Details of the Target

General Information of Target

Target ID LDTP06272
Target Name Pre-mRNA-splicing regulator WTAP (WTAP)
Gene Name WTAP
Gene ID 9589
Synonyms
KIAA0105; Pre-mRNA-splicing regulator WTAP; Female-lethal(2)D homolog; hFL(2)D; WT1-associated protein; Wilms tumor 1-associating protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTNEEPLPKKVRLSETDFKVMARDELILRWKQYEAYVQALEGKYTDLNSNDVTGLRESEE
KLKQQQQESARRENILVMRLATKEQEMQECTTQIQYLKQVQQPSVAQLRSTMVDPAINLF
FLKMKGELEQTKDKLEQAQNELSAWKFTPDSQTGKKLMAKCRMLIQENQELGRQLSQGRI
AQLEAELALQKKYSEELKSSQDELNDFIIQLDEEVEGMQSTILVLQQQLKETRQQLAQYQ
QQQSQASAPSTSRTTASEPVEQSEATSKDCSRLTNGPSNGSSSRQRTSGSGFHREGNTTE
DDFPSSPGNGNKSSNSSEERTGRGGSGYVNQLSAGYESVDSPTGSENSLTHQSNDTDSSH
DPQEEKAVSGKGNRTVGSRHVQNGLDSSVNVQGSVL
Target Bioclass
Other
Family
Fl(2)d family
Subcellular location
Nucleus speckle
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Required for accumulation of METTL3 and METTL14 to nuclear speckle. Acts as a mRNA splicing regulator. Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability. Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes.
Uniprot ID
Q15007
Ensemble ID
ENST00000337387.4
HGNC ID
HGNC:16846
ChEMBL ID
CHEMBL4523298

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.A159V .
HT115 SNV: p.R12Ter .
IM95 SNV: p.T148M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y96(20.00)  LDD0260  [2]
STPyne
 Probe Info  		K19(5.27)  LDD0277  [3]
Probe 1
 Probe Info  		Y44(18.07); Y239(8,931.42)  LDD3495  [4]
BTD
 Probe Info  		C270(0.68)  LDD2124  [5]
NAIA_5
 Probe Info  		C270(1.06)  LDD2227  [6]
DBIA
 Probe Info  		C90(76.70)  LDD0209  [7]
HHS-475
 Probe Info  		Y239(0.35); Y96(0.84)  LDD0264  [8]
Acrolein
 Probe Info  		N.A.  LDD0222  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0025  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
TFBX
 Probe Info  		C270(0.00); C90(0.00)  LDD0027  [12]
Phosphinate-6
 Probe Info  		C90(0.00); C270(0.00); C161(0.00)  LDD0018  [13]
AOyne
 Probe Info  		13.90  LDD0443  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C355
 Probe Info  		22.94  LDD2016  [15]
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C90(0.96)  LDD0531  [17]
 LDCM0215  AC10 HEK-293T C90(0.95)  LDD1508  [18]
 LDCM0216  AC100 HCT 116 C90(1.07)  LDD0533  [17]
 LDCM0217  AC101 HCT 116 C90(1.13)  LDD0534  [17]
 LDCM0218  AC102 HCT 116 C90(1.11)  LDD0535  [17]
 LDCM0219  AC103 HCT 116 C90(1.25)  LDD0536  [17]
 LDCM0220  AC104 HCT 116 C90(1.11)  LDD0537  [17]
 LDCM0221  AC105 HCT 116 C90(1.37)  LDD0538  [17]
 LDCM0222  AC106 HCT 116 C90(1.19)  LDD0539  [17]
 LDCM0223  AC107 HCT 116 C90(1.10)  LDD0540  [17]
 LDCM0224  AC108 HCT 116 C90(0.94)  LDD0541  [17]
 LDCM0225  AC109 HCT 116 C90(0.95)  LDD0542  [17]
 LDCM0226  AC11 HEK-293T C90(0.98)  LDD1509  [18]
 LDCM0227  AC110 HCT 116 C90(1.11)  LDD0544  [17]
 LDCM0228  AC111 HCT 116 C90(1.01)  LDD0545  [17]
 LDCM0229  AC112 HCT 116 C90(1.07)  LDD0546  [17]
 LDCM0230  AC113 HCT 116 C90(1.03)  LDD0547  [17]
 LDCM0231  AC114 HCT 116 C90(0.99)  LDD0548  [17]
 LDCM0232  AC115 HCT 116 C90(1.26)  LDD0549  [17]
 LDCM0233  AC116 HCT 116 C90(1.21)  LDD0550  [17]
 LDCM0234  AC117 HCT 116 C90(1.00)  LDD0551  [17]
 LDCM0235  AC118 HCT 116 C90(1.05)  LDD0552  [17]
