDD1518  [19]
 LDCM0280  AC20 HEK-293T C129(0.98); C34(0.86); C53(1.08)  LDD1519  [19]
 LDCM0281  AC21 HEK-293T C129(1.05); C34(1.02); C245(0.84); C53(0.99)  LDD1520  [19]
 LDCM0282  AC22 HEK-293T C129(1.02); C34(0.96); C245(1.27); C53(0.96)  LDD1521  [19]
 LDCM0283  AC23 HEK-293T C129(0.99); C34(0.92); C245(1.08); C53(0.67)  LDD1522  [19]
 LDCM0284  AC24 HEK-293T C129(0.89); C34(0.97); C53(0.87)  LDD1523  [19]
 LDCM0285  AC25 HEK-293T C129(0.99); C34(1.07); C245(1.02)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C129(0.92); C34(0.94); C245(1.02); C53(0.93)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C129(0.92); C34(0.92); C245(0.91); C53(0.79)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C129(0.88); C34(0.92); C53(0.87)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C129(1.02); C34(0.98); C245(0.91); C53(1.12)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C129(0.96); C34(0.90); C245(1.02); C53(1.00)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C129(1.07); C34(0.91); C245(1.04); C53(1.04)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C129(1.01); C34(1.13); C245(1.27); C53(0.64)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C129(1.03); C34(1.02); C53(0.93)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C129(0.93); C34(0.93); C245(0.97)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C129(0.98); C34(0.95); C245(1.26); C53(0.88)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C129(1.00); C34(0.93); C245(0.92); C53(0.86)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C129(0.95); C34(0.98); C53(0.96)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C129(0.98); C34(0.90); C245(0.98); C53(1.08)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C129(0.97); C34(0.89); C245(1.09); C53(0.94)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C129(0.99); C34(1.02); C245(1.11); C53(0.81)  LDD1539  [19]
 LDCM0301  AC4 HEK-293T C129(0.83); C34(0.87); C53(0.98)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C129(0.94); C34(0.95); C53(0.97)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C129(0.95); C34(1.00); C245(1.03)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C129(0.92); C34(0.96); C245(1.50); C53(0.92)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C129(0.98); C34(0.92); C245(0.93); C53(0.95)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C129(0.89); C34(0.89); C53(0.92)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C129(1.00); C34(1.05); C245(0.93); C53(0.91)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C129(0.98); C34(0.97); C245(1.05); C53(0.98)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C129(1.02); C34(0.91); C245(0.86); C53(0.65)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C129(0.94); C34(1.01); C53(0.91)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C129(0.92); C34(1.02); C245(0.87)  LDD1550  [19]
 LDCM0312  AC5 HEK-293T C129(0.99); C34(0.96); C245(1.07); C53(1.00)  LDD1551  [19]
 LDCM0313  AC50 HEK-293T C129(0.97); C34(0.91); C245(1.10); C53(0.89)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C129(1.00); C34(0.95); C245(0.76); C53(0.83)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C129(0.85); C34(0.94); C53(0.96)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C129(1.00); C34(0.91); C245(0.85); C53(1.00)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C129(0.98); C34(1.04); C245(0.92); C53(0.92)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C129(0.93); C34(0.90); C245(1.04); C53(0.65)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C129(0.92); C34(1.01); C53(0.88)  LDD1558  [19]
