Details of the Target

General Information of Target

Target ID LDTP00208
Target Name AP-4 complex subunit mu-1 (AP4M1)
Gene Name AP4M1
Gene ID 9179
Synonyms
MUARP2; AP-4 complex subunit mu-1; AP-4 adaptor complex mu subunit; Adaptor-related protein complex 4 subunit mu-1; Mu subunit of AP-4; Mu-adaptin-related protein 2; mu-ARP2; Mu4-adaptin; mu4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR
HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG
YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE
LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP
SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA
LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ
VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
Target Bioclass
Transporter and channel
Family
Adaptor complexes medium subunit family
Subcellular location
Golgi apparatus, trans-Golgi network membrane
Function
Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos. The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal.
Uniprot ID
O00189
Ensemble ID
ENST00000359593.9
HGNC ID
HGNC:574

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.66  LDD0402  [1]
DBIA
 Probe Info  		C431(0.95)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD0005  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		16.56  LDD1752  [7]
C355
 Probe Info  		36.25  LDD2016  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C431(0.95)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C431(0.85)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C431(0.80)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C431(0.91)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C431(0.66)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C431(1.28)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C431(1.13)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C431(1.34)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C431(1.02)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C431(1.10)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C431(1.40)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C431(0.98)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C431(0.74)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C431(0.93)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C431(0.88)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C431(0.92)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C431(1.44)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C431(1.12)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C431(1.07)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C431(0.99)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C431(1.21)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C431(0.87); C94(0.94)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C94(0.56); C431(0.84)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C94(0.74); C431(0.84)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C431(1.02)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C431(0.92); C94(1.19)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C431(0.83); C94(0.85)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C431(0.89); C94(0.94)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C94(0.77); C431(1.02)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C431(0.87); C94(0.90)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C431(1.02)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C431(1.03); C235(1.08)  LDD1525  [8]
 LDCM0287  AC27 HEK-293T C431(0.95); C94(0.95); C235(1.00)  LDD1526  [8]
 LDCM0288  AC28 HEK-293T C431(0.97); C235(1.06)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C431(0.97); C94(0.82)  LDD1528  [8]
 LDCM0290  AC3 HCT 116 C431(1.02)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C431(0.92); C94(0.72); C235(1.11)  LDD1530  [8]
 LDCM0292  AC31 HEK-293T C431(0.95); C94(0.99); C235(0.94)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C431(0.99); C235(1.04)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C431(1.02)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C431(1.00); C235(0.96)  LDD1534  [8]
 LDCM0296  AC35 HEK-293T C431(1.03); C94(0.96); C235(0.99)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C431(0.97); C235(0.90)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C431(0.90); C94(1.13)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C431(0.94); C94(0.88); C235(1.08)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C431(0.99); C94(0.80); C235(1.02)  LDD1539  [8]
 LDCM0301  AC4 HCT 116 C431(1.12)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C431(1.03); C235(1.13)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C431(1.04)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C431(1.01); C235(1.02)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C431(0.99); C94(1.22); C235(1.08)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C431(0.95); C235(1.05)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C431(0.94); C94(0.95)  LDD1546  [8]
 LDCM0308  AC46 HCT 116 C431(1.29)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C431(1.34)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C431(1.28)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C431(1.20)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C431(1.10)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C431(1.34)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C431(1.25)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C431(1.16)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C431(1.02)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C431(1.28)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C431(0.90)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C431(1.08)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C431(1.06)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C431(0.92); C235(1.01)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C431(0.99); C94(1.01); C235(1.01)  LDD1561  [8]
 LDCM0323  AC6 HCT 116 C431(1.01)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C431(1.00); C235(0.96)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C431(0.95); C94(0.82)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C431(1.00); C94(0.79); C235(1.03)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C431(0.99); C94(0.80); C235(1.00)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C431(1.01); C235(1.08)  LDD1567  [8]
 LDCM0334  AC7 HCT 116 C431(0.98)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C431(0.93)  LDD0662  [2]
 LDCM0248  AKOS034007472 HCT 116 C431(0.77)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C431(0.85)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C431(0.90)  LDD0592  [2]
 LDCM0156  Aniline NCI-H1299 6.77  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C94(0.96); C431(1.08)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C94(0.92); C431(0.96)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C431(1.08)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C431(0.94)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C431(1.12)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C431(0.97)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C431(0.93)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C431(0.85); C94(0.98)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C431(0.78); C94(0.84)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C431(0.82); C94(0.93)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C431(0.77); C94(1.28)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C431(0.90); C94(0.99)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C431(0.99); C94(1.14)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C431(0.92); C94(0.94)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C94(0.81); C431(0.98)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C431(1.15)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C431(0.96); C94(1.04)  LDD1587  [8]
 LDCM0384  CL114 HEK-293T C431(1.02)  LDD1588  [8]
 LDCM0385  CL115 HEK-293T C431(1.05); C94(0.75)  LDD1589  [8]
 LDCM0386  CL116 HEK-293T C431(1.00)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C431(1.02); C94(1.19)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C431(0.97)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C431(0.98); C94(0.83)  LDD1593  [8]
 LDCM0390  CL12 HCT 116 C431(0.90); C94(1.57)  LDD0707  [2]
 LDCM0391  CL120 HEK-293T C431(0.98)  LDD1595  [8]