 LDCM0236  AC119 HCT 116 C90(1.10)  LDD0553  [17]
 LDCM0237  AC12 HEK-293T C90(0.93)  LDD1510  [18]
 LDCM0238  AC120 HCT 116 C90(1.17)  LDD0555  [17]
 LDCM0239  AC121 HCT 116 C90(0.92)  LDD0556  [17]
 LDCM0240  AC122 HCT 116 C90(0.94)  LDD0557  [17]
 LDCM0241  AC123 HCT 116 C90(0.98)  LDD0558  [17]
 LDCM0242  AC124 HCT 116 C90(0.94)  LDD0559  [17]
 LDCM0243  AC125 HCT 116 C90(0.99)  LDD0560  [17]
 LDCM0244  AC126 HCT 116 C90(1.20)  LDD0561  [17]
 LDCM0245  AC127 HCT 116 C90(1.14)  LDD0562  [17]
 LDCM0246  AC128 HCT 116 C90(1.27)  LDD0563  [17]
 LDCM0247  AC129 HCT 116 C90(0.70)  LDD0564  [17]
 LDCM0249  AC130 HCT 116 C90(0.85)  LDD0566  [17]
 LDCM0250  AC131 HCT 116 C90(0.79)  LDD0567  [17]
 LDCM0251  AC132 HCT 116 C90(0.86)  LDD0568  [17]
 LDCM0252  AC133 HCT 116 C90(0.94)  LDD0569  [17]
 LDCM0253  AC134 HCT 116 C90(0.92)  LDD0570  [17]
 LDCM0254  AC135 HCT 116 C90(0.85)  LDD0571  [17]
 LDCM0255  AC136 HCT 116 C90(0.87)  LDD0572  [17]
 LDCM0256  AC137 HCT 116 C90(0.87)  LDD0573  [17]
 LDCM0257  AC138 HCT 116 C90(0.82)  LDD0574  [17]
 LDCM0258  AC139 HCT 116 C90(0.87)  LDD0575  [17]
 LDCM0259  AC14 HEK-293T C90(0.95)  LDD1512  [18]
 LDCM0260  AC140 HCT 116 C90(0.85)  LDD0577  [17]
 LDCM0261  AC141 HCT 116 C90(0.75)  LDD0578  [17]
 LDCM0262  AC142 HCT 116 C90(0.79)  LDD0579  [17]
 LDCM0263  AC143 HCT 116 C90(1.03)  LDD0580  [17]
 LDCM0264  AC144 HCT 116 C90(1.01)  LDD0581  [17]
 LDCM0265  AC145 HCT 116 C90(1.00)  LDD0582  [17]
 LDCM0266  AC146 HCT 116 C90(0.96)  LDD0583  [17]
 LDCM0267  AC147 HCT 116 C90(1.09)  LDD0584  [17]
 LDCM0268  AC148 HCT 116 C90(1.30)  LDD0585  [17]
 LDCM0269  AC149 HCT 116 C90(1.11)  LDD0586  [17]
 LDCM0270  AC15 HEK-293T C90(0.90)  LDD1513  [18]
 LDCM0271  AC150 HCT 116 C90(0.97)  LDD0588  [17]
 LDCM0272  AC151 HCT 116 C90(0.90)  LDD0589  [17]
 LDCM0273  AC152 HCT 116 C90(1.13)  LDD0590  [17]
 LDCM0274  AC153 HCT 116 C90(1.69)  LDD0591  [17]
 LDCM0621  AC154 HCT 116 C90(1.18)  LDD2158  [17]
 LDCM0622  AC155 HCT 116 C90(1.09)  LDD2159  [17]
 LDCM0623  AC156 HCT 116 C90(1.03)  LDD2160  [17]
 LDCM0624  AC157 HCT 116 C90(1.03)  LDD2161  [17]
 LDCM0276  AC17 HCT 116 C90(0.65)  LDD0593  [17]
 LDCM0277  AC18 HCT 116 C90(0.52)  LDD0594  [17]
 LDCM0278  AC19 HCT 116 C90(0.56)  LDD0595  [17]
 LDCM0279  AC2 HCT 116 C90(0.84)  LDD0596  [17]
 LDCM0280  AC20 HCT 116 C90(0.86)  LDD0597  [17]
 LDCM0281  AC21 HCT 116 C90(0.69)  LDD0598  [17]
 LDCM0282  AC22 HCT 116 C90(0.94)  LDD0599  [17]
 LDCM0283  AC23 HCT 116 C90(0.67)  LDD0600  [17]
 LDCM0284  AC24 HCT 116 C90(0.66)  LDD0601  [17]
 LDCM0285  AC25 HEK-293T C90(1.03)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C90(0.90)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C90(1.06)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C90(1.04)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C90(0.98)  LDD1528  [18]
 LDCM0290  AC3 HCT 116 C90(1.06)  LDD0607  [17]
 LDCM0291  AC30 HEK-293T C90(1.17)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C90(0.93)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C90(1.23)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C90(0.84)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C90(0.85)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C90(0.99)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C90(0.98)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C90(1.03)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C90(1.10)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C90(1.01)  LDD1539  [18]