 LDCM0320  AC57 HEK-293T C129(0.97); C34(0.88); C245(1.05)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C129(1.04); C34(0.99); C245(1.09); C53(0.95)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C129(1.01); C34(0.96); C245(0.90); C53(0.98)  LDD1561  [19]
 LDCM0323  AC6 HEK-293T C129(1.04); C34(0.92); C245(1.11); C53(1.00)  LDD1562  [19]
 LDCM0324  AC60 HEK-293T C129(0.92); C34(0.94); C53(0.91)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C129(1.03); C34(0.94); C245(0.84); C53(0.91)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C129(1.00); C34(0.88); C245(0.92); C53(1.04)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C129(0.97); C34(0.94); C245(1.02); C53(0.66)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C129(0.92); C34(1.00); C53(1.00)  LDD1567  [19]
 LDCM0334  AC7 HEK-293T C129(0.96); C34(1.14); C245(1.08); C53(1.03)  LDD1568  [19]
 LDCM0345  AC8 HEK-293T C129(1.01); C34(0.90); C53(0.85)  LDD1569  [19]
 LDCM0248  AKOS034007472 HEK-293T C129(0.91); C34(0.93); C245(0.81); C53(1.19)  LDD1511  [19]
 LDCM0356  AKOS034007680 HEK-293T C129(0.91); C34(0.94); C245(0.95)  LDD1570  [19]
 LDCM0275  AKOS034007705 HEK-293T C129(1.05); C34(0.94); C53(0.83)  LDD1514  [19]
 LDCM0156  Aniline NCI-H1299 10.01  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [13]
 LDCM0367  CL1 HEK-293T C129(1.00); C34(0.84); C245(1.00); C53(1.21)  LDD1571  [19]
 LDCM0368  CL10 HEK-293T C129(1.31); C34(0.82); C245(1.37); C53(0.86)  LDD1572  [19]
 LDCM0369  CL100 HEK-293T C129(1.03); C34(0.89); C53(0.89)  LDD1573  [19]
 LDCM0370  CL101 HEK-293T C129(0.95); C34(0.90); C245(1.12); C53(1.15)  LDD1574  [19]
 LDCM0371  CL102 HEK-293T C129(0.98); C34(0.81); C53(0.96)  LDD1575  [19]
 LDCM0372  CL103 HEK-293T C129(0.97); C34(0.96); C245(0.98); C53(0.86)  LDD1576  [19]
 LDCM0373  CL104 HEK-293T C129(0.95); C34(0.84); C53(1.23)  LDD1577  [19]
 LDCM0374  CL105 HEK-293T C129(0.96); C34(0.97); C245(0.95); C53(1.02)  LDD1578  [19]
 LDCM0375  CL106 HEK-293T C129(0.99); C34(1.00); C53(1.08)  LDD1579  [19]
 LDCM0376  CL107 HEK-293T C129(0.99); C34(0.92); C245(1.12); C53(0.98)  LDD1580  [19]
 LDCM0377  CL108 HEK-293T C129(0.99); C34(0.95); C53(0.79)  LDD1581  [19]
 LDCM0378  CL109 HEK-293T C129(0.93); C34(0.93); C245(0.90); C53(0.88)  LDD1582  [19]
 LDCM0379  CL11 HEK-293T C129(1.12); C34(0.79); C245(1.08); C53(1.06)  LDD1583  [19]
 LDCM0380  CL110 HEK-293T C129(0.94); C34(0.85); C53(0.94)  LDD1584  [19]
 LDCM0381  CL111 HEK-293T C129(0.96); C34(0.94); C245(1.06); C53(0.95)  LDD1585  [19]
 LDCM0382  CL112 HEK-293T C129(0.93); C34(0.93); C53(0.87)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C129(0.96); C34(0.88); C245(0.89); C53(1.09)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C129(0.99); C34(0.85); C53(1.03)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C129(1.05); C34(0.92); C245(1.14); C53(0.93)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C129(0.98); C34(0.85); C53(0.80)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C129(0.97); C34(0.91); C245(1.00); C53(1.11)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C129(0.95); C34(0.93); C53(1.04)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C129(1.03); C34(0.86); C245(0.89); C53(1.02)  LDD1593  [19]
 LDCM0390  CL12 HEK-293T C129(1.05); C34(0.98); C53(1.07)  LDD1594  [19]
