Details of the Target

General Information of Target

Target ID LDTP05622
Target Name Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2)
Gene Name MGAT2
Gene ID 4247
Synonyms
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; EC 2.4.1.143; Beta-1,2-N-acetylglucosaminyltransferase II; GlcNAc-T II; GNT-II; Mannoside acetylglucosaminyltransferase 2; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRFRIYKRKVLILTLVVAACGFVLWSSNGRQRKNEALAPPLLDAEPARGAGGRGGDHPSV
AVGIRRVSNVSAASLVPAVPQPEADNLTLRYRSLVYQLNFDQTLRNVDKAGTWAPRELVL
VVQVHNRPEYLRLLLDSLRKAQGIDNVLVIFSHDFWSTEINQLIAGVNFCPVLQVFFPFS
IQLYPNEFPGSDPRDCPRDLPKNAALKLGCINAEYPDSFGHYREAKFSQTKHHWWWKLHF
VWERVKILRDYAGLILFLEEDHYLAPDFYHVFKKMWKLKQQECPECDVLSLGTYSASRSF
YGMADKVDVKTWKSTEHNMGLALTRNAYQKLIECTDTFCTYDDYNWDWTLQYLTVSCLPK
FWKVLVPQIPRIFHAGDCGMHHKKTCRPSTQSAQIESLLNNNKQYMFPETLTISEKFTVV
AISPPRKNGGWGDIRDHELCKSYRRLQ
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Glycosyltransferase 16 (GT16) protein family
Subcellular location
Golgi apparatus membrane
Function
Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans.
TTD ID
T67812
Uniprot ID
Q10469
DrugMap ID
TTJOW1I
Ensemble ID
ENST00000305386.4
HGNC ID
HGNC:7045
ChEMBL ID
CHEMBL2321630