 LDCM0301  AC4 HCT 116 C90(1.04)  LDD0618  [17]
 LDCM0302  AC40 HEK-293T C90(0.87)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C90(0.88)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C90(0.88)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C90(0.97)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C90(1.02)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C90(1.09)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C90(1.07)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C90(0.88)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C90(1.01)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C90(0.96)  LDD1550  [18]
 LDCM0312  AC5 HCT 116 C90(0.90)  LDD0629  [17]
 LDCM0313  AC50 HEK-293T C90(0.98)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C90(1.06)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C90(1.12)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C90(1.04)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C90(1.03)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C90(1.00)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C90(0.98)  LDD1558  [18]
 LDCM0320  AC57 HCT 116 C90(1.13)  LDD0637  [17]
 LDCM0321  AC58 HCT 116 C90(0.90)  LDD0638  [17]
 LDCM0322  AC59 HCT 116 C90(0.88)  LDD0639  [17]
 LDCM0323  AC6 HEK-293T C90(1.04)  LDD1562  [18]
 LDCM0324  AC60 HCT 116 C90(0.91)  LDD0641  [17]
 LDCM0325  AC61 HCT 116 C90(0.77)  LDD0642  [17]
 LDCM0326  AC62 HCT 116 C90(1.08)  LDD0643  [17]
 LDCM0327  AC63 HCT 116 C90(0.91)  LDD0644  [17]
 LDCM0328  AC64 HCT 116 C90(0.94)  LDD0645  [17]
 LDCM0329  AC65 HCT 116 C90(0.59)  LDD0646  [17]
 LDCM0330  AC66 HCT 116 C90(0.51)  LDD0647  [17]
 LDCM0331  AC67 HCT 116 C90(0.58)  LDD0648  [17]
 LDCM0334  AC7 HEK-293T C90(0.91)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C90(0.92)  LDD1569  [18]
 LDCM0349  AC83 HCT 116 C90(1.20)  LDD0666  [17]
 LDCM0350  AC84 HCT 116 C90(1.24)  LDD0667  [17]
 LDCM0351  AC85 HCT 116 C90(1.08)  LDD0668  [17]
 LDCM0352  AC86 HCT 116 C90(1.22)  LDD0669  [17]
 LDCM0353  AC87 HCT 116 C90(1.24)  LDD0670  [17]
 LDCM0354  AC88 HCT 116 C90(1.21)  LDD0671  [17]
 LDCM0355  AC89 HCT 116 C90(1.19)  LDD0672  [17]
 LDCM0357  AC90 HCT 116 C90(0.83)  LDD0674  [17]
 LDCM0358  AC91 HCT 116 C90(1.20)  LDD0675  [17]
 LDCM0359  AC92 HCT 116 C90(1.22)  LDD0676  [17]
 LDCM0360  AC93 HCT 116 C90(1.09)  LDD0677  [17]
 LDCM0361  AC94 HCT 116 C90(1.13)  LDD0678  [17]
 LDCM0362  AC95 HCT 116 C90(1.12)  LDD0679  [17]
 LDCM0363  AC96 HCT 116 C90(1.30)  LDD0680  [17]
 LDCM0364  AC97 HCT 116 C90(1.30)  LDD0681  [17]
 LDCM0365  AC98 HCT 116 C90(1.08)  LDD0682  [17]
 LDCM0366  AC99 HCT 116 C90(0.95)  LDD0683  [17]
 LDCM0248  AKOS034007472 HEK-293T C90(0.94)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C90(0.92)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C90(0.92)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 11.75  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0632  CL-Sc Hep-G2 C270(1.06)  LDD2227  [6]
 LDCM0367  CL1 HCT 116 C90(0.83)  LDD0684  [17]