 LDCM0391  CL120 HEK-293T C129(1.01); C34(0.90); C53(0.99)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C129(0.92); C34(0.91); C245(0.92); C53(1.08)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C129(0.93); C34(0.93); C53(0.98)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C129(1.01); C34(0.94); C245(0.90); C53(0.87)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C129(0.92); C34(0.88); C53(0.77)  LDD1599  [19]
 LDCM0396  CL125 HEK-293T C129(0.93); C34(1.00); C245(0.84); C53(1.07)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C129(0.98); C34(0.95); C53(1.06)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C129(1.02); C34(0.94); C245(0.95); C53(0.96)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C129(0.97); C34(0.95); C53(0.93)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C129(0.92); C34(0.87); C245(1.11); C53(0.81)  LDD1604  [19]
 LDCM0401  CL14 HEK-293T C129(0.99); C34(0.93); C53(1.14)  LDD1605  [19]
 LDCM0402  CL15 HEK-293T C129(1.04); C34(0.80); C245(1.17); C53(0.95)  LDD1606  [19]
 LDCM0403  CL16 HEK-293T C129(0.93); C34(0.85); C53(0.93)  LDD1607  [19]
 LDCM0404  CL17 HEK-293T C129(0.99); C34(0.98); C245(0.90)  LDD1608  [19]
 LDCM0405  CL18 HEK-293T C129(1.04); C34(0.86); C245(1.62); C53(1.03)  LDD1609  [19]
 LDCM0406  CL19 HEK-293T C129(0.97); C34(0.81); C245(0.87); C53(0.82)  LDD1610  [19]
 LDCM0407  CL2 HEK-293T C129(0.95); C34(1.01); C53(1.14)  LDD1611  [19]
 LDCM0408  CL20 HEK-293T C129(0.93); C34(0.82); C53(1.04)  LDD1612  [19]
 LDCM0409  CL21 HEK-293T C129(1.07); C34(0.87); C245(1.00); C53(0.92)  LDD1613  [19]
 LDCM0410  CL22 HEK-293T C129(1.10); C34(0.86); C245(1.31); C53(1.16)  LDD1614  [19]
 LDCM0411  CL23 HEK-293T C129(1.12); C34(0.87); C245(1.19); C53(0.63)  LDD1615  [19]
 LDCM0412  CL24 HEK-293T C129(1.15); C34(1.04); C53(1.01)  LDD1616  [19]
 LDCM0413  CL25 HEK-293T C129(0.97); C34(0.81); C245(0.89); C53(0.88)  LDD1617  [19]
 LDCM0414  CL26 HEK-293T C129(1.01); C34(0.93); C53(1.01)  LDD1618  [19]
 LDCM0415  CL27 HEK-293T C129(0.95); C34(0.94); C245(1.09); C53(1.03)  LDD1619  [19]
 LDCM0416  CL28 HEK-293T C129(0.94); C34(0.83); C53(0.83)  LDD1620  [19]
 LDCM0417  CL29 HEK-293T C129(0.91); C34(0.93); C245(0.82)  LDD1621  [19]
 LDCM0418  CL3 HEK-293T C129(1.14); C34(0.86); C245(1.13); C53(0.94)  LDD1622  [19]
 LDCM0419  CL30 HEK-293T C129(1.08); C34(0.92); C245(0.95); C53(1.10)  LDD1623  [19]
 LDCM0420  CL31 HEK-293T C129(1.02); C34(0.89); C245(0.80); C53(0.88)  LDD1624  [19]
 LDCM0421  CL32 HEK-293T C129(0.91); C34(0.85); C53(0.95)  LDD1625  [19]
 LDCM0422  CL33 HEK-293T C129(1.12); C34(0.83); C245(0.81); C53(0.94)  LDD1626  [19]
 LDCM0423  CL34 HEK-293T C129(1.25); C34(0.92); C245(1.24); C53(1.12)  LDD1627  [19]
 LDCM0424  CL35 HEK-293T C129(1.16); C34(0.88); C245(1.25); C53(0.59)  LDD1628  [19]
 LDCM0425  CL36 HEK-293T C129(1.23); C34(0.94); C53(1.11)  LDD1629  [19]
 LDCM0426  CL37 HEK-293T C129(0.87); C34(0.92); C245(0.92); C53(0.98)  LDD1630  [19]
 LDCM0428  CL39 HEK-293T C129(0.96); C34(0.94); C245(1.14); C53(1.05)  LDD1632  [19]
 LDCM0429  CL4 HEK-293T C129(1.05); C34(0.86); C53(0.94)  LDD1633  [19]
 LDCM0430  CL40 HEK-293T C129(0.99); C34(0.85); C53(1.07)  LDD1634  [19]
 LDCM0431  CL41 HEK-293T C129(0.96); C34(0.86); C245(0.91)  LDD1635  [19]
 LDCM0432  CL42 HEK-293T C129(1.03); C34(0.91); C245(0.86); C53(1.08)  LDD1636  [19]
 LDCM0433  CL43 HEK-293T C129(1.09); C34(0.95); C245(0.93); C53(0.97)  LDD1637  [19]
 LDCM0434  CL44 HEK-293T C129(0.95); C34(0.92); C53(1.06)  LDD1638  [19]
 LDCM0435  CL45 HEK-293T C129(1.02); C34(0.87); C245(1.01); C53(0.85)  LDD1639  [19]