 LDCM0392  CL121 HCT 116 C431(1.09)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C431(1.10)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C431(1.47)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C431(1.32)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C431(1.12); C94(1.29)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C431(0.96)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C431(1.06); C94(0.86)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C431(1.01)  LDD1603  [8]
 LDCM0400  CL13 HCT 116 C431(0.94); C94(1.08)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C431(0.98); C94(1.30)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C431(1.20); C94(1.46)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C94(0.59)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C94(0.76)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C94(0.70)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C94(0.73)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C431(1.07); C94(1.33)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C94(0.63)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C94(0.81)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C94(1.05)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C94(0.91)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C94(0.85)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C94(0.86)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C94(0.73)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C94(1.02)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C94(0.82)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C94(0.84)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C431(1.05); C94(0.95)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C94(0.71)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C431(1.17)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C431(1.01)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C431(1.06)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C431(1.13)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C431(1.14)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C431(1.10)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C431(0.95)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C431(0.78)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C431(1.48); C94(1.22)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C431(1.39)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C431(0.94)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C431(0.95)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C431(0.92)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C431(0.87)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C431(1.02)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C431(0.95); C94(1.17)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C431(1.00); C94(0.98)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C431(0.83); C94(1.25)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C431(0.87); C94(1.43)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C431(0.95); C94(1.38)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C431(0.89); C94(1.15)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C431(1.01); C94(1.11)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C431(0.85); C94(1.27)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C431(0.88); C94(0.87)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C431(0.85); C94(1.28)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C431(0.71); C94(1.19)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C431(0.87); C94(0.92)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C431(0.87); C94(1.09)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C431(0.75); C94(1.35)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C431(0.87); C94(1.26)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C431(0.98); C94(1.23)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C431(0.87); C94(1.12)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C431(1.10)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C431(1.22)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C431(1.17)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C431(1.05)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C431(1.08)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C431(1.06)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C431(0.93)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C431(1.13)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C431(1.14)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C431(1.02); C94(1.49)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C431(0.86)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C431(1.07)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C431(1.02)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C431(1.09)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C431(0.98)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C94(0.64)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C94(0.61)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C94(0.58)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C94(0.83)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C431(0.91); C94(1.33)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C94(0.63)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C94(0.90)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C94(0.54)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C94(0.90)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C94(0.67)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C94(0.66)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C94(0.96)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C94(1.09)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C94(0.87)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C94(0.77)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C431(1.13); C94(1.30)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C94(0.83)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C431(1.10)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C431(1.01)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C431(1.01)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C431(1.23)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C431(1.25)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C431(1.10)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C431(1.11)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C431(1.15)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C431(0.98)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C431(1.12); C94(0.88)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C431(2.61)  LDD1702  [9]
 LDCM0625  F8 Ramos C235(0.87); C431(2.06)  LDD2187  [10]
 LDCM0572  Fragment10 Ramos C235(1.01)  LDD2189  [10]
 LDCM0573  Fragment11 Ramos C235(0.28)  LDD2190  [10]
 LDCM0574  Fragment12 Ramos C235(0.87); C431(1.16)  LDD2191  [10]
 LDCM0575  Fragment13 Ramos C235(1.17); C431(1.24)  LDD2192  [10]
 LDCM0576  Fragment14 Ramos C235(0.59); C431(0.79)  LDD2193  [10]
 LDCM0579  Fragment20 Ramos C235(1.25); C431(1.79)  LDD2194  [10]
 LDCM0580  Fragment21 Ramos C235(1.77); C431(1.31)  LDD2195  [10]
 LDCM0582  Fragment23 Ramos C431(1.48)  LDD2196  [10]
 LDCM0578  Fragment27 Ramos C235(1.20); C431(1.05)  LDD2197  [10]
 LDCM0586  Fragment28 Ramos C235(1.04); C431(0.64)  LDD2198  [10]
 LDCM0588  Fragment30 Ramos C235(1.06); C431(1.18)  LDD2199  [10]
 LDCM0589  Fragment31 Ramos C235(1.22); C431(1.03)  LDD2200  [10]
 LDCM0590  Fragment32 Ramos C235(1.10); C431(2.09)  LDD2201  [10]
 LDCM0468  Fragment33 HCT 116 C431(0.98)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C235(1.32); C431(2.57)  LDD2203  [10]
 LDCM0566  Fragment4 Ramos C235(0.88); C431(1.09)  LDD2184  [10]
 LDCM0427  Fragment51 HCT 116 C431(2.15)  LDD0744  [2]
 LDCM0610  Fragment52 Ramos C431(1.45)  LDD2204  [10]
 LDCM0614  Fragment56 Ramos C235(0.91); C431(0.96)  LDD2205  [10]
 LDCM0569  Fragment7 Ramos C235(0.78); C431(1.68)  LDD2186  [10]
 LDCM0571  Fragment9 Ramos C235(0.87); C431(1.17)  LDD2188  [10]
 LDCM0022  KB02 HEK-293T C431(1.03)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C431(1.01)  LDD1497  [8]
 LDCM0024  KB05 COLO792 C416(2.68)  LDD3310  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 47 (USP47) Peptidase C19 family Q96K76
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) Protein prenyltransferase subunit alpha family P49354

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840