 LDCM0368  CL10 HCT 116 C90(0.73)  LDD0685  [17]
 LDCM0369  CL100 HCT 116 C90(0.97)  LDD0686  [17]
 LDCM0370  CL101 HEK-293T C90(0.95)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C90(0.84)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C90(1.05)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C90(1.02)  LDD1577  [18]
 LDCM0374  CL105 HCT 116 C90(0.58)  LDD0691  [17]
 LDCM0375  CL106 HCT 116 C90(0.84)  LDD0692  [17]
 LDCM0376  CL107 HCT 116 C90(0.62)  LDD0693  [17]
 LDCM0377  CL108 HCT 116 C90(0.75)  LDD0694  [17]
 LDCM0378  CL109 HCT 116 C90(0.84)  LDD0695  [17]
 LDCM0379  CL11 HCT 116 C90(0.82)  LDD0696  [17]
 LDCM0380  CL110 HCT 116 C90(0.59)  LDD0697  [17]
 LDCM0381  CL111 HCT 116 C90(0.59)  LDD0698  [17]
 LDCM0382  CL112 HEK-293T C90(0.97)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C90(1.07)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C90(0.82)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C90(0.86)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C90(1.11)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C90(1.00)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C90(0.91)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C90(0.96)  LDD1593  [18]
 LDCM0390  CL12 HCT 116 C90(0.91)  LDD0707  [17]
 LDCM0391  CL120 HEK-293T C90(1.14)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C90(0.99)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C90(0.89)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C90(1.09)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C90(1.04)  LDD1599  [18]
 LDCM0396  CL125 HCT 116 C90(0.83)  LDD0713  [17]
 LDCM0397  CL126 HCT 116 C90(1.23)  LDD0714  [17]
 LDCM0398  CL127 HCT 116 C90(0.99)  LDD0715  [17]
 LDCM0399  CL128 HCT 116 C90(1.15)  LDD0716  [17]
 LDCM0400  CL13 HCT 116 C90(0.81)  LDD0717  [17]
 LDCM0401  CL14 HCT 116 C90(0.80)  LDD0718  [17]
 LDCM0402  CL15 HCT 116 C90(0.83)  LDD0719  [17]
 LDCM0403  CL16 HCT 116 C90(1.04)  LDD0720  [17]
 LDCM0404  CL17 HCT 116 C90(1.25)  LDD0721  [17]
 LDCM0405  CL18 HCT 116 C90(0.92)  LDD0722  [17]
 LDCM0406  CL19 HCT 116 C90(1.03)  LDD0723  [17]
 LDCM0407  CL2 HCT 116 C90(0.96)  LDD0724  [17]
 LDCM0408  CL20 HCT 116 C90(0.91)  LDD0725  [17]
 LDCM0409  CL21 HCT 116 C90(1.41)  LDD0726  [17]
 LDCM0410  CL22 HCT 116 C90(0.90)  LDD0727  [17]
 LDCM0411  CL23 HCT 116 C90(1.03)  LDD0728  [17]
 LDCM0412  CL24 HCT 116 C90(1.19)  LDD0729  [17]
 LDCM0413  CL25 HCT 116 C90(0.85)  LDD0730  [17]
 LDCM0414  CL26 HCT 116 C90(0.97)  LDD0731  [17]
 LDCM0415  CL27 HCT 116 C90(0.94)  LDD0732  [17]
 LDCM0416  CL28 HCT 116 C90(0.90)  LDD0733  [17]
 LDCM0417  CL29 HCT 116 C90(0.93)  LDD0734  [17]
 LDCM0418  CL3 HCT 116 C90(0.82)  LDD0735  [17]
 LDCM0419  CL30 HCT 116 C90(1.08)  LDD0736  [17]
 LDCM0420  CL31 HEK-293T C90(1.03)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C90(1.06)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C90(1.00)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C90(1.02)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C90(1.01)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C90(1.36)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C90(1.10)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C90(0.91)  LDD1632  [18]