 LDCM0436  CL46 HEK-293T C129(1.10); C34(1.02); C245(1.10); C53(1.14)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C129(1.09); C34(0.89); C245(1.09); C53(0.58)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C129(1.15); C34(1.01); C53(1.05)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C129(0.91); C34(0.90); C245(0.84); C53(1.28)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C129(1.03); C34(0.95); C245(0.84)  LDD1644  [19]
 LDCM0441  CL50 HEK-293T C129(0.97); C34(0.89); C53(1.01)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C129(1.04); C34(0.77); C53(1.05)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C129(0.94); C34(0.87); C245(0.96)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C129(1.02); C34(0.88); C245(1.66); C53(0.81)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C129(1.04); C34(0.87); C245(0.91); C53(0.90)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C129(0.96); C34(0.82); C53(1.01)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C129(1.09); C34(0.83); C245(0.91); C53(0.87)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C129(1.07); C34(0.87); C245(1.07); C53(0.91)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C129(1.08); C34(0.88); C245(1.12); C53(0.99)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C129(1.00); C34(0.86); C245(1.44); C53(1.00)  LDD1654  [19]
 LDCM0452  CL60 HEK-293T C129(1.14); C34(0.84); C53(0.98)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C129(0.96); C34(0.87); C245(0.95); C53(1.01)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C129(1.03); C34(0.84); C53(1.04)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C129(1.01); C34(0.86); C245(0.95); C53(0.88)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C129(0.97); C34(0.90); C53(0.88)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C129(0.99); C34(0.99); C245(1.16)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C129(0.95); C34(0.94); C245(1.12); C53(0.93)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C129(0.96); C34(0.90); C245(1.02); C53(1.10)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C129(1.00); C34(0.80); C53(1.03)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C129(1.12); C34(0.81); C245(1.01); C53(1.00)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C129(1.03); C34(0.84); C245(0.87); C53(0.82)  LDD1665  [19]
 LDCM0463  CL70 HEK-293T C129(1.11); C34(0.94); C245(1.18); C53(1.29)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C129(1.05); C34(0.82); C245(1.07); C53(0.90)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C129(1.13); C34(1.01); C53(1.09)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C129(1.07); C34(0.90); C245(1.01); C53(0.86)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C129(0.91); C34(1.02); C53(1.13)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C129(1.02); C34(1.00); C53(1.03)  LDD1672  [19]
 LDCM0470  CL77 HEK-293T C129(0.97); C34(0.93); C245(0.78)  LDD1673  [19]
 LDCM0471  CL78 HEK-293T C129(0.99); C34(0.97); C245(1.16); C53(1.07)  LDD1674  [19]
 LDCM0472  CL79 HEK-293T C129(0.96); C34(0.93); C245(0.85); C53(0.79)  LDD1675  [19]
 LDCM0473  CL8 HEK-293T C129(0.96); C34(0.65); C53(0.88)  LDD1676  [19]
 LDCM0474  CL80 HEK-293T C129(0.98); C34(0.84); C53(1.13)  LDD1677  [19]
 LDCM0475  CL81 HEK-293T C129(1.06); C34(0.97); C245(0.93); C53(0.94)  LDD1678  [19]
 LDCM0476  CL82 HEK-293T C129(1.08); C34(0.96); C245(1.13); C53(1.17)  LDD1679  [19]
 LDCM0477  CL83 HEK-293T C129(1.02); C34(0.93); C245(0.91); C53(0.60)  LDD1680  [19]
 LDCM0478  CL84 HEK-293T C129(1.09); C34(0.98); C53(0.97)  LDD1681  [19]