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K226(6.25); K313(5.56)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0222  [2]
DBIA
 Probe Info  		C378(0.89)  LDD0078  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C210(0.00); C386(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C210(0.00); C386(0.00)  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
AOyne
 Probe Info  		13.00  LDD0443  [7]
NAIA_5
 Probe Info  		C378(0.00); C210(0.00); C440(0.00)  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		10.34  LDD1782  [9]
C094
 Probe Info  		29.86  LDD1785  [9]
C355
 Probe Info  		25.99  LDD2016  [9]
C362
 Probe Info  		31.78  LDD2023  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C378(1.00); C386(0.95)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C378(0.84)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C378(0.75)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C378(0.88)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C378(0.78)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C378(0.86)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C378(0.95)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C378(0.54)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C378(0.64)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C378(0.80)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C378(0.70)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C378(0.78)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C378(0.59)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C378(0.92)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C378(0.90)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C378(0.91)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C378(0.69)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C378(0.83)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C378(0.83)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C378(1.05)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C378(1.14)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C378(0.98)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C378(1.05)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C378(0.73)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C378(2.52)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C378(1.01)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C378(0.93)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C378(0.96)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C378(1.00)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C378(1.25)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C378(0.93)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C378(1.25)  LDD0843  [3]
 LDCM0259  AC14 HEK-293T C378(0.89)  LDD0857  [3]
 LDCM0263  AC143 HEK-293T C378(1.13)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C378(1.56)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C378(1.66)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C378(1.39)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C378(1.30)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C378(1.27)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C378(1.16)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C378(0.87)  LDD0868  [3]
 LDCM0271  AC150 HEK-293T C378(1.30)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C378(1.11)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C378(1.51)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C378(1.41)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C378(1.10)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C378(1.05)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C378(1.10)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C378(1.11)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C378(1.00); C386(0.88)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C378(1.07); C386(0.99)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C378(0.94); C386(1.12)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C378(1.10); C386(1.00)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C378(1.07)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C378(1.09); C386(0.99); C210(1.01)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C378(1.00)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C378(1.03)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C378(1.06)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C378(1.02); C386(0.98)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C378(1.11); C386(1.03)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C378(0.89); C386(1.05)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C378(1.04)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C378(1.02); C386(1.04); C210(1.18)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C378(0.99); C386(1.09)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C378(1.00)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C378(0.98)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C378(1.05)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C378(1.05); C386(1.05)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C378(1.16); C386(1.06)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C378(1.24)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C378(1.31)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C378(1.22)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C378(1.04)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C378(1.16)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C378(1.04)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C378(1.30)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C378(1.26)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C378(1.18)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C378(1.27)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C378(1.30)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C378(1.25)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C378(1.08)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C378(1.06)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C378(1.08)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C378(1.05); C386(0.98)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C378(1.04); C386(0.92); C210(0.88)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C378(1.07); C386(1.04)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C378(0.90); C386(1.05)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C378(1.03)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C378(1.07); C386(1.03); C210(1.13)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C378(1.01)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C378(1.02)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C378(1.08)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C378(1.07); C386(0.97)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C378(1.16); C386(1.11)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C378(1.00); C386(1.09)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C378(0.73)  LDD0921  [3]
 LDCM0324  AC60 HEK-293T C378(1.08)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C378(1.09); C386(1.04); C210(1.02)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C378(1.11)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C378(1.07)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C378(1.11)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C378(0.58)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C378(0.84)  LDD0943  [3]
 LDCM0365  AC98 HEK-293T C378(0.93)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C378(0.79)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C378(0.57)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C378(0.93)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C378(0.79)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C378(0.89)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [2]
 LDCM0367  CL1 HEK-293T C378(1.26)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C378(1.27)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C378(1.09); C386(1.01)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C378(0.67)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C378(0.73)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C378(0.97)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C378(0.98)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C378(1.03)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C378(1.08); C386(0.97); C210(1.19)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C378(1.09)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C378(1.08); C386(1.04)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C378(0.99)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C378(1.05)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C378(1.05); C386(1.11); C210(1.05)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C378(0.99)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C378(1.12); C386(1.09)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C378(1.03)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C378(1.18); C386(1.03); C210(1.51)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C378(0.95)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C378(1.07); C386(0.96)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C378(1.10)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C378(0.97)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C378(1.04)  LDD0987  [3]
 LDCM0390  CL12 HEK-293T C378(1.18)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C378(1.34)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C378(1.04)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C378(1.07); C386(0.99); C210(1.14)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C378(1.06)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C378(1.09); C386(1.13)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C378(1.03)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C378(1.08); C386(1.05); C210(1.11)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C378(1.11)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C378(1.15); C386(1.13)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C378(1.23)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C378(1.19); C386(1.03); C210(1.13)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C378(1.09)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C378(1.08); C386(1.05)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C378(1.11); C386(0.88)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C378(1.10); C386(1.10)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C378(0.98); C386(1.13)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C378(1.18); C386(0.95); C210(1.12)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C378(0.96)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C378(1.26); C386(1.05); C210(1.31)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C378(1.00)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C378(1.04)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C378(1.06)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C378(1.04)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C378(1.06); C386(1.02); C210(1.13)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C378(0.99)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C378(1.11); C386(1.03)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C378(1.03); C386(0.97)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C378(1.01)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C378(1.07); C386(1.03)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C378(0.92); C386(0.95)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C378(1.10)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C378(1.06); C386(1.01); C210(1.32)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C378(0.99)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C378(1.07)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C378(1.09)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C378(0.96)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C378(0.96)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C378(1.21); C386(1.05)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C378(1.11); C386(1.15)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C378(1.01); C386(1.00)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C378(1.06); C386(1.19)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C378(0.80); C386(1.05)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C378(1.05)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C378(1.06); C386(1.11); C210(1.10)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C378(0.96)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C378(0.96)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C378(1.08)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C378(0.99)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C378(0.91); C386(0.95)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C378(1.02); C386(0.96); C210(1.18)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C378(1.06); C386(1.11)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C378(1.07); C386(0.98)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C378(1.13); C386(0.91)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C378(0.91); C386(1.05)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C378(1.08)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C378(1.10); C386(1.23); C210(1.21)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C378(1.01)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C378(1.05)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C378(1.06); C386(0.84)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C378(1.12)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C378(1.23)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C378(1.06)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C378(1.11)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C378(1.21)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C378(1.14)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C378(1.19)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C378(1.22)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C378(1.61)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C378(1.21)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C378(1.12); C386(1.07)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C378(1.36)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C378(1.39)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C378(1.21)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C378(1.21)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C378(1.32)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C378(1.19); C386(1.06)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C378(1.00); C386(1.02)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C378(1.04); C386(1.08)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C378(0.89); C386(0.99)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C378(1.32)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C378(0.97)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C378(1.11); C386(1.09); C210(1.37)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C378(1.01)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C378(1.10)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C378(1.08)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C378(0.98)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C378(0.98); C386(1.07); C210(1.11)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C378(1.03)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C378(1.03); C386(1.17)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C378(1.03); C386(1.09)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C378(1.18); C386(1.16); C210(1.05)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C378(1.27); C386(0.95)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C378(0.99); C386(0.99)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C378(1.05)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C378(1.01); C386(1.01); C210(1.05)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C378(1.01)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C378(1.29)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C378(1.09)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C378(1.05)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C378(1.01); C386(0.96); C210(1.28)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C378(1.00)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C378(0.92)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C378(1.03)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C378(0.95); C386(0.99); C210(1.23)  LDD1631  [10]
 LDCM0022  KB02 HCT 116 C378(1.48)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C378(1.14)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C378(1.30)  LDD0082  [3]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Patented
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Bicyclic Pyrimidine Derivative 1 Small molecular drug D0RC4W
Dihydropyrimidinone Derivative 3 Small molecular drug D0F2KN
Dihydropyrimidinone Derivative 4 Small molecular drug D0U2WQ
N-containing Heterocyclic Derivative 1 Small molecular drug D0NY3W
Phenylmethanesulfonamide Derivative 1 Small molecular drug D0B7JY
Pyrimidine-4(3h)-one Derivative 1 Small molecular drug D0MH7K

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402