 LDCM0429  CL4 HCT 116 C90(1.01)  LDD0746  [17]
 LDCM0430  CL40 HEK-293T C90(1.05)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C90(0.98)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C90(0.94)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C90(1.21)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C90(1.11)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C90(0.88)  LDD1639  [18]
 LDCM0436  CL46 HCT 116 C90(1.02)  LDD0753  [17]
 LDCM0437  CL47 HCT 116 C90(0.98)  LDD0754  [17]
 LDCM0438  CL48 HCT 116 C90(0.89)  LDD0755  [17]
 LDCM0439  CL49 HCT 116 C90(0.83)  LDD0756  [17]
 LDCM0440  CL5 HCT 116 C90(0.83)  LDD0757  [17]
 LDCM0441  CL50 HCT 116 C90(1.04)  LDD0758  [17]
 LDCM0442  CL51 HCT 116 C90(1.07)  LDD0759  [17]
 LDCM0443  CL52 HCT 116 C90(1.09)  LDD0760  [17]
 LDCM0444  CL53 HCT 116 C90(1.08)  LDD0761  [17]
 LDCM0445  CL54 HCT 116 C90(0.81)  LDD0762  [17]
 LDCM0446  CL55 HCT 116 C90(0.81)  LDD0763  [17]
 LDCM0447  CL56 HCT 116 C90(1.05)  LDD0764  [17]
 LDCM0448  CL57 HCT 116 C90(1.13)  LDD0765  [17]
 LDCM0449  CL58 HCT 116 C90(1.16)  LDD0766  [17]
 LDCM0450  CL59 HCT 116 C90(1.06)  LDD0767  [17]
 LDCM0451  CL6 HCT 116 C90(0.87)  LDD0768  [17]
 LDCM0452  CL60 HCT 116 C90(0.98)  LDD0769  [17]
 LDCM0453  CL61 HCT 116 C90(0.85)  LDD0770  [17]
 LDCM0454  CL62 HCT 116 C90(0.59)  LDD0771  [17]
 LDCM0455  CL63 HCT 116 C90(0.63)  LDD0772  [17]
 LDCM0456  CL64 HCT 116 C90(0.87)  LDD0773  [17]
 LDCM0457  CL65 HCT 116 C90(1.03)  LDD0774  [17]
 LDCM0458  CL66 HCT 116 C90(0.78)  LDD0775  [17]
 LDCM0459  CL67 HCT 116 C90(0.62)  LDD0776  [17]
 LDCM0460  CL68 HCT 116 C90(0.73)  LDD0777  [17]
 LDCM0461  CL69 HCT 116 C90(0.73)  LDD0778  [17]
 LDCM0462  CL7 HCT 116 C90(0.84)  LDD0779  [17]
 LDCM0463  CL70 HCT 116 C90(0.75)  LDD0780  [17]
 LDCM0464  CL71 HCT 116 C90(0.77)  LDD0781  [17]
 LDCM0465  CL72 HCT 116 C90(0.69)  LDD0782  [17]
 LDCM0466  CL73 HCT 116 C90(0.65)  LDD0783  [17]
 LDCM0467  CL74 HCT 116 C90(0.72)  LDD0784  [17]
 LDCM0469  CL76 HEK-293T C90(1.13)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C90(0.92)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C90(0.99)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C90(0.98)  LDD1675  [18]
 LDCM0473  CL8 HCT 116 C90(0.72)  LDD0790  [17]
 LDCM0474  CL80 HEK-293T C90(0.94)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C90(0.98)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C90(1.11)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C90(0.88)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C90(1.02)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C90(1.02)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C90(0.90)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C90(0.85)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C90(1.02)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C90(0.91)  LDD1686  [18]
 LDCM0484  CL9 HCT 116 C90(0.79)  LDD0801  [17]
 LDCM0485  CL90 HEK-293T C90(0.87)  LDD1688  [18]
 LDCM0486  CL91 HCT 116 C90(1.01)  LDD0803  [17]
 LDCM0487  CL92 HCT 116 C90(1.12)  LDD0804  [17]
 LDCM0488  CL93 HCT 116 C90(1.32)  LDD0805  [17]
 LDCM0489  CL94 HCT 116 C90(0.99)  LDD0806  [17]
 LDCM0490  CL95 HCT 116 C90(0.94)  LDD0807  [17]
 LDCM0491  CL96 HCT 116 C90(0.95)  LDD0808  [17]