 LDCM0479  CL85 HEK-293T C129(0.93); C34(0.89); C245(0.83); C53(1.05)  LDD1682  [19]
 LDCM0480  CL86 HEK-293T C129(1.03); C34(0.94); C53(1.00)  LDD1683  [19]
 LDCM0481  CL87 HEK-293T C129(1.02); C34(0.87); C245(0.75); C53(1.04)  LDD1684  [19]
 LDCM0482  CL88 HEK-293T C129(1.07); C34(0.85); C53(1.07)  LDD1685  [19]
 LDCM0483  CL89 HEK-293T C129(0.99); C34(1.03); C245(0.76)  LDD1686  [19]
 LDCM0484  CL9 HEK-293T C129(1.10); C34(0.85); C245(0.98); C53(0.90)  LDD1687  [19]
 LDCM0485  CL90 HEK-293T C129(1.16); C34(0.83); C245(1.08); C53(0.91)  LDD1688  [19]
 LDCM0486  CL91 HEK-293T C129(1.04); C34(0.99); C245(0.75); C53(1.08)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C129(0.93); C34(0.86); C53(0.98)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C129(1.08); C34(0.86); C245(0.76); C53(0.86)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C129(1.10); C34(0.90); C245(1.07); C53(0.97)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C129(1.06); C34(0.86); C245(0.72); C53(0.45)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C129(0.99); C34(0.93); C53(0.95)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C129(0.97); C34(0.87); C245(0.83); C53(0.95)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C129(1.01); C34(0.94); C53(1.10)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C129(1.01); C34(0.93); C245(0.93); C53(0.92)  LDD1697  [19]
 LDCM0634  CY-0357 Hep-G2 C34(0.61)  LDD2228  [9]
 LDCM0495  E2913 HEK-293T C129(0.97); C34(0.88); C245(0.97); C53(0.89)  LDD1698  [19]
 LDCM0625  F8 Ramos C34(0.92)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C34(0.28)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C34(0.18)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C34(0.37)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C34(0.95)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C34(0.86)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C34(0.24)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C34(0.53)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C34(0.42)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C34(0.69)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C34(0.65)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C34(0.62)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C34(0.59)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C34(0.46)  LDD2201  [20]
 LDCM0468  Fragment33 HEK-293T C129(1.00); C34(0.86); C245(1.06); C53(0.99)  LDD1671  [19]
 LDCM0596  Fragment38 Ramos C34(1.21)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C34(0.90)  LDD2184  [20]
 LDCM0427  Fragment51 HEK-293T C129(0.96); C34(0.97); C53(1.16)  LDD1631  [19]
 LDCM0610  Fragment52 Ramos C34(1.89)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C34(0.93)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C34(0.83)  LDD2186  [20]
 LDCM0571  Fragment9 Ramos C34(0.26)  LDD2188  [20]
 LDCM0022  KB02 HEK-293T C129(0.96); C34(0.90); C245(0.79); C53(1.19)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C129(0.94); C34(0.97); C245(0.94); C53(1.20)  LDD1497  [19]
 LDCM0024  KB05 COLO792 C129(2.99); C34(3.66)  LDD3310  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C34(0.73)  LDD2099  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C34(0.74)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C34(1.95)  LDD2144  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BRISC and BRCA1-A complex member 1 (BABAM1) BABAM1 family Q9NWV8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
11 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578