 LDCM0492  CL97 HCT 116 C90(0.90)  LDD0809  [17]
 LDCM0493  CL98 HCT 116 C90(1.02)  LDD0810  [17]
 LDCM0494  CL99 HCT 116 C90(1.07)  LDD0811  [17]
 LDCM0495  E2913 HEK-293T C90(0.90)  LDD1698  [18]
 LDCM0625  F8 Ramos C270(1.38)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C270(1.37)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C270(1.85)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C270(0.68)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C270(0.89)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C270(0.74)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C270(0.51)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C270(0.77)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C270(0.70)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C270(0.73)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C270(0.64)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C270(1.07)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C270(0.93)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C270(1.50)  LDD2201  [19]
 LDCM0468  Fragment33 HCT 116 C90(0.86)  LDD0785  [17]
 LDCM0596  Fragment38 Ramos C270(0.74)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C270(0.85)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C90(0.90)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C270(1.12)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C270(1.58)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C270(0.84)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C270(0.77)  LDD2188  [19]
 LDCM0116  HHS-0101 DM93 Y239(0.35); Y96(0.84)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y96(1.06); Y239(1.14)  LDD0265  [8]
 LDCM0119  HHS-0401 DM93 Y96(0.61); Y239(4.02)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y239(0.44); Y96(1.45)  LDD0268  [8]
 LDCM0022  KB02 HEK-293T C90(1.01)  LDD1492  [18]
 LDCM0023  KB03 Jurkat C90(76.70)  LDD0209  [7]
 LDCM0024  KB05 SKMEL24 C90(2.74)  LDD3323  [20]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C270(0.68)  LDD2124  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein ABHD15 (ABHD15) AB hydrolase 4 family Q6UXT9
Cathepsin D (CTSD) Peptidase A1 family P07339
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Serine protease HTRA2, mitochondrial (HTRA2) Peptidase S1C family O43464
Proteasome subunit alpha type-1 (PSMA1) Peptidase T1A family P25786
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Ataxin-3 (ATXN3) . P54252
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Zinc finger protein 239 (ZNF239) Krueppel C2H2-type zinc-finger protein family Q16600
Zinc finger protein 572 (ZNF572) Krueppel C2H2-type zinc-finger protein family Q7Z3I7
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bystin (BYSL) Bystin family Q13895
Pre-mRNA-splicing regulator WTAP (WTAP) Fl(2)d family Q15007
Peripherin (PRPH) Intermediate filament family P41219
N6-adenosine-methyltransferase non-catalytic subunit (METTL14) MT-A70-like family Q9HCE5
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Melanoma-associated antigen 11 (MAGEA11) . P43364
SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP) . Q9GZT3
TNFAIP3-interacting protein 1 (TNIP1) . Q15025

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840